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1. 发明授权

US06217549B1 Methods and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06217549B1
公开(公告)日：2001-04-17
申请号：US09149875
申请日：1998-09-08
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22069 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

2. 发明授权

US06800085B2 Methods and apparatus for treating vascular occlusions 有权
公开(公告)号：US06800085B2
公开(公告)日：2004-10-05
申请号：US09835043
申请日：2001-04-13
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22052 , A61B2017/22069 , A61B2017/22094 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.

3. 发明授权

US06746462B1 Methods and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06746462B1
公开(公告)日：2004-06-08
申请号：US09538850
申请日：2000-03-28
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
IPC分类号： A61B1722
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22069 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

4. 发明授权

US06638247B1 Method and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06638247B1
公开(公告)日：2003-10-28
申请号：US09538441
申请日：2000-03-29
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22052 , A61B2017/22069 , A61B2017/22094 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

5. 发明授权

US06508825B1 Apparatus for treating vascular occlusions 有权
标题翻译：用于治疗血管闭塞的装置
公开(公告)号：US06508825B1
公开(公告)日：2003-01-21
申请号：US09149874
申请日：1998-09-08
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl , Gerald Hansen , E. Richard Hill, III
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22052 , A61B2017/22069 , A61B2017/22094 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be, provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件，用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

6. 发明授权

US06599304B1 Methods and apparatus for treating vascular occlusions 有权
标题翻译：治疗血管闭塞的方法和装置
公开(公告)号：US06599304B1
公开(公告)日：2003-07-29
申请号：US09443924
申请日：1999-11-19
申请人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
发明人： Matthew R. Selmon , Charles F. Milo , Robert L. Wynne , Suresh S. Pai , Kent D. Dell , Charles Gresl
IPC分类号： A61M2900
CPC分类号： A61M29/02 , A61B17/22 , A61B17/22031 , A61B2017/00845 , A61B2017/22052 , A61B2017/22069 , A61B2017/22094 , A61B2017/2933 , A61B2017/2937 , A61B2017/320044 , A61B2017/320741
摘要： An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter. A directed force is applied to the actuator in order to deploy the spreading member and displace a vascular occlusion creating a path to permit the passage of a guidewire or device therethrough.
摘要翻译：一种用于治疗闭塞血管的血管内导管系统，其包括可从闭合位置移动到打开位置的组织移位或铰接扩张构件。可以提供致动组件用于在打开和关闭位置之间移动组织膨胀构件，以在围绕封闭血管的区域上施加基本上横向的远端力。组织膨胀构件可以充分拉伸分开，撕裂或以其它方式破坏血管闭塞，以产生可以支撑导线或介入血管装置穿过闭塞或阻塞的通道或放置的路径。还提供了交叉或移位血管闭塞的方法，其包括定位血管导管，所述血管导管具有定位在导管的远端区域处的至少一个铰接扩张构件，其响应于沿着导管的纵向轴线的定向力。定向力被施加到致动器以便展开铺展构件并且移位血管闭塞，产生路径以允许导线或器件通过其中。

7. 发明授权

US06266550B1 Catheter apparatus for treating arterial occlusions 有权
标题翻译：用于治疗动脉闭塞的导管器械
公开(公告)号：US06266550B1
公开(公告)日：2001-07-24
申请号：US09483173
申请日：2000-01-13
申请人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
发明人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
IPC分类号： A61B1732
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2090/3784 , A61M25/0147
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter, having an occlusion-crossing working element, with a micro-invasive extraluminally operable locator for imaging the progress of the working element through the occlusion. Conical, abrasive, blunt-dissecting, and sharp-pointed, and steering and non-steering working elements including guide wires are described. Acoustic transducers and a flexible imaging tube are described for the locator. A suction cup is described for removably anchoring the imaging tube to a surface. A signal-emitting working element and cooperating signal-receiving locator are described. A method for treating arterial occlusions is described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可透光操作的导管与微创外向可操作的定位器，用于通过闭塞成像工作元件的进展。描述了包括导丝在内的锥形，磨料，钝性解剖和锋利的转向和非转向工作元件。描述了定位器的声学换能器和柔性成像管。描述了用于可移除地将成像管固定到表面的吸盘。描述信号发射工作元件和配合信号接收定位器。描述了治疗动脉闭塞的方法。

8. 发明授权

US06221049B1 Methods and apparatus for crossing vascular occlusions 有权
公开(公告)号：US06221049B1
公开(公告)日：2001-04-24
申请号：US09427966
申请日：1999-10-27
申请人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
发明人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
IPC分类号： A61M5178
CPC分类号： A61B17/3207 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22044 , A61B2017/22077 , A61B2017/22095 , A61B2018/00392 , A61B2090/3925 , A61M25/01 , A61M2025/018 , A61M2025/0197
摘要： Methods and apparatus for crossing totally to substantially occluded blood vessels by passing a redirectable wire such as a guidewire from a relatively proximal point past the occlusion within a subintimal space formed between the intimal layer and the adventitial layer of a blood vessel wall. The wire may be advanced to a point distal to the occlusion, and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. The deflecting catheter may include a flapper valve assembly or preformed actuator wire for redirecting the guidewire. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn, and the guidewire may be available for introduction of other interventional and diagnostic catheters for performing procedures such as stenting.

9. 发明授权

US06217527B1 Methods and apparatus for crossing vascular occlusions 有权
公开(公告)号：US06217527B1
公开(公告)日：2001-04-17
申请号：US09163854
申请日：1998-09-30
申请人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
发明人： Matthew R. Selmon , Charles F. Milo , Fred Co , Mark Campello , Ronald French , Amiel Aguilar
IPC分类号： A61B500
CPC分类号： A61B17/3207 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22044 , A61B2017/22077 , A61B2017/22095 , A61B2018/00392 , A61B2090/3925 , A61M25/01 , A61M2025/018 , A61M2025/0197
摘要： Methods and apparatus for crossing totally to substantially occluded blood vessels by passing a redirectable wire such as a guidewire from a relatively proximal point past the occlusion within a subintimal space formed between the intimal layer and the adventitial layer of a blood vessel wall. The wire may be advanced to a point distal to the occlusion, and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. The deflecting catheter may include a flapper valve assembly or preformed actuator wire for redirecting the guidewire. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn, and the guidewire may be available for introduction of other interventional and diagnostic catheters for performing procedures such as stenting.

10. 发明授权

US6157852A Catheter apparatus for treating arterial occlusions 失效
标题翻译：用于治疗动脉闭塞的导管器械
公开(公告)号：US6157852A
公开(公告)日：2000-12-05
申请号：US8033
申请日：1998-01-16
申请人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
发明人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
IPC分类号： A61B8/12 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61B19/00 , A61M25/01 , A61M29/02 , A61B5/00
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M2025/1097 , A61M25/0147
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter, having an occlusion-crossing working element, with a micro-invasive extraluminally operable locator for imaging the progress of the working element through the occlusion. Conical, abrasive, blunt-dissecting, and sharp-pointed, and steering and non-steering working elements including guide wires are described. Acoustic transducers and a flexible imaging tube are described for the locator. A suction cup is described for removably anchoring the imaging tube to a surface. A signal-emitting working element and cooperating signal-receiving locator are described. A method for treating arterial occlusions is described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可透光操作的导管与微创外向可操作的定位器，用于通过闭塞成像工作元件的进展。描述了包括导丝在内的锥形，磨料，钝性解剖和锋利的转向和非转向工作元件。描述了定位器的声学换能器和柔性成像管。描述了用于可移除地将成像管固定到表面的吸盘。描述信号发射工作元件和配合信号接收定位器。描述了治疗动脉闭塞的方法。

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