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81. 发明授权

US09273950B2 System and method for auto-ranging in optical coherence tomography 有权
标题翻译：光学相干断层扫描中自动测距的系统和方法
公开(公告)号：US09273950B2
公开(公告)日：2016-03-01
申请号：US13335211
申请日：2011-12-22
申请人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
发明人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
IPC分类号： A61B3/14 , G01B9/02 , A61B3/10 , A61B3/12
CPC分类号： G01B9/02044 , A61B3/102 , A61B3/12 , G01B9/02048 , G01B9/02063 , G01B9/02064 , G01B9/02091
摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.
摘要翻译：在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分，从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。

82. 发明授权

US09004688B2 Method for examining or machining a human eye 有权
标题翻译：检查或加工人眼的方法
公开(公告)号：US09004688B2
公开(公告)日：2015-04-14
申请号：US14173664
申请日：2014-02-05
申请人： Waveligh GmbH
发明人： Klaus Vogler , Mario Abraham
IPC分类号： A61B3/14 , G01B11/02 , A61B3/113 , A61B3/10 , G06K9/00 , G01B9/02 , A61B3/00
CPC分类号： A61B3/113 , A61B3/0008 , A61B3/0016 , A61B3/10 , A61B3/102 , A61B3/1025 , A61B3/14 , G01B9/02063 , G01B11/02 , G06K9/00597 , G06K9/00604
摘要： An instrument is proposed for examining or machining a human eye, with an eye-tracker for acquiring eye movements and for outputting a signal that is representative of the acquired eye movements, the eye-tracker including an interferometric image-acquisition device that has been set up for time-resolved acquisition of sectional images of the eye and that operates on the basis of two-dimensional or three-dimensional optical coherence tomography, and also an evaluating module ascertaining the eye movements solely from the sectional images.
摘要翻译：提出了一种用于检查或加工人眼的仪器，具有用于获取眼睛运动并用于输出代表所获取的眼睛运动的信号的眼睛跟踪器，眼动仪包括已经设置的干涉图像采集装置用于时间分辨获取眼睛的截面图像并且基于二维或三维光学相干断层扫描进行操作，以及评估模块仅从截面图像确定眼睛运动。

83. 发明授权

US08860796B2 Optical coherence tomography (OCT) imaging systems for use in ophthalmic applications 有权
标题翻译：用于眼科应用的光学相干断层扫描（OCT）成像系统
公开(公告)号：US08860796B2
公开(公告)日：2014-10-14
申请号：US14154782
申请日：2014-01-14
申请人： Bioptigen, Inc.
发明人： Eric L. Buckland , Robert H. Hart , Glenn A. Myers , Joseph A. Izatt
IPC分类号： A61B3/10 , A61B3/107 , A61B5/00 , G01B9/02
CPC分类号： A61B3/102 , A61B5/0066 , A61B5/0073 , G01B9/02054 , G01B9/02063 , G01B9/02064 , G01B9/02091
摘要： Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path length adjustment module is coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye length of the subject. Related methods and computer program products are also provided.
摘要翻译：提供了用于成像眼睛的光学相干断层摄影（OCT）成像系统，包括具有相关联的源臂路径的源和具有耦合到源路径的相关联的参考臂路径的参考臂，参考臂路径具有相关联的参考臂路径长度。提供具有耦合到源臂和参考臂路径的相关联的样本臂路径的样本。参考臂路径长度调节模块耦合到参考臂。参考臂路径长度调节模块被配置为自动调整参考臂路径长度，使得参考臂路径长度基于被摄体的眼睛长度。还提供了相关方法和计算机程序产品。

84. 发明授权

US08842287B2 System and method for auto-focusing in optical coherence tomography 有权
标题翻译：光学相干断层扫描中自动聚焦的系统和方法
公开(公告)号：US08842287B2
公开(公告)日：2014-09-23
申请号：US13335175
申请日：2011-12-22
申请人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
发明人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B9/02044 , G01B9/02063 , G01B9/02064 , G01B9/02068
摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.
摘要翻译：在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分，从采样臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以在检测器处获得干涉信号。此外，OCT成像系统包括具有被配置为执行自动聚焦处理以确定样本臂中的透镜的最佳位置以便使样本聚焦的逻辑的控制器。

85. 发明申请

US20140218740A1 Method and System for Optical Coherence Tomography 有权
标题翻译：光学相干断层扫描的方法和系统
公开(公告)号：US20140218740A1
公开(公告)日：2014-08-07
申请号：US14009363
申请日：2012-03-30
申请人： Rainer Nebosis , Geert Wellens
发明人： Rainer Nebosis , Geert Wellens
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B5/0066 , A61B2560/0437 , G01B9/02063 , G01B9/02085 , G01B9/02089 , G01N21/4795
摘要： The present invention relates to a method as well as a corresponding system (50) for optical coherence tomography in which a first image (60) is acquired in the region of a first plane of an object (1) by means of an optical coherence tomography equipment, and the first image (60) is displayed on a display device (52).To facilitate a reliable and time-saving examination with straightforward handling, provision is made that a second plane of the object (1) is selected on the basis of the first image (60) that is displayed on the display device (52), wherein the second plane of the object (1) is different from the first plane of the object (1), and a second image (61) is acquired in the region of the selected second plane of the object (1) by means of the optical coherence tomography equipment.
摘要翻译：本发明涉及一种用于光学相干断层摄影的相应系统（50），其中通过光学相干断层扫描在物体（1）的第一平面的区域中获取第一图像（60）设备，并且第一图像（60）被显示在显示设备（52）上。为了便于直接处理的可靠且省时的检查，提供了基于显示在显示装置（52）上的第一图像（60）选择对象（1）的第二平面，其中，物体（1）的第二平面不同于物体（1）的第一平面，并且在物体（1）的所选择的第二平面的区域中通过光学器件（1）获取第二图像（61）相干层析成像设备。

86. 发明申请

US20140152960A1 INSTRUMENT FOR EXAMINING OR MACHINING A HUMAN EYE 审中-公开
标题翻译：用于检查或加工人眼的仪器
公开(公告)号：US20140152960A1
公开(公告)日：2014-06-05
申请号：US14173664
申请日：2014-02-05
申请人： WAVELIGH GMBH
发明人： Klaus Vogler , Mario Abraham
IPC分类号： A61B3/113
CPC分类号： A61B3/113 , A61B3/0008 , A61B3/0016 , A61B3/10 , A61B3/102 , A61B3/1025 , A61B3/14 , G01B9/02063 , G01B11/02 , G06K9/00597 , G06K9/00604
摘要： An instrument is proposed for examining or machining a human eye, with an eye-tracker for acquiring eye movements and for outputting a signal that is representative of the acquired eye movements, the eye-tracker including an interferometric image-acquisition device that has been set up for time-resolved acquisition of sectional images of the eye and that operates on the basis of two-dimensional or three-dimensional optical coherence tomography, and also an evaluating module ascertaining the eye movements solely from the sectional images.
摘要翻译：提出了一种用于检查或加工人眼的仪器，具有用于获取眼睛运动并用于输出代表所获取的眼睛运动的信号的眼睛跟踪器，眼动仪包括已经设置的干涉图像采集装置用于对眼睛的截面图像进行时间分辨的获取，并且基于二维或三维光学相干断层摄影进行操作，以及评估模块仅从截面图像确定眼睛运动。

87. 发明授权

US08668336B2 Optical coherence tomography (OCT) imaging systems for use in ophthalmic applications 有权
公开(公告)号：US08668336B2
公开(公告)日：2014-03-11
申请号：US13862987
申请日：2013-04-15
申请人： Bioptigen, Inc.
发明人： Eric L. Buckland , Robert H. Hart , Glenn A. Myers , Joseph A. Izatt
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , A61B5/0066 , A61B5/0073 , G01B9/02054 , G01B9/02063 , G01B9/02064 , G01B9/02091
摘要： Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path length adjustment module is coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye length of the subject. Related methods and computer program products are also provided.

88. 发明申请

US20130301009A1 METHOD FOR THE MODEL-BASED DETERMINATION OF THE BIOMETRY OF EYES 有权
标题翻译：用于基于模型的眼睛生物测定方法
公开(公告)号：US20130301009A1
公开(公告)日：2013-11-14
申请号：US13884827
申请日：2011-11-09
申请人： Martin Hacker , Ferid Bajramovic
发明人： Martin Hacker , Ferid Bajramovic
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , A61B3/1005 , G01B9/02063 , G01B9/02089 , G01B9/02091
摘要： For the model-based determination of the biometry of eyes, the eye is illuminated by a light source via a scanning unit, the focus of the measuring light beam in the eye is moved or shifted laterally and/or axially via an adjusting device and the light fractions back-scattered by the boundary surfaces and from the tissue of the eye via an interferometer are detected by a sensor and relayed to a control and evaluation unit by which a parametric eye model which describes at least two boundary surfaces present in the eye is adapted to the scan or scans. The invention relates to the field of ophthalmology and serves in particular for the optical determination of the biometry of eyes by application of two-dimensional optical coherence tomography images. However, the method is not limited to the use of coherence tomography nor to the utilisation of optical measurements.
摘要翻译：对于基于模型的眼睛生物测定的确定，通过扫描单元由光源照射眼睛，眼睛中的测量光束的焦点通过调节装置横向和/或轴向移动或移动，并且由传感器检测由边界表面和眼睛组织经由干涉仪反向散射的轻分数，并将其转发到控制和评估单元，通过该控制和评估单元描述存在于眼睛中的至少两个边界表面的参数眼模型是适用于扫描或扫描。本发明涉及眼科领域，特别用于通过应用二维光学相干断层摄影图像来光学确定眼睛生物测量。然而，该方法不限于使用相干断层摄影，也不限于使用光学测量。

89. 发明申请

US20130235388A1 DYNAMIC AUTOFOCUS METHOD AND SYSTEM FOR ASSAY IMAGER 有权
标题翻译：动态自动方法和系统用于测量图像
公开(公告)号：US20130235388A1
公开(公告)日：2013-09-12
申请号：US13853492
申请日：2013-03-29
申请人： ILLUMINA, INC.
发明人： Darren R. Segale , John A. Moon , Hongji Ren
IPC分类号： G01B11/24
CPC分类号： C12Q1/6818 , C12Q1/6874 , G01B9/02063 , G01B11/24 , G01N21/6428 , G01N21/6458 , G02B21/244 , H04N5/23212
摘要： Method of detecting surface features of a microarray. The method includes providing a microarray to an optical scanner, wherein the microarray includes a surface having features. The method also includes carrying out a scanning process using the optical scanner, wherein the scanning process includes: (i) acquiring images of sequential regions on the surface, wherein a defocus spread is applied to the optical scanner during the acquiring, (ii) determining a focus score for the images, (iii) adjusting the optical scanner to a different defocus spread based on the focus score, and (iv) repeating (i) through (iii) at the different defocus spread, thereby acquiring images of further sequential regions on the surface. The method also includes analyzing the images to distinguish different target molecules at the features of the microarray. The images that are analyzed were acquired at the defocus spread and at the different defocus spread during the scanning process.
摘要翻译：检测微阵列表面特征的方法。该方法包括向光学扫描器提供微阵列，其中微阵列包括具有特征的表面。该方法还包括使用光学扫描器进行扫描处理，其中扫描过程包括：（i）获取表面上的顺序区域的图像，其中在获取期间将散焦扩展应用于光学扫描仪，（ii）确定用于图像的焦点得分，（iii）基于焦点得分将光学扫描仪调整到不同的散焦展开，以及（iv）在不同的散焦展开下重复（i）至（iii），从而获取进一步的顺序区域的图像在表面上。该方法还包括分析图像以区分微阵列特征处的不同靶分子。在散焦展开期间以及在扫描过程中的不同散焦点处获取被分析的图像。

90. 发明申请

US20130194541A1 OPTICAL TOMOGRAPHIC APPARATUS AND CONTROL METHOD THEREOF 有权
标题翻译：光学摄影装置及其控制方法
公开(公告)号：US20130194541A1
公开(公告)日：2013-08-01
申请号：US13598743
申请日：2012-08-30
申请人： Hiroshi Aoki , Hirofumi Yoshida , Yukio Sakagawa
发明人： Hiroshi Aoki , Hirofumi Yoshida , Yukio Sakagawa
IPC分类号： A61B3/14 , G01B9/02
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/0203 , G01B9/02044 , G01B9/02063 , G01B9/02089 , G01N21/4795
摘要： In order to change a size of an imaging area of a tomographic image of an object to be inspected easily, provided is an optical tomographic apparatus for acquiring a tomographic image of an object to be inspected, the optical tomographic apparatus including a control unit for controlling a measuring light path length changing unit to change an optical path length of measuring light in a case where the size of the imaging area of the tomographic image is changed, and for controlling a movable unit for moving a focus lens for focusing the measuring light to the object to be inspected along an optical path to move the focus lens in association with the change in the optical path length of the measuring light.
摘要翻译：为了容易地改变待检查对象的断层图像的成像区域的尺寸，提供了一种用于获取待检查对象的断层图像的光学断层摄影装置，该光学断层摄影装置包括：控制单元，用于控制测量光路长度改变单元，用于在所述断层图像的摄像区域的尺寸改变的情况下改变测量光的光路长度，并且用于控制用于移动用于将所述测量光聚焦的聚焦透镜的可移动单元沿着光路检查的物体与测量光的光路长度的变化相关联地移动聚焦透镜。

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