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1. 发明申请

US20150056411A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS 有权
标题翻译：抗微生物，抗血清生成组合物
公开(公告)号：US20150056411A1
公开(公告)日：2015-02-26
申请号：US14533908
申请日：2014-11-05
申请人： Zheng ZHANG , Jun LI , Chad C. HUVAL , Michael A. BOUCHARD , Arthur J. COURY , Christopher R. LOOSE
发明人： Zheng ZHANG , Jun LI , Chad C. HUVAL , Michael A. BOUCHARD , Arthur J. COURY , Christopher R. LOOSE
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
摘要： The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.
摘要翻译：本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。表面抗生物材料的粘附。

2. 发明授权

US08574660B2 Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties 有权
标题翻译：具有非污垢表面的制品及其制备方法，而不改变体积物理性能
公开(公告)号：US08574660B2
公开(公告)日：2013-11-05
申请号：US13156904
申请日：2011-06-09
申请人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： A61L33/00
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
摘要翻译：本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。这些方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理特性，然后在经处理的基材表面上形成接枝聚合物层。

3. 发明申请

US20090149673A1 SYNTHETIC NON-FOULING AMINO ACIDS 审中-公开
标题翻译：合成不溶性氨基酸
公开(公告)号：US20090149673A1
公开(公告)日：2009-06-11
申请号：US12329360
申请日：2008-12-05
申请人： Zheng Zhang , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Christopher R. Loose
发明人： Zheng Zhang , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Christopher R. Loose
IPC分类号： C07C229/06
CPC分类号： C07C229/26 , C07C233/47
摘要： Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: where L is a linker group and Z is a non-fouling group including, but not limited to, polyethylene glycol (PEG); oligoethylene glycol (OEG); zwitterionic group, such as phosphorycholine, carboxybetaine, and sulfobetaine; groups that are hydrogen bond acceptors but not hydrogen bond donors. The non-fouling amino acids can be incorporated into a bioactive peptide as single amino acid residues, multiples amino acid residues, or as blocks of amino acids. The non-fouling amino acids, or peptides containing one or more non-fouling amino acids, can be applied to surfaces in order to improve biocompatibility, reduce thrombogenesis, and/or reduce fouling by proteins or bacteria present in solution.
摘要翻译：含有一个或多个非结垢基团或部分的合成氨基酸在本文中描述。在一个实施方案中，氨基酸具有以下化学式：其中L是连接基团，Z是非结垢基团，包括但不限于聚乙二醇（PEG）; 低聚乙二醇（OEG）; 两性离子基团，如磷酸胆碱，羧基甜菜碱和磺基甜菜碱; 基团是氢键受体而不是氢键供体。非结垢的氨基酸可以作为单个氨基酸残基，多个氨基酸残基或作为氨基酸的嵌段结合到生物活性肽中。含有一个或多个非结垢性氨基酸的非结垢性氨基酸或多肽可以施用于表面，以便提高溶液中存在的蛋白质或细菌的生物相容性，减少血栓发生和/或减少结垢。

4. 发明授权

US09895469B2 Articles having non-fouling surfaces and processes for preparing the same including applying a primer coat 有权
公开(公告)号：US09895469B2
公开(公告)日：2018-02-20
申请号：US13156936
申请日：2011-06-09
申请人： Karen A. Schultz , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Christopher R. Loose
发明人： Karen A. Schultz , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Christopher R. Loose
IPC分类号： A61L33/00 , C09D5/16 , A61L33/02 , B05D3/10 , B05D7/00
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve coating the substrate to conceal or reduce flaws on or in the surface of the medical device or other article substrate, and thereafter forming a grafted polymer layer on the treated substrate surface.

5. 发明申请

US20150045515A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS 审中-公开
标题翻译：非反应性，抗微生物，抗组氨酸衍生物
公开(公告)号：US20150045515A1
公开(公告)日：2015-02-12
申请号：US14531383
申请日：2014-11-03
申请人： Jun LI , Zheng ZHANG , Chad C. HUVAL , Michael A. BOUCHARD , Christopher R. LOOSE , Arthur J. COURY
发明人： Jun LI , Zheng ZHANG , Chad C. HUVAL , Michael A. BOUCHARD , Christopher R. LOOSE , Arthur J. COURY
IPC分类号： C08F255/02 , C08G77/38 , C08G18/83 , C08G64/42
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译：一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。

6. 发明授权

US08308699B2 Layered non-fouling, antimicrobial antithrombogenic coatings 有权
标题翻译：分层无污垢，抗菌抗凝血涂层
公开(公告)号：US08308699B2
公开(公告)日：2012-11-13
申请号：US12632669
申请日：2009-12-07
申请人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
发明人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
IPC分类号： A61M25/00 , C08F290/14 , C08F112/08 , C08F283/04 , C08F120/10 , C08F20/56 , C08F283/02 , C08G77/38
CPC分类号： A61L31/14 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/404 , A61L2420/08 , C09D5/1637 , C09D5/1693 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/31725 , Y10T428/31743 , Y10T428/3175 , Y10T428/31786 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928 , Y10T442/2525 , C08L33/10
摘要： Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
摘要翻译：本文描述了任选地涂覆有底涂层的底物，其具有接枝到其上的一种或多种非结垢材料。非结垢的聚合物材料可以接枝到各种官能化的基底材料，特别是固定在基底上的聚合物基底和/或聚合底涂层。本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。可以将非结垢材料接枝到官能化基材上，或任选地从基底上的底涂层上接枝，优选不显着影响基材的机械和/或物理性能。

7. 发明申请

US20090155335A1 NON-LEACHING NON-FOULING ANTIMICROBIAL COATINGS 审中-公开
标题翻译：非浸出非防腐涂料
公开(公告)号：US20090155335A1
公开(公告)日：2009-06-18
申请号：US12329344
申请日：2008-12-05
申请人： William Shannan O'Shaughnessey , Zheng Zhang , Michael Hencke , Kris Wood , Trevor Squier , Christopher R. Loose
发明人： William Shannan O'Shaughnessey , Zheng Zhang , Michael Hencke , Kris Wood , Trevor Squier , Christopher R. Loose
IPC分类号： A61L29/16 , A61K38/16 , A61K38/10 , C07K14/00 , C07K7/04 , A61L15/44 , A61L31/16 , A61L27/54 , A61P31/04
CPC分类号： C07K17/08 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/404 , C07K7/08 , C07K14/43563 , C09D5/1637
摘要： Compositions containing one or more types of membrane-targeting antimicrobial agents immobilized on a substrate with activity in relevant biological environments, and methods of making and using thereof, are described herein. The antimicrobial agents retain their activity in the presence of blood proteins and/or in vivo due to improved molecular structures which allow for cooperative action of immobilized agents and hydrophilic chemistries which resist non-specific protein adsorption. Suitable molecular structures include branched structures, such as dendrimers and randomly branched polymers. The molecule structures may also include hydrophilic tethers which provide both flexibility and resistance to non-specific protein adsorption. The membrane targeting antimicrobial agent coatings can be applied to a variety of different types of substrates including medical implants such as vascular grafts, orthopedic devices, dialysis access grafts, and catheters; surgical tools, surgical garments; and bandages. The substrates can be composed of metallic materials, ceramics, polymers, fibers, inert materials such as silicon, and combinations thereof. The compositions described herein are substantially non-leaching, resistant to non-specific protein adsorption, and non-hemolytic.
摘要翻译：本文描述了包含固定在具有相关生物环境中的活性的基质上的一种或多种类型的膜靶向抗微生物剂的组合物及其制备和使用方法。抗微生物剂在血液蛋白质存在下和/或体内保留其活性，因为改进的分子结构允许固定化剂和抵抗非特异性蛋白质吸附的亲水化学物质的协同作用。合适的分子结构包括支链结构，例如树枝状聚合物和无规分支的聚合物。分子结构还可以包括提供灵活性和对非特异性蛋白质吸附的抗性的亲水系链。膜靶向抗微生物剂涂层可以应用于各种不同类型的基底，包括医疗植入物，例如血管移植物，矫形装置，透析入口移植物和导管; 手术工具，手术衣服; 和绷带。基板可以由金属材料，陶瓷，聚合物，纤维，惰性材料如硅构成，以及它们的组合。本文所述的组合物基本上是非浸出的，对非特异性蛋白质吸附抗性和非溶血性的。

8. 发明申请

US20110305872A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITONS 有权
标题翻译：抗微生物，抗细菌免疫组织化学
公开(公告)号：US20110305872A1
公开(公告)日：2011-12-15
申请号：US13156677
申请日：2011-06-09
申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： B32B3/00 , D03D15/00 , D04H13/00 , B05D3/10
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译：一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。

9. 发明申请

US20100152708A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS 有权
标题翻译：非反应性，抗微生物，抗组氨酸衍生物
公开(公告)号：US20100152708A1
公开(公告)日：2010-06-17
申请号：US12632686
申请日：2009-12-07
申请人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
发明人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
IPC分类号： A61L29/14 , C08F290/14 , B32B5/02 , B32B15/08 , B32B27/04 , B32B27/36 , B32B9/04 , B32B27/38 , C08F112/08 , C08F283/04 , C08F283/06 , C08F283/12 , C08F220/56 , C08F210/00 , C07H1/00 , C07H23/00 , C08J3/28 , B05D3/06
CPC分类号： A61L33/06 , A61L27/14 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F4/40 , C08F265/04 , C08F283/00 , C08F283/006 , C08F291/18 , C08L25/08 , C08L75/04 , C09D5/1637 , C09D5/1693 , C09D151/003 , C09D151/06 , C09D151/08 , C09D151/085 , C08F220/38 , C08F220/56 , C08L2666/02
摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
摘要翻译：本文描述了任选地涂覆有底涂层的底物，其从一种或多种非结垢材料接枝到其上。不污染的聚合物材料可以从各种基材，特别是聚合物基材和/或聚合物底涂层移植。本文所述的接枝技术可以导致非污染材料相对于接枝与制剂的更高的表面密度。可以使用接枝方法制备共价连接的聚合物。本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。非污染材料可以从衬底或任选地从衬底上的底涂层移植，优选不显着影响衬底材料的机械和/或物理性能。

10. 发明申请

US20100145286A1 LAYERED NON-FOULING, ANTIMICROBIAL ANTITHROMBOGENIC COATINGS 有权
标题翻译：抗微生物涂层
公开(公告)号：US20100145286A1
公开(公告)日：2010-06-10
申请号：US12632669
申请日：2009-12-07
申请人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
发明人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
IPC分类号： A61M25/00 , C08F290/14 , C08F112/08 , C08F283/04 , C08F120/10 , C08F20/56 , C08F283/02 , C08G77/38 , B32B27/04 , C08G59/14 , C08G69/48 , C08F10/00 , C08G75/00 , C08F20/44 , C07H1/00 , B32B27/36 , B32B27/34 , B32B27/38
CPC分类号： A61L31/14 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/404 , A61L2420/08 , C09D5/1637 , C09D5/1693 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/31725 , Y10T428/31743 , Y10T428/3175 , Y10T428/31786 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928 , Y10T442/2525 , C08L33/10
摘要： Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material
摘要翻译：本文描述了任选地涂覆有底涂层的底物，其具有接枝到其上的一种或多种非结垢材料。非结垢的聚合物材料可以接枝到各种官能化的基底材料，特别是固定在基底上的聚合物基底和/或聚合底涂层。本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。非结垢材料可以接枝到功能化基材上，或任选地从基底上的底涂层上接枝，优选不显着影响基材的机械和/或物理性能

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