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1. 发明申请

US20070092433A1 PROCESS FOR PRODUCING STABLE POLYALUMINUM HYDROXYCHLORIDE AND POLYALUMINUM HYDROXYCHLOROSULFATE AQUEOUS SOLUTIONS 审中-公开
标题翻译：生产稳定的羟基氯化汞和聚羟基氯化铵水溶液的方法
公开(公告)号：US20070092433A1
公开(公告)日：2007-04-26
申请号：US11163530
申请日：2005-10-21
申请人： Kevin Janak , Michael Thompson
发明人： Kevin Janak , Michael Thompson
IPC分类号： C01B17/46
CPC分类号： C01F7/007 , C02F1/5245
摘要： The production of polyaluminum hydroxychlorosulfates (PACS) suitable for effective use as flocculants and coagulants in water treatment is described. The product is a fluid, clear solution that is stable with respect to precipitation and gelling for extended periods of time. Key features of the process include: i) the production of a PACS solution of about 12-16% Al2O3 and about 40-60% basicity at moderate temperatures (50-60° C.) using a zerovalent aluminum source, such as aluminum powder, ii) the addition of an alkali metal or alkali earth metal base at low temperatures (20-30° C.) to produce PACS products ranging from 9-12% Al2O3 with basicities ranging from 70-80%, iii) the addition of an alkali metal base at low temperatures without the use of high shear mixing, iv) a PACS product that does not contain significant amounts of the Al13-mer Keggin complex , v) a product with greater than 80-95% of the aluminum polymers bimodally distributed in the range of 20,000-40,000 Daltons and 135-750 Daltons, and vi) the formation a PACS whereby greater than 95% of the sulfate is bound to aluminum and is contained in the aluminum polymers distributed in the range of 20,000-40,000 Daltons.
摘要翻译：描述了适用于在水处理中有效用作絮凝剂和凝结剂的聚羟基氯代硫酸氢铝（PACS）的生产。该产品是一种液体，透明的溶液，对于沉淀和胶凝长时间稳定。该方法的主要特征包括：i）在中等温度下生产约12-16％的Al 2 O 3 3和约40-60％碱度的PACS溶液（ 50-60℃），使用诸如铝粉末的零价铝源，ii）在低温（20-30℃）下加入碱金属或碱土金属碱以产生范围为9- 12％的Al 2 O 3，其碱度范围为70-80％，iii）在低温下加入碱金属碱而不使用高剪切混合，iv ）不含显着量的Al 13+ Keggin络合物的PACS产物，v）具有大于80-95％双峰分布在20,000-40,000范围内的铝聚合物的产物道尔顿和135-750道尔顿，以及vi）形成PACS，其中大于95％的硫酸盐与铝结合并且包含在分布在20,000-40,000道尔顿范围内的铝聚合物中。

2. 发明授权

US07074394B2 Stable aluminum/zirconium antiperspirant solution free of amino acid and polyhydric alcohol 失效
标题翻译：稳定的铝/锆止汗液不含氨基酸和多元醇
公开(公告)号：US07074394B2
公开(公告)日：2006-07-11
申请号：US10625038
申请日：2003-07-22
申请人： Zijun Li , Jawahar Parekh
发明人： Zijun Li , Jawahar Parekh
IPC分类号： A61Q15/00 , A61K8/00 , A61K8/02
CPC分类号： A61K8/28 , A61Q15/00
摘要： A stable aluminum-zirconium aqueous solution of enhanced efficacy having a high concentration free of amino acid and polyhydric alcohol is disclosed. Such aluminum-zirconium salts are selected from aluminum/zirconium tetrachlorohydrate; aluminum/zirconium pentachlorohydrate, and aluminum/zirconium octachlorohydrate in which the aluminum to zirconium (Al/Zr) atomic ratio of said salt falls within the limits of the shaded areas A, B, and C, respectively, of the drawing graph wherein the aluminum/zirconium tetrachlorohydrate has an Al/Zr atomic ratio from about 2 to about 6 and metal/chloride molecular ratio about 0.9 to about 1.25; aluminum/zirconium pentachlorohydrate having Al/Zr atomic ratio from about 6 to about 10 and metal/chloride atomic ratio from about 1.5 to about 1.65; and aluminum/zirconium octachlorohydrate having Al/Zr molecular ratio from about 6 to about 10 and metal/chloride molecular ratio from about 0.9 to about 1.5.
摘要翻译：公开了一种具有高浓度的氨基酸和多元醇的高效率的稳定的铝 - 锆水溶液。这种铝 - 锆盐选自四氯水合铝/锆; 铝/锆五氯水合物，以及所述盐的铝与锆（Al / Zr）原子比分别落在阴影区域A，B和C的限制范围内的铝/锆八水合物，其中铝 /锆四氯水合物具有约2至约6的Al / Zr原子比和约0.9至约1.25的金属/氯化物分子比; 铝/锆五氯水合物，其Al / Zr原子比为约6至约10，金属/氯化物原子比为约1.5至约1.65; 铝/锆八水合物，其Al / Zr分子比为约6至约10，金属/氯化物分子比为约0.9至约1.5。

3. 发明授权

US5254230A Methods for preparing basic aluminum compounds with ultrasound 失效
标题翻译：用超声波制备碱性铝化合物的方法
公开(公告)号：US5254230A
公开(公告)日：1993-10-19
申请号：US916299
申请日：1992-07-17
申请人： Vijay K. Joshi , Jawahar C. Parekh
发明人： Vijay K. Joshi , Jawahar C. Parekh
IPC分类号： C01F7/00 , C01F7/48 , C01F7/56 , C01F7/66 , C01F7/68 , C01F11/36 , C01F11/46 , C01F11/48 , C01B7/00
CPC分类号： C01F7/56 , C01F7/48 , C01F7/66 , C01F7/68
摘要： Processes are provided for preparing basic aluminum compounds of Formula I:Al.sub.2 (OH).sub.6-a X.sub.a (I)wherein X is Cl.sup.-, Br.sup.-, F.sup.-, I.sup.-, SO.sub.4.sup.= or NO.sub.3.sup.- and a is about 0.9 to 4, the compound being characterized by size exclusion chromatography as having a Band I percent aluminum value of about 5% or less and a Band II percent aluminum value of about 50% to 90%, which comprise (a) suspending an aluminum metal in an aqueous medium to form a slurry, (b) applying ultrasonic energy to the slurry, (c) reacting the sonicated slurry with an aluminum compound of Formula IIAl.sub.n X.sub.m (II)or an acid of Formula III:H.sub.n X (III)wherein X is Cl.sup.-, Br.sup.-, F.sup.-, I.sup.-, SO.sub.4.sup.= or NO.sub.3.sup.-, n is 1 or 2 and m is 3, at a temperature of about 45.degree. C. to 100.degree. C. to form a reaction product.
摘要翻译：提供制备式I的碱性铝化合物的方法：其中X是Cl - ，Br-，F-，I-，SO 4 =或NO 3 - 的Al 2（OH）6-a X a（I），a是约0.9-4，该化合物的特征在于尺寸排阻色谱法，其具有约5％或更低的I级铝值，并且具有约50％至90％的Band II％铝值，其包含（a）将铝金属悬浮在水性介质（b）向浆料中施加超声能量，（c）将超声处理的浆料与式IIAlnXm（II）的铝化合物或式III的酸：其中X是Cl-的HnX（III）反应， Br-，F-，I-，SO4 =或NO3-，n为1或2，m为3，在约45℃至100℃的温度下反应形成反应产物。

4. 发明授权

US07153495B2 Fragrance friendly and cost effective antiperspirant actives and method of making the same 失效
标题翻译：香味友好和具有成本效益的止汗活性物质及其制备方法
公开(公告)号：US07153495B2
公开(公告)日：2006-12-26
申请号：US10865397
申请日：2004-06-10
申请人： Jawahar C. Parekh , Pradip T. Amin , Chung Teck Shin
发明人： Jawahar C. Parekh , Pradip T. Amin , Chung Teck Shin
IPC分类号： A61Q15/00 , A61K8/00 , A61K8/02
CPC分类号： A61Q15/00 , A61K8/26
摘要： A cost effective process is provided for making stable, efficacious, amino acid and polyhydric alcohol free concentrated aqueous aluminum zirconium salt solutions. Absence of amino acid, low iron content and low trace metal impurity levels improve compatibility with fragrances and minimizes the probability of the product color change and possibly fabric staining significantly. The novel aluminum zirconium actives also minimize iron contribution to underarm area that supports growth of microflora which is responsible for axillary malodour by the biotransformation of nonodorous precursors present in perspiration. The astringent complexes of the present invention may be obtained in solution or dry powder form. As a result, the complexes are satisfactory for use in any of wide variety of conventional antiperspirant forms.
摘要翻译：提供了一种成本有效的方法，用于制备稳定，有效的氨基酸和多元醇的浓盐酸铝水溶液。缺乏氨基酸，低铁含量和低痕量金属杂质水平提高了与香料的相容性，并最大限度地降低了产品颜色变化和织物染色显着的可能性。新型铝锆活性物质也使铁对腋下区域的贡献最小化，其支持微生物群落的生长，微生物群落通过出汗中存在的无臭前体的生物转化而引起腋窝恶臭。本发明的收敛剂可以以溶液或干粉形式获得。结果，复合物可以用于各种常规止汗剂形式中的任何一种。

5. 发明授权

US07087220B2 High pH antiperspirant compositions of enhanced efficacy 失效
标题翻译：具有增强功效的高pH止汗组合物
公开(公告)号：US07087220B2
公开(公告)日：2006-08-08
申请号：US10857493
申请日：2004-05-28
申请人： Zijun Li
发明人： Zijun Li
IPC分类号： A61Q15/00 , A61Q19/00 , A61K8/00 , A61K8/02
CPC分类号： A61K8/28 , A61Q15/00 , C01F7/56 , C01P2002/87
摘要： Aluminum and aluminum-zirconium antiperspirant compositions of enhanced efficacy and a pH value of at least 3.5 are provided that are made by reaction with insoluble, strongly alkaline strontium or calcium salts. The aluminum and aluminum-zirconium strontium or calcium compositions show high pH values with characteristic HPLC Band III to Band II ratios of at least 0.5. The basic aluminum halohydrate (or nitrate) solutions typically have aluminum to anion ratio of less that 1.9. The solution compositions are stable with respect to both HPLC Band III to Band II ratio and viscosity at concentrations of about 20% to about 40% by weight of anhydrous solid. The solid state compositions form hard sticks with low irritation, at low metal to chloride ratios of about 0.9 to about 1.2.
摘要翻译：提供了增强效力和至少3.5的pH值的铝和铝 - 锆止汗组合物，其通过与不溶性强碱性锶或钙盐的反应制备。铝和铝 - 锆锶或钙组合物显示高pH值，具有至少0.5的特征HPLC带III至带II比率。碱性卤化铝铝（或硝酸盐）溶液的铝阴离子比例通常小于1.9。溶液组合物相对于HPLC Band III至Band II比率和在约20重量％至约40重量％的无水固体的浓度下的粘度是稳定的。固态组合物形成具有低刺激性的硬棒，低金属氯化物比为约0.9至约1.2。

6. 发明授权

US07060258B2 Method of making aluminum-zirconium antiperspirant of enhanced efficacy 失效
标题翻译：制备增强效力的铝 - 锆止汗剂的方法
公开(公告)号：US07060258B2
公开(公告)日：2006-06-13
申请号：US10756620
申请日：2004-02-17
申请人： Zijun Li
发明人： Zijun Li
IPC分类号： A61K8/00 , A61K8/02 , A61Q15/00
CPC分类号： A61K8/44 , A61K8/26 , A61K2800/58 , A61Q15/00
摘要： A novel efficacious and less irritant aluminum-zirconium antiperspirant composition is provided by the addition of a small amount of AlCl3 and/or HCl to the activated aluminum component. After the heating of diluted basic aluminum chlorohydrate solution, cooling to room temperature, mixing with small amount of AlCl3 or HCl and then reacting with zirconium glycine complex, an aluminum-zirconium salt is produced with a maximum amount of depolymerization aluminum and zirconium species. The addition of a small amount of AlCl3 or HCl to the diluted and activated aluminum chlorohydrate solution accelerates the depolymerization of the activated ACH solution, and upon the addition of zirconium glycinate the solution is further depolymerized and results in the formation of less polymerized zirconium species.
摘要翻译：通过向活化的铝组分中加入少量的AlCl 3和/或HCl来提供新的有效和较少刺激性的铝 - 锆止汗组合物。在稀释的碱式氯化铝水溶液加热后，冷却至室温，与少量的AlCl 3或HCl混合，然后与甘氨酸络合物反应，制得铝 - 锆盐，最大量的解聚铝和锆物质。向稀释和活化的氯化铝水溶液中加入少量的AlCl 3或HCl加速了活化的ACH溶液的解聚，并且当加入甘氨酸锆时，溶液进一步解聚，并导致形成较少聚合的锆物质。

7. 发明授权

US06902724B1 Enhanced efficacy basic aluminum halides, antiperspirant active compositions and methods for making 失效
标题翻译：增强功效碱性卤化铝，止汗活性组合物和制备方法
公开(公告)号：US06902724B1
公开(公告)日：2005-06-07
申请号：US10807996
申请日：2004-03-24
申请人： Jawahar C. Parekh , Pradip Amin
发明人： Jawahar C. Parekh , Pradip Amin
IPC分类号： A61K8/26 , A61Q15/00 , A61K7/32 , A61K7/00 , A61K7/34 , A61K7/38
CPC分类号： A61K8/26 , A61Q15/00
摘要： Disclosed are basic aluminum halides having enhanced antiperspirant efficacy; methods of making such materials and antiperspirant compositions containing such basic aluminum halides, and optionally an amino acid, salts of amino acids, antimicrobial agents, or an organic solvent having at least two carbon atoms and at least one hydroxy group and mixture thereof and methods of making such mixtures. Basic aluminum halides having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder; (b) an aluminum halide; and (c) water at a temperature greater than about 85° C. This reaction is maintained until reaction products having an Al:halide ratio of about 1.2:1 to 1.5:1 and preferably 1.3 to 1.4:1; and a solution solids concentration of about 30-40 weight percent on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography (HPLC) Test Band I of less than 5%, preferably less than 1%, Band II percent aluminum value of 20-60% preferably about 35 to 55%, Band III percent aluminum value of 10 to 35% preferably 15-30% and Band IV value of 15 to 50% and preferably 25 to 35% and sum of peak 3 and 4 areas of at least 45% and no more than 70% and preferably 65%. The enhanced efficacy basic aluminum chloride salts of this invention are more economical to produce, show enhanced efficacy and are more stable compared to the conventional enhanced efficacy aluminum salts which show rapid degradation of Band III to Band II peak areas ratio are less irritant and more skin friendly.
摘要翻译：公开了具有增强的止汗功效的碱性卤化铝; 制备这种材料的方法和含有这种碱性卤化铝的任选的止汗组合物，和任选的氨基酸，氨基酸，抗微生物剂或具有至少两个碳原子和至少一个羟基的有机溶剂的盐，以及它们的混合物制造这样的混合物。具有增强止汗功效的碱性卤化铝通过（a）铝粉与（b）卤化铝; 在大于约85℃的温度下加入水。该反应保持至Al:卤化物比为约1.2:1至1.5:1，优选1.3至1.4:1的反应产物; 并且获得以无水为基准的约30-40重量％的溶液固体浓度。该产品的特征在于尺寸排阻色谱（HPLC）测试条带I小于5％，优选小于1％，带II％铝值为20-60％，优选约35至55％，带III％铝值 10至35％，优选15-30％，并且带IV值为15至50％，优选25至35％，峰3和4面积之和为至少45％且不超过70％，优选为65％。本发明的增强的功效碱性氯化铝盐与常规增强的功效性铝盐相比，更有效地生产，显示出增强的功效并且更稳定，显示出带III快速降解至Band II峰面积比较少刺激性和更多皮肤友善。

8. 发明授权

US5908616A Method of inhibiting perspiration with basic aluminum and aluminum/zirconium antiperspirants 失效
标题翻译：碱性铝和铝/锆止汗剂抑制排汗的方法
公开(公告)号：US5908616A
公开(公告)日：1999-06-01
申请号：US24041
申请日：1998-02-16
申请人： Jawahar C. Parekh , Andrew M. Rubino
发明人： Jawahar C. Parekh , Andrew M. Rubino
IPC分类号： A61K8/20 , A61K8/26 , A61K8/28 , A61K8/44 , A61K33/06 , A61Q15/00 , C01F7/48 , C01F7/56 , C01F7/66 , C01G1/06 , C01G1/08 , C01G25/00 , A61K7/38 , A61K7/32 , A61K7/34 , C01B7/00
CPC分类号： C01G25/006 , A61K8/26 , A61K8/28 , A61Q15/00 , C01F7/56 , C01F7/66 , C01P2002/87 , C01P2004/61
摘要： Basic aluminum halides and nitrates having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder, (b) an aluminum halide or nitrate solution and (c) water at a temperature greater than about 85.degree. C. This reaction is maintained until reaction products having an Al:anion ratio of about 1.2 to 1.8 and a solution solids concentration of about 30-40 wt. % on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography Test Band having a relative retention time corresponding to Band II of a Standard Basic Aluminum Chloride Size Exclusion Chromatogram and a Band II percent aluminum value of at least about 50% and a Band III percent aluminum value of less than 20%.
摘要翻译：通过使（a）铝粉末，（b）卤化铝或硝酸盐溶液和（c）水在大于约85℃的温度下反应来制备具有增强的止汗功效的碱性卤化铝和硝酸盐。将该反应保持至反应产物 Al：阴离子比为约1.2至1.8，溶液固体浓度为约30-40重量％。得到无水基的％。该产品的特征在于具有尺寸排阻色谱测试带，其具有对应于标准碱性氯化铝尺寸排阻色谱图的带II的相对保留时间和至少约50％的带II％铝值和至少约百分之三的铝值小于20％。

9. 发明申请

US20070286830A1 Aluminum compositions of enhanced efficacy having high HPLC Bands III and IV 审中-公开
标题翻译：具有高效液相色谱三级和四级的增强功效的铝组合物
公开(公告)号：US20070286830A1
公开(公告)日：2007-12-13
申请号：US11452101
申请日：2006-06-13
申请人： Zijun Li , Mark Rerek , Kevin Janak
发明人： Zijun Li , Mark Rerek , Kevin Janak
IPC分类号： A61K8/26
CPC分类号： A61Q15/00 , A61K8/26
摘要： Novel aluminum antiperspirant compositions of enhanced efficacy activated by both heat and acid are produced comprising basic aluminum salts of having the formula: Al2(OH)6-aXa wherein X is Cl−, Br−, l−, or NO3−, a is from abut 1.1 to about 1.7, with basic aluminum chloride being the preferred salt. When analyzed by SEC-HPLC at about 10% concentration (i.e., by 2% Al) in water, these compositions exhibit an SEC-HPLC Band I area of less than 10%, a Band III area of at least 20%, with a Band III/II area ratio of at least 0.7, a Band IV area of at least 20%, and have at least 60% aluminum species contained in Bands III and Band IV.
摘要翻译：产生由热和酸热活化的增强功效的新型铝止汗剂组合物，其包含具有下列通式的碱式铝盐：<？in-line-formula description =“In-line Formulas”end =“lead”？> （OH）6-a X a <βin-line-formula description =“In-line Formulas”end =“tail”？>其中 X是Cl - ， - ， - ， - ， - ， - ， - ，a为约1.1至约1.7，碱性氯化铝为优选的盐。当通过SEC-HPLC在水中以约10％浓度（即，2％Al）分析时，这些组合物显示小于10％的SEC-HPLC带I面积，至少20％的Band III面积，其中a Band III / II面积比至少为0.7，Band IV面积至少为20％，并且在III组和Band IV中含有至少60％的铝种类。

10. 发明申请

US20070020211A1 Betaine with Calcium and/or Strontium Antiperspirants 审中-公开
标题翻译：甜菜碱与钙和/或锶止汗剂
公开(公告)号：US20070020211A1
公开(公告)日：2007-01-25
申请号：US11161117
申请日：2005-07-22
申请人： Zijun Li , Mark Rerek
发明人： Zijun Li , Mark Rerek
IPC分类号： A61K8/26
CPC分类号： A61Q15/00 , A61K8/26 , A61K8/44
摘要： Aluminum and aluminum-zirconium antiperspirant compositions comprising basic aluminum chlorides that have a particular molecular size distribution defined by having an SEC-HPLC Band III/II ratio of at least 0.5, having SEC-HPLC Band III plus Band II area of at least 70% of the total area and having SEC-HPLC Band I content no more than 5% and containing betaine (trimethylglycine), calcium and/or strontium are disclosed. Also disclosed are the methods of making these compositions and the use thereof in consumer acceptable antiperspirant vehicles such as aerosols, gels, roll-on, sticks and soft solids.
摘要翻译：铝和铝 - 锆止汗剂组合物，其包含碱性氯化铝，其具有通过具有SEC-HPLC Band III / II比率至少为0.5的SEC-HPLC Band III / II比定义的特定分子尺寸分布，其中SEC-HPLC Band III + Band II面积为至少70％的SEC-HPLC带I含量不超过5％，并且含有甜菜碱（三甲基甘氨酸），钙和/或锶。还公开了使这些组合物及其在消费者可接受的止汗剂载体如气溶胶，凝胶，滚涂，粘合剂和软固体中的用途的方法。

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