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1. 发明申请

US20140218740A1 Method and System for Optical Coherence Tomography 有权
标题翻译：光学相干断层扫描的方法和系统
公开(公告)号：US20140218740A1
公开(公告)日：2014-08-07
申请号：US14009363
申请日：2012-03-30
申请人： Rainer Nebosis , Geert Wellens
发明人： Rainer Nebosis , Geert Wellens
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B5/0066 , A61B2560/0437 , G01B9/02063 , G01B9/02085 , G01B9/02089 , G01N21/4795
摘要： The present invention relates to a method as well as a corresponding system (50) for optical coherence tomography in which a first image (60) is acquired in the region of a first plane of an object (1) by means of an optical coherence tomography equipment, and the first image (60) is displayed on a display device (52).To facilitate a reliable and time-saving examination with straightforward handling, provision is made that a second plane of the object (1) is selected on the basis of the first image (60) that is displayed on the display device (52), wherein the second plane of the object (1) is different from the first plane of the object (1), and a second image (61) is acquired in the region of the selected second plane of the object (1) by means of the optical coherence tomography equipment.
摘要翻译：本发明涉及一种用于光学相干断层摄影的相应系统（50），其中通过光学相干断层扫描在物体（1）的第一平面的区域中获取第一图像（60）设备，并且第一图像（60）被显示在显示设备（52）上。为了便于直接处理的可靠且省时的检查，提供了基于显示在显示装置（52）上的第一图像（60）选择对象（1）的第二平面，其中，物体（1）的第二平面不同于物体（1）的第一平面，并且在物体（1）的所选择的第二平面的区域中通过光学器件（1）获取第二图像（61）相干层析成像设备。

2. 发明授权

US09200886B2 Method and system for optical coherence tomography 有权
标题翻译：光学相干断层扫描的方法和系统
公开(公告)号：US09200886B2
公开(公告)日：2015-12-01
申请号：US14009363
申请日：2012-03-30
申请人： Rainer Nebosis , Geert Wellens
发明人： Rainer Nebosis , Geert Wellens
IPC分类号： G01B11/02 , G01B9/02 , A61B5/00 , G01N21/47
CPC分类号： G01B9/02091 , A61B5/0066 , A61B2560/0437 , G01B9/02063 , G01B9/02085 , G01B9/02089 , G01N21/4795
摘要： A method and a corresponding system for optical coherence tomography acquires a first image in a region of a first plane of an object by optical coherence tomography equipment, and the first image is displayed on a display device. To facilitate a reliable and time-saving examination with straightforward handling, a second plane of the object is selected on the basis of the first image that is displayed on the display device, wherein the second plane of the object is different from the first plane of the object, and a second image is acquired in the region of the selected second plane of the object by the optical coherence tomography equipment.
摘要翻译：用于光学相干断层摄影的方法和相应的系统通过光学相干断层摄影设备获取物体的第一平面区域中的第一图像，并且将第一图像显示在显示装置上。为了通过简单的处理来促进可靠和省时的检查，基于显示在显示装置上的第一图像来选择对象的第二平面，其中物体的第二平面不同于第一平面通过光学相干断层摄影设备在对象的所选择的第二平面的区域中获取对象和第二图像。

3. 发明申请

US20140204391A1 Method and System for Optical Coherence Tomography 审中-公开
标题翻译：光学相干断层扫描的方法和系统
公开(公告)号：US20140204391A1
公开(公告)日：2014-07-24
申请号：US14009371
申请日：2012-03-30
申请人： Rainer Nebosis , Geert Wellens , Wolfgang Schorre
发明人： Rainer Nebosis , Geert Wellens , Wolfgang Schorre
IPC分类号： G01B9/02
CPC分类号： G01B9/02089 , A61B5/0066 , A61B5/0073 , A61B5/444 , A61B2560/0437 , A61B2562/0233 , G01B9/02063 , G01B9/02091 , G01N21/4795 , G06T2219/028
摘要： The present invention relates to a method as well as a corresponding system (50) for optical coherence tomography, where, by means of an optical coherence tomography equipment, a first image (60) is acquired in the region of a first plane of an object (1) and a second image (61) is acquired in the region of a second plane of the object (1), wherein the second plane of the object (1) is different from the first plane of the object (1).To facilitate a reliable and time-saving examination of the object (1), with the most straightforward handling possible, the first image (60) is acquired in the region of the first plane (S) of the object (1) and the second image (61) is acquired in the region of the second plane (F) of the object (1) in real time, and the first image (60) or the second image (61) is rendered as a real time image and the respectively other image, i.e. the second or the first image (61 or 60 respectively), is rendered as a still image on the display device (52) depending on a control command, in particular one entered by an operator.
摘要翻译：本发明涉及一种用于光学相干断层摄影的方法以及相应的系统（50），其中通过光学相干断层摄影设备，在物体的第一平面的区域中获取第一图像（60）（1）和第二图像（61）在对象（1）的第二平面的区域中获取，其中对象（1）的第二平面不同于对象（1）的第一平面。为了便于对物体（1）的可靠和省时的检查，以最直接的处理可能，在物体（1）的第一平面（S）的区域中获取第一图像（60），第二图像实时地在物体（1）的第二平面（F）的区域中获取图像（61），并且将第一图像（60）或第二图像（61）分别呈现为实时图像，并且分别其他图像，即第二图像或第一图像（分别为61或60）根据控制命令，特别是由操作者输入的控制命令，在显示装置（52）上呈现为静止图像。

4. 发明申请

US20100027029A1 System and Method for Optical Coherence Tomography and Method for Calibrating Said Type of System 失效
标题翻译：用于光学相干断层扫描的系统和方法以及校准所述系统类型的方法
公开(公告)号：US20100027029A1
公开(公告)日：2010-02-04
申请号：US12527292
申请日：2008-02-20
申请人： Rainer Nebosis , Rainer Scheunemann , Edgar-Gerald Kopp
发明人： Rainer Nebosis , Rainer Scheunemann , Edgar-Gerald Kopp
IPC分类号： G01B11/14
CPC分类号： G01B9/02091 , G01B9/02002 , G01B9/02012 , G01B9/02063 , G01B9/02072
摘要： The invention relates to a system and to a corresponding method for optical coherence tomography having an interferometer (10) for emitting light with which a specimen (1) is irradiated, the interferometer (1) comprising a beam splitter (13) and at least one reflector (12) the optical distance (I) of which from the beam splitter (13) is changeable, a specimen objective by means of which light emitted by the interferometer (10) is focussed in a focus lying within the specimen (1), and a detector (30) for collecting light which is reflected by the specimen (1).For simpler and quicker recording of the sharpest possible images of the specimen (1) provision is made such that during a change of the optical distance (I) between the reflector (12) and the beam splitter (13) the light respectively reflected at a number of different depths of the specimen (1) is collected by the detector (30), and during the collection of the light respectively reflected at the different depths of the specimen (1) the imaging properties of the specimen objective are changed such that the focus comes within the range of the respective depth of the specimen (1).
摘要翻译：本发明涉及一种用于光学相干断层摄影的系统和相应的方法，该方法具有用于发射照射样本（1）的光的干涉仪（10），所述干涉仪（1）包括分束器（13）和至少一个反射器（12），来自分束器（13）的光学距离（I）可以改变，由干涉仪（10）发射的光聚焦在位于样品（1）内的焦点上的样本物镜，以及用于收集被样品（1）反射的光的检测器（30）。为了更简单和更快速地记录样本的最清晰可能的图像（1），提供这样的设置，使得在反射器（12）和分束器（13）之间的光学距离（I）的改变期间，分别在一个样品（1）的不同深度的数量由检测器（30）收集，并且在分别在样品（1）的不同深度处反射的光的收集期间，改变样品物镜的成像特性，使得焦点在样本（1）的相应深度的范围内。

5. 发明申请

US20100027021A1 System for Optical Coherence Tomography 有权
标题翻译：光学相干断层扫描系统
公开(公告)号：US20100027021A1
公开(公告)日：2010-02-04
申请号：US12527312
申请日：2008-02-20
申请人： Rainer Nebosis , Rainer Scheunemann , Edgar-Gerald Kopp
发明人： Rainer Nebosis , Rainer Scheunemann , Edgar-Gerald Kopp
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0073 , G01B9/02002 , G01B9/02012 , G01B9/02063 , G01B9/02065 , G01B9/02072 , G01B9/02091
摘要： The invention relates to a system for optical coherence tomography having an interferometer (20), a detector (30) with a first number of detector elements for collecting light, and an optical fibre (29) with a second number of individual fibres for transmitting light from the interferometer (20) to the detector (30).In order to increase the compactness of the system with at the same time high image quality provision is made such that the detector elements have a first centre-centre distance and the individual fibres have a second centre-centre distance, the first centre-centre distance between the detector elements being greater than the second centre-centre distance between the individual fibres.
摘要翻译：本发明涉及一种用于光学相干断层摄影的系统，其具有干涉仪（20），具有用于收集光的第一数量的检测器元件的检测器（30）和具有第二数量的单独光纤的光纤（29），用于透射光从干涉仪（20）到检测器（30）。为了提高系统的紧凑性，同时提供高图像质量，使得检测器元件具有第一中心距离，并且各个光纤具有第二中心距离，第一中心距离检测器元件之间的距离大于各个光纤之间的第二中心距离。

6. 发明授权

US09551565B2 Method and system for optical coherence tomography including obtaining at least two two-dimensional images of an object in three-dimensional space 有权
标题翻译：用于光学相干断层摄影的方法和系统，包括在三维空间中获得物体的至少两个二维图像
公开(公告)号：US09551565B2
公开(公告)日：2017-01-24
申请号：US14009379
申请日：2012-03-30
申请人： Rainer Nebosis , Roland Reuter
发明人： Rainer Nebosis , Roland Reuter
IPC分类号： G01B9/02 , A61B5/00 , G01N21/47
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0073 , A61B5/444 , A61B2560/0437 , A61B2562/0233 , G01B9/02063 , G01B9/02085 , G01B9/02089 , G01N21/4795
摘要： A method and corresponding system for optical coherence tomography includes optical coherence tomography equipment that acquires at least two two-dimensional initial images of an object in planes of the object that are spaced apart from one another, in particular running parallel to one another, wherein the initial images each include a plurality of initial image values. In order to assure an examination of the object in the case of medical applications that is as reliable as possible, an interpolation of the initial image values of the at least two two-dimensional initial images is performed in three-dimensional space, wherein interpolation values are obtained that form a two-dimensional final image.
摘要翻译：用于光学相干断层摄影的方法和相应的系统包括光学相干断层摄影设备，其获取彼此间隔开的物体平面中的物体的至少两个二维初始图像，特别是彼此平行地延伸，其中初始图像各自包括多个初始图像值。为了确保在尽可能可靠的医疗应用的情况下的对象的检查，在三维空间中执行至少两个二维初始图像的初始图像值的插值，其中插值获得形成二维最终图像。

7. 发明授权

US08810797B2 System and method for optical coherence tomography 有权
标题翻译：光学相干断层扫描系统和方法
公开(公告)号：US08810797B2
公开(公告)日：2014-08-19
申请号：US12527287
申请日：2008-02-20
申请人： Rainer Nebosis , Rainer Scheunemann , Edgar-Gerald Kopp
发明人： Rainer Nebosis , Rainer Scheunemann , Edgar-Gerald Kopp
IPC分类号： G01B11/02
CPC分类号： G01B9/02012 , G01B9/02002 , G01B9/02063 , G01B9/02071 , G01B9/02072 , G01B9/02091
摘要： The invention relates to a system and to a corresponding method for optical coherence tomography having an interferometer (10) for emitting light with which a specimen (1) is irradiated, the interferometer (1) comprising a beam splitter (13) and at least one reflector (12) the optical distance (I) of which from the beam splitter (13) is changeable, and a detector (30) which has a plurality of detector elements arranged in an area by means of which the light which is reflected by the specimen (1) is collected.In order to simplify and speed up the recording of three-dimensional images of the specimen (1) provision is made such that the optical distance (I) between the reflector (12) and the beam splitter (13) is changed by an optical path (L) which is substantially greater than an average wavelength (λ0) of light (14) which is injected into the interferometer (10): L>>λ0, during the change of the optical distance (I) between the reflector (12) and the beam splitter (13) by the optical path (L) the light reflected by the specimen (1) being collected a number of times by the detector elements of the detector (30), by means of which the light reflected by a number of two-dimensional sections at different depths of the specimen (1) is collected.
摘要翻译：本发明涉及一种用于光学相干断层摄影的系统和相应的方法，该方法具有用于发射照射样本（1）的光的干涉仪（10），所述干涉仪（1）包括分束器（13）和至少一个反射器（12），来自分束器（13）的光学距离（I）可以改变;以及检测器（30），其具有多个检测器元件，所述检测器元件布置在通过该区域反射的光的区域中，收集样品（1）。为了简化和加快样本的三维图像的记录（1），提供反射器（12）和分束器（13）之间的光学距离（I）由光路（L），其在反射器（12）之间的光学距离（I）的改变期间基本上大于注入到干涉仪（10）中的光（14）的平均波长（λ0）：L >>λ0 并且通过光路（L）的分束器（13）被检体（1）反射的光被检测器（30）的检测器元件收集多次，通过该检测器元件反射数量收集样品（1）不同深度的二维截面。

8. 发明授权

US08593639B2 System and method for optical coherence tomography with light or detector modulation 有权
标题翻译：具有光或检测器调制的光学相干断层扫描的系统和方法
公开(公告)号：US08593639B2
公开(公告)日：2013-11-26
申请号：US12527322
申请日：2008-02-20
申请人： Rainer Nebosis
发明人： Rainer Nebosis
IPC分类号： G01B11/02
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0073 , A61B5/444 , G01B9/02002 , G01B9/02012 , G01B9/02063 , G01B9/02072 , G01N21/4785 , G01N21/4795 , G01N2021/4709
摘要： The invention relates to a system and to a corresponding method for optical coherence tomography having an interferometer (10) for emitting light with which a specimen (1) is irradiated, the interferometer (10) comprising a beam splitter (13) and at least one reflector (12) the optical distance (I) of which from the beam splitter (13) can be changed by an optical path (L), and a detector (30) with a first number of detector elements arranged in a first area for collecting light which is reflected by the specimen (1).In order to be able to record images of a specimen, in particular in real time, more simply and quickly, the system is operated in a first mode in which light reflected by the specimen (1) is only collected by a second number of detector elements of the detector (30) and converted into corresponding detector signals, the second number of detector elements being smaller than the first number of detector elements.
摘要翻译：本发明涉及一种用于光学相干断层摄影的系统和相应的方法，该方法具有用于发射照射样本（1）的光的干涉仪（10），所述干涉仪（10）包括分束器（13）和至少一个反射器（12）可以通过光路（L）改变来自分束器（13）的光学距离（I），以及具有第一数量的检测器元件的检测器（30），其布置在第一区域中用于收集由样品（1）反射的光。为了能够更简单快速地记录样本的图像，特别是实时地，快速地记录图像，其中由样本（1）反射的光仅由第二数量的检测器收集的第一模式操作检测器（30）的元件并转换成对应的检测器信号，第二数量的检测器元件小于第一数量的检测器元件。

9. 发明申请

US20100097616A1 System and Method for Optical Coherence Tomography 有权
标题翻译：光学相干断层扫描的系统和方法
公开(公告)号：US20100097616A1
公开(公告)日：2010-04-22
申请号：US12527300
申请日：2008-02-20
申请人： Rainer Nebosis , Rainer Scheunemann
发明人： Rainer Nebosis , Rainer Scheunemann
IPC分类号： G01B9/02 , A61B6/00
CPC分类号： G01B9/02012 , A61B5/0066 , A61B5/0073 , G01B9/02002 , G01B9/02063 , G01B9/02072 , G01B9/02091 , G01N21/4795
摘要： The invention relates to a system and to a corresponding method for optical coherence tomography having an interferometer (10) and a detector system (30, 31) which comprises a detector (30) for collecting the light reflected by a specimen (1) to be examined and has a sensitivity to the light reflected by the specimen (1).In order to reduce the times required for the most reliable possible recording of interference signals provision is made such that the sensitivity of the detector system (30, 31) to the light reflected by the specimen (1) and impinging on the detector (30) is modulated with a modulation frequency.
摘要翻译：本发明涉及一种具有干涉仪（10）和检测器系统（30,31）的光学相干断层摄影的系统和相应的方法，所述干涉仪（10）和检测器系统（30,31）包括用于收集由样品（1）反射的光的检测器（30）检测并且对由样品（1）反射的光具有敏感性。为了减少最可靠地记录干扰信号所需的时间，提供检测器系统（30,31）对被检体（1）反射并撞击检测器（30）的光的灵敏度，用调制频率进行调制。

10. 发明申请

US20100033726A1 System and Method for Optical Coherence Tomography 失效
标题翻译：光学相干断层扫描的系统和方法
公开(公告)号：US20100033726A1
公开(公告)日：2010-02-11
申请号：US12527298
申请日：2008-02-20
申请人： Rainer Nebosis , Rainer Scheunemann
发明人： Rainer Nebosis , Rainer Scheunemann
IPC分类号： G01B9/02
CPC分类号： G01B9/02012 , G01B9/02002 , G01B9/02063 , G01B9/02072 , G01B9/02091
摘要： The invention relates to a system and to a corresponding method for optical coherence tomography having an interferometer (10) which has a beam splitter (13), a first reflector (11) and a reflector (12) the optical distance (I) of which from the beam splitter (13) is changeable by a speed (v), and a detector (30) for collecting light which is reflected by a specimen (1) to be examined.In order to reduce the times required for the most reliable possible recording of interference patterns, provision is made such that the intensity of the light (14 or 4) injected into the interferometer (10) or emitted by the interferometer (10) is modulated with a modulation frequency (fM) which is not equal to the Doppler frequency (fD), the Doppler frequency (fD) being given by twice the ratio of the speed (v) of the change of the optical distance (I) between the reflector (12) and the beam splitter (13) to the average wavelength (λ0) of the injected light (14): fM≠fD=2·v/λ0.
摘要翻译：本发明涉及一种具有干涉仪（10）的光学相干断层摄影的系统和相应方法，所述干涉仪具有分束器（13），第一反射器（11）和反射器（12），光学距离（I）来自分束器（13）的速度可以通过速度（v）变化;以及检测器（30），用于收集被检查样本（1）反射的光。为了减少最可靠地记录干涉图案所需的时间，提供这样的设置，使得注入干涉仪（10）或由干涉仪（10）发射的光（14或4）的强度用不等于多普勒频率（fD）的调制频率（fM），多普勒频率（fD）由反射器（1）之间的光学距离（I）的变化的速度（v） 12）和分束器（13）到注入的光（14）的平均波长（λ0）：fMfD = 2.v /λ0。

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