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1. 发明授权

US07414723B2 Automated interleaved spectral imaging calibration 失效
标题翻译：自动交错光谱成像校准
公开(公告)号：US07414723B2
公开(公告)日：2008-08-19
申请号：US11063051
申请日：2005-02-22
申请人： E. Neil Lewis , Joseph William Schoppelrei , Eunah Lee
发明人： E. Neil Lewis , Joseph William Schoppelrei , Eunah Lee
IPC分类号： G01J3/46
CPC分类号： G01J3/28 , G01J3/0267 , G01J3/2823 , G01J3/524
摘要： An imaging spectrometric instrument is disclosed. This instrument can include an imaging detector and one or more calibration standards having different optical properties. Portions of one or more actuators can move the calibration standards between the imaging detector and a sample. This instrument can use the actuator(s) to acquire an image of a sample and measure light and dark reference calibration values in quick succession at a given wavelength, before the instrument is tuned to another wavelength.
摘要翻译：公开了一种成像光谱仪。该仪器可以包括成像检测器和具有不同光学性质的一个或多个校准标准。一个或多个致动器的部分可以在成像检测器和样品之间移动校准标准。在仪器调谐到另一波长之前，该仪器可以使用执行器来获取样品的图像，并在给定波长下快速连续测量光和暗参考校准值。

2. 发明申请

US20080180660A1 Spectrometric investigation of heterogeneity 有权
标题翻译：异质性光谱测量
公开(公告)号：US20080180660A1
公开(公告)日：2008-07-31
申请号：US12006677
申请日：2008-01-04
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01J3/00
CPC分类号： G01J3/02 , G01J3/021 , G01J3/0289 , G01J3/2823 , G01N15/1475 , G01N2015/1486 , G01N2015/1497
摘要： In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.
摘要翻译：在一般的方面，公开了一种用于调查样品区域的异质性的分光装置。所述装置包括：图像采集系统，用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口，用于接收指定已获得图像的子区域之一的选择。光谱仪具有视场，并且可操作以在其视野中获取一个子区域的至少一部分的光谱，并且定位机构响应于子区域选择界面并且可操作地定位场基于接收到的选择，相对于样品区域的光谱仪的视图。

3. 发明授权

US07391025B2 High-throughput infrared spectroscopy 失效
标题翻译：高通量红外光谱
公开(公告)号：US07391025B2
公开(公告)日：2008-06-24
申请号：US10299577
申请日：2002-11-19
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01J5/02
CPC分类号： G01N21/253 , B01J2219/00605 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C40B40/06 , G01J3/02 , G01J3/0291 , G01J3/42 , G01N21/03 , G01N21/35 , G01N21/3563 , G01N21/3577 , G01N2021/0378
摘要： A spectrometer includes an infrared source, a spectrally selective element, and a cell array. The cell array includes walls that define a number of cavities. The spectrometer also includes an infrared spatial detector responsive to infrared radiation travelling from the infrared source through contents of at least two of the cavities as well as through the spectrally selective element.
摘要翻译：光谱仪包括红外源，光谱选择元件和单元阵列。电池阵列包括限定多个空腔的壁。光谱仪还包括红外空间检测器，其响应于从红外源通过至少两个空腔的内容以及通过光谱选择性元件传播的红外辐射。

4. 发明申请

US20080130001A1 Hybrid-imaging spectrometer 审中-公开
标题翻译：混合成像光谱仪
公开(公告)号：US20080130001A1
公开(公告)日：2008-06-05
申请号：US10996189
申请日：2004-11-22
申请人： E. Neil Lewis , Kenneth S. Haber
发明人： E. Neil Lewis , Kenneth S. Haber
IPC分类号： G01N21/25
CPC分类号： G01J3/51 , G01J3/2823 , G01J3/44 , G01J2003/1217 , G01J2003/1243
摘要： An imaging optical instrument for acquiring images of a sample area is disclosed. The instrument includes a spatial detector with aligned detector elements and a variable filter having filter characteristics that vary in at least one direction and are located in an optical path between the sample area and the spatial detector. An actuator is operatively connected between the variable filter and the spatial detector and is operative to move the variable filter along the direction in which the filter characteristics vary.
摘要翻译：公开了一种用于获取样本区域的图像的成像光学仪器。仪器包括具有对准的检测器元件的空间检测器和具有在至少一个方向上变化并且位于样品区域和空间检测器之间的光路中的滤波器特性的可变滤波器。致动器可操作地连接在可变滤波器和空间检测器之间，并且可操作以沿着滤波器特性变化的方向移动可变滤波器。

5. 发明授权

US09816922B2 Dual-mode characterization of particulates 有权
公开(公告)号：US09816922B2
公开(公告)日：2017-11-14
申请号：US14239039
申请日：2012-08-17
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01N21/00 , G01N21/51 , G01J3/44 , G01N15/02 , G01N21/65 , G01N15/14 , G01N21/80 , G01N21/47
CPC分类号： G01N21/51 , G01J3/44 , G01N15/0205 , G01N15/1434 , G01N21/65 , G01N21/80 , G01N2021/4709 , G01N2201/06113 , G01N2201/068
摘要： The invention relates to methods and apparatus for detecting properties of suspended particles. Embodiments disclosed include an optical instrument (200) for detecting properties of a sample, comprising: a sample cell (103) for holding a sample of a particulate dispersion; a coherent light source (101) configured to illuminate the sample in the sample cell (103); a light intensity detector (104, 106) positioned to receive and measure an intensity of light from the coherent light source (101) elastically scattered by the sample in the sample cell (103); and a spectral light detector (212) positioned and configured to receive and measure a range of wavelengths of light from the coherent radiation source (101) inelastically scattered by the sample in the sample cell (103).

6. 发明申请

US20130010105A1 SPECTROMETRIC INVESTIGATION OF HETEROGENEITY 有权
标题翻译：异质性的光谱研究
公开(公告)号：US20130010105A1
公开(公告)日：2013-01-10
申请号：US13367359
申请日：2012-02-06
申请人： E. Neil Lewis
发明人： E. Neil Lewis
IPC分类号： G01J3/00 , H04N7/18
CPC分类号： G01J3/02 , G01J3/021 , G01J3/0289 , G01J3/2823 , G01N15/1475 , G01N2015/1486 , G01N2015/1497
摘要： In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.
摘要翻译：在一般的方面，公开了一种用于调查样品区域的异质性的分光装置。所述装置包括：图像采集系统，用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口，用于接收指定已获得图像的子区域之一的选择。光谱仪具有视场，并且可操作以在其视野中获取一个子区域的至少一部分的光谱，并且定位机构响应于子区域选择界面并且可操作地定位场基于接收到的选择，相对于样品区域的光谱仪的视图。

7. 发明授权

US08004662B2 Pharmaceutical mixture evaluation 有权
标题翻译：药物混合物评价
公开(公告)号：US08004662B2
公开(公告)日：2011-08-23
申请号：US11265796
申请日：2005-10-17
申请人： E. Neil Lewis , Kenneth S. Haber
发明人： E. Neil Lewis , Kenneth S. Haber
IPC分类号： G01N21/00
CPC分类号： A61K31/00 , G01N21/9508 , G01N33/15
摘要： A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent.
摘要翻译：公开了获得有关异质药物混合物的信息的方法。该方法包括将诸如污渍的图像增强剂施加到混合物。然后可以获得混合物的图像，并且还可以基于从图像增强剂的应用导出的空间信息来获得关于图像中混合物的分量分布的信息。

8. 发明申请

US20100007877A1 Narrow-band spectrometric Measurements 审中-公开
标题翻译：窄带光谱测量
公开(公告)号：US20100007877A1
公开(公告)日：2010-01-14
申请号：US12319817
申请日：2009-01-12
申请人： E. Neil Lewis , Linda K. Yarlott , Kenneth S. Haber
发明人： E. Neil Lewis , Linda K. Yarlott , Kenneth S. Haber
IPC分类号： G01J3/28
CPC分类号： G01J3/42 , G01J3/10 , G01N21/3563 , G01N2021/3133
摘要： Spectrometers and spectrometric measurement methods are disclosed. These employ narrow-band sources positioned in a circular array to perform spectrometric measurements that can employ Hadamard sequences.
摘要翻译：公开了光谱仪和光谱测量方法。这些采用位于圆形阵列中的窄带源进行可采用Hadamard序列的光谱测量。

9. 发明授权

US07399968B2 Spectroscopic instruments and methods employing array detector and variable filtering 失效
标题翻译：使用阵列检测器和可变滤波器的光谱仪器和方法
公开(公告)号：US07399968B2
公开(公告)日：2008-07-15
申请号：US10776029
申请日：2004-02-10
申请人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
发明人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
IPC分类号： G01J3/28
CPC分类号： G01N21/31 , G01N21/253
摘要： Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.
摘要翻译：公开了药物剂量单位制造过程控制装置和方法。这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供关于基于加工步骤的药物剂量单位的流动的指示。

10. 发明授权

US06690464B1 High-volume on-line spectroscopic composition testing of manufactured pharmaceutical dosage units 失效
标题翻译：制造药物剂量单位的大容量在线光谱组成测试
公开(公告)号：US06690464B1
公开(公告)日：2004-02-10
申请号：US09507293
申请日：2000-02-18
申请人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
发明人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
IPC分类号： G01J328
CPC分类号： G01N21/31 , G01N21/253
摘要： Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.
摘要翻译：公开了药物剂量单位制造过程控制装置和方法。这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供关于基于加工步骤的药物剂量单位的流动的指示。

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