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81. 发明授权

US08388549B2 Anatomical thermal sensing device and method 有权
公开(公告)号：US08388549B2
公开(公告)日：2013-03-05
申请号：US12751946
申请日：2010-03-31
申请人： Saurav Paul , Todd Stangenes , Riki Thao
发明人： Saurav Paul , Todd Stangenes , Riki Thao
IPC分类号： A61B5/00
CPC分类号： A61B18/1402 , A61B5/01 , A61B5/015 , A61B5/053 , A61B5/6852 , A61B5/6885 , A61B2562/0271
摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.

82. 发明申请

US20120035460A1 MOVABLE MAGNET FOR MAGNETICALLY GUIDED CATHETER 有权
标题翻译：用于磁导管的可变磁铁
公开(公告)号：US20120035460A1
公开(公告)日：2012-02-09
申请号：US12851407
申请日：2010-08-05
申请人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
发明人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
IPC分类号： A61M25/092 , A61B5/055 , A61B6/12
CPC分类号： A61M25/0127 , A61B5/0422 , A61B5/055 , A61B5/062 , A61B5/6857 , A61B6/12 , A61B6/487 , A61B18/1492 , A61B34/32 , A61B34/73 , A61B2018/00375 , A61B2018/00577 , A61B2018/00791 , A61B2034/301 , A61B2034/303 , A61B2034/731 , A61B2034/732 , A61B2562/0271 , A61M25/0158
摘要： A catheter is disclosed having a flexible tubing with a proximal end and a distal end. The catheter comprising at least one movable magnet provided within the distal end of the flexible tubing. A control mechanism is operable to selectively activate the at least one movable magnet from the proximal end of the flexible tubing. The at least one movable magnet is responsive to an external magnetic field to position and guide the distal end of the flexible tubing within a body of a patient.
摘要翻译：公开了一种具有近端和远端的柔性管的导管。导管包括设置在柔性管的远端内的至少一个可动磁体。控制机构可操作以从柔性管的近端选择性地启动至少一个可动磁体。所述至少一个可移动磁体响应外部磁场来定位和引导患者体内的柔性管的远端。

83. 发明申请

US20110270191A1 Fast-acting or rotating transseptal needle 有权
标题翻译：快速或旋转经口针
公开(公告)号：US20110270191A1
公开(公告)日：2011-11-03
申请号：US13142957
申请日：2009-12-23
申请人： Saurav Paul , Todd R. Stangenes , Reer R. Heimbecher
发明人： Saurav Paul , Todd R. Stangenes , Reer R. Heimbecher
IPC分类号： A61B17/34
CPC分类号： A61B17/3403 , A61B17/3478 , A61B17/3498 , A61B2017/00243 , A61B2017/3405 , A61M29/00
摘要： A transseptal medical device (10, 110) is provided including a dilator (12, 112), a needle (14, 114), and a needle control mechanism (22, 122). The needle (14, 114) may be disposed within the dilator (12, 112), and the needle control mechanism (22, 122) may be operably connected to a proximal end (24, 124, 16, 116) of the needle (14, 114) or the dilator (12, 112) for selective adjustment of the distal end (26, 126) of the needle (14, 114) from a first position within the dilator (12, 112) to a second position external to the dilator (12, 112). The needle control mechanism (22) may include an actuator (32) configured for rotation within the dilator in one embodiment.
摘要翻译：提供了一种经血管医疗装置（10,110），其包括扩张器（12,112），针（14,114）和针控制机构（22,122）。针（14,114）可以设置在扩张器（12,112）内，并且针控制机构（22,122）可以可操作地连接到针的近端（24,124,16,116） 14,114）或扩张器（12,112），用于选择性地将针（14,114）的远端（26,126）从扩张器（12,112）内的第一位置调节到第二位置扩张器（12,112）。针控制机构（22）可以包括在一个实施例中构造成用于在扩张器内旋转的致动器（32）。

84. 发明申请

US20110022045A1 Ablation electrodes with capacitive sensors for resolving magnitude and direction of forces imparted to a distal portion of a cardiac catheter 审中-公开
标题翻译：具有电容传感器的消融电极，用于分辨施加到心脏导管的远端部分的力的大小和方向
公开(公告)号：US20110022045A1
公开(公告)日：2011-01-27
申请号：US12893707
申请日：2010-09-29
申请人： Hong Cao , Riki Thao , Saurav Paul
发明人： Hong Cao , Riki Thao , Saurav Paul
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/6852 , A61B5/6885 , A61B2090/065
摘要： A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. In an exemplary embodiment the assembly includes a catheter shaft and a trio of pressure sensitive capacitive members each of whose electrical resistance varies with a pressure vector applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive capacitive members. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive capacitors.
摘要翻译：公开了一种用于评估导管组件和组织之间的接触的导管组件。在示例性实施例中，组件包括导管轴和三个压敏电容构件，每个电阻构件的电阻随着施加到导管组件的压力矢量而变化。组件还包括至少一个测量端子，以允许测量压敏电容构件的电特性的变化。组件可以可选地包括测量电阻，阻抗和/或其他电特性的测量装置。组件可以利用固定到患者组织的参考电极，其允许测量装置测量参考电极和至少一个测量终端之间的变化。可选地，组件可以包括导电外层。还公开了传感器组件，接触传感器，接触感测方法以及与使用压敏电容器有关的制造方法。

85. 发明授权

US07824377B2 Tissue anchoring catheter systems and methods 有权
标题翻译：组织锚固导管系统及方法
公开(公告)号：US07824377B2
公开(公告)日：2010-11-02
申请号：US11962512
申请日：2007-12-21
申请人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
发明人： James V. Kauphusman , Israel A. Byrd , Saurav Paul
IPC分类号： A61M5/178
CPC分类号： A61M25/04 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2090/065 , A61M25/0084 , A61M2025/0089 , A61M2025/0095
摘要： Catheter systems and methods are disclosed for anchoring the catheter system to tissue, e.g., for delivery of biologic or chemical agents, or other therapeutic fluid during various procedures. An exemplary tissue anchoring catheter comprises an outer catheter shaft connected to a catheter handle. A delivery sheath is provided within the outer catheter shaft, the delivery sheath housing a needle. At least one anchor is operatively associated with the delivery sheath, the at least one anchor operable at the catheter handle to secure the delivery sheath to tissue for conveying biologic or chemical agents, or other therapeutic fluid from the needle to the tissue. The tissue anchoring catheter may further comprise sensing means such as piezoelectric, pressure, thermistor, thermocouple, or ultrasound sensors.
摘要翻译：公开了用于将导管系统锚定到组织的导管系统和方法，例如用于在各种程序期间递送生物或化学试剂或其它治疗性流体。示例性组织锚定导管包括连接到导管手柄的外导管轴。输送护套设置在外导管轴内，输送护套容纳针。至少一个锚定件与输送护套可操作地相关联，所述至少一个锚固件可在导管手柄处操作以将输送护套固定到组织，用于将生物或化学试剂或其它治疗流体从针输送到组织。组织锚定导管还可以包括诸如压电，压力，热敏电阻，热电偶或超声波传感器的感测装置。

86. 发明申请

US20090163904A1 System and Method for Assessing Coupling Between an Electrode and Tissue 有权
标题翻译：用于评估电极和组织之间耦合的系统和方法
公开(公告)号：US20090163904A1
公开(公告)日：2009-06-25
申请号：US12253637
申请日：2008-10-17
申请人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
发明人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算出表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

87. 发明申请

US20050267460A1 Ablation catheter with suspension system incorporating rigid and flexible components 失效
标题翻译：消融导管与悬挂系统结合刚性和柔性组件
公开(公告)号：US20050267460A1
公开(公告)日：2005-12-01
申请号：US10856544
申请日：2004-05-27
申请人： John Roop , Kedar Belhe , Hong Cao , Saurav Paul
发明人： John Roop , Kedar Belhe , Hong Cao , Saurav Paul
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00867 , A61B2018/00351 , A61B2018/143 , C08L2201/12
摘要： A curved ablation catheter imparts ablative energy to target tissue, for example, along a trabecular slope, e.g., in the right atrium along the isthmus between the ostium of the inferior vena cava and the tricuspid valve. The catheter is formed with a preset curvature that, when deployed, both translates linearly and increases in radius to aid in the formation of spot or continuous linear lesions. A method of treating atrial flutter employs the curved ablation catheter.
摘要翻译：弯曲的消融导管向靶组织提供消融能量，例如沿着小梁斜面，例如沿着下腔静脉的口和三尖瓣之间的峡谷的右心房。导管形成有预设曲率，当展开时，两者均线性地平移并且半径增加以帮助形成斑点或连续的线性损伤。治疗心房扑动的方法采用弯曲消融导管。

88. 发明授权

US10555685B2 Method and apparatus for determining tissue morphology based on phase angle 有权
公开(公告)号：US10555685B2
公开(公告)日：2020-02-11
申请号：US13584368
申请日：2012-08-13
申请人： Hong Cao , Saurav Paul
发明人： Hong Cao , Saurav Paul
IPC分类号： A61B5/00 , A61B5/053
摘要： A compensation circuit has a predetermined, known complex impedance and is located in a handle of a catheter or in a distal end of a cable that connects to the catheter. The compensation circuit is probed with a pilot signal produced by a compensation control. The compensation control measures the complex impedance, which is the combination of the circuit's known impedance as well as that of the cable and then determines the difference between the measured and the known complex impedances which represents that which is attributable to the cable, and is used to cancel out such cable-related contributions to complex impedance in other electrical connections in the same cable. In another aspect, an unknown tissue is identified as one of a plurality of possible tissue types such as regular myocardium, scar and fat based on the measured phase angle of the complex impedance of the unknown tissue.

89. 发明授权

US09198726B2 Photodynamic-based cardiac ablation device and method via the esophagus 有权
标题翻译：基于光动力学的心脏消融装置和通过食道的方法
公开(公告)号：US09198726B2
公开(公告)日：2015-12-01
申请号：US11967350
申请日：2007-12-31
申请人： Saurav Paul , Israel A. Byrd
发明人： Saurav Paul , Israel A. Byrd
IPC分类号： A61B18/18 , A61B18/24 , A61N5/06 , A61B18/22
CPC分类号： A61B18/24 , A61B2018/2272 , A61N5/0601 , A61N5/062
摘要： A method and system for ablation of cardiac tissue in a living being via the esophagus is provided. The method includes the step of introducing a photodynamic substance to the cardiac tissue. A deformable, elongated body defining a proximal end and a distal end is inserted into an esophagus of the living being. The distal end of the elongated body is located proximate the cardiac tissue. A first set of electromagnetic radiation is then directed from the distal end of the elongated body towards the cardiac tissue. Reflective and opaque surfaces at the distal end of the elongated body may be used to direct the electromagnetic radiation and an expandable membrane at the distal end may be used to urge the distal end of the elongated body to a predetermined position within the esophagus.
摘要翻译：提供了一种通过食道消融心脏组织的方法和系统。该方法包括将光动力学物质引入心脏组织的步骤。限定近端和远端的可变形的细长主体被插入到生命的食道中。细长体的远端位于心脏组织附近。然后将第一组电磁辐射从细长体的远端引向心脏组织。在细长体的远端处的反射和不透明表面可以用于引导电磁辐射，并且在远端处的可扩张膜可以用于将细长体的远端推动到食道内的预定位置。

90. 发明授权

US08449535B2 System and method for assessing coupling between an electrode and tissue 有权
标题翻译：用于评估电极和组织之间的耦合的系统和方法
公开(公告)号：US08449535B2
公开(公告)日：2013-05-28
申请号：US12253637
申请日：2008-10-17
申请人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
发明人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

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