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1. 发明授权

US11338295B2 Thermocycling system and manufacturing method 有权
公开(公告)号：US11338295B2
公开(公告)日：2022-05-24
申请号：US16264262
申请日：2019-01-31
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L3/00 , B01L1/00 , B01L7/00 , H05K1/18 , H05K3/30 , H05K3/46
摘要： A system for thermocycling biological samples within detection chambers comprising: a set of heater-sensor dies, each heater-sensor die comprising a heating surface configured to interface with a detection chamber and a second surface, inferior to the heating surface, including a first connection point; an electronics substrate, comprising a first substrate surface coupled to the second surface of each heater-sensor die, an aperture providing access through the electronics substrate to at least one heater-sensor die, and a second substrate surface inferior to the first substrate surface, wherein the electronics substrate comprises a set of substrate connection points at least at one of the first substrate surface, an aperture surface defined within the aperture, and the second substrate surface, and wherein the electronics substrate is configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of wire bonds, including a wire bond coupled between the first connection point of at least one of the set of heater-sensor dies and one of the set of substrate connection points.

2. 发明授权

US11273448B2 Thermocycling system, composition, and microfabrication method 有权
公开(公告)号：US11273448B2
公开(公告)日：2022-03-15
申请号：US16273795
申请日：2019-02-12
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L3/00 , B01L1/00 , B01L7/00 , C23C14/02 , C23C14/16 , C23C14/24 , C23C14/34
摘要： A system and method of manufacture for the system, comprising a set of heater-sensor dies, each heater-sensor die comprising an assembly including a first insulating layer, a heating region comprising an adhesion material layer coupled to the first insulating layer and a noble material layer, and a second insulating layer coupled to the heating region and to the first insulating layer through a pattern of voids in the heating region, wherein the pattern of voids in heating region defines a coarse pattern associated with a heating element of the heating region and a fine pattern, integrated into the coarse pattern and associated with a sensing element of the heating region; an electronics substrate configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of elastic elements configured to bias each of the set of heater-sensor dies against a detection chamber.

3. 发明授权

US10633647B2 Method and materials for isolation of nucleic acid materials 有权
公开(公告)号：US10633647B2
公开(公告)日：2020-04-28
申请号：US15363323
申请日：2016-11-29
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Michelle Mastronardi , Elizabeth Craig , Maureen Carey
IPC分类号： C12N15/10 , B01L3/00 , C12Q1/6806 , C12Q1/70
CPC分类号： C12N15/1013 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502761 , C12N15/1006 , C12Q1/6806 , C12Q1/701 , B01L2200/0631 , B01L2300/0627 , B01L2400/086
摘要： A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH.

4. 发明申请

US20170036209A1 THERMOCYCLING SYSTEM, COMPOSITION, AND MICROFABRICATION METHOD 审中-公开
标题翻译：热循环系统，组成和微生物方法
公开(公告)号：US20170036209A1
公开(公告)日：2017-02-09
申请号：US15297736
申请日：2016-10-19
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L7/00 , C23C14/24 , C23C14/16 , C23C14/34
CPC分类号： B01L7/52 , B01L2200/12 , B01L2200/147 , B01L2300/0819 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2300/1827 , B01L2300/1883 , C23C14/025 , C23C14/165 , C23C14/24 , C23C14/34
摘要： A system and method of manufacture for the system, comprising a set of heater-sensor dies, each heater-sensor die comprising an assembly including a first insulating layer, a heating region comprising an adhesion material layer coupled to the first insulating layer and a noble material layer, and a second insulating layer coupled to the heating region and to the first insulating layer through a pattern of voids in the heating region, wherein the pattern of voids in heating region defines a coarse pattern associated with a heating element of the heating region and a fine pattern, integrated into the coarse pattern and associated with a sensing element of the heating region; an electronics substrate configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of elastic elements configured to bias each of the set of heater-sensor dies against a detection chamber.
摘要翻译：一种用于系统的系统和制造方法，包括一组加热器 - 传感器模具，每个加热器传感器模具包括组件，该组件包括第一绝缘层，加热区域，该加热区域包括耦合到第一绝缘层的粘附材料层和贵重物品材料层和通过加热区域中的空隙图案耦合到加热区域和第一绝缘层的第二绝缘层，其中加热区域中的空隙图案限定与加热区域的加热元件相关联的粗略图案以及精细图案，其集成到粗糙图案中并与加热区域的感测元件相关联; 电子基板，被配置为将所述一组加热器 - 传感器管芯的加热元件和感测元件耦合到控制器; 以及一组弹性元件，其构造成将所述一组加热器 - 传感器模具中的每一个偏压到检测室。

5. 发明授权

US09499896B2 Thermocycling system, composition, and microfabrication method 有权
标题翻译：热循环系统，组成和微细加工方法
公开(公告)号：US09499896B2
公开(公告)日：2016-11-22
申请号：US14487808
申请日：2014-09-16
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L3/00 , B01L7/00 , C23C14/02
CPC分类号： B01L7/52 , B01L2200/12 , B01L2200/147 , B01L2300/0819 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2300/1827 , B01L2300/1883 , C23C14/025 , C23C14/165 , C23C14/24 , C23C14/34
摘要： A system and method of manufacture for the system, comprising a set of heater-sensor dies, each heater-sensor die comprising an assembly including a first insulating layer, a heating region comprising an adhesion material layer coupled to the first insulating layer and a noble material layer, and a second insulating layer coupled to the heating region and to the first insulating layer through a pattern of voids in the heating region, wherein the pattern of voids in heating region defines a coarse pattern associated with a heating element of the heating region and a fine pattern, integrated into the coarse pattern and associated with a sensing element of the heating region; an electronics substrate configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of elastic elements configured to bias each of the set of heater-sensor dies against a detection chamber.
摘要翻译：一种用于系统的系统和制造方法，包括一组加热器 - 传感器模具，每个加热器传感器模具包括组件，该组件包括第一绝缘层，加热区域，该加热区域包括耦合到第一绝缘层的粘附材料层和贵重物品材料层和通过加热区域中的空隙图案耦合到加热区域和第一绝缘层的第二绝缘层，其中加热区域中的空隙图案限定与加热区域的加热元件相关联的粗略图案以及精细图案，其集成到粗糙图案中并与加热区域的感测元件相关联; 电子基板，被配置为将所述一组加热器 - 传感器管芯的加热元件和感测元件耦合到控制器; 以及一组弹性元件，其构造成将所述一组加热器 - 传感器模具中的每一个偏压到检测室。

6. 发明授权

US09452430B1 Microfluidic cartridge for processing and detecting nucleic acids 有权
公开(公告)号：US09452430B1
公开(公告)日：2016-09-27
申请号：US15182187
申请日：2016-06-14
申请人： NeuMoDx Molecular, Inc.
发明人： Jeffrey Williams , Michael T. Kusner
IPC分类号： B01L3/00 , C12Q1/68 , F04B43/02 , B01L7/00 , C12M3/00 , B29C65/08 , B29C65/60 , B29L31/00 , B29C65/00 , B29C65/48 , C12N13/00
CPC分类号： C12N15/1013 , B01L3/502 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/508 , B01L3/527 , B01L3/567 , B01L7/52 , B01L7/525 , B01L9/00 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0615 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/06 , B01L2300/0609 , B01L2300/0627 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0809 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2300/14 , B01L2300/16 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , B01L2400/0655 , B01L2400/0694 , B01L2400/086 , B29C65/08 , B29C65/484 , B29C65/606 , B29C66/71 , B29C66/81423 , B29C66/8322 , B29L2031/756 , C12M23/42 , C12N13/00 , C12Q1/68 , C12Q1/6806 , C12Q1/6813 , C12Q1/686 , B29K2021/00
摘要： A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of Detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a Detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region.

7. 发明授权

US09382532B2 Method and materials for isolation of nucleic acid materials 有权
标题翻译：用于分离核酸材料的方法和材料
公开(公告)号：US09382532B2
公开(公告)日：2016-07-05
申请号：US14168760
申请日：2014-01-30
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Michelle Mastronardi , Elizabeth Craig , Maureen Carey
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12N15/1013 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2300/0627 , B01L2400/086 , C12N15/1006 , C12Q1/6806 , C12Q1/701
摘要： A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH.
摘要翻译：一种用于核酸分离的方法，包括：在处理室内接收结合部分溶液; 将结合部分溶液与生物样品在处理室内混合以产生部分样品混合物; 在时间窗口期间孵育部分样品混合物，从而产生包含一组部分结合的核酸颗粒和废物体积的溶液; 将所述一组部分结合的核酸颗粒与废物体积分离; 洗涤该部分结合的核酸颗粒; 以及从所述一组部分结合的核酸颗粒中释放核酸样品。该方法优选使用包含聚（烯丙胺）和聚丙烯亚胺四胺树枝状聚合物中的至少一种的结合部分，两者都可以基于环境pH可逆地结合和解链至核酸。

8. 发明公开

US20230356224A1 SYSTEM AND METHOD FOR PROCESSING AND DETECTING NUCLEIC ACIDS 审中-公开
公开(公告)号：US20230356224A1
公开(公告)日：2023-11-09
申请号：US18218454
申请日：2023-07-05
申请人： NeuMoDx Molecular, Inc.
发明人： Jeffrey WILLIAMS , Sundaresh BRAHMASANDRA , Michelle MASTRONARDI
IPC分类号： B01L3/00 , B01L7/00 , G01N35/00 , C12Q1/686
CPC分类号： B01L3/502761 , B01L7/525 , B01L3/502738 , B01L3/50851 , G01N35/0098 , B01L7/52 , C12Q1/686 , B01L2400/0622 , B01L2400/0481 , B01L3/50855 , B01L2300/044 , B01L2300/0627 , B01L2300/168 , B01L2400/0633 , B01L2400/043 , B01L2200/0668 , B01L2300/0681 , B01L2300/1822 , B01L2400/0487 , B01L2400/0655 , B01L2200/10 , B01L2200/0684 , B01L2200/0689 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/0694
摘要： A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

9. 发明公开

US20230287387A1 SYSTEM AND METHOD FOR PROCESSING AND DETECTING NUCLEIC ACIDS 审中-公开
公开(公告)号：US20230287387A1
公开(公告)日：2023-09-14
申请号：US18321681
申请日：2023-05-22
申请人： NeuMoDx Molecular, Inc.
发明人： Jeffrey WILLIAMS , Sundaresh BRAHMASANDRA , Michael T. KUSNER
IPC分类号： C12N15/10 , B01L3/00 , B01L7/00 , C12Q1/68 , C12M3/00 , C12Q1/686 , C12Q1/6806 , C12Q1/6813
CPC分类号： C12N15/1013 , B01L3/5027 , B01L3/50273 , B01L3/502 , B01L3/502723 , B01L3/502707 , B01L3/502738 , B01L7/525 , C12Q1/68 , B01L7/52 , C12M23/42 , C12Q1/686 , B01L3/508 , B01L3/567 , C12Q1/6806 , B01L3/502761 , B01L3/527 , C12Q1/6813 , B01L3/502715 , B01L2300/0867 , C12N13/00
摘要： A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

10. 发明申请

US20220280947A1 THERMOCYCLING SYSTEM AND MANUFACTURING METHOD 有权
公开(公告)号：US20220280947A1
公开(公告)日：2022-09-08
申请号：US17752699
申请日：2022-05-24
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L7/00 , H05K1/18 , H05K3/30 , H05K3/46
摘要： A system for thermocycling biological samples within detection chambers comprising: a set of heater-sensor dies, each heater-sensor die comprising a heating surface configured to interface with a detection chamber and a second surface, inferior to the heating surface, including a first connection point; an electronics substrate, comprising a first substrate surface coupled to the second surface of each heater-sensor die, an aperture providing access through the electronics substrate to at least one heater-sensor die, and a second substrate surface inferior to the first substrate surface, wherein the electronics substrate comprises a set of substrate connection points at least at one of the first substrate surface, an aperture surface defined within the aperture, and the second substrate surface, and wherein the electronics substrate is configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of wire bonds, including a wire bond coupled between the first connection point of at least one of the set of heater-sensor dies and one of the set of substrate connection points.

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