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1. 发明申请

US20230010710A1 METHOD AND MATERIALS FOR ISOLATION OF NUCLEIC ACID MATERIALS 有权
公开(公告)号：US20230010710A1
公开(公告)日：2023-01-12
申请号：US17942864
申请日：2022-09-12
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh BRAHMASANDRA , Michelle MASTRONARDI , Elizabeth CRAIG , Maureen CAREY
IPC分类号： C12N15/10 , B01L3/00 , C12Q1/6806 , C12Q1/70
摘要： A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH.

2. 发明申请

US20220193682A1 THERMOCYCLING SYSTEM, COMPOSITION, AND MICROFABRICATION METHOD 有权
公开(公告)号：US20220193682A1
公开(公告)日：2022-06-23
申请号：US17694438
申请日：2022-03-14
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L7/00 , C23C14/02 , C23C14/16 , C23C14/24 , C23C14/34
摘要： A system and method of manufacture for the system, comprising a set of heater-sensor dies, each heater-sensor die comprising an assembly including a first insulating layer, a heating region comprising an adhesion material layer coupled to the first insulating layer and a noble material layer, and a second insulating layer coupled to the heating region and to the first insulating layer through a pattern of voids in the heating region, wherein the pattern of voids in heating region defines a coarse pattern associated with a heating element of the heating region and a fine pattern, integrated into the coarse pattern and associated with a sensing element of the heating region; an electronics substrate configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of elastic elements configured to bias each of the set of heater-sensor dies against a detection chamber.

3. 发明申请

US20220023862A1 MICROFLUIDIC CARTRIDGE FOR PROCESSING AND DETECTING NUCLEIC ACIDS 有权
公开(公告)号：US20220023862A1
公开(公告)日：2022-01-27
申请号：US17450529
申请日：2021-10-11
申请人： NeuMoDx Molecular, Inc.
发明人： Jeffrey S. Williams , Sundaresh BRAHMASANDRA , Michael T. KUSNER
IPC分类号： B01L3/00
摘要： A microfluidic cartridge, configured to facilitate processing and detection of nucleic acids, comprising: a top layer comprising a set of cartridge-aligning indentations, a set of sample port-reagent port pairs, a shared fluid port, a vent region, a heating region, and a set of detection chambers; an intermediate substrate, coupled to the top layer comprising a waste chamber; an elastomeric layer, partially situated on the intermediate substrate; and a set of fluidic pathways, each formed by at least a portion of the top layer and a portion of the elastomeric layer, wherein each fluidic pathway is fluidically coupled to a sample port-reagent port pair, the shared fluid port, and a detection chamber, comprises a turnabout portion passing through the heating region, and is configured to be occluded upon deformation of the elastomeric layer, to transfer a waste fluid to the waste chamber, and to pass through the vent region.

4. 发明授权

US10041062B2 System and method for processing and detecting nucleic acids 有权
公开(公告)号：US10041062B2
公开(公告)日：2018-08-07
申请号：US15134765
申请日：2016-04-21
申请人： NeuMoDx Molecular, Inc.
发明人： Jeffrey Williams , Sundaresh Brahmasandra , Michael T. Kusner
IPC分类号： C12N15/10 , B01L3/00 , C12M3/00 , C12Q1/68 , B01L7/00 , C12Q1/686 , B01L9/00 , C12Q1/6806 , C12Q1/6813 , C12N13/00 , B29C65/08 , B29C65/60 , B29C65/00 , B29L31/00 , B29C65/48
摘要： A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

5. 发明申请

US20170072400A1 THERMOCYCLING SYSTEM AND MANUFACTURING METHOD 审中-公开
标题翻译：热循环系统和制造方法
公开(公告)号：US20170072400A1
公开(公告)日：2017-03-16
申请号：US15363107
申请日：2016-11-29
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L7/00 , H05K3/30 , H05K1/18 , H05K3/46
CPC分类号： B01L7/52 , B01L2200/12 , B01L2200/147 , B01L2300/0819 , B01L2300/123 , B01L2300/168 , B01L2300/1827 , H05K1/18 , H05K3/30 , H05K3/4644 , H05K2201/10151 , Y10T29/49083
摘要： A system for thermocycling biological samples within detection chambers comprising: a set of heater-sensor dies, each heater-sensor die comprising a heating surface configured to interface with a detection chamber and a second surface, inferior to the heating surface, including a first connection point; an electronics substrate, comprising a first substrate surface coupled to the second surface of each heater-sensor die, an aperture providing access through the electronics substrate to at least one heater-sensor die, and a second substrate surface inferior to the first substrate surface, wherein the electronics substrate comprises a set of substrate connection points at least at one of the first substrate surface, an aperture surface defined within the aperture, and the second substrate surface, and wherein the electronics substrate is configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of wire bonds, including a wire bond coupled between the first connection point of at least one of the set of heater-sensor dies and one of the set of substrate connection points.
摘要翻译：一种用于在检测室内热循环生物样品的系统，包括：一组加热器 - 传感器管芯，每个加热器传感器管芯包括被配置成与检测室和第二表面接合的加热表面，该第二表面比加热表面低，包括第一连接点; 电子衬底，包括耦合到每个加热器 - 传感器裸片的第二表面的第一衬底表面，提供通过电子器件衬底到达至少一个加热器 - 传感器裸片的通孔，以及低于第一衬底表面的第二衬底表面，其中所述电子衬底包括至少在所述第一衬底表面中的一个，限定在所述孔内的孔表面和所述第二衬底表面的一组衬底连接点，并且其中所述电子衬底被配置为将加热元件和感测元件该组加热器传感器模具到控制器; 以及一组引线键合，其包括耦合在所述一组加热器 - 传感器管芯中的至少一个的所述第一连接点和所述一组衬底连接点中的一个之间的引线接合。

6. 发明授权

US09539576B2 Thermocycling system and manufacturing method 有权
标题翻译：热循环系统及制造方法
公开(公告)号：US09539576B2
公开(公告)日：2017-01-10
申请号：US14487837
申请日：2014-09-16
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L1/00 , B01L3/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/12 , B01L2200/147 , B01L2300/0819 , B01L2300/123 , B01L2300/168 , B01L2300/1827 , H05K1/18 , H05K3/30 , H05K3/4644 , H05K2201/10151 , Y10T29/49083
摘要： A system for thermocycling biological samples within detection chambers comprising: a set of heater-sensor dies, each heater-sensor die comprising a heating surface configured to interface with a detection chamber and a second surface, inferior to the heating surface, including a first connection point; an electronics substrate, comprising a first substrate surface coupled to the second surface of each heater-sensor die, an aperture providing access through the electronics substrate to at least one heater-sensor die, and a second substrate surface inferior to the first substrate surface, wherein the electronics substrate comprises a set of substrate connection points at least at one of the first substrate surface, an aperture surface defined within the aperture, and the second substrate surface, and wherein the electronics substrate is configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of wire bonds, including a wire bond coupled between the first connection point of at least one of the set of heater-sensor dies and one of the set of substrate connection points.
摘要翻译：一种用于在检测室内热循环生物样品的系统，包括：一组加热器 - 传感器管芯，每个加热器传感器管芯包括被配置成与检测室和第二表面接合的加热表面，该第二表面比加热表面低，包括第一连接点; 电子衬底，包括耦合到每个加热器 - 传感器裸片的第二表面的第一衬底表面，提供通过电子器件衬底到达至少一个加热器 - 传感器裸片的通孔，以及低于第一衬底表面的第二衬底表面，其中所述电子衬底包括至少在所述第一衬底表面中的一个，限定在所述孔内的孔表面和所述第二衬底表面的一组衬底连接点，并且其中所述电子衬底被配置为将加热元件和感测元件该组加热器传感器模具到控制器; 以及一组引线键合，其包括耦合在所述一组加热器 - 传感器管芯中的至少一个的所述第一连接点和所述一组衬底连接点中的一个之间的引线接合。

7. 发明申请

US20160281080A1 METHOD AND MATERIALS FOR ISOLATION OF NUCLEIC ACID MATERIALS 有权
标题翻译：用于分离核酸材料的方法和材料
公开(公告)号：US20160281080A1
公开(公告)日：2016-09-29
申请号：US15173880
申请日：2016-06-06
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Michelle Mastronardi , Elizabeth Craig , Maureen Carey
IPC分类号： C12N15/10 , B01L3/00 , C12Q1/68
CPC分类号： C12N15/1013 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2300/0627 , B01L2400/086 , C12N15/1006 , C12Q1/6806 , C12Q1/701
摘要： A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH.
摘要翻译：一种用于核酸分离的方法，包括：在处理室内接收结合部分溶液; 将结合部分溶液与生物样品在处理室内混合以产生部分样品混合物; 在时间窗口期间孵育部分样品混合物，从而产生包含一组部分结合的核酸颗粒和废物体积的溶液; 将所述一组部分结合的核酸颗粒与废物体积分离; 洗涤该部分结合的核酸颗粒; 以及从所述一组部分结合的核酸颗粒中释放核酸样品。该方法优选使用包含聚（烯丙胺）和聚丙烯亚胺四胺树枝状聚合物中的至少一种的结合部分，两者都可以基于环境pH可逆地结合和解链至核酸。

8. 发明授权

US09441219B2 System and method for processing and detecting nucleic acids 有权
公开(公告)号：US09441219B2
公开(公告)日：2016-09-13
申请号：US14704215
申请日：2015-05-05
申请人： NeuMoDx Molecular, Inc.
发明人： Jeffrey Williams , Sundaresh Brahmasandra , Michael T. Kusner
IPC分类号： C12N15/10 , C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： C12N15/1013 , B01L3/502 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/508 , B01L3/527 , B01L3/567 , B01L7/52 , B01L7/525 , B01L9/00 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0615 , B01L2200/0668 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/06 , B01L2300/0609 , B01L2300/0627 , B01L2300/0636 , B01L2300/0672 , B01L2300/0681 , B01L2300/0809 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2300/0893 , B01L2300/123 , B01L2300/14 , B01L2300/16 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , B01L2400/0655 , B01L2400/0694 , B01L2400/086 , B29C65/08 , B29C65/484 , B29C65/606 , B29C66/71 , B29C66/81423 , B29C66/8322 , B29L2031/756 , C12M23/42 , C12N13/00 , C12Q1/68 , C12Q1/6806 , C12Q1/6813 , C12Q1/686 , B29K2021/00
摘要： A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

9. 发明授权

US11338295B2 Thermocycling system and manufacturing method 有权
公开(公告)号：US11338295B2
公开(公告)日：2022-05-24
申请号：US16264262
申请日：2019-01-31
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L3/00 , B01L1/00 , B01L7/00 , H05K1/18 , H05K3/30 , H05K3/46
摘要： A system for thermocycling biological samples within detection chambers comprising: a set of heater-sensor dies, each heater-sensor die comprising a heating surface configured to interface with a detection chamber and a second surface, inferior to the heating surface, including a first connection point; an electronics substrate, comprising a first substrate surface coupled to the second surface of each heater-sensor die, an aperture providing access through the electronics substrate to at least one heater-sensor die, and a second substrate surface inferior to the first substrate surface, wherein the electronics substrate comprises a set of substrate connection points at least at one of the first substrate surface, an aperture surface defined within the aperture, and the second substrate surface, and wherein the electronics substrate is configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of wire bonds, including a wire bond coupled between the first connection point of at least one of the set of heater-sensor dies and one of the set of substrate connection points.

10. 发明授权

US11273448B2 Thermocycling system, composition, and microfabrication method 有权
公开(公告)号：US11273448B2
公开(公告)日：2022-03-15
申请号：US16273795
申请日：2019-02-12
申请人： NeuMoDx Molecular, Inc.
发明人： Sundaresh Brahmasandra , Thomas Haddock , Patrick Duffy , Jeffrey Williams
IPC分类号： B01L3/00 , B01L1/00 , B01L7/00 , C23C14/02 , C23C14/16 , C23C14/24 , C23C14/34
摘要： A system and method of manufacture for the system, comprising a set of heater-sensor dies, each heater-sensor die comprising an assembly including a first insulating layer, a heating region comprising an adhesion material layer coupled to the first insulating layer and a noble material layer, and a second insulating layer coupled to the heating region and to the first insulating layer through a pattern of voids in the heating region, wherein the pattern of voids in heating region defines a coarse pattern associated with a heating element of the heating region and a fine pattern, integrated into the coarse pattern and associated with a sensing element of the heating region; an electronics substrate configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of elastic elements configured to bias each of the set of heater-sensor dies against a detection chamber.

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