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1. 发明授权

US09612183B2 Modular capillary bridge viscometer 有权
公开(公告)号：US09612183B2
公开(公告)日：2017-04-04
申请号：US13825623
申请日：2011-09-23
申请人： Paul G. Clarke , Michael P. Murphy
发明人： Paul G. Clarke , Michael P. Murphy
IPC分类号： G01N11/08
CPC分类号： G01N11/08
摘要： A capillary bridge viscometer (120), comprises at least two at least generally balanced bridge arm conduits (R1, R2) a bulkhead supporting structure (122,134) supporting removable connection portions for each of a plurality of the arms in a bridge configuration, a bridge supporting structure (124,136) supporting the bridge arm conduits (R1,R2) and supporting two further removable connection portions (132) for each of the bridge arm conduits, wherein each of the further removable connection portions (132) supported by the bridge supporting structure are positioned to mate with a corresponding one of the removable connection portions (130) supported by the bulkhead supporting structure concurrently to hydraulically connect the bridge arm conduits in the bridge configuration; and a balance detector having hydraulic connections for connection between first and second differential detection points in the bridge when the removable connection portions on the bridge are mated to corresponding ones of the removable connection portions supported by the bulkhead supporting structure.

2. 发明申请

US20140060162A1 MODULAR CAPILLARY BRIDGE VISCOMETER 有权
标题翻译：模块化毛细管粘度计
公开(公告)号：US20140060162A1
公开(公告)日：2014-03-06
申请号：US13825623
申请日：2011-09-23
申请人： Paul G. Clarke , Michael P. Murphy
发明人： Paul G. Clarke , Michael P. Murphy
IPC分类号： G01N11/08
CPC分类号： G01N11/08
摘要： A capillary bridge viscometer (120), comprises at least two at least generally balanced bridge arm conduits (R1, R2) a bulkhead supporting structure (122,134) supporting removable connection portions for each of a plurality of the arms in a bridge configuration, a bridge supporting structure (124,136) supporting the bridge arm conduits (R1,R2) and supporting two further removable connection portions (132) for each of the bridge arm conduits, wherein each of the further removable connection portions (132) supported by the bridge supporting structure are positioned to mate with a corresponding one of the removable connection portions (130) supported by the bulkhead supporting structure concurrently to hydraulically connect the bridge arm conduits in the bridge configuration; and a balance detector having hydraulic connections for connection between first and second differential detection points in the bridge when the removable connection portions on the bridge are mated to corresponding ones of the removable connection portions supported by the bulkhead supporting structure.
摘要翻译：一种毛细管桥式粘度计（120），包括至少两个至少大体上平衡的桥臂导管（R1，R2），隔板支撑结构（122,134），其以桥式结构支撑多个臂中的每一个的可移除连接部分，支撑结构（124,136），其支撑桥臂导管（R1，R2），并为每个桥臂导管支撑两个另外的可移除的连接部分（132），其中每个所述另外可移除的连接部分（132）由所述桥梁支撑结构定位成与由隔板支撑结构支撑的可拆卸连接部分（130）同时配合以使桥臂配置中的桥臂管道液压连接; 以及具有液压连接的平衡检测器，当桥上的可移除连接部分与由隔板支撑结构支撑的相应的可拆卸连接部分配合时，在桥中的第一和第二差动检测点之间进行连接。

3. 发明授权

US07966734B2 Tack strip cutter 有权
标题翻译：粘扣机
公开(公告)号：US07966734B2
公开(公告)日：2011-06-28
申请号：US11781876
申请日：2007-07-23
申请人： Lance D. Crain , Michael P. Murphy
发明人： Lance D. Crain , Michael P. Murphy
IPC分类号： B26B17/02
CPC分类号： B26B17/02
摘要： A tack strip cutter including a top blade holder and a bottom blade holder having a leverage handle for bringing the blade holders together with a leverage force. A splay inhibition guide on one of the blade holders prevents lateral movement of the blade holders when the tool is used.
摘要翻译：一种定位条切割器，包括顶部刀片保持器和底部刀片保持器，该刀片保持器具有杠杆柄，用于利用杠杆力使刀片保持器在一起。其中一个刀片支架上的喷射禁止引导件防止刀具保持器在使用刀具时的横向运动。

4. 发明授权

US4423309A Quick heat self regulating electric glow heater 失效
标题翻译：快速热调节电热加热器
公开(公告)号：US4423309A
公开(公告)日：1983-12-27
申请号：US392600
申请日：1982-06-28
申请人： Michael P. Murphy , Gary F. Stack , James W. Hoppenrath , John R. Taylor
发明人： Michael P. Murphy , Gary F. Stack , James W. Hoppenrath , John R. Taylor
IPC分类号： F02B3/06 , F23Q7/00 , F23Q7/22
CPC分类号： F23Q7/001 , F02B3/06
摘要： A sheathed electric heater especially of the type used as diesel engine glow plugs has a dual coil heating element including separate tip heater and PTC body control coils thermally isolated by a low resistance connector section made from interengaging small diameter coiled connector portions integral with the tip and body coils and preferably welded together. Preferred material and dimensional specifications and pertinent design considerations are also included.
摘要翻译：特别是用作柴油发动机电热塞类型的护套电加热器具有双线圈加热元件，其包括单独的尖端加热器和PTC体控制线圈，该主体线圈加热器由低阻抗连接器部分隔离，该低阻抗连接器部分由与尖端成一体的相互接合的小直径螺旋连接器部分身体线圈并优选焊接在一起。还包括优选的材料和尺寸规格以及相关的设计考虑。

5. 发明授权

US08667844B1 Ultrasonic scalar adhesion test apparatus and method for paints and finishes 有权
标题翻译：超声波标量附着试验装置及涂料和表面处理方法
公开(公告)号：US08667844B1
公开(公告)日：2014-03-11
申请号：US13016905
申请日：2011-01-28
申请人： Christopher L. Broadbent , Michael P. Murphy , Randall Jahren
发明人： Christopher L. Broadbent , Michael P. Murphy , Randall Jahren
IPC分类号： G01M7/00
CPC分类号： G01N19/04 , G01N2203/0008 , G01N2203/0055
摘要： Presented is a system and method for testing the adhesion of coatings to substrates using an ultrasonic scalar. The system comprises a body, a flexible scalpel extending from said body, and a source of ultrasonic waves. The flexible scalpel applies pressure and ultrasonic waves to a coating that is removed when the adhesion of the coating to the substrate is substandard. The method comprises applying an flexible scalpel extending from an ultrasonic adhesion test device to a coating, applying ultrasonic waves through the flexible scalpel to the coating while moving across the coating, removing the coating if there is less than an acceptable adhesion of the coating to the substrate, and inspecting the coating to determine if coating was removed from the substrate.
摘要翻译：提出了一种用于使用超声波标量测试涂层对基底的粘附性的系统和方法。该系统包括主体，从所述主体延伸的柔性手术刀和超声波源。柔性手术刀将压力和超声波施加到当涂层粘附到基底上时被去除的涂层。该方法包括将从超声波粘附测试装置延伸的柔性手术刀涂覆到涂层上，在移动穿过涂层的同时将超声波穿过柔性手术刀施加到涂层，如果涂层小于可接受的粘附力底物，并检查涂层以确定涂层是否从基底上去除。

6. 发明申请

US20130064768A1 LIPOPHILIC CATIONIC PROBE FOR PET-IMAGING 审中-公开
标题翻译：用于PET成像的LIPOPHILIC阳离子探针
公开(公告)号：US20130064768A1
公开(公告)日：2013-03-14
申请号：US13636106
申请日：2011-03-24
申请人： David K. Menon , Michael P. Murphy , Franklin I. Aigbirhio , Robin A. Smith
发明人： David K. Menon , Michael P. Murphy , Franklin I. Aigbirhio , Robin A. Smith
IPC分类号： A61K51/04 , C07F9/54
CPC分类号： A61K51/0404 , C07B59/004
摘要： The present invention provides an imaging probe which comprises a lipophilic cation, a hydrophobic moiety and a PET nucleus. The present invention also provides a precursor molecule for the production of such an imaging probe and methods for using the probe for analysing mitochondrial membrane potential in a subject.
摘要翻译：本发明提供了一种成像探针，其包含亲脂性阳离子，疏水部分和PET核。本发明还提供了用于制备这种成像探针的前体分子和用于分析受试者线粒体膜电位的探针的方法。

7. 发明授权

US08047373B2 Suspended utensil storage system and method 有权
标题翻译：悬挂式器具储存系统及方法
公开(公告)号：US08047373B2
公开(公告)日：2011-11-01
申请号：US12772876
申请日：2010-05-03
申请人： Michael P. Murphy
发明人： Michael P. Murphy
IPC分类号： B65D21/00
CPC分类号： A47B88/90 , Y10T29/49826
摘要： A suspended utensil storage system includes a utensil tray including a plurality of utensil compartments having a mesh material therein; and a debris collector tray underlying the utensil tray and receiving the utensil tray. The mesh material of the utensil compartments of the utensil tray supports utensils and includes holes sized to allow debris to fall there through into the debris collector tray for collecting the debris.
摘要翻译：一种悬挂式餐具储存系统，包括：餐具托盘，其包括多个在其中具有网状材料的餐具隔间; 以及在器皿托盘下方的碎屑收集器托盘，并接收餐具托盘。餐具托盘的餐具隔间的网状材料支撑餐具，并且包括尺寸适于允许碎屑通过碎屑收集器托盘落入其中以收集碎屑的孔。

8. 外观设计

USD628381S1 Cleaning kit 有权
标题翻译：清洁套件
公开(公告)号：USD628381S1
公开(公告)日：2010-12-07
申请号：US29350392
申请日：2009-11-16
申请人： Michael P. Murphy , Zachary I. Eyman
设计人： Michael P. Murphy , Zachary I. Eyman

9. 发明申请

US20090197945A1 Method for Generating Reference Controls for Pharmacogenomic Testing 审中-公开
标题翻译：生成药物基因组检测参考控制的方法
公开(公告)号：US20090197945A1
公开(公告)日：2009-08-06
申请号：US12162199
申请日：2007-01-29
申请人： Michael P. Murphy , Scott L. Clark , Pamela J. Nakhle , Kenneth G. Butz
发明人： Michael P. Murphy , Scott L. Clark , Pamela J. Nakhle , Kenneth G. Butz
IPC分类号： C12Q1/68 , A61K31/352 , A61P3/00 , A61P9/00 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C12N5/0635 , C12N2503/00 , C12N2510/04
摘要： Reference controls for use with pharmacogenomic testing, and methods for their identification, preparation, and use, are disclosed. The reference controls can confirm that pharmacogenomic testing correctly identifies individuals that do or do not have the mutation of interest, in both clinical trial and patient treatment settings. The reference controls can be selected to include one or more mutations to be identified, and prescreened to confirm that they bind to one or more of the primers used in the pharmacogenomic testing. The reference controls are human genomic DNA that includes certain identified polymorphisms (mutations) of interest, ideally derived from individuals, pre-selected and optionally properly consented, which have one or more of the polymorphism(s) of interest. The reference controls can be prepared by targeted pre-screening of human patients, by examining the genotype or genetic profile of the patients, isolating cells with the desired mutation, optionally immortalizing the cells, and obtaining DNA from the cells. The prescreening of prospective donors can be targeted based on any of a number of factors, such as genes of interest, mutations within the genes of interest, and membership in a specific ethnic or disease state population. The genomic DNA can be pre-screened for its ability to be detected, using a standard pharmacogenomic test, as including a specific mutation. Examples of mutations of interest include those present in a Phase I or Phase II metabolic enzyme such as CYP2D6, CYP2C19, CYP2C9, CYP2C8, and CYP3A5, CYP3A4, CYP2A6, CYP2B6, UGT1A1, DPD, ERCC1, MDR1, ADH2, NAT1 and NAT2 or any other metabolic or disease gene.
摘要翻译：公开了用于药物基因组测试的参考对照及其鉴定，制备和使用的方法。在临床试验和患者治疗环境中，参照对照可以证实药物基因组检测正确地识别出有或没有感兴趣突变的个体。可以选择参考对照以包括待鉴定的一个或多个突变，并进行预筛选以确认它们与药物基因组测试中使用的一种或多种引物结合。参考对照是人基因组DNA，其包括某些鉴定的目的多态性（突变），理想地衍生自预先选择的和任选正确同意的个体，其具有一个或多个感兴趣的多态性。通过检查患者的基因型或遗传概况，分离具有所需突变的细胞，任选地使细胞永生化，以及从细胞中获得DNA，可以通过靶向预筛选人类患者来制备参照对照。可以基于许多因素，如感兴趣的基因，感兴趣的基因内的突变以及特定种族或疾病状态群体的成员中的任何一个因素来预先预先筛选前瞻性供体。可以使用标准药物基因组测试将基因组DNA的筛选能力进行预筛选，作为包括特异性突变。感兴趣的突变的实例包括存在于I期或II期代谢酶如CYP2D6，CYP2C19，CYP2C9，CYP2C8和CYP3A5，CYP3A4，CYP2A6，CYP2B6，UGT1A1，DPD，ERCC1，MDR1，ADH2，NAT1和NAT2中的那些，任何其他代谢或疾病基因。

10. 发明授权

US07109189B2 Mitochondrially targeted antioxidants 失效
标题翻译：线粒体靶向抗氧化剂
公开(公告)号：US07109189B2
公开(公告)日：2006-09-19
申请号：US11056978
申请日：2005-02-11
申请人： Michael P. Murphy , Robin A. J. Smith
发明人： Michael P. Murphy , Robin A. J. Smith
IPC分类号： A61K31/555 , A61K31/70 , A61K31/41 , C07D487/22
CPC分类号： A61K31/555 , A61K47/543 , C07D293/12 , C07F9/5475 , C07F9/58 , C07F9/6539 , C07F13/005
摘要： The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.
摘要翻译：本发明提供线粒体靶向抗氧化剂化合物，其包含与谷胱甘肽过氧化物酶模拟物共价偶联的亲脂性阳离子部分。这些化合物可用于治疗从减少氧化应激中受益的患者。

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