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1. 发明授权

US08637109B2 Manufacturing methods for covering endoluminal prostheses 有权
标题翻译：用于覆盖腔内假体的制造方法
公开(公告)号：US08637109B2
公开(公告)日：2014-01-28
申请号：US12959023
申请日：2010-12-02
申请人： David Grewe , Blayne Roeder , Steven Charlebois , Adam Griebel
发明人： David Grewe , Blayne Roeder , Steven Charlebois , Adam Griebel
IPC分类号： B05D1/32 , B05D1/16
CPC分类号： B05D1/007 , D01D5/0069 , D01D5/0076
摘要： The disclosure relates to a method for coating a target. The method includes providing a target and an electrospinning apparatus. The target comprises a first surface and an opposing second surface. The electrospinning apparatus comprises a mandrel, a mask including an aperture, a reservoir loaded with a solution, and an orifice fluidly coupled to the reservoir. The mandrel is located adjacent the target second surface. The orifice is located at a distance from the target first surface. The mask is located intermediate the orifice and the target first surface. The solution is electrospun through the mask aperture onto the target first surface. In one example the target is an endoluminal prosthesis.
摘要翻译：本公开涉及涂覆靶的方法。该方法包括提供靶和静电纺丝装置。靶包括第一表面和相对的第二表面。静电纺丝装置包括心轴，包括孔的掩模，装有溶液的储存器和流体耦合到储存器的孔。心轴位于目标第二表面附近。孔口位于离目标第一表面一定距离处。掩模位于孔口和目标第一表面之间。该溶液通过掩模孔电纺到目标第一表面上。在一个示例中，目标是腔内假体。

2. 发明申请

US20070219464A1 Guidewire with deflectable re-entry tip 审中-公开
标题翻译：导丝具有可偏转的再入口尖端
公开(公告)号：US20070219464A1
公开(公告)日：2007-09-20
申请号：US11590537
申请日：2006-10-31
申请人： Stephen Davis , David Grewe , Hikmat Hojeibane , Steven Omiecinski
发明人： Stephen Davis , David Grewe , Hikmat Hojeibane , Steven Omiecinski
IPC分类号： A61M25/01
CPC分类号： A61M25/09 , A61B2017/22044 , A61B2017/22095 , A61M25/0045 , A61M25/0138 , A61M25/0147 , A61M25/0152 , A61M25/09033 , A61M2025/0042 , A61M2025/0046 , A61M2025/09066 , A61M2025/09083 , A61M2025/091 , A61M2025/09133
摘要： A steerable guidewire having a sharpened re-entry tip which comprises a longitudinal hypotube and an interlocking spring coil attached to the distal end of the hypotube and also includes a longitudinally movable deflection member which is attached to the distal end of the spring coil and a tip retaining member which extends from the distal end of the hypotube to the distal end of the spring coil for providing very precise deflection of the re-entry tip.
摘要翻译：一种可转向导丝，其具有锐化的再进入尖端，其包括纵向海波管和附接到海波管的远端的互锁弹簧线圈，并且还包括连接到弹簧线圈的远端的可纵向移动的偏转构件，保持构件，其从海波波的远端延伸到弹簧线圈的远端，以提供重入口尖端的非常精确的偏转。

3. 发明申请

US20070073385A1 Eluting, implantable medical device 审中-公开
标题翻译：洗脱，植入式医疗器械
公开(公告)号：US20070073385A1
公开(公告)日：2007-03-29
申请号：US11523797
申请日：2006-09-18
申请人： Darin Schaeffer , David Grewe , Patrick Ruane
发明人： Darin Schaeffer , David Grewe , Patrick Ruane
IPC分类号： A61F2/90
CPC分类号： A61L31/082 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0023 , A61F2250/0026 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： An intraluminal device is provided with a porous structure. The porous structure may be loaded with a bioactive substance to treat surrounding tissues after the intraluminal device has been implanted. The porous structure may be made by depositing a metal film on a foam structure using chemical vapor deposition. Porous structures may also be made by sintering or applying a ceramic layer to the intraluminal device. An intraluminal device is also provided with a ceramic material applied to generally straight portions of the device structure but not to portions adapted to bend. One advantage is that the ceramic material is less likely to fracture since it is applied to regions that experience less strain.
摘要翻译：管腔内装置具有多孔结构。在植入腔内装置之后，多孔结构可装载生物活性物质以治疗周围组织。多孔结构可以通过使用化学气相沉积在金属泡沫结构上沉积金属膜来制造。也可以通过烧结或将陶瓷层施加到腔内装置来制造多孔结构。管腔内装置还设置有施加到装置结构的大致直线部分的陶瓷材料，但是不适于弯曲的部分。一个优点是陶瓷材料不太可能破裂，因为它被应用于经历较小应变的区域。

4. 发明申请

US20110034989A1 RAPID-EXCHANGE BALLOON CATHETER SHAFT AND METHOD 有权
标题翻译：快速交换气囊导管轴和方法
公开(公告)号：US20110034989A1
公开(公告)日：2011-02-10
申请号：US12906976
申请日：2010-10-18
申请人： Laila Al-Marashi , David Grewe , Stephen Griffin , Elaine Lim , David Majercak , Roger Stevens
发明人： Laila Al-Marashi , David Grewe , Stephen Griffin , Elaine Lim , David Majercak , Roger Stevens
IPC分类号： A61F2/84
CPC分类号： A61M25/10 , A61F2/915 , A61F2/958 , A61F2002/91558 , A61F2230/0054 , A61F2250/0018 , A61M25/0054 , A61M2025/0183
摘要： A balloon catheter or stent delivery system for medical treatment of a patient has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a rapid-exchange configuration, and a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near a proximal leg of the balloon. An inner tubular body defines a guidewire lumen extending from a distal guidewire port at the catheter distal end to a proximal port located at a position between the balloon and the hub. A distal leg of the balloon is directly or indirectly affixed to the inner body, and a proximal leg of the balloon is affixed to the distal end of the outer body. The hypotube has an aperture for accepting the inner body proximal end, and a circumferential cut pattern. The cut pattern adds flexibility, and may extend from the hypotube distal end to a position proximal of the proximal guidewire port. The cut pattern may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The hypotube has a fluid-tight covering such as a heat-shrink polymer, so the outer body supports pressure of an inflation medium. The proximal guidewire port may be positioned on or between the individual portions of the cut pattern, or at a position beyond the cut pattern.
摘要翻译：用于患者医疗的球囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。导管轴具有快速交换构造，以及管状外体，其包括从导管近端延伸到球囊的近端腿处或附近的位置的海波管。内部管状体限定从导管远端处的远端导丝端口延伸到位于气囊和轮毂之间的位置的近端口的导丝管腔。球囊的远端腿直接或间接地固定到内体上，并且气球的近端腿固定到外体的远端。海波管具有用于接纳内体近端的孔和圆周切割图案。切割图案增加了柔性，并且可以从海波管远端延伸到近端导丝端口的近端。切割图案可以具有任何期望的形状，例如包括螺旋形，螺旋形起伏路径或具有拐点的重叠蛇形路径。海波管具有流体密封的覆盖物，例如热收缩聚合物，因此外壳支撑膨胀介质的压力。近端导丝端口可以定位在切割图案的各个部分之间或之间，或位于切割图案之外的位置。

5. 发明授权

US07815600B2 Rapid-exchange balloon catheter shaft and method 有权
标题翻译：快速交换球囊导管轴和方法
公开(公告)号：US07815600B2
公开(公告)日：2010-10-19
申请号：US12008509
申请日：2008-01-11
申请人： Laila Al-Marashi , David Grewe , Stephen Griffin , Elaine Lim , David Majercak , Roger Stevens
发明人： Laila Al-Marashi , David Grewe , Stephen Griffin , Elaine Lim , David Majercak , Roger Stevens
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/915 , A61F2/958 , A61F2002/91558 , A61F2230/0054 , A61F2250/0018 , A61M25/0054 , A61M2025/0183
摘要： A rapid-exchange balloon catheter or stent delivery system, for medically treating a patient, has a proximal hub, a balloon, and an improved shaft design. The catheter shaft has a tubular outer body that includes a hypotube extending from the catheter proximal end to a position at or near the proximal leg of the balloon. An inner tubular body defines a guidewire lumen and extends from a distal guidewire port at the catheter distal end to proximal guidewire port located between the balloon and the proximal hub. The hypotube has an aperture for accepting the inner body proximal end and a circumferential cut pattern. The cut pattern adds flexibility and may have any desired shape, including a spiral, a helical undulating path, or an overlapping serpentine path with inflection points, for example. The proximal guidewire port may be positioned on or in between the individual portions of the cut pattern.
摘要翻译：用于医疗治疗患者的快速交换气囊导管或支架输送系统具有近端毂，球囊和改进的轴设计。导管轴具有管状外体，其包括从导管近端延伸到球囊近端腿处或附近的位置的海波管。内管状体限定了导丝内腔，并且从导管远端处的远端导丝端口延伸到位于气囊和近端毂之间的近端导丝端口。海波管具有用于接纳内体近端和圆周切割图案的孔。切割图案增加了柔性，并且可以具有任何期望的形状，例如包括螺旋形，螺旋形波形路径或具有拐点的重叠蛇形路径。近端导丝端口可以定位在切割图案的各个部分之间或之中。

6. 发明授权

US07520863B2 Guidewire with deflectable tip having improved torque characteristics 有权
标题翻译：具有可偏转尖端的导丝具有改善的扭矩特性
公开(公告)号：US07520863B2
公开(公告)日：2009-04-21
申请号：US10691823
申请日：2003-10-23
申请人： David Grewe , David C. Majercak
发明人： David Grewe , David C. Majercak
IPC分类号： A61M25/00 , A61M31/00 , A61M37/00 , A61B18/18
CPC分类号： A61M25/09033 , A61M25/0045 , A61M25/0138 , A61M25/0147 , A61M25/0152 , A61M25/09 , A61M2025/0042 , A61M2025/0046 , A61M2025/09066 , A61M2025/09083 , A61M2025/091 , A61M2025/09133
摘要： A bi-directional steerable guidewire having a deflectable distal tip which comprises a longitudinal hypotube and an interlocking spring coil attached to the distal end of the hypotube and also includes a longitudinally movable deflection member which is attached to the distal end of the spring coil and a tip retaining member which extends from the distal end of the hypotube to the distal end of the spring coil for providing very precise deflection of the distal tip.
摘要翻译：一种双向可导向导丝，其具有可偏转的远端，其包括纵向海波管和附接到海波管的远端的互锁弹簧线圈，并且还包括连接到弹簧线圈的远端的可纵向移动的偏转构件，尖端保持构件，其从海波波的远端延伸到弹簧线圈的远端，以提供远端尖端的非常精确的偏转。

7. 发明申请

US20070213805A1 Expandable stent grafts and methods of use thereof 有权
标题翻译：可扩展的支架移植物及其使用方法
公开(公告)号：US20070213805A1
公开(公告)日：2007-09-13
申请号：US11714058
申请日：2007-03-05
申请人： Darin Schaeffer , David Grewe
发明人： Darin Schaeffer , David Grewe
IPC分类号： A61F2/88
CPC分类号： A61F2/885 , A61F2/07 , A61F2/88 , A61F2/915 , A61F2002/075 , A61F2002/30459 , A61F2002/30461 , A61F2002/3052 , A61F2220/0025 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075
摘要： This invention relates to a medical device and, in particular, to a prosthesis or stent graft assembly for use within the human or animal body and, more particularly, to the fastening of a stent to the graft material of the stent graft assembly or prosthesis.
摘要翻译：本发明涉及一种医疗装置，特别涉及一种在人体或动物体内使用的假体或支架移植物组件，更具体地说，涉及将支架固定在支架移植物组件或假体的移植材料上。

8. 发明申请

US20070050010A1 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US20070050010A1
公开(公告)日：2007-03-01
申请号：US11515395
申请日：2006-09-01
申请人： Brian Bates , Anthony Ragheb , Neal Fearnot , William Voorhees , Thomas Kozma , David Grewe , Darin Schaeffer
发明人： Brian Bates , Anthony Ragheb , Neal Fearnot , William Voorhees , Thomas Kozma , David Grewe , Darin Schaeffer
IPC分类号： A61F2/86 , A61F2/06
CPC分类号： A61F2/91 , A61F2/24 , A61F2/82 , A61F2/885 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

9. 发明申请

US20070043423A1 Intraluminal device with a hollow structure 审中-公开
标题翻译：具有中空结构的管腔内装置
公开(公告)号：US20070043423A1
公开(公告)日：2007-02-22
申请号：US11502589
申请日：2006-08-10
申请人： David Grewe
发明人： David Grewe
IPC分类号： A61F2/06
CPC分类号： A61F2/885 , A61F2/90 , A61F2250/0068
摘要： Intraluminal devices are provided with an inner cavity. The inner cavity may be loaded with a bioactive substance. Fenestrations extend between an outer surface and the inner cavity. Thus, the bioactive substance may be released from the intraluminal device through the fenestrations.
摘要翻译：腔内装置设置有内腔。内腔可以装载生物活性物质。开窗在外表面和内腔之间延伸。因此，生物活性物质可以通过开窗从管腔内装置释放。

10. 发明授权

US07128718B2 Guidewire with deflectable tip 有权
公开(公告)号：US07128718B2
公开(公告)日：2006-10-31
申请号：US10224168
申请日：2002-08-20
申请人： Hikmat Hojeibane , David Grewe
发明人： Hikmat Hojeibane , David Grewe
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61M25/0147 , A61M25/0138 , A61M25/0152 , A61M25/09 , A61M25/09033 , A61M2025/0042 , A61M2025/09083 , A61M2025/09133
摘要： A bi-directional steerable guidewire having a deflectable distal tip which comprises a longitudinal hypotube and a spring coil attached to the distal end of the hypotube and also includes a longitudinally movable deflection member which is attached to the distal end of the spring coil and a tip retaining member which extends from the distal end of the hypotube to the distal end of the spring coil for providing very precise deflection of the distal tip.

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