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1. 发明申请

US20160363548A1 AUTOMATIC ISOTHERMAL TITRATION MICROCALORIMETER APPARATUS AND METHOD OF USE 审中-公开
公开(公告)号：US20160363548A1
公开(公告)日：2016-12-15
申请号：US15192712
申请日：2016-06-24
申请人： Malvern Instruments Incorporated
发明人： Martin BROGA , Phillip PRICE , Stephen SMITH
IPC分类号： G01N25/48 , G01N35/00 , G01N35/10
CPC分类号： G01N25/4873 , B01L3/02 , G01K17/006 , G01N1/14 , G01N25/20 , G01N25/48 , G01N25/4813 , G01N25/4866 , G01N35/00584 , G01N35/0092 , G01N35/1002
摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

2. 发明授权

US09404876B2 Automatic isothermal titration microcalorimeter apparatus and method of use 有权
公开(公告)号：US09404876B2
公开(公告)日：2016-08-02
申请号：US14736905
申请日：2015-06-11
申请人： Malvern Instruments Incorporated
发明人： Martin Broga , Phillip Price , Stephen Smith
IPC分类号： G01N25/20 , B01L3/02 , G01N35/00 , G01N35/10 , G01N25/48 , G01K17/00 , G01N1/14
CPC分类号： G01N25/4873 , B01L3/02 , G01K17/006 , G01N1/14 , G01N25/20 , G01N25/48 , G01N25/4813 , G01N25/4866 , G01N35/00584 , G01N35/0092 , G01N35/1002
摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

3. 发明授权

US09103782B2 Automatic isothermal titration microcalorimeter apparatus and method of use 有权
标题翻译：自动等温滴定微量热仪的使用方法
公开(公告)号：US09103782B2
公开(公告)日：2015-08-11
申请号：US12326300
申请日：2008-12-02
申请人： Martin Broga , Phillip Price , Stephen Smith
发明人： Martin Broga , Phillip Price , Stephen Smith
IPC分类号： G01N25/20 , B01L3/02 , G01N25/48 , G01K17/00 , G01N1/14
CPC分类号： G01N25/4873 , B01L3/02 , G01K17/006 , G01N1/14 , G01N25/20 , G01N25/48 , G01N25/4813 , G01N25/4866 , G01N35/00584 , G01N35/0092 , G01N35/1002
摘要： Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.
摘要翻译：自动等温滴定微量热法（ITC）系统，其包括具有样品池和参比细胞的微量热计，样品池可通过样品细胞茎进行，参考细胞可通过参考细胞茎进入。所述系统还包括自动移液管组件，其包括具有滴定针的注射器，所述滴定针被布置成插入到所述样品池中用于供应滴定剂，所述移液管组件包括用于驱动所述注射器中的柱塞的活化剂，支持所述移液管组件的移液管平移单元，布置成将移液管放置在适当位置用于滴定，洗涤和灌装操作，用于滴定针的洗涤台，以及细胞制备单元，其被配置为当移液管放置在另一位置时执行替换样品池中的样品液体的操作，滴定的位置。

4. 发明授权

US07582872B2 Volumetric spectral imaging 有权
标题翻译：体积光谱成像
公开(公告)号：US07582872B2
公开(公告)日：2009-09-01
申请号：US10684965
申请日：2003-10-14
申请人： E. Neil Lewis , Donald Craig Lynch
发明人： E. Neil Lewis , Donald Craig Lynch
IPC分类号： G01J5/02
CPC分类号： G01N1/06 , G01N21/3563
摘要： A spectral acquisition method includes actively processing a sample, such as a an opaque, friable pharmaceutical dosage unit, to expose characteristics of interior portions of the sample, and acquiring spectral information from the interior portions.
摘要翻译：光谱采集方法包括主动处理样品，例如不透明，易碎的药物剂量单位，以暴露样品内部部分的特征，以及从内部部分获取光谱信息。

5. 发明授权

US08842266B2 Pharmaceutical mixture evaluation 有权
标题翻译：药物混合物评价
公开(公告)号：US08842266B2
公开(公告)日：2014-09-23
申请号：US13216038
申请日：2011-08-23
申请人： E. Neil Lewis , Kenneth S. Haber
发明人： E. Neil Lewis , Kenneth S. Haber
IPC分类号： G01N21/00 , G01N21/95 , A61K31/00 , G01N33/15
CPC分类号： A61K31/00 , G01N21/9508 , G01N33/15
摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.
摘要翻译：公开了获得有关异质药物混合物的信息的方法。该方法包括将诸如污渍的图像增强剂施加到混合物。然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

6. 发明申请

US20170299532A1 DIFFERENTIAL SCANNING CALORIMETRY METHOD AND APPARATUS 审中-公开
公开(公告)号：US20170299532A1
公开(公告)日：2017-10-19
申请号：US15132859
申请日：2016-04-19
申请人： Malvern Instruments Incorporated
发明人： Vishal Patil , Ronan O'Brien , Edward A. Esposito , Ben E. Pattison
IPC分类号： G01N25/48
CPC分类号： G01N25/4866 , B01L3/502784 , B01L7/52 , B01L2300/14 , B01L2300/1822 , B01L2300/1827 , G01N25/4886 , G01N25/4893
摘要： A method of determining thermal properties of a sample using differential scanning calorimetry (DSC), the method comprises injecting a first separation fluid, a sample plug, and a second separation fluid into a sample cell. The first separation fluid and the sample plug have a first separation interface, and the sample plug and the second fluid have a second separation interface. The method further comprises injecting a reference fluid into a reference cell, heating the sample cell and reference cell, and determining thermal properties of the sample using DSC analysis.

7. 发明授权

US09759644B2 Balanced capillary bridge viscometer 有权
公开(公告)号：US09759644B2
公开(公告)日：2017-09-12
申请号：US13825622
申请日：2011-09-23
申请人： Mark Nicholls , Michael P. Murphy
发明人： Mark Nicholls , Michael P. Murphy
IPC分类号： G01N11/04 , G01N11/08 , G01N11/02
CPC分类号： G01N11/08 , G01N11/02 , G01N11/04 , G01N11/06 , G01N2011/0006 , G01N2011/0093 , G01N2011/147
摘要： A capillary bridge viscometer, comprises an input port (flow in) an output port (flow out) a first capillary tubing arm (R1) in a first hydraulic path between the input port and a first differential detection point (DP+), a second capillary tubing arm (R3) in a second hydraulic path between the first differential detection point (DP+) and the output port (flow out), a third capillary tubing arm (R2) in a third hydraulic path between the input port (flow in) and a second differential detection point (DP−), a fourth capillary tubing arm (R4) in a fourth hydraulic path between the second differential detection point (DP−) and the output port (flow out), an adjustable mechanical flow restrictor (20) in one of the first, second, third, and fourth hydraulic paths, wherein the adjustable mechanical flow restrictor (20) is operative to mechanically adjust a resistance to flow of a fluid while the fluid flows through the adjustable mechanical flow restrictor.

8. 发明授权

US08448534B2 Method and apparatus for dispersing a sample of particulate material 失效
标题翻译：用于分散颗粒材料样品的方法和装置
公开(公告)号：US08448534B2
公开(公告)日：2013-05-28
申请号：US12451563
申请日：2008-05-19
申请人： Nicholas Craig Davidson , Margaret Ellen Dyson , Jonathan Powell , Andrew John Prior
发明人： Nicholas Craig Davidson , Margaret Ellen Dyson , Jonathan Powell , Andrew John Prior
IPC分类号： G01N15/00
CPC分类号： G01N1/2813 , G01N1/286
摘要： An apparatus for dispersing a sample of particulate material, includes a carrier (31;35;37;38;39) having a sample-bearing surface on which to place the sample, and a housing (10;44;48) for forming a dispersion chamber (17), at least when closed off at a base (46;51). The carrier is arranged such that the sample-bearing surface is removed from contact with the sample upon application of a sufficient pressure differential across the carrier between the sample-bearing surface and an opposite side of the carrier. The housing (10;44;48) has an inlet (26) at least partially facing the base (46;51). The apparatus includes an apparatus (15;16) for passing a volume of fluid past the carrier (31;35;37;38;39) through the inlet (26) by subjecting the carrier (31;35;37;38;39) to a pulsed positive pressure differential relative to the dispersion chamber (17).
摘要翻译：一种用于分散颗粒材料样品的装置，包括具有放置样品的样品承载表面的载体（31; 35; 37; 38; 39）和用于形成至少在基部（46; 51）处封闭时分散室（17）。载体被布置成使得在载体表面和承载体的相对侧之间施加足够的压力差，载体表面与样品脱离接触。壳体（10; 44; 48）具有至少部分地面向基部（46; 51）的入口（26）。该装置包括一个装置（15; 16），用于使一定体积的流体经过载体（31; 35; 37; 38; 39）穿过入口（26），使载体（31; 35; 37; 38; 39 ）相对于分散室（17）的脉冲正压差。

9. 发明授权

US07414723B2 Automated interleaved spectral imaging calibration 失效
标题翻译：自动交错光谱成像校准
公开(公告)号：US07414723B2
公开(公告)日：2008-08-19
申请号：US11063051
申请日：2005-02-22
申请人： E. Neil Lewis , Joseph William Schoppelrei , Eunah Lee
发明人： E. Neil Lewis , Joseph William Schoppelrei , Eunah Lee
IPC分类号： G01J3/46
CPC分类号： G01J3/28 , G01J3/0267 , G01J3/2823 , G01J3/524
摘要： An imaging spectrometric instrument is disclosed. This instrument can include an imaging detector and one or more calibration standards having different optical properties. Portions of one or more actuators can move the calibration standards between the imaging detector and a sample. This instrument can use the actuator(s) to acquire an image of a sample and measure light and dark reference calibration values in quick succession at a given wavelength, before the instrument is tuned to another wavelength.
摘要翻译：公开了一种成像光谱仪。该仪器可以包括成像检测器和具有不同光学性质的一个或多个校准标准。一个或多个致动器的部分可以在成像检测器和样品之间移动校准标准。在仪器调谐到另一波长之前，该仪器可以使用执行器来获取样品的图像，并在给定波长下快速连续测量光和暗参考校准值。

10. 发明授权

US09612183B2 Modular capillary bridge viscometer 有权
公开(公告)号：US09612183B2
公开(公告)日：2017-04-04
申请号：US13825623
申请日：2011-09-23
申请人： Paul G. Clarke , Michael P. Murphy
发明人： Paul G. Clarke , Michael P. Murphy
IPC分类号： G01N11/08
CPC分类号： G01N11/08
摘要： A capillary bridge viscometer (120), comprises at least two at least generally balanced bridge arm conduits (R1, R2) a bulkhead supporting structure (122,134) supporting removable connection portions for each of a plurality of the arms in a bridge configuration, a bridge supporting structure (124,136) supporting the bridge arm conduits (R1,R2) and supporting two further removable connection portions (132) for each of the bridge arm conduits, wherein each of the further removable connection portions (132) supported by the bridge supporting structure are positioned to mate with a corresponding one of the removable connection portions (130) supported by the bulkhead supporting structure concurrently to hydraulically connect the bridge arm conduits in the bridge configuration; and a balance detector having hydraulic connections for connection between first and second differential detection points in the bridge when the removable connection portions on the bridge are mated to corresponding ones of the removable connection portions supported by the bulkhead supporting structure.

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