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81. 发明授权

US5786510A Preparation of amines from olefins over crystalline oxides based on aluminum phosphates and having faujasite structure 失效
标题翻译：基于磷酸铝制成结晶氧化物并具有八面沸石结构的烯烃中的胺
公开(公告)号：US5786510A
公开(公告)日：1998-07-28
申请号：US784772
申请日：1997-01-16
申请人： Karsten Eller , Rudolf Kummer , Peter Stops
发明人： Karsten Eller , Rudolf Kummer , Peter Stops
IPC分类号： B01J29/83 , C07B61/00 , C07C209/60 , C07C211/07 , C07C211/30 , C07C209/02
CPC分类号： C07C209/60 , Y02P20/582
摘要： A process for the preparation of amines of the general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 denote hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkynyl, C.sub.3 -C.sub.20 cycloalkyl, C.sub.4 -C.sub.20 alkylcycloalkyl, C.sub.4 -C.sub.20 cycloalkylalkyl, aryl, C.sub.7 -C.sub.20 alkylaryl or C.sub.7 -C.sub.20 aralkyl, R.sup.1 and R.sup.2 together denote a saturated or unsaturated C.sub.3 -C.sub.9 alkylene dichain and R.sup.3 or R.sup.5 denotes C.sub.21 -C.sub.200 alkyl, C.sub.21 -C.sub.200 alkenyl or they together form a C.sub.2 -C.sub.12 alkylene dichain, by the reaction of olefins of the general formula II ##STR2## in which R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the aforementioned meanings, with ammonia or primary or secondary amines of the general formula III ##STR3## in which R.sup.1 and R.sup.2 have the aforementioned meanings, at temperatures ranging from 200.degree. to 350.degree. C. and pressures of from 100 to 300 bar in the presence of a heterogeneous catalyst, wherein the heterogeneous catalysts used are crystalline oxides based on aluminum phosphates and having faujasite structure.
摘要翻译：制备通式I的胺的方法（Ⅰ）其中R1，R2，R3，R4，R5和R6表示氢，C1-C20烷基，C2-C20炔基，C3-C20环烷基， C 4 -C 20烷基环烷基，C 4 -C 20环烷基烷基，芳基，C 7 -C 20烷基芳基或C 7 -C 20芳烷基，R 1和R 2一起表示饱和或不饱和的C 3 -C 9亚烷基二酮，R 3或R 5表示C 21 -C 200烷基，C 21 -C 20烯基或者它们一起形成C 2 -C 12亚烷基二酮，通过其中R3，R4，R5和R6具有上述含义的通式II（II）的烯烃与一般的氨或伯或仲胺反应，式III（III）其中R1和R2具有上述含义，在200〜350℃的温度和100〜300巴的压力下，在多相催化剂存在下使用，其中使用的多相催化剂是基于磷酸铝并具有八面沸石结构的结晶氧化物。

82. 发明授权

US5780485A Use of .alpha..sub.1c specific compounds to treat benign prostatic hyperplasia 失效
标题翻译：使用α1c特异性化合物治疗良性前列腺增生
公开(公告)号：US5780485A
公开(公告)日：1998-07-14
申请号：US415681
申请日：1995-04-03
申请人： Charles Gluchowski , Carlos C. Forray , George Chiu , Theresa A. Branchek , John M. Wetzel , Paul R. Hartig
发明人： Charles Gluchowski , Carlos C. Forray , George Chiu , Theresa A. Branchek , John M. Wetzel , Paul R. Hartig
IPC分类号： A61K31/00 , A61K31/135 , A61K31/137 , A61K31/44 , A61K31/4409 , A61K31/4427 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/4545 , A61K31/505 , A61K31/517 , A61K31/55 , A61K45/00 , A61P13/02 , A61P15/00 , A61P43/00 , C07C211/30 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07D211/58 , C07D401/12 , C07D405/12 , C07D495/06
CPC分类号： C07D401/12 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/44 , A61K31/4409 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/4545 , A61K31/505 , A61K31/517 , A61K31/55 , C07C211/30 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07D211/58 , C07D405/12 , C07D495/06 , C07C2102/08 , C07C2102/10 , C07C2102/12
摘要： A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human .alpha..sub.1C adrenergic receptor with a binding affinity greater than ten-fold higher than the binding affinity with which the compound binds to a human .alpha..sub.1A adrenergic receptor, a human .alpha..sub.1B adrenergic receptor, and a human histamine H.sub.1 receptor, and, binds to a human .alpha..sub.2 adrenergic receptor with a binding affinity which is greater than ten-fold lower than the binding affinity with which the compound binds to such .alpha..sub.1C adrenergic receptor. Compounds meeting these criteria are provided.
摘要翻译：一种治疗受试者的良性前列腺增生的方法，其包括向受试者施用治疗有效量的结合人α1C肾上腺素能受体的化合物，其结合亲和力比结合亲和力高10倍，化合物与人α1B肾上腺素能受体，人α1B肾上腺素能受体和人组胺H1受体结合，并且结合人α2肾上腺素能受体，其结合亲和力比结合亲和力低10倍该化合物与这种α1C肾上腺素能受体结合。提供符合这些标准的化合物。

83. 发明授权

US5624922A Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents 失效
标题翻译：芳基稠合和杂芳基稠合-2,4-二氮杂和2,4-二氮辛胆碱抗心律失常药
公开(公告)号：US5624922A
公开(公告)日：1997-04-29
申请号：US449457
申请日：1995-05-24
申请人： Robert E. Johnson , Donald C. Schlegel , Alan M. Ezrin
发明人： Robert E. Johnson , Donald C. Schlegel , Alan M. Ezrin
IPC分类号： C07C211/27 , C07C211/29 , C07C211/30 , C07C217/08 , C07C217/58 , C07C217/84 , C07C233/36 , C07C233/40 , C07C235/34 , C07C311/06 , C07D243/04 , C07D245/06 , C07D295/13 , C07D295/15 , C07D333/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D521/00 , A61K31/55
CPC分类号： C07D295/13 , C07C211/27 , C07C211/29 , C07C211/30 , C07C217/08 , C07C217/58 , C07C217/84 , C07C233/36 , C07C233/40 , C07C235/34 , C07C311/06 , C07D231/12 , C07D233/56 , C07D243/04 , C07D245/06 , C07D249/08 , C07D295/15 , C07D333/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07C2101/02 , C07C2101/08
摘要： Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II ##STR1## .delta.-aminoamides of formula III and aryldimethanamines of formula XXXVII ##STR2## wherein A is an aryl or hetaryl ring;R.sup.1 is hydrogen, alkyl, aryl or hetaryl;R.sup.2 is hydrogen, alkyl, substituted alkyl, or aryl;R.sup.3 is alkyl, aryl, aralkyl or heteroatom substituted alkyl or aralkyl;R.sup.4 is hydrogen or alkyl;R.sup.5 is hydrogen, alkyl, aryl or hetaryl;R.sup.6 is hydrogen, alkyl, alkoxy, halogen or a fused benzene ring;R.sup.9 is hydrogen, alkyl, or substituted alkyl; andR.sup.10 is hydrogen, alkyl, or substituted alkyl the invention further relates to processes for the preparation of, pharmaceutical compositions containing, and methods of treating cardiac arrhythmia with the compounds of formulas XXXVI, XXX, II, III, and XXXVII.
摘要翻译：式XXXVI的芳基 - 稠合 - 和杂芳基 - 稠合-2,4-二氮杂，式XXX的苯并二氮杂环庚烷，式II的苯并二氮杂式III的三 - 氨基酰胺和式XXXVII的芳基二甲胺芳基或杂芳基环; R1是氢，烷基，芳基或杂芳基; R2是氢，烷基，取代的烷基或芳基; R3是烷基，芳基，芳烷基或杂原子取代的烷基或芳烷基; R4是氢或烷基; R5是氢，烷基，芳基或杂芳基; R6是氢，烷基，烷氧基，卤素或稠合苯环; R9是氢，烷基或取代的烷基; 并且R 10是氢，烷基或取代的烷基，本发明还涉及制备含有式XXXVI，XXX，II，III和XXXVII化合物的药物组合物和治疗心律不齐的方法。

84. 发明授权

US5587398A Meta substituted arylalkylamines and therapeutic and diagnostic uses therefor 失效
标题翻译：元取代的芳基烷基胺及其治疗和诊断用途
公开(公告)号：US5587398A
公开(公告)日：1996-12-24
申请号：US461577
申请日：1995-06-02
申请人： David R. Elmaleh , Alan J. Fischman
发明人： David R. Elmaleh , Alan J. Fischman
IPC分类号： A61K31/40 , A61K31/135 , A61K31/403 , A61K31/404 , A61P3/00 , A61P25/24 , A61P25/26 , A61P43/00 , C07C211/27 , C07C211/29 , C07C211/30 , C07C225/16 , C07D209/08 , C07C15/04
CPC分类号： C07C211/27 , C07C211/29 , C07C211/30 , Y10S514/909
摘要： Novel meta substituted arylakylamine compounds are disclosed. These compounds can be administered as small molecule drugs to treat diseases or conditions associated with insufficient serotonin mediated nerve transmission (e.g. depression and obesity).
摘要翻译：公开了新的间位取代的芳基芳胺化合物。这些化合物可以作为小分子药物施用以治疗与5-羟色胺介导的神经传递不足（例如抑郁症和肥胖症）有关的疾病或病症。

85. 发明授权

US5403847A Use of .alpha..sub.1C specific compounds to treat benign prostatic hyperlasia 失效
标题翻译：使用α1C特异性化合物治疗良性前列腺增生
公开(公告)号：US5403847A
公开(公告)日：1995-04-04
申请号：US975867
申请日：1992-11-13
申请人： Charles Gluchowski , Carlos C. Forray , George Chiu , Theresa A. Branchek , John M. Wetzel , Paul R. Hartig
发明人： Charles Gluchowski , Carlos C. Forray , George Chiu , Theresa A. Branchek , John M. Wetzel , Paul R. Hartig
IPC分类号： A61K31/00 , A61K31/135 , A61K31/137 , A61K31/44 , A61K31/4409 , A61K31/4427 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/4545 , A61K31/505 , A61K31/517 , A61K31/55 , A61K45/00 , A61P13/02 , A61P15/00 , A61P43/00 , C07C211/30 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07D211/58 , C07D401/12 , C07D405/12 , C07D495/06
CPC分类号： C07D401/12 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/44 , A61K31/4409 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/4545 , A61K31/505 , A61K31/517 , A61K31/55 , C07C211/30 , C07C215/50 , C07C215/52 , C07C217/58 , C07C217/60 , C07D211/58 , C07D405/12 , C07D495/06 , C07C2102/08 , C07C2102/10 , C07C2102/12
摘要： A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human .alpha..sub.1C adrenergic receptor with a binding affinity greater than ten-fold higher than the binding affinity with which the compound binds to a human .alpha..sub.1A adrenergic receptor, a human .alpha..sub.1B adrenergic receptor, and a human histamine H.sub.1 receptor, and, binds to a human .alpha..sub.2 adrenergic receptor with a binding affinity which is greater than ten-fold lower than the binding affinity with which the compound binds to such .alpha..sub.1C adrenergic receptor. Compounds meeting these criteria are provided.
摘要翻译：一种治疗受试者的良性前列腺增生的方法，其包括向受试者施用治疗有效量的结合人α1C肾上腺素能受体的化合物，其结合亲和力比结合亲和力高10倍，化合物与人α1B肾上腺素能受体，人α1B肾上腺素能受体和人组胺H1受体结合，并且结合人α2肾上腺素能受体，其结合亲和力比结合亲和力低10倍该化合物与这种α1C肾上腺素能受体结合。提供符合这些标准的化合物。

86. 发明授权

US5380721A Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents 失效
标题翻译：芳基稠合和杂芳基稠合-2,4-二氮杂和2,4-二氮辛胆碱抗心律失常药
公开(公告)号：US5380721A
公开(公告)日：1995-01-10
申请号：US250995
申请日：1994-05-31
申请人： Robert E. Johnson , Donald C. Schlegel , Alan M. Ezrin
发明人： Robert E. Johnson , Donald C. Schlegel , Alan M. Ezrin
IPC分类号： C07C211/27 , C07C211/29 , C07C211/30 , C07C217/08 , C07C217/58 , C07C217/84 , C07C233/36 , C07C233/40 , C07C235/34 , C07C311/06 , C07D243/04 , C07D245/06 , C07D295/13 , C07D295/15 , C07D333/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07D521/00 , A61K31/395 , A61K31/55
CPC分类号： C07D295/13 , C07C211/27 , C07C211/29 , C07C211/30 , C07C217/08 , C07C217/58 , C07C217/84 , C07C233/36 , C07C233/40 , C07C235/34 , C07C311/06 , C07D231/12 , C07D233/56 , C07D243/04 , C07D245/06 , C07D249/08 , C07D295/15 , C07D333/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D471/04 , C07D487/04 , C07D495/04 , C07C2101/02 , C07C2101/08
摘要： Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II ##STR1## .delta.-aminoamides of formula III and aryldimethanamines of formula XXXVII ##STR2## wherein A is an aryl or hetaryl ring;R.sup.1 is hydrogen, alkyl, aryl or hetaryl;R.sup.2 is hydrogen, alkyl, substituted alkyl, or aryl;R.sup.3 is alkyl, aryl, aralkyl or heteroatom substituted alkyl or aralkyl;R.sup.4 is hydrogen or alkyl;R.sup.5 is hydrogen, alkyl, aryl or hetaryl;R.sup.6 is hydrogen, alkyl, alkoxy, halogen or a fused benzene ring;R.sup.9 is hydrogen, alkyl, or substituted alkyl; andR.sup.10 is hydrogen, alkyl, or substituted alkyl.The invention further relates to processes for the preparation of, pharmaceutical compositions containing, and methods of treating cardiac arrhythmia with the compounds of formulas XXXVI, XXX, II, III, and XXXVII.
摘要翻译：式XXXVI的芳基 - 稠合 - 和杂芳基 - 稠合-2,4-二氮杂，式XXX的苯并二氮杂环庚烷，式II的苯并二氮杂式III的三 - 氨基酰胺和式XXXVII的芳基二甲胺芳基或杂芳基环; R1是氢，烷基，芳基或杂芳基; R2是氢，烷基，取代的烷基或芳基; R3是烷基，芳基，芳烷基或杂原子取代的烷基或芳烷基; R4是氢或烷基; R5是氢，烷基，芳基或杂芳基; R6是氢，烷基，烷氧基，卤素或稠合苯环; R9是氢，烷基或取代的烷基; 和R 10是氢，烷基或取代的烷基。本发明还涉及制备含有式XXXVI，XXX，II，III和XXXVII化合物的药物组合物和治疗心律不齐的方法。

87. 发明授权

US5260331A Composition for treating depression with (S- or O-heteroaryl)alkyl amines 失效
标题翻译：用（S-或O-杂芳基）烷基胺治疗抑郁症的组合物
公开(公告)号：US5260331A
公开(公告)日：1993-11-09
申请号：US970352
申请日：1992-11-02
申请人： John F. White , Michael C. W. Minchin , Christine Ennis
发明人： John F. White , Michael C. W. Minchin , Christine Ennis
IPC分类号： A61K31/135 , C07C211/27 , C07C211/29 , C07C211/30 , C07C215/50 , C07C217/58 , C07C309/14 , C07C335/32 , A61K31/34 , A61K31/38 , A61K31/405
CPC分类号： C07C217/58 , A61K31/135 , C07C211/27 , C07C211/29 , C07C211/30 , C07C215/50 , C07C309/14 , C07C335/32
摘要： The invention concerns compounds having formula: ##STR1## or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar.sup.1 --A.sup.1 --; Ar and Ar.sup.1 are the same or different aryl groups (including heteroaryl) which are optionally substituted, e.g. by one or more substituents commonly used in pharmaceutical chemistry; A and A.sup.1 are the same or different alkylene groups having one or two carbon atoms linking Ar or Ar.sup.1 to N and optionally substituted by lower alkyl and/or optionally substituted aryl, B is an alkylene group of 3 or 4 carbon atoms, which may be substituted by lower alkyl; D.sup.1 represents halogen, CH.sub.3, CR.sup.1 R.sup.2 NH.sub.2, SO.sub.3 H or SO.sub.2 NR.sup.6 R.sup.7 where R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl and R.sup.6 and R.sup.7 are each hydrogen, lower alkyl or aralkyl of 7 to 12 carbon atoms or R.sup.6 and R.sup.7 together with the nitrogen atom to which they are attached represent a 5 or 6 membered ring, which compounds are useful, for treating depression or cerebral insufficiency or dementias in animals.
摘要翻译：本发明涉及具有下式的化合物：其中E表示氢，低级烷基或基团Ar1-A1-; Ar和Ar 1是相同或不同的任选被取代的芳基（包括杂芳基）。通过药物化学中通常使用的一种或多种取代基; A和A1是具有一个或两个连接Ar或Ar1至N的碳原子的相同或不同的亚烷基，并且任选地被低级烷基和/或任选取代的芳基取代，B是3或4个碳原子的亚烷基，其可以是被低级烷基取代; D1表示卤素，CH3，CR1R2NH2，SO3H或SO2NR6R7，其中R1和R2独立地为氢或低级烷基，R6和R7各自为氢，7-12个碳原子的低级烷基或芳烷基或R6和R7与氮原子一起它们是连接的5或6元环，该化合物可用于治疗动物的抑郁或脑功能不全或痴呆。

88. 发明授权

US5079245A 2-trifluoromethyl-7-substitute-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes 失效
标题翻译： 2-三氟甲基-7-取代基-6,7,8,9-四氢 - （5H） - 苄氧基羰基
公开(公告)号：US5079245A
公开(公告)日：1992-01-07
申请号：US375591
申请日：1989-07-05
申请人： Michel Wierzbicki , Pierre Hugon , Jacques Duhault , Francoise Lacour
发明人： Michel Wierzbicki , Pierre Hugon , Jacques Duhault , Francoise Lacour
IPC分类号： A61K31/045 , A61K31/12 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/10 , C07C29/38 , C07C35/23 , C07C45/00 , C07C49/697 , C07C67/00 , C07C209/00 , C07C209/40 , C07C209/48 , C07C209/50 , C07C209/52 , C07C209/62 , C07C211/30 , C07C211/42 , C07C211/52 , C07C215/08 , C07C215/42 , C07C215/44 , C07C219/14 , C07C223/02 , C07C229/14 , C07C231/06 , C07C231/10 , C07C233/13 , C07C233/14 , C07C233/36 , C07C233/66 , C07C241/00 , C07C251/04 , C07C251/18 , C07C251/20 , C07C251/24 , C07D211/18 , C07D233/04 , C07D295/06 , C07D295/073 , C07D521/00
CPC分类号： C07D295/073 , C07C211/30 , C07C211/42 , C07C215/08 , C07C215/44 , C07C219/14 , C07C229/14 , C07C233/14 , C07C233/36 , C07C251/18 , C07D233/04 , C07C2102/12
摘要： The compounds 2-trifluoromethyl-7-substituted-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes are disclosed and disclosed to be useful in the treatment of metabolic illnesses such as diabetes, obesity, and their complications. A perferred compound is 2-trifluoromethyl-7-amino-6,7,8,9-tetrahydro-[5H-benzocycloheptane.
摘要翻译：公开和公开了化合物2-三氟甲基-7-取代-6,7,8,9-四氢 - [5H] - 苯并环庚烯，可用于治疗代谢疾病如糖尿病，肥胖及其并发症。延迟化合物是2-三氟甲基-7-氨基-6,7,8,9-四氢 - [5H-苯并环庚烷。

89. 发明授权

US5001251A Optical resolution of DL-3-acylthio-2-methylpropanoic acid 失效
标题翻译： DL-3-酰基硫代-2-甲基丙酸的光学拆分
公开(公告)号：US5001251A
公开(公告)日：1991-03-19
申请号：US144159
申请日：1988-01-15
申请人： Patrick A. MacManus , Peter Walsh , Adrian J. Kilbane
发明人： Patrick A. MacManus , Peter Walsh , Adrian J. Kilbane
IPC分类号： C07C209/08 , C07C211/30 , C07C327/32
CPC分类号： C07C327/32 , C07C209/08 , C07C211/30
摘要： An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R.sup.1 are independently H, lower alkyl or halogen, R.sup.2 is H or lower alkyl and R.sup.3 is lower alkyl, the optically active amine is useful in the optical resolution of DL-3-acylthio-2-methylpropanoic acid wherein acyl is acetyl or benzoyl. The optically active D-(+)-3-acylthio-2-methylpropanoic acids are used as intermediated for preparing antihypertensive agents, such as captopril.
摘要翻译：提供了一种光学活性胺化合物及其制备方法，该化合物具有其R - （+）对映体或S - （ - ）对映体形式的结构，其中R和R 1独立地为H，低级烷基或卤素，R2是H或低级烷基，R3是低级烷基，光学活性胺可用于DL-3-酰基硫代-2-甲基丙酸的光学拆分，其中酰基是乙酰基或苯甲酰基。光学活性的D - （+） - 3-酰硫基-2-甲基丙酸用作制备抗高血压药如卡托普利的中间体。

90. 发明授权

US4822822A Benzylamine derivatives, and use thereof 失效
标题翻译：苄胺衍生物及其用途
公开(公告)号：US4822822A
公开(公告)日：1989-04-18
申请号：US923274
申请日：1986-10-27
申请人： Masanobu Arita , Kiyoshi Arai , Nobuo Komoto , Setsuko Hirose , Takeshi Sekine
发明人： Masanobu Arita , Kiyoshi Arai , Nobuo Komoto , Setsuko Hirose , Takeshi Sekine
IPC分类号： C07C211/27 , A01N33/04 , A61K31/135 , A61P31/04 , C07C67/00 , C07C209/00 , C07C209/08 , C07C209/16 , C07C211/30 , C07C211/31 , A01N33/02 , C07C87/28
CPC分类号： A61K31/135
摘要： Benzylamine derivatives having the general formula ##STR1## wherein R.sub.1 is an iso-propyl or tert-butyl group, R.sub.2 is a group of the formula: ##STR2## and R.sub.3 is a lower alkyl or lower alkenyl group, or its acid addition salt. These derivatives are useful for the treatment of animal epidemics or infectious diseases induced by fungi as an antimycotic agent for humans and animals, for the control of plant diseases as an agricultural fungicide, and for the control of fungi and bacteria in industrial materials or products as an industrial fungicide.
摘要翻译：具有通式为其中R1为异丙基或叔丁基的通式为（I）的苄胺衍生物，R2为下式基团：R3为低级烷基或低级链烯基，或其酸加盐。这些衍生物可用于治疗由真菌诱导的动物疫病或感染性疾病，作为人和动物的抗真菌剂，用于控制作为农业杀真菌剂的植物病害，以及用于控制工业材料或产品中的真菌和细菌一种工业杀菌剂。

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