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1. 发明申请

US20080213333A1 Methods and compositions for fostering and preserving bone growth 有权
标题翻译：促进和保留骨骼生长的方法和组合物
公开(公告)号：US20080213333A1
公开(公告)日：2008-09-04
申请号：US11796439
申请日：2007-04-27
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan , Keiran P. Murphy
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan , Keiran P. Murphy
IPC分类号： A61F2/28 , A61K38/18 , A61K31/592 , A61B19/02 , A61K38/22
CPC分类号： A61B17/58 , A61B2017/564 , A61L27/12 , A61L27/54 , A61L2300/112 , A61L2300/252 , A61L2300/414 , A61L2300/43
摘要： A method for augmenting bone in a subject in need thereof including installing within an interior portion of a bone located in the subject a sufficient amount of a biocompatible material to form a scaffold within the bone interior, wherein the scaffold serves as a support for the formation of new bone within the bone interior portion, and administering to the subject a sufficient amount of at least one bone augmentation agent to elevate blood concentration of at least one anabolic agent in the subject. The method may further include administering at least one anti-resorptive agent to the subject in an amount sufficient to substantially prevent resorption of new bone growth. In another embodiment, the method may further include a step of mechanically inducing an increase in osteoblast activity in the subject, wherein the elevation in blood concentration of the anabolic agent and the increase in osteoblast activity at least partially overlap in time.
摘要翻译：一种用于在有需要的受试者中增加骨的方法，包括在位于受试者内的骨的内部部分内安装足够量的生物相容性材料以在骨内部形成支架，其中所述支架用作所述形成的支撑体的骨内部部分中的新骨，并且向受试者施用足够量的至少一种骨增强剂以提高受试者中至少一种合成代谢物的血液浓度。该方法还可以包括以足以基本上防止新骨生长再吸收的量向受试者施用至少一种抗吸收剂。在另一个实施方案中，该方法还可以包括机械诱导受试者中成骨细胞活性增加的步骤，其中合成代谢剂的血液浓度升高和成骨细胞活性的增加在时间上至少部分重叠。

2. 发明申请

US20080057051A1 METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION 有权
标题翻译：诱导骨形成和保存的方法
公开(公告)号：US20080057051A1
公开(公告)日：2008-03-06
申请号：US11839957
申请日：2007-08-16
申请人： Agnes Vignery , Nozer Mehta , James Gilligan
发明人： Agnes Vignery , Nozer Mehta , James Gilligan
IPC分类号： A61K31/56 , A61H1/00 , A61K38/00 , A61K38/48 , A61P19/00
CPC分类号： A61K38/1833 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.
摘要翻译：在需要这种诱导的受试者中诱导骨形成的方法包括以下步骤：机械诱导受试者中成骨细胞活性的增加并提高受试者中至少一种骨合成代谢物的血液浓度。方法步骤可以以任何顺序进行，但是在足够的时间接近度下，合成代谢剂的升高浓度和机械诱导的成骨细胞活性增加重叠。该方法可另外包括向受试者提供至少一种抗再吸收剂的升高的血液浓度，其中提高的浓度足以防止由于成骨细胞活性而产生的新骨生长的再吸收。使用该方法允许靶向受试者的特定骨骼用于骨生产和保存，更快的骨生产和早期停止骨合成代谢药物。提供适用于执行该方法的套件。

3. 发明申请

US20080183134A1 METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION 审中-公开
公开(公告)号：US20080183134A1
公开(公告)日：2008-07-31
申请号：US12059605
申请日：2008-03-31
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A61M37/00 , A61B17/58 , A61F2/28
CPC分类号： A61K38/1825 , A61F2002/2817 , A61K38/1833 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

4. 发明申请

US20080181880A1 METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION 有权
公开(公告)号：US20080181880A1
公开(公告)日：2008-07-31
申请号：US12059662
申请日：2008-03-31
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A61K38/48 , A61K31/56 , A61K38/16 , A61P19/00
CPC分类号： A61K38/1825 , A61F2002/2817 , A61K38/1833 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

5. 发明授权

US07776826B2 Method for fostering bone formation and preservation 有权
公开(公告)号：US07776826B2
公开(公告)日：2010-08-17
申请号：US12059662
申请日：2008-03-31
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A61K38/22 , A61K38/23 , A61K38/29
CPC分类号： A61K38/1825 , A61F2002/2817 , A61K38/1833 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

6. 发明授权

US07648700B2 Method for fostering bone formation and preservation 有权
标题翻译：促进骨形成和保存的方法
公开(公告)号：US07648700B2
公开(公告)日：2010-01-19
申请号：US11839957
申请日：2007-08-16
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A01N63/00 , A61K38/00 , A61F2/02
CPC分类号： A61K38/1833 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.
摘要翻译：在需要这种诱导的受试者中诱导骨形成的方法包括以下步骤：机械诱导受试者中成骨细胞活性的增加并提高受试者中至少一种骨合成代谢物的血液浓度。方法步骤可以以任何顺序进行，但是在足够的时间接近度下，合成代谢剂的升高浓度和机械诱导的成骨细胞活性增加重叠。该方法可另外包括向受试者提供至少一种抗再吸收剂的升高的血液浓度，其中提高的浓度足以防止由于成骨细胞活性产生的新骨生长的再吸收。使用该方法允许靶向受试者的特定骨骼用于骨生产和保存，更快的骨生产和早期停止骨合成代谢药物。提供适用于执行该方法的套件。

7. 发明申请

US20050256047A1 Method for fostering bone formation and preservation 有权
标题翻译：促进骨形成和保存的方法
公开(公告)号：US20050256047A1
公开(公告)日：2005-11-17
申请号：US11128095
申请日：2005-05-11
申请人： Agnes Vignery , Nozer Mehta , James Gilligan
发明人： Agnes Vignery , Nozer Mehta , James Gilligan
IPC分类号： A61H1/02 , A61K38/17 , A61K38/18 , A61K38/22 , A61K38/29 , A61K38/30
CPC分类号： A61K38/1833 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.
摘要翻译：在需要这种诱导的受试者中诱导骨形成的方法包括以下步骤：机械诱导受试者中成骨细胞活性的增加并提高受试者中至少一种骨合成代谢物的血液浓度。方法步骤可以以任何顺序进行，但是在足够的时间接近度下，合成代谢剂的升高浓度和机械诱导的成骨细胞活性增加重叠。该方法可另外包括向受试者提供至少一种抗再吸收剂的升高的血液浓度，其中提高的浓度足以防止由于成骨细胞活性而产生的新骨生长的再吸收。使用该方法允许靶向受试者的特定骨骼用于骨生产和保存，更快的骨生产和早期停止骨合成代谢药物。提供适用于执行该方法的套件。

8. 发明申请

US20100104582A1 CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts 审中-公开
标题翻译： CD200及其受体CD200R通过破骨细胞的分化调节骨量
公开(公告)号：US20100104582A1
公开(公告)日：2010-04-29
申请号：US12521363
申请日：2008-01-10
申请人： Agnes Vignery , Juan Zhang Ke , Jun Li
发明人： Agnes Vignery , Juan Zhang Ke , Jun Li
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , A61K38/14 , C12Q1/02 , A61P19/10 , A61P35/00 , A61P29/00
CPC分类号： C07K16/2803 , A61K38/177 , A61K38/1774 , A61K2039/505
摘要： Disclosed are methods and compositions relating to CD200 and its receptor, CD200R which modulate bone mass via the differentiation of osteoclasts.
摘要翻译：公开了与CD200及其受体CD200R相关的方法和组合物，其通过破骨细胞的分化调节骨量。

9. 发明申请

US20080051343A1 METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION 审中-公开
公开(公告)号：US20080051343A1
公开(公告)日：2008-02-28
申请号：US11839993
申请日：2007-08-16
申请人： Agnes Vignery , Nozer Mehta , James Gilligan
发明人： Agnes Vignery , Nozer Mehta , James Gilligan
IPC分类号： A61K38/22 , A61P19/00
CPC分类号： A61K38/1833 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

10. 发明申请

US20060293667A1 Bone implant device and methods of using same 审中-公开
标题翻译：骨植入装置及其使用方法
公开(公告)号：US20060293667A1
公开(公告)日：2006-12-28
申请号：US11430752
申请日：2006-05-09
申请人： Agnes Vignery , Nozer Mehta , James Gilligan
发明人： Agnes Vignery , Nozer Mehta , James Gilligan
IPC分类号： A61F2/30
CPC分类号： A61B17/72 , A61B17/7258 , A61B17/7283 , A61B17/742
摘要： A bone implant device comprising a plurality of interconnected plate members, at least one plate member defining a plurality of apertures therein adapted for permitting bone growth there through from an interior portion of the bone in which the device is implanted for aiding in securing the device within the interior portion, and wherein the device is configured and adapted to minimize contact with an interior surface of the bone. The device is useful in applications including, but not limited to, repairing bone fractures, modeling bone in growing subjects, service as artificial joints and anchoring prostheses, such as an artificial limb, to a bone stub in the body of a subject.
摘要翻译：一种骨植入装置，包括多个互连的板构件，至少一个板构件，其限定多个孔，其中适于允许骨头从其内植入骨骼的内部，其中植入装置，用于帮助将装置固定在内所述内部部分，并且其中所述装置被构造和适于最小化与所述骨的内表面的接触。该装置可用于包括但不限于修复骨折，将成长中的受试者中的骨骼模拟成人造关节的服务，以及诸如假肢的锚定假体到受试者体内的骨头。

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