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1. 发明授权

US09895470B2 Non-fouling, anti-microbial, anti-thrombogenic graft—from compositions 有权
公开(公告)号：US09895470B2
公开(公告)日：2018-02-20
申请号：US12632686
申请日：2009-12-07
申请人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
发明人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
IPC分类号： A61L33/06 , A61L27/34 , A61L27/50 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , C07H23/00 , C09D5/16 , C09D151/00 , C09D151/06 , C09D151/08 , C08L75/04 , C08L25/08
CPC分类号： A61L33/06 , A61L27/14 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F4/40 , C08F265/04 , C08F283/00 , C08F283/006 , C08F291/18 , C08L25/08 , C08L75/04 , C09D5/1637 , C09D5/1693 , C09D151/003 , C09D151/06 , C09D151/08 , C09D151/085 , C08F220/38 , C08F220/56 , C08L2666/02
摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

2. 发明申请

US20130236972A1 Liver Sinusoid Model 审中-公开
标题翻译：肝正弦模型
公开(公告)号：US20130236972A1
公开(公告)日：2013-09-12
申请号：US13413679
申请日：2012-03-07
申请人： Hongseok Noh , Michael Bouchard
发明人： Hongseok Noh , Michael Bouchard
IPC分类号： C12N5/071 , C12M3/00
CPC分类号： C12N5/067 , C12N2533/54 , C12N2535/00
摘要： A liver sinusoid model includes a generally planar substrate having first and second generally parallel microchannels formed therein. A microporous membrane is disposed between and separating the first and second generally parallel microchannels. A first layer of cells lines one side of the membrane in the first microchannel. The first layer of cells are all a first common cell type. A second layer of cells extends parallel to the first layer of cells in one of the first microchannel and the second microchannel. The second layer of cells is all of a second common cell type. A liver sinusoid bioreactor utilizing the inventive model is also disclosed.
摘要翻译：肝窦状模型包括具有在其中形成的第一和第二大致平行的微通道的大致平面的基底。微孔膜设置在第一和第二大致平行的微通道之间并分离。第一层细胞在第一微通道中排列膜的一侧。第一层细胞都是第一种细胞类型。细胞的第二层平行于第一微通道和第二微通道之一中的第一细胞层延伸。第二层细胞都是第二种细胞类型。还公开了利用本发明模型的肝窦状生物反应器。

3. 发明申请

US20100152708A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS 有权
标题翻译：非反应性，抗微生物，抗组氨酸衍生物
公开(公告)号：US20100152708A1
公开(公告)日：2010-06-17
申请号：US12632686
申请日：2009-12-07
申请人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
发明人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
IPC分类号： A61L29/14 , C08F290/14 , B32B5/02 , B32B15/08 , B32B27/04 , B32B27/36 , B32B9/04 , B32B27/38 , C08F112/08 , C08F283/04 , C08F283/06 , C08F283/12 , C08F220/56 , C08F210/00 , C07H1/00 , C07H23/00 , C08J3/28 , B05D3/06
CPC分类号： A61L33/06 , A61L27/14 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F4/40 , C08F265/04 , C08F283/00 , C08F283/006 , C08F291/18 , C08L25/08 , C08L75/04 , C09D5/1637 , C09D5/1693 , C09D151/003 , C09D151/06 , C09D151/08 , C09D151/085 , C08F220/38 , C08F220/56 , C08L2666/02
摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
摘要翻译：本文描述了任选地涂覆有底涂层的底物，其从一种或多种非结垢材料接枝到其上。不污染的聚合物材料可以从各种基材，特别是聚合物基材和/或聚合物底涂层移植。本文所述的接枝技术可以导致非污染材料相对于接枝与制剂的更高的表面密度。可以使用接枝方法制备共价连接的聚合物。本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。非污染材料可以从衬底或任选地从衬底上的底涂层移植，优选不显着影响衬底材料的机械和/或物理性能。

4. 发明申请

US20100145286A1 LAYERED NON-FOULING, ANTIMICROBIAL ANTITHROMBOGENIC COATINGS 有权
标题翻译：抗微生物涂层
公开(公告)号：US20100145286A1
公开(公告)日：2010-06-10
申请号：US12632669
申请日：2009-12-07
申请人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
发明人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
IPC分类号： A61M25/00 , C08F290/14 , C08F112/08 , C08F283/04 , C08F120/10 , C08F20/56 , C08F283/02 , C08G77/38 , B32B27/04 , C08G59/14 , C08G69/48 , C08F10/00 , C08G75/00 , C08F20/44 , C07H1/00 , B32B27/36 , B32B27/34 , B32B27/38
CPC分类号： A61L31/14 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/404 , A61L2420/08 , C09D5/1637 , C09D5/1693 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/31725 , Y10T428/31743 , Y10T428/3175 , Y10T428/31786 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928 , Y10T442/2525 , C08L33/10
摘要： Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material
摘要翻译：本文描述了任选地涂覆有底涂层的底物，其具有接枝到其上的一种或多种非结垢材料。非结垢的聚合物材料可以接枝到各种官能化的基底材料，特别是固定在基底上的聚合物基底和/或聚合底涂层。本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。非结垢材料可以接枝到功能化基材上，或任选地从基底上的底涂层上接枝，优选不显着影响基材的机械和/或物理性能

5. 发明授权

US08308699B2 Layered non-fouling, antimicrobial antithrombogenic coatings 有权
标题翻译：分层无污垢，抗菌抗凝血涂层
公开(公告)号：US08308699B2
公开(公告)日：2012-11-13
申请号：US12632669
申请日：2009-12-07
申请人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
发明人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
IPC分类号： A61M25/00 , C08F290/14 , C08F112/08 , C08F283/04 , C08F120/10 , C08F20/56 , C08F283/02 , C08G77/38
CPC分类号： A61L31/14 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/404 , A61L2420/08 , C09D5/1637 , C09D5/1693 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/31725 , Y10T428/31743 , Y10T428/3175 , Y10T428/31786 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928 , Y10T442/2525 , C08L33/10
摘要： Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
摘要翻译：本文描述了任选地涂覆有底涂层的底物，其具有接枝到其上的一种或多种非结垢材料。非结垢的聚合物材料可以接枝到各种官能化的基底材料，特别是固定在基底上的聚合物基底和/或聚合底涂层。本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。可以将非结垢材料接枝到官能化基材上，或任选地从基底上的底涂层上接枝，优选不显着影响基材的机械和/或物理性能。

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