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1. 发明申请

US20100009381A1 Compositions and methods for detection and isolation of phosphorylated molecules 审中-公开
标题翻译：用于磷酸化分子检测和分离的组合物和方法
公开(公告)号：US20100009381A1
公开(公告)日：2010-01-14
申请号：US12500854
申请日：2009-07-10
申请人： Brian Agnew , Joseph Beechem , Kyle Gee , Richard Haugland , Thomas Steinberg , Wayne Patton
发明人： Brian Agnew , Joseph Beechem , Kyle Gee , Richard Haugland , Thomas Steinberg , Wayne Patton
IPC分类号： G01N33/53
CPC分类号： G01N33/5008 , C12Q1/42 , C12Q1/485 , G01N33/502 , G01N33/5091 , G01N2333/4709 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/201666
摘要： The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.
摘要翻译：本发明涉及用于结合，检测和分离磷酸化靶分子的磷酸盐结合化合物，包括随后鉴定与磷酸化靶分子或能够被磷酸化的分子相互作用的靶分子。提供的结合溶液包括磷酸盐结合化合物，酸和金属离子，其中金属离子同时与靶分子上暴露的磷酸基团相互作用，并且磷酸盐结合化合物的金属螯合部分形成在磷酸化结合化合物和导致三元复合物的磷酸化靶分子。本发明的结合溶液用于结合和检测固定和溶解的磷酸化靶分子，从复杂混合物中分离磷酸化靶分子，并辅助蛋白质组分析，其中可以鉴定激酶和磷酸酶底物和酶。

2. 发明申请

US20060024209A1 Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte 审中-公开
标题翻译：用于测定常见分析物的多个流体样品的装置，方法和试剂盒
公开(公告)号：US20060024209A1
公开(公告)日：2006-02-02
申请号：US11193069
申请日：2005-07-28
申请人： Brian Agnew
发明人： Brian Agnew
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L3/5085 , B01L2300/0806 , B01L2300/0829
摘要： Methods and apparatus useful for the processing of fluid samples are disclosed. The apparatus can be used to process samples containing one or more biological, chemical, or clinical analytes of interest. The apparatus contains a microplate component and a backing plate. The microplate component and/or the backing plate can have a matrix of throughbores, each being mutually fluidly noncommunicating with each other. The support can be fixedly positioned between the microplate component and the backing plate, and can be removed from the apparatus for further processing.
摘要翻译：公开了用于处理流体样品的方法和设备。该装置可用于处理含有一种或多种感兴趣的生物，化学或临床分析物的样品。该装置包含微板组件和背板。微板组件和/或背板可以具有通孔的矩阵，每个通孔彼此相互流体地不通信。支撑件可以固定地定位在微板组件和背板之间，并且可以从设备中移除以进一步处理。

3. 发明申请

US20130209364A1 Anti-Viral Azide Containing Compounds 审中-公开
公开(公告)号：US20130209364A1
公开(公告)日：2013-08-15
申请号：US13812533
申请日：2011-07-28
申请人： Brian Agnew , Upinder Singh , Scott Grecian
发明人： Brian Agnew , Upinder Singh , Scott Grecian
IPC分类号： A61K31/655
CPC分类号： A61K31/655 , A61K31/7008 , C12N7/00 , C12N2710/14151 , C12N2710/14163 , C12N2740/16051 , C12N2740/16063
摘要： Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

4. 发明申请

US20130089884A1 Protein Modification from the Oxidation of Clickable Polyunsaturated Fatty Acid Analogs 审中-公开
标题翻译：从可点击的多不饱和脂肪酸类似物的氧化中的蛋白质修饰
公开(公告)号：US20130089884A1
公开(公告)日：2013-04-11
申请号：US13515561
申请日：2010-12-22
申请人： Brian Agnew , Chad Pickens , Upinder Singh
发明人： Brian Agnew , Chad Pickens , Upinder Singh
IPC分类号： C07C247/04 , G01N33/68 , C07C233/09
CPC分类号： C07C247/04 , C07C233/09 , G01N33/5008 , G01N33/5308 , G01N33/68 , G01N33/6842 , G01N2440/00 , G01N2440/12
摘要： Clickable polyunsaturated fatty acid analogs, methods of using these analogs and kits comprising these analogs.
摘要翻译：可点击的多不饱和脂肪酸类似物，使用这些类似物的方法和包含这些类似物的试剂盒。

5. 发明申请

US20120301894A1 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS 审中-公开
标题翻译：翻译后检测翻译后修饰蛋白
公开(公告)号：US20120301894A1
公开(公告)日：2012-11-29
申请号：US13399850
申请日：2012-02-17
申请人： Brian AGNEW , Kyle R. Gee , Tamara G. Nyberg
发明人： Brian AGNEW , Kyle R. Gee , Tamara G. Nyberg
IPC分类号： C12P21/00 , G01N21/64
CPC分类号： C12P21/005 , A61K47/549 , C07K1/13 , C07K14/47 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12Y302/01096 , G01N33/5005 , G01N33/5008 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/581 , G01N33/582 , G01N33/583 , Y10T436/17
摘要： Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.
摘要翻译：在某些实施方案中提供了形成报道分子，载体分子或固体支持物的叠氮基改性的生物分子缀合物的新方法。在其它实施方案中提供了用叠氮化物基团对生物分子进行酶标记的方法。

6. 发明申请

US20110207171A1 OLIGOSACCHARIDE MODIFICATION AND LABELING OF PROTEINS 有权
标题翻译：蛋白质的寡糖修饰和标记
公开(公告)号：US20110207171A1
公开(公告)日：2011-08-25
申请号：US13007506
申请日：2011-01-14
申请人： Brian Agnew , Schuyler B. CORRY , Kyle R. GEE
发明人： Brian Agnew , Schuyler B. CORRY , Kyle R. GEE
IPC分类号： C12P33/00 , C12P21/00 , C07K16/00 , C12N9/96
CPC分类号： C12P21/005 , A61K47/549 , A61K47/61 , C07K1/13 , C07K14/47 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12Y302/01096 , G01N33/5005 , G01N33/5008 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/581 , G01N33/582 , G01N33/583 , Y10T436/17
摘要： The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.
摘要翻译：本发明通常涉及在寡糖键上官能化蛋白质，特别是抗体的方法，通过修饰糖基化来人源化抗体的方法，以及与修饰的寡糖连接的新型抗体。本发明还涉及可用于产生本发明抗体的试剂盒。

7. 发明授权

US07445894B2 Compositions and methods for detection and isolation of phosphorylated molecules 有权
标题翻译：用于磷酸化分子检测和分离的组合物和方法
公开(公告)号：US07445894B2
公开(公告)日：2008-11-04
申请号：US10821522
申请日：2004-04-09
申请人： Brian Agnew , Kyle R. Gee , Vladimir V. Martin
发明人： Brian Agnew , Kyle R. Gee , Vladimir V. Martin
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , G01N33/502 , G01N33/5091 , G01N2333/4709
摘要： The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.
摘要翻译：本发明涉及用于结合，检测和分离磷酸化靶分子的磷酸盐结合化合物，包括随后鉴定与磷酸化靶分子或能够被磷酸化的分子相互作用的靶分子。提供的结合溶液包括磷酸盐结合化合物，酸和金属离子，其中金属离子同时与靶分子上暴露的磷酸基团相互作用，并且磷酸盐结合化合物的金属螯合部分形成在磷酸化结合化合物和导致三元复合物的磷酸化靶分子。本发明的结合溶液用于结合和检测固定和溶解的磷酸化靶分子，从复杂混合物中分离磷酸化靶分子，并辅助蛋白质组分析，其中可以鉴定激酶和磷酸酶底物和酶。

8. 发明授权

US07102005B2 Compositions and methods for detection and isolation of phosphorylated molecules 有权
标题翻译：用于磷酸化分子检测和分离的组合物和方法
公开(公告)号：US07102005B2
公开(公告)日：2006-09-05
申请号：US10428192
申请日：2003-05-02
申请人： Brian Agnew , Joseph Beechem , Kyle Gee , Richard Haugland , Jixiang Liu , Vladimir Martin , Wayne Patton , Thomas Steinberg
发明人： Brian Agnew , Joseph Beechem , Kyle Gee , Richard Haugland , Jixiang Liu , Vladimir Martin , Wayne Patton , Thomas Steinberg
IPC分类号： C07D239/88 , C07D277/62 , C07D311/82 , C07D417/02 , C07D495/04
CPC分类号： G01N33/50 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N2333/4709
摘要： The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and a metal ion wherein the metal ion simultaneously interacts with an exposed phosphate group on a target molecule and the metal chelating moiety of the phosphate-binding compound forming a bridge between the phosphate-binding compound and a phosphorylated target molecule resulting in a ternary complex. The binding solution of the present invention finds use in binding and detecting immobilized and solubilized phosphorylated target molecules, isolation of phosphorylated target molecules from a complex mixture and aiding in proteomic analysis wherein kinase and phosphatase substrates and enzymes can be identified.
摘要翻译：本发明涉及用于结合，检测和分离磷酸化靶分子的磷酸盐结合化合物，包括随后鉴定与磷酸化靶分子或能够被磷酸化的分子相互作用的靶分子。提供的结合溶液包括磷酸盐结合化合物，酸和金属离子，其中金属离子同时与靶分子上暴露的磷酸基团相互作用，并且磷酸盐结合化合物的金属螯合部分形成在磷酸化结合化合物和导致三元复合物的磷酸化靶分子。本发明的结合溶液用于结合和检测固定和溶解的磷酸化靶分子，从复杂混合物中分离磷酸化靶分子，并辅助蛋白质组分析，其中可以鉴定激酶和磷酸酶底物和酶。

9. 发明授权

US08785212B2 Oligosaccharide modification and labeling of proteins 有权
标题翻译：寡糖修饰和蛋白质标记
公开(公告)号：US08785212B2
公开(公告)日：2014-07-22
申请号：US13007506
申请日：2011-01-14
申请人： Brian Agnew , Kyle Gee , Schuyler Corry
发明人： Brian Agnew , Kyle Gee , Schuyler Corry
IPC分类号： G01N33/532 , G01N33/534 , G01N33/533 , G01N33/50 , A61K47/48
CPC分类号： C12P21/005 , A61K47/549 , A61K47/61 , C07K1/13 , C07K14/47 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C12Y302/01096 , G01N33/5005 , G01N33/5008 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/581 , G01N33/582 , G01N33/583 , Y10T436/17
摘要： The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.
摘要翻译：本发明通常涉及在寡糖键上官能化蛋白质，特别是抗体的方法，通过修饰糖基化来人源化抗体的方法，以及与修饰的寡糖连接的新型抗体。本发明还涉及可用于产生本发明抗体的试剂盒。

10. 发明申请

US20130209550A1 Anti-Viral Azide Containing Compounds 审中-公开
公开(公告)号：US20130209550A1
公开(公告)日：2013-08-15
申请号：US13812807
申请日：2011-07-28
申请人： Brian Agnew , David Graham , Upinder Singh , Scott Grecian
发明人： Brian Agnew , David Graham , Upinder Singh , Scott Grecian
IPC分类号： A61K31/655 , A61K45/06 , A61K31/7024
CPC分类号： A61K31/655 , A61K31/7024 , A61K31/7088 , A61K38/212 , A61K38/215 , A61K45/06 , A61K2300/00
摘要： Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

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