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81. 发明授权

US4759793A N-phenylsulfonyl-N'-pyrimidinyl-ureas 失效
标题翻译： N-苯基磺酰基-N'-嘧啶基 - 脲
公开(公告)号：US4759793A
公开(公告)日：1988-07-26
申请号：US30529
申请日：1987-03-27
申请人： Willy Meyer , Konrad Oertle
发明人： Willy Meyer , Konrad Oertle
IPC分类号： C07D249/16 , A01N43/70 , A01N47/36 , C07C20060101 , C07C67/00 , C07C301/00 , C07C309/86 , C07C311/15 , C07C311/16 , C07C311/17 , C07C311/29 , C07C311/39 , C07C311/53 , C07C311/65 , C07C325/00 , C07C331/16 , C07C331/32 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/69 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/46 , C07D251/52 , C07D521/00 , A01N43/54
CPC分类号： C07C309/86 , A01N47/36 , C07C311/65 , C07D521/00
摘要： N-Phenylsulfonyl-N'-pyrimidinyl- and -triazinylureas of the formula I ##STR1## wherein A is 3,3,3-trifluoropropyl or 3,3-difluorobutyl,R.sup.1 is hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkylsulfinyl, C.sub.1 -C.sub.4 -alkylsulfonyl, --CO-R.sup.6, --NR.sup.7 R.sup.8, --CO--NR.sup.9 R.sup.10 or --SO.sub.2 --NR.sup.11 R.sup.12,R.sup.2 is hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkylsulfinyl or C.sub.1 -C.sub.4 -alkylsulfonyl,R.sup.3 and R.sup.4 independently of one another are each hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.2 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkylthio, C.sub.2 -C.sub.4 -alkoxyalkyl, C.sub.1 -C.sub.4 -alkoxy or --NR.sup.12 R.sup.13,R.sup.5 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy,R.sup.6 is C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.2 -C.sub.6 -alkoxyalkoxy, hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -haloalkyl,R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12 and R.sup.13 independently of one another are each hydrogen or C.sub.1 -C.sub.4 -alkyl,E is nitrogen or the methine bridge, andZ is oxygen or sulfur;and also the salts of these compounds.
摘要翻译：式I的N-苯基磺酰基-N'-嘧啶基 - 和 - 三嗪基脲其中A是3,3,3-三氟丙基或3,3-二氟丁基，R 1是氢，卤素，硝基，氰基，C 1 C 1-4烷基，C 1 -C 4 - 卤代烷基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 烷硫基，C 1 -C 4 - 烷基亚磺酰基，C 1 -C 4烷基磺酰基，-CO-R 6，-NR 7 R 8，-CO-NR 9 R 10或-SO 2 -NR 11 R 12，R 2是氢，卤素，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 烷硫基，C 1 -C 4烷基亚磺酰基或C 1 -C 4烷基磺酰基，R 3和R 4彼此独立地各自为氢，卤素，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 2 -C 4卤代烷氧基，C 1 -C 4烷硫基，C 1 -C 4卤代烷硫基，C 2 -C 4烷氧基烷基，C 1 -C 4烷氧基或-NR 12 R 13，，C 1 -C 4烷基或C 1 -C 4 - 烷氧基，R 6是C 1 -C 4 - 烷氧基，C 1 -C 4卤代烷氧基，C 1 -C 4 - 烷硫基，C 2 -C 6 - 烷氧基烷氧基，氢，C 1 -C 4烷基或C 1 -C 4 卤代烷基，R 7，R 8，R 9，R 10，R 11，R 12和R 13各自独立地为氢或C 1 -C 4烷基，E为氮或次甲基桥，Z为氧或硫; 以及这些化合物的盐。

82. 发明授权

US4731478A Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them 失效
公开(公告)号：US4731478A
公开(公告)日：1988-03-15
申请号：US803204
申请日：1985-11-27
申请人： Kunihiro Niigata , Takashi Fujikura
发明人： Kunihiro Niigata , Takashi Fujikura
IPC分类号： A61K31/18 , A61K31/205 , A61K31/255 , A61P9/04 , A61P9/12 , C07C67/00 , C07C301/00 , C07C303/40 , C07C311/15 , C07C311/16 , C07C311/29 , C07C311/37 , C07C317/00 , C07D203/10 , C07C143/80
CPC分类号： C07D203/10 , C07C309/00
摘要： A novel process is provided for the preparation of optical isomers of certain sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking agents which can be used for various treatments such as for the treatment of congestive heart failure.

83. 发明授权

US4705854A Phenothiazine compounds 失效
标题翻译：吩噻嗪化合物
公开(公告)号：US4705854A
公开(公告)日：1987-11-10
申请号：US738846
申请日：1985-05-28
申请人： Harry J. Leighton
发明人： Harry J. Leighton
IPC分类号： A61K31/54 , A61K31/5415 , A61P37/08 , A61P43/00 , C07C67/00 , C07C301/00 , C07C311/16 , C07C313/00 , C07C323/67 , C07D279/28 , C07D417/04 , C07D417/06 , C07D453/02 , C07F9/6547
CPC分类号： C07D417/04 , C07D279/28 , C07D417/06 , C07D453/02 , C07F9/6547
摘要： The present invention relates to compounds of the formula (I): ##STR1## or a salt, ester or amide thereof; wherein R.sup.1 is a C.sub.1-7 bivalent aliphatic hydrocarbon group or a single bond;R.sub.2 and R.sub.3 are the same or different and are each hydrogen, C.sub.1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members;R.sup.4 is hydrogen, halogen, C.sub.1-4 alkoxy, C.sub.1-4 alkyl optionally substituted by one to three halogen atoms; or a group R.sub.1 CO.sub.2 H as hereinbefore defined; andA is C.sub.1-4 alkylene or ANR.sub.2 R.sub.3 forms a group --CH.sub.2 --(CH.sub.2).sub.2 or CH.sub.2 --(CH.sub.2).sub.2B is an acidic group other than a mono-carboxylic acid group of comparable or greater acid strength than a carboxylic acid group in a similar chemical environment, provided that any sulphonamide group contains at least one N-H bond.Also disclosed are processes for the preparation of the compounds of the formula (I), chemical intermediates for use in their preparation, and pharmaceutical formulations containing the said compounds.The compounds have antiallergic activity as defined by blockade of anaphylactoid activity. Certain of the compounds also have good antihistaminic activity.
摘要翻译：本发明涉及式（I）的化合物或其盐，酯或酰胺：其中R1是C1-7二价脂族烃基或单键; R2和R3相同或不同，各自为氢，C1-4烷基或与氮一起包含含有4-6个环成员的含氮杂环; R4是氢，卤素，C1-4烷氧基，任选被一至三个卤素原子取代的C 1-4烷基; 或如上文所定义的基团R 1 CO 2 H; 和A是C 1-4亚烷基或ANR2R 3形成基团-CH 2 - （CH 2）2或CH 2 - （CH 2）2 B是与羧酸基相当或更大的酸强度的单羧酸基团以外的酸性基团在类似的化学环境中，条件是任何磺酰胺基团含有至少一个NH键。还公开了制备式（I）化合物，其制备中使用的化学中间体和含有所述化合物的药物制剂的方法。该化合物具有通过阻断过敏性活性所定义的抗过敏活性。某些化合物也具有良好的抗组胺活性。

84. 发明授权

US4680400A Herbicidal cyclohexane-1,3-dione-5-isoquinoline derivatives 失效
标题翻译：除草环己烷-1,3-二酮-5-异喹啉衍生物
公开(公告)号：US4680400A
公开(公告)日：1987-07-14
申请号：US929473
申请日：1986-11-12
申请人： Graham J. Bird , Graeme J. Farquharson , Keith G. Watson
发明人： Graham J. Bird , Graeme J. Farquharson , Keith G. Watson
IPC分类号： A01N31/08 , A01N35/10 , A01N37/00 , A01N37/02 , A01N37/10 , A01N37/18 , A01N37/22 , A01N37/34 , A01N37/44 , A01N37/50 , A01N37/52 , A01N41/02 , A01N43/40 , A01N43/42 , A01N43/48 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/707 , A01N43/713 , A01N47/44 , C07C43/188 , C07C43/20 , C07C45/00 , C07C45/45 , C07C45/46 , C07C45/56 , C07C45/63 , C07C45/67 , C07C47/55 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753 , C07C49/755 , C07C49/835 , C07C49/84 , C07C67/00 , C07C239/00 , C07C251/42 , C07C251/44 , C07C251/48 , C07C251/52 , C07C251/54 , C07C251/58 , C07C301/00 , C07C303/30 , C07C309/63 , C07C311/16 , C07C313/00 , C07C317/30 , C07C317/32 , C07C317/36 , C07C317/46 , C07C323/12 , C07C323/19 , C07C323/47 , C07C323/60 , C07C323/63 , C07D215/12 , C07D215/14 , C07D215/18 , C07D217/10 , C07D217/12 , C07D217/16 , C07D217/22 , C07D217/24 , C07D217/26 , C07D471/04
CPC分类号： C07D217/26 , A01N35/10 , A01N37/50 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/707 , C07C205/45 , C07C309/00 , C07C43/188 , C07C43/202 , C07C45/455 , C07C45/46 , C07C45/565 , C07C45/63 , C07C45/673 , C07C47/55 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753 , C07C49/755 , C07C49/835 , C07D215/14 , C07D215/18 , C07D217/22 , C07D217/24
摘要： The invention concerns novel compounds of the formula I ##STR1## wherein: A, B, D and E are selected from CH, N and N-Z wherein Z is selected from oxygen and the group YAn wherein Y is selected from alkyl and benzyl and An is an anion, and provided that no more than three of A, B, D and E are selected from N and N-Z and no more than one of A, B, D and E is selected from N-Z;W is a saturated or unsaturated C.sub.2 to C.sub.5 hydrocarbon chain;X and X.sup.1 are independently selected from halogen, nitro, cyano, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, alkenyl, alkenyloxy, alkynyl, alkynyloxy, acyloxy, alkoxycarbonyl, alkylthio, alkylsulfinyl, alkylsulfonyl, sulfamoyl, substituted sulfamoyl, alkanoyloxy, benzyloxy, substituted benzyloxy, amino, substituted amino and the groups formyl and alkanoyl and the oxime, imine and Schiff base derivatives thereof, or two of X.sup.1 on the same carbon atom may form an oxo group;R.sup.1 is selected from hydrogen, alkyl, alkenyl, alkynyl, substituted alkyl, alkylsulfonyl, arylsulfonyl, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl, alkynyl and haloalkynyl;R.sup.3 is selected from alkyl, fluoroalkyl, alkenyl, alkynyl, and phenyl;R.sup.4 is selected from hydrogen, halogen, alkyl, cyano and alkoxycarbonyl;n is 0 or an integer chosen from 1 to 3; andn.sup.1 is 0 or an integer chosen from 1 to 5.The compounds of the invention show herbicidal properties and plant growth regulating properties and in further embodiments the invention provides processes for the preparation of compounds of formula I, intermediates useful in the preparation of the compounds of formula I, compositions containing as active ingredient a compound of formula I, and herbicidal and plant growth regulating processes utilizing compounds of formula I.

85. 发明授权

US4069318A N.sup.2 -Alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
标题翻译： N {HU 2 {B-烷氧基萘磺酰基-L-精氨酰胺及其药学上可接受的盐
公开(公告)号：US4069318A
公开(公告)日：1978-01-17
申请号：US760727
申请日：1977-01-19
申请人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
发明人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
IPC分类号： A61K31/18 , A61K31/195 , A61K31/335 , A61K31/395 , A61K31/445 , A61K38/00 , C07C311/15 , C07C311/16 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D213/79 , C07D295/185 , C07D307/14 , C07D307/52 , C07D307/91 , C07D319/22 , A61K37/00 , C07C103/52
CPC分类号： C07D295/185 , A61K31/18 , A61K31/195 , A61K31/335 , A61K31/395 , A61K31/445 , C07C311/15 , C07C311/16 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D213/79 , C07D307/14 , C07D307/52 , C07D307/91 , C07D319/22 , A61K38/00
摘要： N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals, and are prepared by reacting N.sup.2 -alkoxynaphthalenesulfonyl-L-arginyl halide with a secondary amine.
摘要翻译：已经发现，N-烷氧基萘磺酰基-L-精氨酸酰胺及其药学上可接受的盐作为用于抑制和抑制哺乳动物血栓形成的药剂是有效的，并且通过使N-烷氧基萘磺酰基-L-精氨酰卤与仲胺反应来制备。

86. 发明授权

US4069254A .omega.-(Arylsulfonamido)-alkylamine 失效
标题翻译： {107 - （芳基磺酰氨基） - 烷基胺
公开(公告)号：US4069254A
公开(公告)日：1978-01-17
申请号：US620274
申请日：1975-10-07
申请人： Hiroyoshi Hidaka , Ikuo Matsumoto , Masaaki Hosoi , Nobuo Aoki
发明人： Hiroyoshi Hidaka , Ikuo Matsumoto , Masaaki Hosoi , Nobuo Aoki
IPC分类号： A61K31/18 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P7/02 , C07C67/00 , C07C301/00 , C07C303/38 , C07C311/14 , C07C311/16 , C07C311/18 , C07D209/48 , C07C143/78
CPC分类号： C07D209/48 , Y10S514/822
摘要： .omega.-(Arylsulfonamido)-alkylamines having the formulaR'-SO.sub.2 NH(CH.sub.2).sub.n R Iwherein R represents an amino group which can be acylated; R' represents phenyl or naphthyl which can be substituted by halogen or lower alkyl; and n represents an integer from 5 - 8 are effective in inhibiting blood platelet aggregation.
摘要翻译：具有式R'-SO2NH（CH2）nRⅠ的ω-（芳基磺酰胺基） - 烷基胺其中R表示可被酰化的氨基; R'表示可被卤素或低级烷基取代的苯基或萘基; 并且n表示5-8的整数有效抑制血小板聚集。

87. 发明授权

US4046876A N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
公开(公告)号：US4046876A
公开(公告)日：1977-09-06
申请号：US656870
申请日：1976-02-10
申请人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura , Yoshikuni Tamao , Akiko Hijikata
发明人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura , Yoshikuni Tamao , Akiko Hijikata
IPC分类号： A61K31/18 , A61K31/195 , A61K31/335 , A61K31/395 , A61K31/445 , A61K38/00 , C07C311/15 , C07C311/16 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , C07D213/79 , C07D295/185 , C07D307/14 , C07D307/52 , C07D307/91 , C07D319/22 , C07C103/52 , A61K37/00
CPC分类号： C07D295/185 , A61K31/18 , A61K31/195 , A61K31/335 , A61K31/395 , A61K31/445 , C07C311/15 , C07C311/16 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , C07D213/79 , C07D307/14 , C07D307/52 , C07D307/91 , C07D319/22 , A61K38/00
摘要： N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.

88. 发明授权

US3984399A Bis-stilbene compounds 失效
标题翻译：双 - 二苯乙烯化合物
公开(公告)号：US3984399A
公开(公告)日：1976-10-05
申请号：US509768
申请日：1974-09-27
申请人： Kurt Weber , Peter Liechti , Hans Rudolf Meyer , Adolf Emil Siegrist
发明人： Kurt Weber , Peter Liechti , Hans Rudolf Meyer , Adolf Emil Siegrist
IPC分类号： C07C1/32 , C07C1/34 , C07C17/26 , C07C17/32 , C07C25/24 , C07C45/44 , C07C47/546 , C07C47/55 , C07C57/42 , C07C57/72 , C07C63/66 , C07C309/29 , C07C309/32 , C07C309/39 , C07C309/73 , C07C309/86 , C07C309/87 , C07C311/16 , C07C311/17 , C07C313/04 , C07C317/14 , C07D295/192 , C07D295/26 , C07F9/32 , C07F9/40 , C07F9/535 , C07F9/54 , C08K5/00 , C09B23/14 , D06L3/12 , C07D23/00
CPC分类号： C07D295/192 , C07C1/324 , C07C17/2635 , C07C17/32 , C07C25/24 , C07C309/00 , C07C309/29 , C07C309/39 , C07C309/73 , C07C309/86 , C07C309/87 , C07C311/16 , C07C311/17 , C07C313/04 , C07C317/00 , C07C317/14 , C07C45/44 , C07C47/546 , C07C47/55 , C07C57/42 , C07C57/72 , C07C63/66 , C07D295/26 , C07F9/32 , C07F9/3241 , C07F9/4056 , C07F9/5352 , C07F9/54 , C07F9/5456 , C08K5/0041 , C09B23/141 , C09B23/148 , D06L3/12
摘要： The present invention provides the new bis-stilbene compounds, which are useful as optical brighteners and correspond to the formulaR.sub.1 -- CH = CH -- X -- CH = CH -- R.sub.2in which X represents a diphenyl residue bound in positions 4 and 4' to the =CH-- groups; R.sub.1 and R.sub.2 independently of each other, each represents a monocyclic benzene residue, a diphenyl, naphthyl or pyridyl residue, and in which at least one of the cyclic systems R.sub.1, R.sub.2, X contains a possibly functionally modified sulphonic acid group, a sulphone group, a possibly functionally modified carboxylic acid group, a nitrile, hydroxyl, mercapto or methyl group.
摘要翻译：本发明提供了可用作荧光增白剂并且对应于式R 1 -CH = CH-X-CH = CH-R 2的新的双 - 芪化合物，其中X表示在4和4'位结合的二苯基残基 = CH-基团; R1和R2各自独立地表示单环苯残基，二苯基，萘基或吡啶基残基，其中至少一个环状体系R1，R2，X含有可能的官能改性磺酸基，砜基，可能的官能改性的羧酸基团，腈，羟基，巯基或甲基。

89. 发明授权

US3897476A Sulfamylbenzoic acid derivatives 失效
标题翻译：磺酰基苯甲酸衍生物
公开(公告)号：US3897476A
公开(公告)日：1975-07-29
申请号：US34982673
申请日：1973-04-10
申请人： LEO PHARM PROD LTD
发明人： FEIT PETER WERNER , NIELSEN OLE BENT TVAERMOSE
IPC分类号： C07C67/00 , C07C205/61 , C07C301/00 , C07C303/38 , C07C309/89 , C07C311/16 , C07C311/29 , C07C313/00 , C07C319/20 , C07C323/66 , C07C323/67 , C07D213/30 , C07D213/32 , C07D275/04 , C07D275/06 , C07D277/24 , C07D277/26 , C07D307/38 , C07D307/40 , C07D333/16 , C07D333/18 , C07D333/24 , C07D333/34 , C07C143/78
CPC分类号： C07D213/30 , C07C205/61 , C07C309/89 , C07C311/29 , C07C323/66 , C07D213/32 , C07D275/04 , C07D275/06 , C07D277/26 , C07D307/38 , C07D333/16 , Y10S514/869
摘要： Compounds of the general formulae

IN WHICH R1 represents a straight or branched, optionally substituted alkyl, alkenyl or alkynyl radical; R2 stands for an optionally substituted phenyl radical; Y stands for oxygen, sulphur or a methylene radical; X stands for O or H2; their salts and esters and methods for their preparation. The compounds of the invention possess an outstanding diuretic and saluretic activity with a very low excretion of potassium ions and a low toxicity.
摘要翻译：通式为I的化合物，其中R 1表示直链或支链，任选取代的烷基，烯基或炔基; R2代表任选取代的苯基; Y代表氧，硫或亚甲基; X代表O或H2; 其盐和酯及其制备方法。

90. 发明授权

US3860582A Derivatives of 4-chloro-5-sulfamoyl-anthranilic acid 失效
标题翻译： 4-氯代-5-磺酰氨基苯甲酸的衍生物
公开(公告)号：US3860582A
公开(公告)日：1975-01-14
申请号：US27131472
申请日：1972-07-12
申请人： TEVA MIDDLE EAST PHARM
发明人： SCHOENBERG SHLOMO , YELLIN HAIM
IPC分类号： C07C311/16 , C07C303/40 , C07C311/40 , C07D307/52 , C07D5/16 , A61K27/00
CPC分类号： C07D307/52
摘要： New derivatives of 4-chloro-5-sulfamoyl-anthranilic acid. In the new derivatives the 5-sulfamoyl group is substituted by R1XCH2, where X is oxygen or sulfur and R1 is a straight or branchedchain lower alkyl radical of up to 10 carbon atoms which may be substituted by a hydroxy or alkoxy group or several such groups, a cycloalkyl radical, an alkenyl or alkinyl radical, an aralkyl or heteroarylalkyl radical. The novel compounds are valuable diuretics and saluretics and they are prepared from corresponding free sulfamoyl compounds by reaction with formaldehyde or paraformaldehyde and a compound R1-XH where R1 and X have the same meaning as above.
摘要翻译： 4-氯-5-氨磺酰 - 邻氨基苯甲酸的新衍生物。在新衍生物中，5-氨磺酰基被R1XCH2取代，其中X是氧或硫，R1是至多10个碳原子的直链或支链低级烷基，其可被羟基或烷氧基取代或几个这些基团，环烷基，烯基或炔基，芳烷基或杂芳基烷基。新型化合物是有价值的利尿剂和盐溶剂，它们是通过与甲醛或多聚甲醛反应制备的相应的游离氨磺酰化合物和化合物R1-XH，其中R1和X具有与上述相同的含义。

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