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1. 发明授权

US09404737B2 Dynamic autofocus method and system for assay imager 有权
标题翻译：动态自动对焦方法和分析成像仪系统
公开(公告)号：US09404737B2
公开(公告)日：2016-08-02
申请号：US13853492
申请日：2013-03-29
申请人： ILLUMINA, INC.
发明人： Darren R. Segale , John A. Moon , Hongji Ren
IPC分类号： G01B11/24 , G01N21/64 , G02B21/24 , H04N5/232
CPC分类号： C12Q1/6818 , C12Q1/6874 , G01B9/02063 , G01B11/24 , G01N21/6428 , G01N21/6458 , G02B21/244 , H04N5/23212
摘要： Method of detecting surface features of a microarray. The method includes providing a microarray to an optical scanner, wherein the microarray includes a surface having features. The method also includes carrying out a scanning process using the optical scanner, wherein the scanning process includes: (i) acquiring images of sequential regions on the surface, wherein a defocus spread is applied to the optical scanner during the acquiring, (ii) determining a focus score for the images, (iii) adjusting the optical scanner to a different defocus spread based on the focus score, and (iv) repeating (i) through (iii) at the different defocus spread, thereby acquiring images of further sequential regions on the surface. The method also includes analyzing the images to distinguish different target molecules at the features of the microarray. The images that are analyzed were acquired at the defocus spread and at the different defocus spread during the scanning process.
摘要翻译：检测微阵列表面特征的方法。该方法包括向光学扫描器提供微阵列，其中微阵列包括具有特征的表面。该方法还包括使用光学扫描器进行扫描处理，其中扫描过程包括：（i）获取表面上的顺序区域的图像，其中在获取期间将散焦扩展应用于光学扫描仪，（ii）确定用于图像的焦点得分，（iii）基于焦点得分将光学扫描仪调整到不同的散焦展开，以及（iv）在不同的散焦展开处重复（i）到（iii），从而获取进一步的顺序区域的图像在表面上。该方法还包括分析图像以区分微阵列特征处的不同靶分子。在散焦展开期间以及在扫描过程中的不同散焦点处获取被分析的图像。

2. 发明申请

US20130235388A1 DYNAMIC AUTOFOCUS METHOD AND SYSTEM FOR ASSAY IMAGER 有权
标题翻译：动态自动方法和系统用于测量图像
公开(公告)号：US20130235388A1
公开(公告)日：2013-09-12
申请号：US13853492
申请日：2013-03-29
申请人： ILLUMINA, INC.
发明人： Darren R. Segale , John A. Moon , Hongji Ren
IPC分类号： G01B11/24
CPC分类号： C12Q1/6818 , C12Q1/6874 , G01B9/02063 , G01B11/24 , G01N21/6428 , G01N21/6458 , G02B21/244 , H04N5/23212
摘要： Method of detecting surface features of a microarray. The method includes providing a microarray to an optical scanner, wherein the microarray includes a surface having features. The method also includes carrying out a scanning process using the optical scanner, wherein the scanning process includes: (i) acquiring images of sequential regions on the surface, wherein a defocus spread is applied to the optical scanner during the acquiring, (ii) determining a focus score for the images, (iii) adjusting the optical scanner to a different defocus spread based on the focus score, and (iv) repeating (i) through (iii) at the different defocus spread, thereby acquiring images of further sequential regions on the surface. The method also includes analyzing the images to distinguish different target molecules at the features of the microarray. The images that are analyzed were acquired at the defocus spread and at the different defocus spread during the scanning process.
摘要翻译：检测微阵列表面特征的方法。该方法包括向光学扫描器提供微阵列，其中微阵列包括具有特征的表面。该方法还包括使用光学扫描器进行扫描处理，其中扫描过程包括：（i）获取表面上的顺序区域的图像，其中在获取期间将散焦扩展应用于光学扫描仪，（ii）确定用于图像的焦点得分，（iii）基于焦点得分将光学扫描仪调整到不同的散焦展开，以及（iv）在不同的散焦展开下重复（i）至（iii），从而获取进一步的顺序区域的图像在表面上。该方法还包括分析图像以区分微阵列特征处的不同靶分子。在散焦展开期间以及在扫描过程中的不同散焦点处获取被分析的图像。

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