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1. 发明授权

US5254230A Methods for preparing basic aluminum compounds with ultrasound 失效
标题翻译：用超声波制备碱性铝化合物的方法
公开(公告)号：US5254230A
公开(公告)日：1993-10-19
申请号：US916299
申请日：1992-07-17
申请人： Vijay K. Joshi , Jawahar C. Parekh
发明人： Vijay K. Joshi , Jawahar C. Parekh
IPC分类号： C01F7/00 , C01F7/48 , C01F7/56 , C01F7/66 , C01F7/68 , C01F11/36 , C01F11/46 , C01F11/48 , C01B7/00
CPC分类号： C01F7/56 , C01F7/48 , C01F7/66 , C01F7/68
摘要： Processes are provided for preparing basic aluminum compounds of Formula I:Al.sub.2 (OH).sub.6-a X.sub.a (I)wherein X is Cl.sup.-, Br.sup.-, F.sup.-, I.sup.-, SO.sub.4.sup.= or NO.sub.3.sup.- and a is about 0.9 to 4, the compound being characterized by size exclusion chromatography as having a Band I percent aluminum value of about 5% or less and a Band II percent aluminum value of about 50% to 90%, which comprise (a) suspending an aluminum metal in an aqueous medium to form a slurry, (b) applying ultrasonic energy to the slurry, (c) reacting the sonicated slurry with an aluminum compound of Formula IIAl.sub.n X.sub.m (II)or an acid of Formula III:H.sub.n X (III)wherein X is Cl.sup.-, Br.sup.-, F.sup.-, I.sup.-, SO.sub.4.sup.= or NO.sub.3.sup.-, n is 1 or 2 and m is 3, at a temperature of about 45.degree. C. to 100.degree. C. to form a reaction product.
摘要翻译：提供制备式I的碱性铝化合物的方法：其中X是Cl - ，Br-，F-，I-，SO 4 =或NO 3 - 的Al 2（OH）6-a X a（I），a是约0.9-4，该化合物的特征在于尺寸排阻色谱法，其具有约5％或更低的I级铝值，并且具有约50％至90％的Band II％铝值，其包含（a）将铝金属悬浮在水性介质（b）向浆料中施加超声能量，（c）将超声处理的浆料与式IIAlnXm（II）的铝化合物或式III的酸：其中X是Cl-的HnX（III）反应， Br-，F-，I-，SO4 =或NO3-，n为1或2，m为3，在约45℃至100℃的温度下反应形成反应产物。

2. 发明授权

US07153495B2 Fragrance friendly and cost effective antiperspirant actives and method of making the same 失效
标题翻译：香味友好和具有成本效益的止汗活性物质及其制备方法
公开(公告)号：US07153495B2
公开(公告)日：2006-12-26
申请号：US10865397
申请日：2004-06-10
申请人： Jawahar C. Parekh , Pradip T. Amin , Chung Teck Shin
发明人： Jawahar C. Parekh , Pradip T. Amin , Chung Teck Shin
IPC分类号： A61Q15/00 , A61K8/00 , A61K8/02
CPC分类号： A61Q15/00 , A61K8/26
摘要： A cost effective process is provided for making stable, efficacious, amino acid and polyhydric alcohol free concentrated aqueous aluminum zirconium salt solutions. Absence of amino acid, low iron content and low trace metal impurity levels improve compatibility with fragrances and minimizes the probability of the product color change and possibly fabric staining significantly. The novel aluminum zirconium actives also minimize iron contribution to underarm area that supports growth of microflora which is responsible for axillary malodour by the biotransformation of nonodorous precursors present in perspiration. The astringent complexes of the present invention may be obtained in solution or dry powder form. As a result, the complexes are satisfactory for use in any of wide variety of conventional antiperspirant forms.
摘要翻译：提供了一种成本有效的方法，用于制备稳定，有效的氨基酸和多元醇的浓盐酸铝水溶液。缺乏氨基酸，低铁含量和低痕量金属杂质水平提高了与香料的相容性，并最大限度地降低了产品颜色变化和织物染色显着的可能性。新型铝锆活性物质也使铁对腋下区域的贡献最小化，其支持微生物群落的生长，微生物群落通过出汗中存在的无臭前体的生物转化而引起腋窝恶臭。本发明的收敛剂可以以溶液或干粉形式获得。结果，复合物可以用于各种常规止汗剂形式中的任何一种。

3. 发明授权

US06902724B1 Enhanced efficacy basic aluminum halides, antiperspirant active compositions and methods for making 失效
标题翻译：增强功效碱性卤化铝，止汗活性组合物和制备方法
公开(公告)号：US06902724B1
公开(公告)日：2005-06-07
申请号：US10807996
申请日：2004-03-24
申请人： Jawahar C. Parekh , Pradip Amin
发明人： Jawahar C. Parekh , Pradip Amin
IPC分类号： A61K8/26 , A61Q15/00 , A61K7/32 , A61K7/00 , A61K7/34 , A61K7/38
CPC分类号： A61K8/26 , A61Q15/00
摘要： Disclosed are basic aluminum halides having enhanced antiperspirant efficacy; methods of making such materials and antiperspirant compositions containing such basic aluminum halides, and optionally an amino acid, salts of amino acids, antimicrobial agents, or an organic solvent having at least two carbon atoms and at least one hydroxy group and mixture thereof and methods of making such mixtures. Basic aluminum halides having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder; (b) an aluminum halide; and (c) water at a temperature greater than about 85° C. This reaction is maintained until reaction products having an Al:halide ratio of about 1.2:1 to 1.5:1 and preferably 1.3 to 1.4:1; and a solution solids concentration of about 30-40 weight percent on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography (HPLC) Test Band I of less than 5%, preferably less than 1%, Band II percent aluminum value of 20-60% preferably about 35 to 55%, Band III percent aluminum value of 10 to 35% preferably 15-30% and Band IV value of 15 to 50% and preferably 25 to 35% and sum of peak 3 and 4 areas of at least 45% and no more than 70% and preferably 65%. The enhanced efficacy basic aluminum chloride salts of this invention are more economical to produce, show enhanced efficacy and are more stable compared to the conventional enhanced efficacy aluminum salts which show rapid degradation of Band III to Band II peak areas ratio are less irritant and more skin friendly.
摘要翻译：公开了具有增强的止汗功效的碱性卤化铝; 制备这种材料的方法和含有这种碱性卤化铝的任选的止汗组合物，和任选的氨基酸，氨基酸，抗微生物剂或具有至少两个碳原子和至少一个羟基的有机溶剂的盐，以及它们的混合物制造这样的混合物。具有增强止汗功效的碱性卤化铝通过（a）铝粉与（b）卤化铝; 在大于约85℃的温度下加入水。该反应保持至Al:卤化物比为约1.2:1至1.5:1，优选1.3至1.4:1的反应产物; 并且获得以无水为基准的约30-40重量％的溶液固体浓度。该产品的特征在于尺寸排阻色谱（HPLC）测试条带I小于5％，优选小于1％，带II％铝值为20-60％，优选约35至55％，带III％铝值 10至35％，优选15-30％，并且带IV值为15至50％，优选25至35％，峰3和4面积之和为至少45％且不超过70％，优选为65％。本发明的增强的功效碱性氯化铝盐与常规增强的功效性铝盐相比，更有效地生产，显示出增强的功效并且更稳定，显示出带III快速降解至Band II峰面积比较少刺激性和更多皮肤友善。

4. 发明授权

US5908616A Method of inhibiting perspiration with basic aluminum and aluminum/zirconium antiperspirants 失效
标题翻译：碱性铝和铝/锆止汗剂抑制排汗的方法
公开(公告)号：US5908616A
公开(公告)日：1999-06-01
申请号：US24041
申请日：1998-02-16
申请人： Jawahar C. Parekh , Andrew M. Rubino
发明人： Jawahar C. Parekh , Andrew M. Rubino
IPC分类号： A61K8/20 , A61K8/26 , A61K8/28 , A61K8/44 , A61K33/06 , A61Q15/00 , C01F7/48 , C01F7/56 , C01F7/66 , C01G1/06 , C01G1/08 , C01G25/00 , A61K7/38 , A61K7/32 , A61K7/34 , C01B7/00
CPC分类号： C01G25/006 , A61K8/26 , A61K8/28 , A61Q15/00 , C01F7/56 , C01F7/66 , C01P2002/87 , C01P2004/61
摘要： Basic aluminum halides and nitrates having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder, (b) an aluminum halide or nitrate solution and (c) water at a temperature greater than about 85.degree. C. This reaction is maintained until reaction products having an Al:anion ratio of about 1.2 to 1.8 and a solution solids concentration of about 30-40 wt. % on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography Test Band having a relative retention time corresponding to Band II of a Standard Basic Aluminum Chloride Size Exclusion Chromatogram and a Band II percent aluminum value of at least about 50% and a Band III percent aluminum value of less than 20%.
摘要翻译：通过使（a）铝粉末，（b）卤化铝或硝酸盐溶液和（c）水在大于约85℃的温度下反应来制备具有增强的止汗功效的碱性卤化铝和硝酸盐。将该反应保持至反应产物 Al：阴离子比为约1.2至1.8，溶液固体浓度为约30-40重量％。得到无水基的％。该产品的特征在于具有尺寸排阻色谱测试带，其具有对应于标准碱性氯化铝尺寸排阻色谱图的带II的相对保留时间和至少约50％的带II％铝值和至少约百分之三的铝值小于20％。

5. 发明授权

US07014843B2 Enhanced efficacy basic aluminum halides/metal cation salt, antiperspirants actives and compositions containing such materials and methods for making 失效
标题翻译：增强功效碱性卤化铝/金属阳离子盐，止汗剂活性剂和含有这些材料的组合物和制备方法
公开(公告)号：US07014843B2
公开(公告)日：2006-03-21
申请号：US10807872
申请日：2004-03-24
申请人： Jawahar C. Parekh , Pradip Amin
发明人： Jawahar C. Parekh , Pradip Amin
IPC分类号： A61K7/32 , A61K7/34 , A61K7/38 , A61K7/00
CPC分类号： A61K8/27 , A61K8/26 , A61K8/28 , A61K8/29 , A61Q15/00
摘要： Disclosed are aqueous antiperspirant active compositions comprising an admixtures of basic aluminum halides and a metal cation salts which yield enhanced antiperspirant efficacy; and methods of making such antiperspirant compositions. The basic aluminum halides, optionally contain an amino acid or salts of amino acids, and/or antimicrobial agent and are combined with a metal cation antiperspirant (e.g., Ti salt or Hf salt or Sn salt or Zr salt) and optionally with a organic solvent having at least two carbon atoms and at least one hydroxy group and mixtures thereof and methods of making such mixtures. Basic aluminum halides having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder; (b) an aluminum halide; and (c) water at a temperature greater than about 85° C. This reaction is maintained until reaction products having an Al:halide ratio of about 1.2 to 1.5 and preferably 1.3 to 1.4:1; and a solution solids concentration of about 30-40 weight percent on an anhydrous basis are obtained. The basic aluminum halide of this invention are characterized as having a Size Exclusion Chromatography (HPLC) Test Band I of less than 5%, preferably less than 1%, Band II percent aluminum value of 20%-60% preferably about 35% to 55%, Band III percent aluminum value of 10% to 35% preferably 15%-30% and Band IV value of 15% to 50% preferably 25% to 35% and sum of peak 3 and 4 areas of at least 45% and no more than 70% and preferably 65%.
摘要翻译：公开了含有止汗剂活性组合物，其包含碱性卤化铝和金属阳离子盐的混合物，其产生增强的止汗效力; 以及制备这种止汗组合物的方法。碱性卤化铝，任选地含有氨基酸或氨基酸盐和/或抗微生物剂，并与金属阳离子止汗剂（例如Ti盐或Hf盐或Sn盐或Zr盐）和任选地与有机溶剂具有至少两个碳原子和至少一个羟基及其混合物，以及制备此类混合物的方法。具有增强止汗功效的碱性卤化铝通过（a）铝粉与（b）卤化铝; 并且（c）在大于约85℃的温度下的水。保持该反应直到Al:卤化物比为约1.2至1.5，优选1.3至1.4:1的反应产物; 并且获得以无水为基准的约30-40重量％的溶液固体浓度。本发明的碱性卤化铝的特征在于尺寸排阻色谱（HPLC）测试条带I小于5％，优选小于1％，带II％铝值为20％-60％，优选约35％至55 ％，III组铝值为10％至35％，优选为15％-30％，Band IV值为15％至50％，优选25％至35％，峰3和4面积之和为至少45％，无大于70％，优选65％。

6. 发明授权

US5718876A Basic aluminum and aluminum/zirconium antiperspirants and method of making the same 失效
标题翻译：碱性铝和铝/锆止汗剂及其制造方法
公开(公告)号：US5718876A
公开(公告)日：1998-02-17
申请号：US635290
申请日：1996-04-19
申请人： Jawahar C. Parekh , Andrew M. Rubino
发明人： Jawahar C. Parekh , Andrew M. Rubino
IPC分类号： A61K8/20 , A61K8/26 , A61K8/28 , A61K8/44 , A61K33/06 , A61Q15/00 , C01F7/48 , C01F7/56 , C01F7/66 , C01G1/06 , C01G1/08 , C01G25/00 , C01B7/00 , A61K7/34 , A61K7/38
CPC分类号： C01G25/006 , A61K8/26 , A61K8/28 , A61Q15/00 , C01F7/56 , C01F7/66 , C01P2002/87 , C01P2004/61
摘要： Basic aluminum halides and nitrates having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder, (b) an aluminum halide or nitrate solution and (c) water at a temperature greater than about 85.degree. C. This reaction is maintained until reaction products having an Al:anion ratio of about 1.2 to 1.8 and a solution solids concentration of about 30-40 wt. % on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography Test Band having a relative retention time corresponding to Band II of a Standard Basic Aluminum Chloride Size Exclusion Chromatogram and a Band II percent aluminum value of at least about 50% and a Band III percent aluminum value of less than 20%.
摘要翻译：通过使（a）铝粉末，（b）卤化铝或硝酸盐溶液和（c）水在大于约85℃的温度下反应来制备具有增强的止汗功效的碱性卤化铝和硝酸盐。将该反应保持至反应产物 Al：阴离子比为约1.2至1.8，溶液固体浓度为约30-40重量％。得到无水基的％。该产品的特征在于具有尺寸排阻色谱测试带，其具有对应于标准碱性氯化铝尺寸排阻色谱图的带II的相对保留时间和至少约50％的带II％铝值和至少约百分之三的铝值小于20％。

7. 发明授权

US06835374B2 Antiperspirant/deodorant active for no white residue sticks and soft solids 失效
标题翻译：止汗剂/除臭剂无活性白色残留物和软固体
公开(公告)号：US06835374B2
公开(公告)日：2004-12-28
申请号：US10278673
申请日：2002-10-23
申请人： Jawahar C. Parekh , Pradip T. Amin
发明人： Jawahar C. Parekh , Pradip T. Amin
IPC分类号： A61K732
CPC分类号： A61K8/26 , A61K8/28 , A61Q15/00
摘要： Antiperspirant actives that produce practically no visible white residue, even against a black background is provided by the reduction of the particle size, using a refractive index modifier, to a point where the antiperspirant active on application provides no discernible whiteness. When formulated into an antiperspirant stick, the antiperspirant actives produce an improved combination of functional properties, including excellent antiperspirancy, smooth skin feel, nontacky, quick drying and leave no visible residue. The exceptionally high surface area of the antiperspirant active results in rapid and efficient delivery of the active to the sweat glands and possible absorption. The absence or reduced quantity of suspending and flow enhancing agents, of gellant and surfactant, is believed to improve the antiperspirant active's ability to physically reach the sweat glands and improve efficacy.
摘要翻译：通过使用折射率调节剂将颗粒尺寸减少到施用的止汗剂活性物质不提供可辨别的白度的点，提供几乎不产生可见白色残留物的甚至是黑色背景的止汗剂。当配制成止汗剂时止汗活性物质产生功能性能的改善的组合，包括优异的止汗性，光滑的皮肤感觉，非粘性，快速干燥并且不留下可见的残留物。止汗活性物质的特别高的表面积导致活性物质的快速和有效递送汗腺和可能的吸收。据信，胶凝剂和表面活性剂的悬浮和流动增强剂的量不足或减少量被提高，以提高止汗剂活性物质达到汗腺的能力并提高功效。

8. 发明授权

US06803401B2 Halogen scavenger for olefin formulations 失效
标题翻译：烯烃制剂的卤素清除剂
公开(公告)号：US06803401B2
公开(公告)日：2004-10-12
申请号：US09960097
申请日：2001-09-21
申请人： Jawahar C. Parekh , Rajanikant D. Desai
发明人： Jawahar C. Parekh , Rajanikant D. Desai
IPC分类号： C08K504
CPC分类号： C08K9/04 , C08L57/08
摘要： A halogen scavenging system is provided for inhibiting the corrosion-causing tendency and coloration of halogen-containing olefin polymers or copolymers, comprising incorporating about 0.01% to about 1% of a hydroltalcite-like solid solution having the formula Al2(Mg)a(OH)b(CO3)c(G)d.eH2O and a crystallite size in the direction of about 190 Å to about 225 Å, and having bidentate coordination for carbonate ion as shown by an infrared spectrum, and wherein 3≦a≦5.5; 8≦b≦14; 1.2≦c≦3; 0≦d≦1; 1≦e≦10 and G is a surface active agent into the halogen containing olefin polymer.
摘要翻译：提供了一种卤素清除系统，用于抑制含卤烯烃聚合物或共聚物的腐蚀倾向和着色，包括掺入约0.01％至约1％的具有式Al2（Mg）a（OH）的水滑石样固体溶液）b（CO 3）c（G）d.eH 2 O，并且在大约190至大约225的方向上的微晶尺寸，并且如红外光谱所示具有碳酸根离子的二齿配位，并且其中3 < a <= 5.5; 8 <= b <= 14; 1.2 <= c <= 3; 0 <= d <= 1; 1 <= e <= 10，G是含卤素烯烃聚合物中的表面活性剂。

9. 发明授权

US06649153B1 Skin friendly antiperspirant composition and method of making 失效
标题翻译：皮肤友好的止汗剂组合物和制造方法
公开(公告)号：US06649153B1
公开(公告)日：2003-11-18
申请号：US10244701
申请日：2002-09-16
申请人： Jawahar C. Parekh , Zijun Li
发明人： Jawahar C. Parekh , Zijun Li
IPC分类号： A61K732
CPC分类号： A61K8/44 , A61K8/26 , A61K8/28 , A61K8/345 , A61K2800/58 , A61Q15/00
摘要： An improved skin friendly antiperspirant is provided in which a suitable polyhydric alcohol e.g., glycerin, is complexed with the antiperspirant of the type of activated or nonactivated aluminum or aluminum/zirconium salt that are commonly considered antiperspirant active materials and are covered by FDA OTC Tentative Final Monograph as Category I. Suitable antiperspirant salts include (but are not limited to): aluminum chlorohydrate, aluminum sesquichlorohydrate, aluminum chlorohydrex PG, aluminum dichlorohydrex PG, aluminum sesquichlorohydrex PG, aluminum chlorohydrex PEG, aluminum sesquichlorohydrex PEG, aluminum chloride (15 percent or less aqueous solutions), aluminum zirconium chlorohydrates, aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium octachlorohydrate, aluminum zirconium trichlorohydrex Gly, aluminum zirconium penta chlorohydrex Gly, aluminum zirconium tetrachlorohydrex Gly, aluminum zirconium octachlorohydrex Gly, buffered aluminum sulfate, basic aluminum chlorides, zirconium hydroxychloride, zirconyl chloride, basic aluminum nitrates, basic aluminum chlorides combined with zirconyl oxychloride and/or hydroxychloride and organic complexes of each of basic aluminum chlorides with or without zirconyl chloride or zirconium hydroxychloride and mixture of any of the foregoing. Aluminum, zinc or zinc and zirconium complexes or aluminum, zinc and zirconium complexes with having metals/anion ratio of 0.9:1 to 2:1 where the anion is Cl, Br, I and/or NO, with or without additives such as amino acids or polyhydric alcohols.
摘要翻译：提供了一种改进的皮肤友好的止汗剂，其中合适的多元醇例如甘油与通常被认为是止汗活性物质的活化或未活化的铝或铝/锆盐类型的止汗剂络合，并被FDA OTC试验性终点合适的止汗剂盐包括（但不限于）：氯化铝水合铝，倍半氯化铝，氯代水合氯化铝PG，二氯水合铝PG，倍半氯化铝PG，氯化铝水PEG，倍半氯化铝，PEG，氯化铝（15％或更少）水溶液），氯铝酸锆锆，三氯水合锆锆，四氯水合锆锆，五氯水合铝锆，八氯水合锆锆，三氯水合铝，Gly，五氯化铝锆Gly，四氯水铝锆Gly，氧化锆硝酸八氯水合Gly，缓冲硫酸铝，碱式氯化铝，羟基氯化锆，氧化锆，碱式硝酸铝，碱式氯化铝与氧氯化氧锆和/或羟基氯化物组合，碱式氯化铝与有或没有氯化锆或羟基氯化锆的有机络合物和任何上述的混合物。铝，锌或锌和锆配合物或金属/阴离子比为0.9:1至2:1的铝，锌和锆络合物，其中阴离子为Cl，Br，I和/或NO，有或没有添加剂如氨基酸或多元醇。

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