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1. 发明授权

US4258192A N.sup.2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
标题翻译： N 2 - 芳基磺酰基-L-精氨酸酰胺及其药学上可接受的盐
公开(公告)号：US4258192A
公开(公告)日：1981-03-24
申请号：US41419
申请日：1979-05-22
申请人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
发明人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
IPC分类号： C07D209/44 , C07D211/60 , C07D217/26 , C07D265/30 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K31/47 , C07D215/36
CPC分类号： C07D265/30 , C07D209/44 , C07D211/60 , C07D217/26 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , Y10S514/822
摘要： N.sup.2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.
摘要翻译：已经发现N 2 - 芳基磺酰基-L-精氨酸酰胺及其药学上可接受的盐作为用于抑制和抑制哺乳动物血栓形成的药剂是有效的。

2. 发明授权

US4125619A N.sup.2 -naphthalenesulfonyl-L-arginine derivatives and the pharmaceutically acceptable acid addition salts thereof 失效
标题翻译： N {HU 2 {B-萘磺酰基-L-精氨酸衍生物及其药学上可接受的酸加成盐
公开(公告)号：US4125619A
公开(公告)日：1978-11-14
申请号：US760673
申请日：1977-01-19
申请人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura , Yoshikuni Tamao , Akiko Hijikata
发明人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura , Yoshikuni Tamao , Akiko Hijikata
IPC分类号： A61K38/00 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/90 , C07D295/185 , A61K31/445
CPC分类号： C07D295/185 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/90 , A61K38/00 , Y10S514/822
摘要： N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
摘要翻译：已经发现，N2-萘磺酰基-L-精氨酸酯和酰胺及其药学上可接受的盐作为用于抑制和抑制血栓形成的药物是有效的。

3. 发明授权

US4072743A N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
公开(公告)号：US4072743A
公开(公告)日：1978-02-07
申请号：US760744
申请日：1977-01-19
申请人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
发明人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
IPC分类号： A61K38/00 , C07D209/44 , C07D211/60 , C07D217/26 , C07D265/30 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K37/00 , C07C103/52
CPC分类号： C07D265/30 , C07D209/44 , C07D211/60 , C07D217/26 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K38/00
摘要： N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.

4. 发明授权

US4066758A N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof 失效
公开(公告)号：US4066758A
公开(公告)日：1978-01-03
申请号：US671436
申请日：1976-03-29
申请人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Shinji Tonomura , Yoshikuni Tamao , Tohru Tezuka , Akiko Hijikata
发明人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Shinji Tonomura , Yoshikuni Tamao , Tohru Tezuka , Akiko Hijikata
IPC分类号： A61K38/00 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , C07D295/185 , A61K31/445
CPC分类号： C07D295/185 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , A61K38/00 , Y10S514/822
摘要： N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is selected from the class consisting of (1) alkoxy, alkenyloxy, cycloalkoxy and halogenated alkoxy, respectively containing not more than 10 carbon atoms, aralkyloxy of not more than 15 carbon atoms, and alkoxy of not more than 10 carbon atoms substitured with an alkoxy group of not more than 10 carbon atoms; ##STR2## wherein R.sub.1 and R.sub.2 are members selected from the class consisting of hydrogen, alkyl, aryl, alkenyl and cycloalkyl, respectively containing not more than 10 carbon atoms, and aralkyl and cycloalkylalkyl, respectively containing not more than 15 carbon atoms, and substituted alkyl containing not more than 20 carbon atoms, said substituent being selected from the class consisting of alkoxy, alkoxycarbonyl, acyl, acyloxy, arylcarbamoyl and N,N-polymethylenecarbamoyl, respectively containing not more than 10 carbon atoms, and carboxy; and ##STR3## wherein Z is a divalent group containing up to 10 carbons atoms, which consists of more than one group selected from the class consisting of methylene --CH.sub.2 --, monosubstituted methylene ##STR4## wherein R.sub.3 is selected from the class consisting of alkyl, acyl, alkoxy, and alkoxycarbonyl, respectively containing not more than 10 carbon atoms, and carbamoyl; and disubstituted methylene ##STR5## wherein R.sub.4 and R.sub.5 are alkyl groups of not more than 10 carbon atoms, and which may further contain at least one member selected from the class consisting of oxy--O--, thio --S--, cycloalkylene of not more than 10 carbon atoms, imino ##STR6## alkyl-substituted imino ##STR7## wherein R.sub.6 is an alkyl group of not more than 10 carbon atoms, acyl-substituted imino ##STR8## wherein R.sub.7 is an alkyl group of not more than 10 carbon atoms, and phenylene ##STR9## which may be arranged in any order and complete the ##STR10## ring together with the said methylene, monosubstituted methylene or disubstituted methylene; and R' is a member selected from the class consisting of 1-naphthyl substituted alkoxy or alkoxycarbonyloxy, respectively containing not more than 10 carbon atoms; and 2-naphthyl substituted with alkoxy or alkoxycarbonyloxy, respectively containing not more than 10 carbon atoms.

5. 发明授权

US4055651A N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
标题翻译： N {HU 2 {B-烷氧基萘磺酰基-L-精氨酰胺及其药学上可接受的盐
公开(公告)号：US4055651A
公开(公告)日：1977-10-25
申请号：US653217
申请日：1976-01-28
申请人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura , Yoshikuni Tamao , Akiko Hijikata
发明人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura , Yoshikuni Tamao , Akiko Hijikata
IPC分类号： A61K31/18 , A61K31/195 , A61K31/335 , A61K31/395 , A61K31/445 , A61K38/00 , C07C311/15 , C07C311/16 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , C07D213/79 , C07D295/185 , C07D307/14 , C07D307/52 , C07D307/91 , C07D319/22
CPC分类号： C07D295/185 , A61K31/18 , A61K31/195 , A61K31/335 , A61K31/395 , A61K31/445 , C07C311/15 , C07C311/16 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , C07D213/79 , C07D307/14 , C07D307/52 , C07D307/91 , C07D319/22 , A61K38/00
摘要： N.sup.2 -alkoxynaphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
摘要翻译：已经发现，N-烷氧基萘磺酰基-L-精氨酸酰胺及其药学上可接受的盐作为用于抑制和抑制血栓形成的药物是有效的。

6. 发明授权

US4049645A N.sup.2 -naphthalenesulfonyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof 失效
标题翻译： N {HU 2 {B-萘磺酰基-L-精氨酸衍生物及其药学上可接受的酸加成盐
公开(公告)号：US4049645A
公开(公告)日：1977-09-20
申请号：US671568
申请日：1976-03-29
申请人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Shinji Tonomura , Yoshikuni Tamao , Tohru Tezuka , Akiko Hijikata
发明人： Shosuke Okamoto , Ryoji Kikumoto , Kazuo Ohkubo , Shinji Tonomura , Yoshikuni Tamao , Tohru Tezuka , Akiko Hijikata
IPC分类号： A61K38/00 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , C07D295/185 , C07D223/04 , A61K31/04 , A61K31/18 , A61K31/395 , A61K31/445 , C07D211/08 , C07D225/02 , C07D295/10
CPC分类号： C07D295/185 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/60 , C07D211/90 , A61K38/00 , Y10S514/822
摘要： N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is wherein R.sub.1 and R.sub.2 are members selected from the class consisting of hydrogen, alkyl, aryl, alkenyl and cycloalkyl, respectively containing not more than 10 carbon atoms, and aralykyl and cycloalkylalkyl, respectively containing not more than 15 carbon atoms; and R' is a member selected from the class consisting of 5,6,7,8-tetrahydro-l-naphthyl, 5,6,7,8-tetrahydro-2-naphthyl, 1-naphthyl, 2-naphthyl, 1-naphthyl substituted with halogen, nitro, cyano, hydroxy, alkyl containing not more than 10 carbon atoms, and 2-naphthyl substituted with halogen, nitro, cyano, hydroxy, alkyl containing ot more than 10 carbon atoms.
摘要翻译：具有式I的N 2 - 萘磺酰基-L-精氨酸酯和酰胺或其药学上可接受的酸的酸加成盐，其中R是＆lt; IMAGE＆gt;其中R 1和R 2是选自氢，烷基分别含有不超过10个碳原子的芳基，烯基和环烷基，以及分别含有不超过15个碳原子的芳烷基和环烷基烷基; 并且R'是选自5,6,7,8-四氢-1-萘基，5,6,7,8-四氢-2-萘基，1-萘基，2-萘基，1-萘基，被卤素，硝基，氰基，羟基，不超过10个碳原子的烷基取代的萘基和被卤素，硝基，氰基，羟基，含有大于10个碳原子的烷基取代的2-萘基。

7. 发明授权

US4125604A N2-Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
标题翻译： N 2 - 芳基磺酰基-L-精氨酸酰胺及其药学上可接受的盐
公开(公告)号：US4125604A
公开(公告)日：1978-11-14
申请号：US804334
申请日：1977-06-07
申请人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
发明人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
IPC分类号： A61K38/00 , C07C311/19 , C07D209/44 , C07D211/60 , C07D217/26 , C07D265/30 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K37/00 , C07C103/52
CPC分类号： C07D265/30 , C07C311/19 , C07D209/44 , C07D211/60 , C07D217/26 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K38/00
摘要： N.sup.2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.
摘要翻译：已经发现N2-芳基磺酰基-L-精氨酸酰胺及其药学上可接受的盐作为用于抑制和抑制哺乳动物血栓形成的药物是有效的。

8. 发明授权

US4073916A N.sup.2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
公开(公告)号：US4073916A
公开(公告)日：1978-02-14
申请号：US760719
申请日：1977-01-19
申请人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
发明人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
IPC分类号： A61K38/00 , C07C311/19 , C07D209/44 , C07D211/60 , C07D217/26 , C07D265/30 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K31/445
CPC分类号： C07D265/30 , C07C311/19 , C07D209/44 , C07D211/60 , C07D217/26 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K38/00 , Y10S514/822
摘要： N.sup.2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.

9. 发明授权

US4073891A N.sup.2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof 失效
标题翻译： N {HU 2 {B-酰基磺酰基-L-精氨酰胺及其药学上可接受的盐
公开(公告)号：US4073891A
公开(公告)日：1978-02-14
申请号：US760667
申请日：1977-01-19
申请人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
发明人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
IPC分类号： A61K38/00 , C07C311/19 , C07D209/44 , C07D211/60 , C07D217/26 , C07D265/30 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K37/00 , C07C103/52
CPC分类号： C07D265/30 , C07C311/19 , C07D209/44 , C07D211/60 , C07D217/26 , C07D277/06 , C07D279/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/04 , C07D309/30 , C07D319/12 , C07D319/18 , C07D319/22 , C07D333/20 , A61K38/00
摘要： N.sup.2 -arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis in mammals.
摘要翻译：已经发现N-芳基磺酰基-L-精氨酸酰胺及其药学上可接受的盐作为用于抑制和抑制哺乳动物血栓形成的药物是有效的。

10. 发明授权

US4069323A N.sup.2 -substituted-L-arginine derivatives and the pharmaceutically acceptable acid addition salts thereof 失效
标题翻译： N {HU 2 {B-取代-L-精氨酸衍生物及其药学上可接受的酸加成盐
公开(公告)号：US4069323A
公开(公告)日：1978-01-17
申请号：US703704
申请日：1976-07-08
申请人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
发明人： Shosuke Okamoto , Akiko Hijikata , Ryoji Kikumoto , Yoshikuni Tamao , Kazuo Ohkubo , Tohru Tezuka , Shinji Tonomura
IPC分类号： A61K38/00 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/90 , C07D295/185 , C07D311/82 , C07D321/10 , A61K31/445
CPC分类号： C07D295/185 , C07D211/16 , C07D211/32 , C07D211/46 , C07D211/90 , C07D311/82 , C07D321/10 , A61K38/00
摘要： N.sup.2 -substituted-L-arginine esters and amides, and the pharmaceutically acceptable acid addition salts thereof have been found to be effective as pharmaceutical agents for the inhibition and suppression of thrombosis.
摘要翻译：已经发现，N-取代的L-精氨酸酯和酰胺及其药学上可接受的酸加成盐作为用于抑制和抑制血栓形成的药物是有效的。

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