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1. 发明授权

US08652203B2 Replacement heart valves, delivery devices and methods 有权
标题翻译：更换心脏瓣膜，输送装置和方法
公开(公告)号：US08652203B2
公开(公告)日：2014-02-18
申请号：US13244080
申请日：2011-09-23
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
摘要翻译：替代心脏瓣膜和治疗瓣膜功能不全的方法包括构造成接合天然瓣膜环的可扩张框架。阀体联接到框架。阀体可以包括叶片部分和可能的裙部部分。框架的一部分具有缩回部分，其构造成当被推动到径向压实状态时纵向膨胀，并且当被推动到径向膨胀状态时纵向收缩。在一个实施例中，阀裙部附接到框架，使得其可以适应框架的长度的改变。在一些实施例中，输送装置可以使用一个或多个覆盖物，例如护套，以在天然心脏瓣膜处可控地释放置换的心脏瓣膜。

2. 发明授权

US09023100B2 Replacement heart valves, delivery devices and methods 有权
标题翻译：更换心脏瓣膜，输送装置和方法
公开(公告)号：US09023100B2
公开(公告)日：2015-05-05
申请号：US13756424
申请日：2013-01-31
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
摘要翻译：替代心脏瓣膜和治疗瓣膜功能不全的方法包括构造成接合天然瓣膜环的可扩张框架。阀体联接到框架。阀体可以包括叶片部分和可能的裙部部分。框架的一部分具有缩回部分，其构造成当被推动到径向压实状态时纵向膨胀，并且当被推动到径向膨胀状态时纵向收缩。在一个实施例中，阀裙部附接到框架，使得其可以适应框架的长度的改变。在一些实施例中，输送装置可以使用一个或多个覆盖物，例如护套，以在天然心脏瓣膜处可控地释放置换的心脏瓣膜。

3. 发明申请

US20140172085A1 VASCULAR IMPLANT 有权
公开(公告)号：US20140172085A1
公开(公告)日：2014-06-19
申请号：US14186957
申请日：2014-02-21
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.

4. 发明申请

US20130131793A1 REPLACEMENT HEART VALVE AND METHOD 有权
标题翻译：更换心瓣和方法
公开(公告)号：US20130131793A1
公开(公告)日：2013-05-23
申请号：US13747384
申请日：2013-01-22
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/848 , A61F2002/8483 , A61F2002/8486 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0013 , A61F2230/0054 , Y10T29/49426
摘要： A heart valve includes a valve body made of a flexible material such as pericardium. The valve body is made of two layers of material, an outer layer, and an inner layer that defines a plurality of leaflets. The leaflets of the inner layer are attached to the outer layer. In some embodiments the valve body is made by cutting a single piece of flat source tissue, folding the cut tissue and forming it into a tubular pattern having the inner and outer layers. The multi-layer valve body can be mounted on a stent for delivery within a patient's heart.
摘要翻译：心脏瓣膜包括由诸如心包膜的柔性材料制成的阀体。阀体由两层材料，外层和限定多个传单的内层制成。内层的小叶附着到外层。在一些实施例中，阀体通过切割单个平坦的源组织，折叠切割的组织并将其形成具有内层和外层的管状图案而制成。多层阀体可以安装在支架上，用于在患者心脏内输送。

5. 发明申请

US20120215303A1 REPLACEMENT HEART VALVE AND METHOD 有权
标题翻译：更换心瓣和方法
公开(公告)号：US20120215303A1
公开(公告)日：2012-08-23
申请号：US13403929
申请日：2012-02-23
申请人： Arshad Quadri , J. Brent Ratz , Robrecht Michiels
发明人： Arshad Quadri , J. Brent Ratz , Robrecht Michiels
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2412 , A61F2/2427 , A61F2/2439 , A61F2210/0014 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2250/0039 , A61F2250/006 , A61F2250/0069 , A61F2250/0071
摘要： A replacement heart valve has an expandable frame configured to engage a native valve annulus and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.
摘要翻译：替换心脏瓣膜具有被构造成接合天然瓣膜环的可膨胀框架和安装到可扩张框架的阀体。阀体可以具有多个阀单元，其构造成打开以允许在第一方向上流动并且彼此接合，以便关闭并防止在第二方向上流动，第二方向与第一方向相反。

6. 发明申请

US20120078353A1 REPLACEMENT HEART VALVES, DELIVERY DEVICES AND METHODS 有权
标题翻译：更换心阀，输送装置和方法
公开(公告)号：US20120078353A1
公开(公告)日：2012-03-29
申请号：US13244080
申请日：2011-09-23
申请人： Arshad Quadri , J. Brent Ratz
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
摘要翻译：替代心脏瓣膜和治疗瓣膜功能不全的方法包括构造成接合天然瓣膜环的可扩张框架。阀体联接到框架。阀体可以包括叶片部分和可能的裙部部分。框架的一部分具有缩回部分，其构造成当被推动到径向压实状态时纵向膨胀，并且当被推动到径向膨胀状态时纵向收缩。在一个实施例中，阀裙部附接到框架，使得其可以适应框架的长度的改变。在一些实施例中，输送装置可以使用一个或多个覆盖物，例如护套，以在天然心脏瓣膜处可控地释放置换的心脏瓣膜。

7. 发明申请

US20090306768A1 PERCUTANEOUS VALVE PROSTHESIS AND SYSTEM AND METHOD FOR IMPLANTING SAME 审中-公开
标题翻译： PERCUTANEOUSO VALVE PROSTHISIS AND SYSTEM AND METHOD FOR IMPLANTING SAME
公开(公告)号：US20090306768A1
公开(公告)日：2009-12-10
申请号：US12309680
申请日：2007-07-27
申请人： Arshad Quadri
发明人： Arshad Quadri
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2230/0054 , A61F2250/006
摘要： A heart valve prosthesis includes a cylindrical valve cage stent constructed to be implanted percutaneously in the planar axis of a native valve annulus, an elastic and compressible, multi-leaflet valve insertable percutaneously into the body, and an attachment mechanism for attaching the valve to the superior rim of the valve cage stent. The valve can be of a bi-leaflet or a tri-leaflet type and includes a valve frame made from a memory metal and a tissue cover attached to the valve frame. The valve cage stent is self-expanding or balloon expandable, made respectively from memory metal or stainless steel but otherwise structurally the same.
摘要翻译：心脏瓣膜假体包括圆柱形阀笼支架，其被构造成经皮植入在天然瓣膜环的平面轴上，经皮插入体内的弹性和可压缩多瓣叶瓣，以及用于将瓣膜连接到阀笼支架的上缘。阀可以是双叶或三叶型，并且包括由记忆金属制成的阀框和附接到阀框的组织盖。阀笼支架是自膨胀或气球膨胀，分别由记忆金属或不锈钢制成，但其结构相同。

8. 发明授权

US08911455B2 Delivery system for vascular implant 有权
标题翻译：输血系统用于血管植入
公开(公告)号：US08911455B2
公开(公告)日：2014-12-16
申请号：US13725896
申请日：2012-12-21
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61B17/10 , A61F2/06 , A61F2/24 , A61F2/95
CPC分类号： A61F2/246 , A61F2/2418 , A61F2/243 , A61F2/2439 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067
摘要： A medical treatment system and method of treatment is described having an implant that can be positioned and deployed, then undeployed to allow repositioning of the implant. The system includes a self-expanding medical implant that longitudinally foreshortens upon radially expanding from a radially compacted state, a distal interface configured to attach the implant to a distal mount of a delivery device, and a proximal interface configured to attach the implant to a proximal mount of the delivery device. Moving the distal mount longitudinally away from the proximal mount applies a longitudinal tension to the implant causing the implant to expand longitudinally and contract radially, and moving the distal mount toward the proximal mount reduces a longitudinal tension in the implant allowing the implant to expand radially toward a fully expanded state.
摘要翻译：描述了一种治疗系统和治疗方法，其具有能够定位和展开的植入物，然后去除部署以允许植入物的重新定位。该系统包括自动扩张的医用植入物，其在从径向压实状态径向膨胀时纵向缩短，构造成将植入物附接到输送装置的远端安装件的远端界面，以及被配置为将植入物附接到近端输送装置的安装。将远端安装件纵向远离近侧安装件移动，对植入物施加纵向张力，使得植入物纵向膨胀并径向收缩，并使远端安装件向近端安装件移动，减小了植入物中的纵向张力，使植入物径向扩张一个完全扩张的状态。

9. 发明申请

US20140277422A1 PROSTHESIS WITH OUTER SKIRT 有权
标题翻译：与外套的外观
公开(公告)号：US20140277422A1
公开(公告)日：2014-09-18
申请号：US14197639
申请日：2014-03-05
申请人： CardiAQ Valve Technologies, Inc.
发明人： J. Brent Ratz , Arshad Quadri , Luca Pesce
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2457 , A61F2220/0025 , A61F2230/0041 , A61F2230/0065
摘要： A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity, and an outer skirt positioned annularly around an exterior of the expandable frame. In some embodiments, the outer skirt can extend outward from the frame and be secured to an outwardly extending anchor on the frame to create an axial barrier to fluid flow exterior to the frame when deployed within the body cavity.
摘要翻译：假体可以被构造成在部署在体腔内时抓住腔内组织，并且防止围绕假体外部的流体的轴向流动。假体可以包括可扩张的框架，其被配置为径向地膨胀和收缩以在体腔内展开，以及环形地围绕可扩张框架的外部定位的外裙部。在一些实施例中，外裙部可以从框架向外延伸并且被固定到框架上的向外延伸的锚固件，以在展开在体腔内时产生对框架外部的流体流动的轴向屏障。

10. 发明授权

US08795356B2 Vascular implant 有权
标题翻译：血管植入
公开(公告)号：US08795356B2
公开(公告)日：2014-08-05
申请号：US14186957
申请日：2014-02-21
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
摘要翻译：用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。为了交付，植入物在输送装置内压实并固定在一端。在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。如果需要，植入物可以至少部分地重新固定并重新定位。

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