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1. 发明申请

US20080213333A1 Methods and compositions for fostering and preserving bone growth 有权
标题翻译：促进和保留骨骼生长的方法和组合物
公开(公告)号：US20080213333A1
公开(公告)日：2008-09-04
申请号：US11796439
申请日：2007-04-27
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan , Keiran P. Murphy
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan , Keiran P. Murphy
IPC分类号： A61F2/28 , A61K38/18 , A61K31/592 , A61B19/02 , A61K38/22
CPC分类号： A61B17/58 , A61B2017/564 , A61L27/12 , A61L27/54 , A61L2300/112 , A61L2300/252 , A61L2300/414 , A61L2300/43
摘要： A method for augmenting bone in a subject in need thereof including installing within an interior portion of a bone located in the subject a sufficient amount of a biocompatible material to form a scaffold within the bone interior, wherein the scaffold serves as a support for the formation of new bone within the bone interior portion, and administering to the subject a sufficient amount of at least one bone augmentation agent to elevate blood concentration of at least one anabolic agent in the subject. The method may further include administering at least one anti-resorptive agent to the subject in an amount sufficient to substantially prevent resorption of new bone growth. In another embodiment, the method may further include a step of mechanically inducing an increase in osteoblast activity in the subject, wherein the elevation in blood concentration of the anabolic agent and the increase in osteoblast activity at least partially overlap in time.
摘要翻译：一种用于在有需要的受试者中增加骨的方法，包括在位于受试者内的骨的内部部分内安装足够量的生物相容性材料以在骨内部形成支架，其中所述支架用作所述形成的支撑体的骨内部部分中的新骨，并且向受试者施用足够量的至少一种骨增强剂以提高受试者中至少一种合成代谢物的血液浓度。该方法还可以包括以足以基本上防止新骨生长再吸收的量向受试者施用至少一种抗吸收剂。在另一个实施方案中，该方法还可以包括机械诱导受试者中成骨细胞活性增加的步骤，其中合成代谢剂的血液浓度升高和成骨细胞活性的增加在时间上至少部分重叠。

2. 发明申请

US20080183134A1 METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION 审中-公开
公开(公告)号：US20080183134A1
公开(公告)日：2008-07-31
申请号：US12059605
申请日：2008-03-31
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A61M37/00 , A61B17/58 , A61F2/28
CPC分类号： A61K38/1825 , A61F2002/2817 , A61K38/1833 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

3. 发明申请

US20080181880A1 METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION 有权
公开(公告)号：US20080181880A1
公开(公告)日：2008-07-31
申请号：US12059662
申请日：2008-03-31
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A61K38/48 , A61K31/56 , A61K38/16 , A61P19/00
CPC分类号： A61K38/1825 , A61F2002/2817 , A61K38/1833 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

4. 发明授权

US07776826B2 Method for fostering bone formation and preservation 有权
公开(公告)号：US07776826B2
公开(公告)日：2010-08-17
申请号：US12059662
申请日：2008-03-31
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A61K38/22 , A61K38/23 , A61K38/29
CPC分类号： A61K38/1825 , A61F2002/2817 , A61K38/1833 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.

5. 发明授权

US07648700B2 Method for fostering bone formation and preservation 有权
标题翻译：促进骨形成和保存的方法
公开(公告)号：US07648700B2
公开(公告)日：2010-01-19
申请号：US11839957
申请日：2007-08-16
申请人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
发明人： Agnes Vignery , Nozer M. Mehta , James P. Gilligan
IPC分类号： A01N63/00 , A61K38/00 , A61F2/02
CPC分类号： A61K38/1833 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/225 , A61K38/29 , A61K38/30 , Y10S435/81
摘要： A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.
摘要翻译：在需要这种诱导的受试者中诱导骨形成的方法包括以下步骤：机械诱导受试者中成骨细胞活性的增加并提高受试者中至少一种骨合成代谢物的血液浓度。方法步骤可以以任何顺序进行，但是在足够的时间接近度下，合成代谢剂的升高浓度和机械诱导的成骨细胞活性增加重叠。该方法可另外包括向受试者提供至少一种抗再吸收剂的升高的血液浓度，其中提高的浓度足以防止由于成骨细胞活性产生的新骨生长的再吸收。使用该方法允许靶向受试者的特定骨骼用于骨生产和保存，更快的骨生产和早期停止骨合成代谢药物。提供适用于执行该方法的套件。

6. 发明申请

US20120302497A1 METHODS OF TREATING MEDICAL CONDITIONS USING CALCITONIN ANALOGS 有权
标题翻译：使用CALCITONIN ANALOGS处理医疗条件的方法
公开(公告)号：US20120302497A1
公开(公告)日：2012-11-29
申请号：US13544256
申请日：2012-07-09
申请人： Nozer M. Mehta , Amy Sturmer , William Stern , James P. Gilligan
发明人： Nozer M. Mehta , Amy Sturmer , William Stern , James P. Gilligan
IPC分类号： A61K38/16 , A61P19/02 , A61P19/10 , A61P3/04 , A61P3/10
CPC分类号： A61K38/1706 , A61K9/0053 , A61K9/28 , A61K9/4891 , A61K38/00 , C07K14/00 , C07K14/585
摘要： The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like.
摘要翻译：本发明提供了用于食欲抑制和体重控制的肽及其药物组合物。优选的肽是降钙素类似物，优选具有特定的氨基酸改变以使肽更像胰岛淀粉样多肽。

7. 发明申请

US20120142586A1 TREATMENT FOR OBESITY 有权
公开(公告)号：US20120142586A1
公开(公告)日：2012-06-07
申请号：US13295906
申请日：2011-11-14
申请人： Nozer M. Mehta , Amy Sturmer , William Stern , James P. Gilligan
发明人： Nozer M. Mehta , Amy Sturmer , William Stern , James P. Gilligan
IPC分类号： A61K38/23 , C07K14/585 , A61P3/00 , A61P3/04 , A61P3/10
CPC分类号： A61K38/1706 , A61K9/0053 , A61K9/28 , A61K9/4891 , A61K38/00 , C07K14/00 , C07K14/585
摘要： The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like.

8. 发明授权

US08076291B2 Treatment for obesity 有权
标题翻译：治疗肥胖
公开(公告)号：US08076291B2
公开(公告)日：2011-12-13
申请号：US12692502
申请日：2010-01-22
申请人： Nozer M. Mehta , Amy Sturmer , William Stern , James P. Gilligan
发明人： Nozer M. Mehta , Amy Sturmer , William Stern , James P. Gilligan
IPC分类号： A61K38/00 , C07K14/585
CPC分类号： A61K38/1706 , A61K9/0053 , A61K9/28 , A61K9/4891 , A61K38/00 , C07K14/00 , C07K14/585
摘要： The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like.
摘要翻译：本发明提供了用于食欲抑制和体重控制的肽及其药物组合物。优选的肽是降钙素类似物，优选具有特定的氨基酸改变以使肽更像胰岛淀粉样多肽。

9. 发明申请

US20090023892A1 Enzymatic reactions in the presence of keto acids 有权
标题翻译：在酮酸存在下的酶反应
公开(公告)号：US20090023892A1
公开(公告)日：2009-01-22
申请号：US12284552
申请日：2008-09-22
申请人： Angelo P. Consalvo , Nozer M. Mehta , William Stern , James P. Gilligan
发明人： Angelo P. Consalvo , Nozer M. Mehta , William Stern , James P. Gilligan
IPC分类号： C07K7/00
CPC分类号： C12Y114/17003 , C12P13/02 , C12P21/02 , C12Y403/02005
摘要： Conversion in vitro of X-Gly to X-alpha-hydroxy-Gly or X-NH2 (X being a peptide or any other compound having a carbonyl group capable of forming a covalent bond with glycine) is accomplished enzymatically in the presence of keto acids, or salts or esters thereof, to provide a good yield without the necessity of catalase or similar enzymatic reaction enhancers. Peptidylglycine α-amidating monooxygenase (PAM) is a preferred enzyme for catalyzing the conversion. Alternatively, peptidylglycine α-hydroxylating monooxygenase (PHM) is utilized to convert X-Gly to X-alpha-hydroxy-Gly which may be recovered, or optionally may be simultaneously or sequentially converted to an amide by either a Lewis base or action of the enzyme peptidyl α-hydroxyglycine α-amidating lyase (PAL). Both PHM and PAL are functional domains of PAM.
摘要翻译：将X-Gly体外转化为X-α-羟基-Gly或X-NH2（X为肽或具有能与甘氨酸形成共价键的羰基的任何其它化合物）在酮酸存在下酶促完成，或其盐或酯，以提供良好的产率而不需要过氧化氢酶或类似的酶促反应增强剂。肽基甘氨酸α-酰胺化单加氧酶（PAM）是催化转化的优选酶。或者，使用肽基甘氨酸α-羟化化单加氧酶（PHM）将X-Gly转化为可被回收的X-α-羟基-Gly，或任选地可以通过路易斯碱同时或顺序地转化为酰胺，或通过酶肽肽α-羟基甘氨酸α-酰胺化裂解酶（PAL）。 PHM和PAL都是PAM的功能域。

10. 发明申请

US20120071410A1 CALCITONIN PRODUCTS AND THERAPIES FOR TREATING INFLAMMATORY OR DEGENERATIVE DISEASES 审中-公开
标题翻译：用于治疗炎症或变应性疾病的CALCITONIN产品和治疗
公开(公告)号：US20120071410A1
公开(公告)日：2012-03-22
申请号：US13238801
申请日：2011-09-21
申请人： Nozer M. Mehta , James P. Gilligan
发明人： Nozer M. Mehta , James P. Gilligan
IPC分类号： A61K38/23 , A61P31/00 , A61P29/00
CPC分类号： A61K38/23 , A61K9/0043 , A61K9/0053 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/573 , A61K31/65 , A61K38/17 , A61K45/06 , A61K2300/00
摘要： Calcitonin products and therapies for treating inflammatory or degenerative diseases are disclosed herein. The pharmaceutical compositions disclosed herein include a first therapeutic agent that is calcitonin, in free or salt form; a second therapeutic agent selected from the group consisting of a protease inhibitor, an antibiotic, a non-steroidal anti-inflammatory agent, a COX-2 inhibitor and a steroidal anti-inflammatory agent other than glucocorticoid; and a pharmaceutically acceptable excipient, carrier or diluent. The methods disclosed herein for treating inflammatory or degenerative diseases in a subject include administering a therapeutically effective amount of calcitonin, in free or salt form, to the subject; and co-administering, as part of a combination therapy, a therapeutically effective amount of a second therapeutic agent selected from the group consisting of a protease inhibitor, an antibiotic, a non-steroidal anti-inflammatory agent, a COX-2 inhibitor and a steroidal anti-inflammatory agent other than glucocorticoid to the subject.
摘要翻译：本文公开了用于治疗炎性或退行性疾病的降钙素产品和疗法。本文公开的药物组合物包括游离或盐形式的降钙素的第一治疗剂; 选自蛋白酶抑制剂，抗生素，非甾体抗炎药，COX-2抑制剂和除糖皮质激素以外的甾族抗炎剂的第二治疗剂; 和药学上可接受的赋形剂，载体或稀释剂。本文公开的用于治疗受试者的炎性或退行性疾病的方法包括向受试者施用治疗有效量的游离或盐形式的降钙素; 作为组合治疗的一部分，共同施用治疗有效量的第二治疗剂，其选自蛋白酶抑制剂，抗生素，非甾体抗炎药，COX-2抑制剂和除了糖皮质激素以外的甾族抗炎药物。

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