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1. 发明申请

US20100099779A1 Biocompatible material composition adaptable to diverse therapeutic indications 有权
标题翻译：适用于多种治疗适应症的生物相容性材料组合物
公开(公告)号：US20100099779A1
公开(公告)日：2010-04-22
申请号：US12455561
申请日：2009-06-03
申请人： Olexander Hnojewyj , Charles F. Milo , Gregory M. Cruise
发明人： Olexander Hnojewyj , Charles F. Milo , Gregory M. Cruise
IPC分类号： A61K47/30 , C08L89/00 , A61K47/42
CPC分类号： A61K9/0024 , A61B17/0057 , A61B2017/00004 , A61B2017/00495 , A61K47/34 , A61L24/043 , A61L31/041 , Y10S530/815 , C08L89/00
摘要： A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form. The polymer includes a degradation control region selected to achieve a desired degradation period and a cross-linking group selected to achieve a desired cross-linking period. The kit provides instructions for forming a mixture of the protein solution and polymer solution and for applying the mixture. The mixture serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
摘要翻译：用于形成生物相容性材料的试剂盒提供蛋白质溶液和包含官能度至少为3的亲水性聚合物的衍生物的聚合物溶液。混合后蛋白质溶液和聚合物溶液交联以形成非液体三维网络，随着时间的推移而退化成液体形式。聚合物包括选择以实现期望的降解期的降解控制区域和选择用于实现期望的交联期的交联基团。该试剂盒提供了形成蛋白质溶液和聚合物溶液的混合物并施加混合物的说明书。该混合物用作多种材料组合物种的基础，每种物质组合物种类适合特定的治疗适应症。

2. 发明授权

US07247314B2 Biocompatible material composition adaptable to diverse therapeutic indications 有权
标题翻译：适用于多种治疗适应症的生物相容性材料组合物
公开(公告)号：US07247314B2
公开(公告)日：2007-07-24
申请号：US11002837
申请日：2004-12-02
申请人： Olexander Hnojewyj , Charles F. Milo , Gregory M Cruise
发明人： Olexander Hnojewyj , Charles F. Milo , Gregory M Cruise
IPC分类号： A61K47/42 , C08L89/00 , C12N11/04
CPC分类号： A61K9/0024 , A61B17/0057 , A61B2017/00004 , A61B2017/00495 , A61K47/34 , A61L24/043 , A61L31/041 , Y10S530/815 , C08L89/00
摘要： A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
摘要翻译：生物相容性材料属于多种材料组成物种的基础，每一种物质都适合特定的治疗适应症。

3. 发明授权

US06616652B1 Osmotic pump delivery system with pre-hydrated membrane(s) and/or primable catheter 失效
标题翻译：具有预水合膜和/或可引导导管的渗透泵输送系统
公开(公告)号：US06616652B1
公开(公告)日：2003-09-09
申请号：US09504603
申请日：2000-02-15
申请人： Derek J. Harper , Charles F. Milo
发明人： Derek J. Harper , Charles F. Milo
IPC分类号： A61K922
CPC分类号： A61K9/0004 , A61K9/0024
摘要： An implantable osmotic pump system includes a pre-hydrated semipermeable membrane to reduce the time interval between implantation of the system into the patient and full operation of the pump system. The semipermeable membrane is maintained in a hydrated state prior to implantation by fluid contact with a saline solution maintained in a saturated state by a salt tablet. As the differential osmotic pressure across the hydrated semipermeable membrane is negligible as the saline concentration on both sides of the membrane is the same, the pump system does not operate and does not infuse the pharmaceutical agent as long as this osmotic equipotential state is maintained. When the saturated saline solution is removed from fluid contact with the semipermeable membrane and the system is implanted in a patient, the osmotic pressure differential across the semipermeable membrane increases, thereby causing the pump to immediately begin operation at or near its intended and designed steady state infusion rate. To further decrease the delay between implantation and effusion of a pharmaceutical agent from the system, the infusion lumen of an attached catheter may be at least partially flushed with the same or a different pharmaceutical agent as is loaded in the pharmaceutical agent compartment of the pump system.
摘要翻译：可植入渗透泵系统包括预水合的半透膜，以减少将系统植入患者之间的时间间隔和泵系统的完全操作。在通过与盐片保持在饱和状态的盐水溶液的液体接触之前，将半透膜保持在水合状态。由于膜两侧的盐水浓度相同，水合半透膜两侧的差异渗透压可忽略不计，只要保持渗透等电位状态，泵系统就不会运行，也不会注入药剂。当将饱和盐水溶液从与半透膜接触的液体中除去并将该系统植入患者体内时，半透膜上的渗透压差增加，从而使泵立即在其预期和设计的稳定状态或其附近开始操作输液速度。为了进一步减少来自系统的药剂的植入和渗出之间的延迟，附着的导管的输液腔可以用与泵系统的药剂隔室中所装载的相同或不同的药剂至少部分地冲洗。

4. 发明授权

US06217549B1 Methods and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06217549B1
公开(公告)日：2001-04-17
申请号：US09149875
申请日：1998-09-08
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22069 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

5. 发明授权

US06719725B2 Re-entry catheter 有权
标题翻译：再进入导管
公开(公告)号：US06719725B2
公开(公告)日：2004-04-13
申请号：US10308568
申请日：2002-12-03
申请人： Charles F. Milo , Matthew R. Selmon , Richard E. Hill , Fred H. Co , Ronald G. French
发明人： Charles F. Milo , Matthew R. Selmon , Richard E. Hill , Fred H. Co , Ronald G. French
IPC分类号： A61M5178
CPC分类号： A61B17/3207 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22044 , A61B2017/22077 , A61B2017/22095 , A61B2018/00392 , A61B2090/3925 , A61M25/01 , A61M2025/0096
摘要： Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal to the occlusion and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn and the guidewire is available for introduction of other interventional and diagnostic catheters.
摘要翻译：通过将导线或其他穿透线从接近闭塞的点通过血管壁的内膜层和外膜层之间的内膜下间隔来跨越全部闭塞。导线前进到远离闭塞的点，然后偏转回血管内腔，通常使用偏转导管，该导管在定位于内膜下空间之前在引导线上前进。在将导丝返回到血管内腔之后，偏转导管可以被拉出并且导丝可用于引入其它介入和诊断导管。

6. 发明授权

US06514217B1 Methods and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06514217B1
公开(公告)日：2003-02-04
申请号：US09557379
申请日：2000-04-25
申请人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
发明人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
IPC分类号： A61B500
CPC分类号： A61B17/3207 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22044 , A61B2017/22077 , A61B2017/22095 , A61B2018/00392 , A61B2090/3925 , A61M25/01 , A61M2025/018 , A61M2025/0197
摘要： Methods and apparatus for crossing totally to substantially occluded blood vessels by passing a redirectable wire such as a guidewire from a relatively proximal point past the occlusion within a subintimal space formed between the intimal layer and the adventitial layer of a blood vessel wall. The wire may be advanced to a point distal to the occlusion, and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. The deflecting catheter may include a flapper valve assembly or preformed actuator wire for redirecting the guidewire. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn, and the guidewire may be available for introduction of other interventional and diagnostic catheters for performing procedures such as stenting.
摘要翻译：通过将可重定向的线（例如导丝）从相对近端点通过闭塞的方法和装置穿过形成在血管壁的内膜层和外膜层之间的内膜下空间。线可以前进到远离闭塞的点，然后通过使用偏转导管偏转回到血管内腔中，该导管在定位在子膜内空间之前在引导线上前进。偏转导管可以包括挡板阀组件或用于重定向导丝的预制的致动器线。在将导丝返回到血管腔之后，可以撤回偏转导管，并且导丝可用于引入用于执行诸如支架置入的程序的其它介入和诊断导管。

7. 发明授权

US06511458B2 Vascular re-entry catheter 有权
标题翻译：血管再导管
公开(公告)号：US06511458B2
公开(公告)日：2003-01-28
申请号：US09765777
申请日：2001-01-19
申请人： Charles F. Milo , Matthew R. Selmon , Richard E. Hill , Fred H. Co , Ronald G. French
发明人： Charles F. Milo , Matthew R. Selmon , Richard E. Hill , Fred H. Co , Ronald G. French
IPC分类号： A61M5178
CPC分类号： A61B17/3207 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22044 , A61B2017/22077 , A61B2017/22095 , A61B2018/00392 , A61B2090/3925 , A61M25/01 , A61M2025/0096
摘要： Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal to the occlusion and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn and the guidewire is available for introduction of other interventional and diagnostic catheters.
摘要翻译：通过将导线或其他穿透线从接近闭塞的点通过血管壁的内膜层和外膜层之间的内膜下间隔来跨越全部闭塞。导线前进到远离闭塞的点，然后偏转回血管内腔，通常使用偏转导管，该导管在定位于内膜下空间之前在引导线上前进。在将导丝返回到血管内腔之后，偏转导管可以被拉出并且导丝可用于引入其它介入和诊断导管。

8. 发明授权

US06241667B1 Catheter apparatus for guided transvascular treatment of arterial occlusions 失效
标题翻译：用于导管经血管内治疗动脉闭塞的导管器
公开(公告)号：US06241667B1
公开(公告)日：2001-06-05
申请号：US09008198
申请日：1998-01-15
申请人： James W. Vetter , Tomoaki Hinohara , Matthew R. Selmon , Charles F. Milo
发明人： James W. Vetter , Tomoaki Hinohara , Matthew R. Selmon , Charles F. Milo
IPC分类号： A61B1700
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M25/0147 , A61M2025/1097
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter having an occlusion-crossing working element, with an extraluminally operable locator for imaging the progress of the working element through the occlusion. Suction coupling means are described for removably anchoring the locator to a surface proximate the heart. A method for treating arterial occlusions is described in which the distal end of the catheter shaft exits a lumen of the locator, penetrates the arterial wall distal to the occlusion, crosses the occlusion retrograde and passes into a separately introduced standard intravascular catheter, whereupon the distal end of the shaft may be manipulated from the proximal end of the standard catheter. The proximal end of the shaft is then released from external attachments and drawn into the artery to perform treatment or guiding functions. Spatial interrelationships are observed real-time via the locator. Conical, abrasive, blunt-dissecting, sharp-pointed and guide-wire type working elements, steerable and non-steering, are described. Acoustic transducers and a flexible imaging tube are described for the locator. A signal-emitting working element and cooperating signal-receiving locator are described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可内窥术操作的导管与可外部操作的定位器，用于通过闭塞成像工作元件的进展。吸入联接装置被描述为用于可移除地将定位器锚定到靠近心脏的表面。描述了治疗动脉闭塞的方法，其中导管轴的远端离开定位器的内腔，穿过远端阻塞的动脉壁，逆行阻塞并进入单独引入的标准血管内导管，于是远端可以从标准导管的近端操纵轴的端部。然后将轴的近端从外部附件释放并拉入动脉以执行治疗或引导功能。通过定位器实时观察空间相互关系。描述了锥形，磨料，钝性解剖，尖锐和导丝式工作元件，可转向和非转向。描述了定位器的声学换能器和柔性成像管。描述信号发射工作元件和配合信号接收定位器。

9. 发明授权

US06235000B1 Apparatus for crossing total occlusion in blood vessels 有权
标题翻译：用于穿过血管中的全部闭塞的装置
公开(公告)号：US06235000B1
公开(公告)日：2001-05-22
申请号：US09440308
申请日：1999-11-17
申请人： Charles F. Milo , Matthew R. Selmon , Richard E. Hill , Fred H. Co , Ronald G. French
发明人： Charles F. Milo , Matthew R. Selmon , Richard E. Hill , Fred H. Co , Ronald G. French
IPC分类号： A61M5178
CPC分类号： A61B17/3207 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22044 , A61B2017/22077 , A61B2017/22095 , A61B2018/00392 , A61B2090/3925 , A61M25/01 , A61M2025/0096
摘要： Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal to the occlusion and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn and the guidewire is available for introduction of other interventional and diagnostic catheters.
摘要翻译：通过将导线或其他穿透线从接近闭塞的点通过血管壁的内膜层和外膜层之间的内膜下间隔来跨越全部闭塞。导线前进到远离闭塞的点，然后偏转回血管内腔，通常使用偏转导管，该导管在定位于内膜下空间之前在引导线上前进。在将导丝返回到血管内腔之后，偏转导管可以被拉出并且导丝可用于引入其它介入和诊断导管。

10. 发明申请

US20080175817A1 Biocompatible material composition adaptable to diverse therapeutic indications 审中-公开
标题翻译：适用于多种治疗适应症的生物相容性材料组合物
公开(公告)号：US20080175817A1
公开(公告)日：2008-07-24
申请号：US11880552
申请日：2007-07-23
申请人： Olexander Hnojewyj , Charles F. Milo , Gregory M. Cruise
发明人： Olexander Hnojewyj , Charles F. Milo , Gregory M. Cruise
IPC分类号： A61K35/00
CPC分类号： A61K9/0024 , A61B17/0057 , A61B2017/00004 , A61B2017/00495 , A61K47/34 , A61L24/043 , A61L31/041 , Y10S530/815 , C08L89/00
摘要： A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.
摘要翻译：生物相容性材料属于多种材料组成物种的基础，每一种物质都适合特定的治疗适应症。

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