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1. 发明申请

US20150081009A1 DELIVERY SYSTEM FOR VASCULAR IMPLANT 有权
标题翻译：用于血管植入的输送系统
公开(公告)号：US20150081009A1
公开(公告)日：2015-03-19
申请号：US14551338
申请日：2014-11-24
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/95
CPC分类号： A61F2/246 , A61F2/2418 , A61F2/243 , A61F2/2439 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067
摘要： A medical treatment system and method of treatment is described having an implant that can be positioned and deployed, then undeployed to allow repositioning of the implant. The system includes a self-expanding medical implant that longitudinally foreshortens upon radially expanding from a radially compacted state, a distal interface configured to attach the implant to a distal mount of a delivery device, and a proximal interface configured to attach the implant to a proximal mount of the delivery device. Moving the distal mount longitudinally away from the proximal mount applies a longitudinal tension to the implant causing the implant to expand longitudinally and contract radially, and moving the distal mount toward the proximal mount reduces a longitudinal tension in the implant allowing the implant to expand radially toward a fully expanded state.
摘要翻译：描述了一种治疗系统和治疗方法，其具有能够定位和展开的植入物，然后去除部署以允许植入物的重新定位。该系统包括自动扩张的医用植入物，其在从径向压实状态径向膨胀时纵向缩短，构造成将植入物附接到输送装置的远端安装件的远端界面，以及被配置为将植入物附接到近端输送装置的安装。将远端安装件纵向远离近侧安装件移动，对植入物施加纵向张力，使得植入物纵向膨胀并径向收缩，并使远端安装件向近端安装件移动，减小了植入物中的纵向张力，使植入物径向扩张一个完全扩张的状态。

2. 发明申请

US20150066140A1 VASCULAR IMPLANT AND DELIVERY METHOD 有权
标题翻译：血管植入和输送方法
公开(公告)号：US20150066140A1
公开(公告)日：2015-03-05
申请号：US14538638
申请日：2014-11-11
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
摘要翻译：用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。为了交付，植入物在输送装置内压实并固定在一端。在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。如果需要，植入物可以至少部分地重新固定并重新定位。

3. 发明申请

US20140309731A1 VASCULAR IMPLANT 有权
标题翻译：血管植入
公开(公告)号：US20140309731A1
公开(公告)日：2014-10-16
申请号：US14313160
申请日：2014-06-24
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
摘要翻译：用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。为了交付，植入物在输送装置内压实并固定在一端。在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。如果需要，植入物可以至少部分地重新固定并重新定位。

4. 发明申请

US20150032153A1 SYSTEMS AND METHODS FOR SEALING OPENINGS IN AN ANATOMICAL WALL 有权
标题翻译：用于在解剖壁中密封开口的系统和方法
公开(公告)号：US20150032153A1
公开(公告)日：2015-01-29
申请号：US14341693
申请日：2014-07-25
申请人： CardiAQ Valve Technologies, Inc.
发明人： ARSHAD QUADRI , J. Brent Ratz , Glen Rabito , Garrett Johnson
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/3421 , A61B17/3423 , A61B2017/00243 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/0061 , A61B2017/00623 , A61B2017/00867 , A61B2017/3425 , A61B2017/3435 , A61M1/1008 , A61M1/101 , A61M1/1034 , A61M1/122 , A61M1/125
摘要： Devices, systems and methods are described herein for sealing openings in an anatomical wall. A sealing system includes an elongate tubular support for delivery to an anatomical opening to be sealed, a cover of bio-compatible material covering a distal portion of the tubular support, and an anchor assembly, the anchor assembly being designed to secure the cover material to the opening. The anchor assembly can include a plurality of distal anchors and a plurality of proximal anchors, a button, ring or donut, and/or a C-clip. In some embodiments, the system further comprises a closure member for closing off an end of the cover material after removal of the tubular support.
摘要翻译：本文描述了用于密封解剖壁中的开口的装置，系统和方法。密封系统包括用于输送到待密封的解剖学开口的细长管状支撑件，覆盖管状支撑件的远侧部分的生物兼容材料的盖和锚固组件，所述锚固组件设计成将覆盖材料固定到开幕。锚固组件可以包括多个远端锚固件和多个近端锚固件，按钮，环或环形部件和/或C形夹具。在一些实施例中，系统还包括用于在移除管状支撑件之后封闭盖材料的端部的封闭构件。

5. 发明授权

US08894702B2 Replacement heart valve and method 有权
标题翻译：更换心脏瓣膜及方法
公开(公告)号：US08894702B2
公开(公告)日：2014-11-25
申请号：US13747384
申请日：2013-01-22
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/848 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/848 , A61F2002/8483 , A61F2002/8486 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0013 , A61F2230/0054 , Y10T29/49426
摘要： A method of treating a native heart valve includes delivering a replacement valve to the native heart valve. The native heart valve can be any one of aortic, pulmonary, mitral and tricuspid valves. The replacement valve comprising an expandable frame and a valve body attached to the expandable frame. The method can also include expanding the frame at a patient's valve annulus, wherein expansion of the frame causes respective ends of both proximal anchors and distal anchors connected to the frame to draw closer together to grasp native tissue between the respective ends of the proximal anchors and distal anchors.
摘要翻译：治疗天然心脏瓣膜的方法包括向天然心脏瓣膜递送置换瓣膜。天然心脏瓣膜可以是主动脉瓣，肺动脉，二尖瓣和三尖瓣中的任何一个。替换阀包括可膨胀框架和连接到可膨胀框架的阀体。该方法还可以包括在患者的瓣膜环上扩大框架，其中，框架的扩张引起两个近端锚固件和连接到框架的远端锚固件的相应端部以更靠近地拉近，以抓住近端锚固件的相应端部之间的天然组织和远端锚。

6. 发明申请

US20140277427A1 PROSTHESIS FOR ATRAUMATICALLY GRASPING INTRALUMENAL TISSUE AND METHODS OF DELIVERY 审中-公开
标题翻译：用于ATRAUMATICALLY GRASPING INTRALUMENAL TISSUE的方法和方法
公开(公告)号：US20140277427A1
公开(公告)日：2014-09-18
申请号：US14197690
申请日：2014-03-05
申请人： CardiAQ Valve Technologies, Inc.
发明人： J. Brent Ratz , Arshad Quadri , Luca Pesce
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2418 , A61F2/2457 , A61F2220/0008
摘要： A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the frame can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. As another example, the anchors can have looped ends, the entire anchor may loop out from the frame.
摘要翻译：假体可以包括可扩张框架，多个远侧锚固件和多个近端锚固件。锚杆可以从框架向外延伸。框架可以被配置为径向扩张和收缩以在体腔内展开。框架和锚可以具有许多不同形状和配置中的一种。例如，当框架处于扩展构型时，框架可以在框架的中间部分具有较大的横截面尺寸，并且在框架的近端部分和远端部分中具有较小的横截面尺寸，其中，中间部分在近端部分和远端部分之间。作为另一示例，锚定器可以具有环形端部，整个锚定器可以从框架环出。

7. 发明申请

US20150328000A1 REPLACEMENT MITRAL VALVE WITH ANNULAR FLAP 审中-公开
标题翻译：替换具有瓣膜的麻醉阀
公开(公告)号：US20150328000A1
公开(公告)日：2015-11-19
申请号：US14716507
申请日：2015-05-19
申请人： CardiAQ Valve Technologies, Inc.
发明人： J. Brent Ratz , Luca Pesce , Glen Rabito , Christine Thanh Nguyen
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2445 , A61F2220/0008 , A61F2220/005 , A61F2220/0075 , A61F2250/0039 , A61F2250/0069
摘要： A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity, and an annular flap positioned around an exterior of the expandable frame. In some embodiments, the annular flap can extend outward from the frame and have a collapsed configuration and an expanded configuration.
摘要翻译：假体可以被构造成在部署在体腔内时抓住腔内组织，并且防止围绕假体外部的流体的轴向流动。假体可以包括被构造成径向膨胀和收缩以用于在体腔内展开的可扩张框架，以及围绕可扩张框架的外部定位的环形折片。在一些实施例中，环形挡板可以从框架向外延伸并且具有收缩构型和扩张构型。

8. 发明申请

US20150305864A1 REPLACEMENT HEART VALVES, DELIVERY DEVICES AND METHODS 有权
标题翻译：更换心阀，输送装置和方法
公开(公告)号：US20150305864A1
公开(公告)日：2015-10-29
申请号：US14702233
申请日：2015-05-01
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2436 , A61F2220/0008 , A61F2220/0041 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
摘要翻译：替代心脏瓣膜和治疗瓣膜功能不全的方法包括构造成接合天然瓣膜环的可扩张框架。阀体联接到框架。阀体可以包括叶片部分和可能的裙部部分。框架的一部分具有缩回部分，其构造成当被推动到径向压实状态时纵向膨胀，并且当被推动到径向膨胀状态时纵向收缩。在一个实施例中，阀裙部附接到框架，使得其可以适应框架的长度的改变。在一些实施例中，输送装置可以使用一个或多个覆盖物，例如护套，以在天然心脏瓣膜处可控地释放置换的心脏瓣膜。

9. 发明申请

US20150238315A1 PROSTHESIS, DELIVERY DEVICE AND METHODS OF USE 有权
标题翻译： PROSTHESIS，交付设备和使用方法
公开(公告)号：US20150238315A1
公开(公告)日：2015-08-27
申请号：US14628034
申请日：2015-02-20
申请人： CardiAQ Valve Technologies, Inc.
发明人： Glen Rabito , J. Brent Ratz , Luca Pesce , Arshad Quadri , Lindsay Lam , Yen Liao , Julio Cesar Sanchez , David Landon , Garrett Johnson , Alexander H. Cooper
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2220/0008 , A61F2220/0025 , A61F2220/0033 , A61F2230/0067 , A61F2250/001
摘要： Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery devices for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components which are moveable relative to each other. The delivery system can include a nose cone which can cover at least a first end of the prosthesis, an outer elongate member which can cover at least a second end of the prosthesis, and a tether which can at least partially restrain the prosthesis from deployment.
摘要翻译：装置，系统和方法在本文中描述用于植入管腔或体腔内的假体和用于将假体递送到植入位置的输送装置。传送系统可以包括可相对于彼此移动的多个部件。输送系统可以包括可以覆盖假体的至少第一端的鼻锥体，可以覆盖假体的至少第二端的外部细长构件，以及可以至少部分地限制假体部署的系绳。

10. 发明申请

US20150209137A1 VASCULAR IMPLANT AND DELIVERY SYSTEM 有权
标题翻译：血管植入和输送系统
公开(公告)号：US20150209137A1
公开(公告)日：2015-07-30
申请号：US14598568
申请日：2015-01-16
申请人： CardiAQ Valve Technologies, Inc.
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
摘要翻译：用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。为了交付，植入物在输送装置内压实并固定在一端。在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。如果需要，植入物可以至少部分地重新固定并重新定位。

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