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1. 发明授权

US07414723B2 Automated interleaved spectral imaging calibration 失效
标题翻译：自动交错光谱成像校准
公开(公告)号：US07414723B2
公开(公告)日：2008-08-19
申请号：US11063051
申请日：2005-02-22
申请人： E. Neil Lewis , Joseph William Schoppelrei , Eunah Lee
发明人： E. Neil Lewis , Joseph William Schoppelrei , Eunah Lee
IPC分类号： G01J3/46
CPC分类号： G01J3/28 , G01J3/0267 , G01J3/2823 , G01J3/524
摘要： An imaging spectrometric instrument is disclosed. This instrument can include an imaging detector and one or more calibration standards having different optical properties. Portions of one or more actuators can move the calibration standards between the imaging detector and a sample. This instrument can use the actuator(s) to acquire an image of a sample and measure light and dark reference calibration values in quick succession at a given wavelength, before the instrument is tuned to another wavelength.
摘要翻译：公开了一种成像光谱仪。该仪器可以包括成像检测器和具有不同光学性质的一个或多个校准标准。一个或多个致动器的部分可以在成像检测器和样品之间移动校准标准。在仪器调谐到另一波长之前，该仪器可以使用执行器来获取样品的图像，并在给定波长下快速连续测量光和暗参考校准值。

2. 发明申请

US20080180660A1 Spectrometric investigation of heterogeneity 有权
标题翻译：异质性光谱测量
公开(公告)号：US20080180660A1
公开(公告)日：2008-07-31
申请号：US12006677
申请日：2008-01-04
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01J3/00
CPC分类号： G01J3/02 , G01J3/021 , G01J3/0289 , G01J3/2823 , G01N15/1475 , G01N2015/1486 , G01N2015/1497
摘要： In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.
摘要翻译：在一般的方面，公开了一种用于调查样品区域的异质性的分光装置。所述装置包括：图像采集系统，用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口，用于接收指定已获得图像的子区域之一的选择。光谱仪具有视场，并且可操作以在其视野中获取一个子区域的至少一部分的光谱，并且定位机构响应于子区域选择界面并且可操作地定位场基于接收到的选择，相对于样品区域的光谱仪的视图。

3. 发明授权

US07391025B2 High-throughput infrared spectroscopy 失效
标题翻译：高通量红外光谱
公开(公告)号：US07391025B2
公开(公告)日：2008-06-24
申请号：US10299577
申请日：2002-11-19
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01J5/02
CPC分类号： G01N21/253 , B01J2219/00605 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C40B40/06 , G01J3/02 , G01J3/0291 , G01J3/42 , G01N21/03 , G01N21/35 , G01N21/3563 , G01N21/3577 , G01N2021/0378
摘要： A spectrometer includes an infrared source, a spectrally selective element, and a cell array. The cell array includes walls that define a number of cavities. The spectrometer also includes an infrared spatial detector responsive to infrared radiation travelling from the infrared source through contents of at least two of the cavities as well as through the spectrally selective element.
摘要翻译：光谱仪包括红外源，光谱选择元件和单元阵列。电池阵列包括限定多个空腔的壁。光谱仪还包括红外空间检测器，其响应于从红外源通过至少两个空腔的内容以及通过光谱选择性元件传播的红外辐射。

4. 发明申请

US20080130001A1 Hybrid-imaging spectrometer 审中-公开
标题翻译：混合成像光谱仪
公开(公告)号：US20080130001A1
公开(公告)日：2008-06-05
申请号：US10996189
申请日：2004-11-22
申请人： E. Neil Lewis , Kenneth S. Haber
发明人： E. Neil Lewis , Kenneth S. Haber
IPC分类号： G01N21/25
CPC分类号： G01J3/51 , G01J3/2823 , G01J3/44 , G01J2003/1217 , G01J2003/1243
摘要： An imaging optical instrument for acquiring images of a sample area is disclosed. The instrument includes a spatial detector with aligned detector elements and a variable filter having filter characteristics that vary in at least one direction and are located in an optical path between the sample area and the spatial detector. An actuator is operatively connected between the variable filter and the spatial detector and is operative to move the variable filter along the direction in which the filter characteristics vary.
摘要翻译：公开了一种用于获取样本区域的图像的成像光学仪器。仪器包括具有对准的检测器元件的空间检测器和具有在至少一个方向上变化并且位于样品区域和空间检测器之间的光路中的滤波器特性的可变滤波器。致动器可操作地连接在可变滤波器和空间检测器之间，并且可操作以沿着滤波器特性变化的方向移动可变滤波器。

5. 发明申请

US20150146202A1 DUAL-MODE CHARACTERIZATION OF PARTICULATES 有权
标题翻译：颗粒的双模式表征
公开(公告)号：US20150146202A1
公开(公告)日：2015-05-28
申请号：US14239039
申请日：2012-08-17
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01N21/51 , G01N21/65 , G01N15/02 , G01N15/14
CPC分类号： G01N21/51 , G01J3/44 , G01N15/0205 , G01N15/1434 , G01N21/65 , G01N21/80 , G01N2021/4709 , G01N2201/06113 , G01N2201/068
摘要： The invention relates to methods and apparatus for detecting properties of suspended particles. Embodiments disclosed include an optical instrument (200) for detecting properties of a sample, comprising: a sample cell (103) for holding a sample of a particulate dispersion; a coherent light source (101) configured to illuminate the sample in the sample cell (103); a light intensity detector (104, 106) positioned to receive and measure an intensity of light from the coherent light source (101) elastically scattered by the sample in the sample cell (103); and a spectral light detector (212) positioned and configured to receive and measure a range of wavelengths of light from the coherent radiation source (101) inelastically scattered by the sample in the sample cell (103).
摘要翻译：本发明涉及用于检测悬浮颗粒性质的方法和装置。公开的实施例包括用于检测样品性质的光学仪器（200），包括：用于保持颗粒分散体样品的样品池（103）; 被配置为照射样品池中的样品的相干光源（101）; 定位成接收和测量由样品池（103）中的样品弹性散射的相干光源（101）的光强度的光强度检测器（104,106）; 以及光谱光检测器（212），其定位和配置为接收和测量来自所述样品池（103）中的所述样品被弹性散射的来自所述相干辐射源（101）的光的波长范围。

6. 发明授权

US08564774B2 Spectrometric investigation of heterogeneity 有权
标题翻译：异质性光谱测量
公开(公告)号：US08564774B2
公开(公告)日：2013-10-22
申请号：US13367359
申请日：2012-02-06
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , G01J3/021 , G01J3/0289 , G01J3/2823 , G01N15/1475 , G01N2015/1486 , G01N2015/1497
摘要： In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.
摘要翻译：在一般的方面，公开了一种用于调查样品区域的异质性的分光装置。所述装置包括：图像采集系统，用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口，用于接收指定已获得图像的子区域之一的选择。光谱仪具有视场，并且可操作以在其视野中获取一个子区域的至少一部分的光谱，并且定位机构响应于子区域选择界面并且可操作地定位场基于接收到的选择，相对于样品区域的光谱仪的视图。

7. 发明授权

US08111395B2 Spectrometric investigation of heterogeneity 有权
标题翻译：异质性光谱测量
公开(公告)号：US08111395B2
公开(公告)日：2012-02-07
申请号：US12006677
申请日：2008-01-04
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , G01J3/021 , G01J3/0289 , G01J3/2823 , G01N15/1475 , G01N2015/1486 , G01N2015/1497
摘要： In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.
摘要翻译：在一般的方面，公开了一种用于调查样品区域的异质性的分光装置。所述装置包括：图像采集系统，用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口，用于接收指定已获得图像的子区域之一的选择。光谱仪具有视场，并且可操作以在其视野中获取一个子区域的至少一部分的光谱，并且定位机构响应于子区域选择界面并且可操作地定位场基于接收到的选择，相对于样品区域的光谱仪的视图。

8. 发明申请

US20110238327A1 SPECTROMETRIC CHARACTERIZATION OF HETEROGENEITY 审中-公开
标题翻译：异构体的光谱特征
公开(公告)号：US20110238327A1
公开(公告)日：2011-09-29
申请号：US13008884
申请日：2011-01-18
申请人： E. Neil Lewis , Kenneth S. Haber
发明人： E. Neil Lewis , Kenneth S. Haber
IPC分类号： G01J3/44 , G01J3/28 , G06F17/18
CPC分类号： G01N21/85 , B01F9/00 , G01J3/0218 , G01J3/0294 , G01J3/453 , G01N21/31
摘要： In one general aspect, a spectroscopic method is disclosed. This method includes acquiring a plurality of separate spectral measurements at different locations on a sample and evaluating results of the measurements based on one or more predetermined test criteria. Information from measurements made at the different locations is categorized based on results of the step of evaluating, and results are reported that include information from both the step of acquiring and the step of categorizing.
摘要翻译：在一般的方面，公开了一种光谱方法。该方法包括在样本上的不同位置获取多个单独的光谱测量值，并基于一个或多个预定测试标准评估测量结果。来自不同地点的测量信息根据评估步骤的结果进行分类，报告结果包括获取步骤和分类步骤的信息。

9. 发明授权

US07582872B2 Volumetric spectral imaging 有权
标题翻译：体积光谱成像
公开(公告)号：US07582872B2
公开(公告)日：2009-09-01
申请号：US10684965
申请日：2003-10-14
申请人： E. Neil Lewis , Donald Craig Lynch
发明人： E. Neil Lewis , Donald Craig Lynch
IPC分类号： G01J5/02
CPC分类号： G01N1/06 , G01N21/3563
摘要： A spectral acquisition method includes actively processing a sample, such as a an opaque, friable pharmaceutical dosage unit, to expose characteristics of interior portions of the sample, and acquiring spectral information from the interior portions.
摘要翻译：光谱采集方法包括主动处理样品，例如不透明，易碎的药物剂量单位，以暴露样品内部部分的特征，以及从内部部分获取光谱信息。

10. 发明授权

US09816922B2 Dual-mode characterization of particulates 有权
公开(公告)号：US09816922B2
公开(公告)日：2017-11-14
申请号：US14239039
申请日：2012-08-17
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01N21/00 , G01N21/51 , G01J3/44 , G01N15/02 , G01N21/65 , G01N15/14 , G01N21/80 , G01N21/47
CPC分类号： G01N21/51 , G01J3/44 , G01N15/0205 , G01N15/1434 , G01N21/65 , G01N21/80 , G01N2021/4709 , G01N2201/06113 , G01N2201/068
摘要： The invention relates to methods and apparatus for detecting properties of suspended particles. Embodiments disclosed include an optical instrument (200) for detecting properties of a sample, comprising: a sample cell (103) for holding a sample of a particulate dispersion; a coherent light source (101) configured to illuminate the sample in the sample cell (103); a light intensity detector (104, 106) positioned to receive and measure an intensity of light from the coherent light source (101) elastically scattered by the sample in the sample cell (103); and a spectral light detector (212) positioned and configured to receive and measure a range of wavelengths of light from the coherent radiation source (101) inelastically scattered by the sample in the sample cell (103).

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