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1. 发明授权

US08449535B2 System and method for assessing coupling between an electrode and tissue 有权
标题翻译：用于评估电极和组织之间的耦合的系统和方法
公开(公告)号：US08449535B2
公开(公告)日：2013-05-28
申请号：US12253637
申请日：2008-10-17
申请人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
发明人： Don Curtis Deno , Stephan Paul Miller , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

2. 发明申请

US20100069921A1 SYSTEM AND METHOD FOR ASSESSING LESIONS IN TISSUE 有权
标题翻译：用于评估组织中LESIONS的系统和方法
公开(公告)号：US20100069921A1
公开(公告)日：2010-03-18
申请号：US12622488
申请日：2009-11-20
申请人： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liare R. Teplitsky
发明人： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liare R. Teplitsky
IPC分类号： A61B5/053 , A61B19/00 , A61B5/00
CPC分类号： A61B18/1492 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00577 , A61B2018/00648 , A61B2018/00696 , A61B2018/00773 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2090/065
摘要： A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire values for first and second components of a complex impedance between the electrode and the tissue, and to calculate an index responsive to the first and second values. The ECU is further configured to process the ECI to assess lesion formation in the tissue.
摘要翻译：提供了一种用于评估组织中病变形成的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的第一和第二分量的值，并且响应于第一和第二值来计算索引。 ECU还被配置为处理ECI以评估组织中的病变形成。

3. 发明申请

US20090163904A1 System and Method for Assessing Coupling Between an Electrode and Tissue 有权
标题翻译：用于评估电极和组织之间耦合的系统和方法
公开(公告)号：US20090163904A1
公开(公告)日：2009-06-25
申请号：US12253637
申请日：2008-10-17
申请人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
发明人： Stephan P. Miller , Don Curtis Deno , Saurav Paul
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/053 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. From these values, a coupling index is calculated that that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。根据这些值，计算出表示电极和组织之间的耦合程度的耦合指数。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

4. 发明授权

US08403925B2 System and method for assessing lesions in tissue 有权
标题翻译：用于评估组织病变的系统和方法
公开(公告)号：US08403925B2
公开(公告)日：2013-03-26
申请号：US12622488
申请日：2009-11-20
申请人： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liane R. Teplitsky
发明人： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liane R. Teplitsky
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00577 , A61B2018/00648 , A61B2018/00696 , A61B2018/00773 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2090/065
摘要： A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire values for first and second components of a complex impedance between the electrode and the tissue, and to calculate an index responsive to the first and second values. The ECU is further configured to process the ECI to assess lesion formation in the tissue.
摘要翻译：提供了一种用于评估组织中病变形成的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的第一和第二分量的值，并且响应于第一和第二值来计算索引。 ECU还被配置为处理ECI以评估组织中的病变形成。

5. 发明授权

US08406866B2 System and method for assessing coupling between an electrode and tissue 有权
公开(公告)号：US08406866B2
公开(公告)日：2013-03-26
申请号：US12650060
申请日：2009-12-30
申请人： Don Curtis Deno , Stephan P. Miller , Lewis C Hill , Yuriy Malinin , Haris Sih
发明人： Don Curtis Deno , Stephan P. Miller , Lewis C Hill , Yuriy Malinin , Haris Sih
IPC分类号： A61B5/05
CPC分类号： A61B18/00 , A61B5/053 , A61B5/6885 , A61B5/6886 , A61B18/1233 , A61B18/14 , A61B18/1492 , A61B2018/00178 , A61B2018/00642 , A61B2018/00773 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. These values are used together with a standardization value indicative of a deviation from a reference standard by a parameter associated with at least one of the body, the electrode and another component of the system to calculate a coupling index that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.

6. 发明申请

US20140107430A1 System and method for assessing coupling between an electrode and tissue 有权
标题翻译：用于评估电极和组织之间的耦合的系统和方法
公开(公告)号：US20140107430A1
公开(公告)日：2014-04-17
申请号：US13777580
申请日：2013-02-26
申请人： Don Curtis Deno , Stephan P. Miller , Lewis C. Hill , Yuriy Malinin , Haris J. Sih
发明人： Don Curtis Deno , Stephan P. Miller , Lewis C. Hill , Yuriy Malinin , Haris J. Sih
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B18/00 , A61B5/053 , A61B5/6885 , A61B5/6886 , A61B18/1233 , A61B18/14 , A61B18/1492 , A61B2018/00178 , A61B2018/00642 , A61B2018/00773 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. These values are used together with a standardization value indicative of a deviation from a reference standard by a parameter associated with at least one of the body, the electrode and another component of the system to calculate a coupling index that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。这些值与表示与参考标准的偏差的标准化值一起使用与系统的主体，电极和另一部件中的至少一个相关联的参数来计算表示耦合度的耦合指数在电极和组织之间。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

7. 发明授权

US08231569B2 Torque-limiting catheter handle 有权
标题翻译：扭矩限制导管手柄
公开(公告)号：US08231569B2
公开(公告)日：2012-07-31
申请号：US12968149
申请日：2010-12-14
申请人： Martin Maitre Grasse , Anthony D. Hill , Don Curtis Deno
发明人： Martin Maitre Grasse , Anthony D. Hill , Don Curtis Deno
IPC分类号： A61M37/00 , A61M25/00 , B25B23/157
CPC分类号： A61M25/01 , A61M25/0136 , A61M25/0147
摘要： A catheter includes a handle that advantageously limits the amount of torque that can be imparted to the body of the catheter. This advantageously reduces the likelihood of catheter failure, damage to tissue, or damage to medical devices introduced into the vasculature via the catheter. The catheter handle includes a grip portion that the practitioner manipulates in order to impart a torque and a torque transmitting portion operably coupled thereto that transmits the torque to the catheter body. A torque limiting mechanism decouples the torque transmitting portion from the grip portion, the body, and/or any pull wires when the torque imparted to the grip portion exceeds a torque threshold, thereby preventing excessive torques from being transmitted to the catheter body and/or pull wires. A practitioner may be able to adjust the torque threshold and may be able to disable the torque limiting mechanism.
摘要翻译：导管包括有利地限制可以赋予导管主体的扭矩的量的手柄。这有利地减少导管失效，组织损伤或通过导管引入脉管系统的医疗装置的损伤的可能性。该导管手柄包括一个把手部分，该把手部分被操作以便施加一个转矩，和一个可操作地耦合到其上的转矩传递部分，该扭矩传递部分将扭矩传递到导管主体。当施加到把手部分的扭矩超过扭矩阈值时，转矩限制机构将扭矩传递部分与把持部分，主体和/或任何拉线分离，从而防止过大扭矩传递到导管主体和/或拉线。从业者可能能够调整转矩阈值，并且可能能够禁用转矩限制机构。

8. 发明授权

US5766230A Pacemaker with intra-stimulus capture detection 失效
标题翻译：起搏器内刺激捕获检测
公开(公告)号：US5766230A
公开(公告)日：1998-06-16
申请号：US744577
申请日：1996-11-06
申请人： Andre Guy Routh , Don Curtis Deno , William Bruce Rottenber
发明人： Andre Guy Routh , Don Curtis Deno , William Bruce Rottenber
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/3712
摘要： A pacemaker is disclosed that includes circuitry for monitoring the current and/or voltage delivered to the heart during a pacing pulse. A microprocessor connects to the monitoring circuitry and analyzes the current (and/or voltage) to determine when capture occurs. When capture occurs, the microprocessor terminates the pacing pulse to save energy. Conversely, if capture does not occur within a predetermined maximum time period, or if the pacing pulse amplitude falls below a predetermined threshold value, the processor immediately causes a safety pulse to fire to insure a regular beating of the heart. By monitoring the current and/or voltage delivered, and by permitting the pacing pulse width to be variable, the pacemaker of the present invention can closely track the pacing threshold of the patient with a minimum expenditure of energy.
摘要翻译：公开了一种起搏器，其包括用于在起搏脉冲期间监测输送到心脏的电流和/或电压的电路。微处理器连接到监控电路并分析电流（和/或电压）以确定何时捕获发生。当发生捕获时，微处理器终止起搏脉冲以节省能量。相反，如果在预定的最大时间段内没有发生捕捉，或者如果起搏脉冲幅度低于预定阈值，则处理器立即引起安全脉冲点火以确保心脏的正常跳动。通过监测所输送的电流和/或电压，并且通过允许起搏脉冲宽度是可变的，本发明的起搏器可以以最小的能量消耗密切地跟踪患者的起搏阈值。

9. 发明授权

US07957784B2 Body surface mapping system 有权
标题翻译：身体表面测绘系统
公开(公告)号：US07957784B2
公开(公告)日：2011-06-07
申请号：US11647305
申请日：2006-12-29
申请人： Eric Jon Voth , Don Curtis Deno
发明人： Eric Jon Voth , Don Curtis Deno
IPC分类号： A61B5/04
CPC分类号： A61B5/04011 , A61B5/6805
摘要： A body-surface mapping system is disclosed that uses a plurality of electrodes to map at least a portion of a human torso without having to adjust the positions of the electrodes. The body-surface mapping system energizes groupings or regions of electrodes, then compares and adjusts the current driven through each grouping or region of electrodes to produce near-uniform fields. The electrodes of the body-surface mapping system may be interconnected by wires capable of sensing interelectrode distances, such that the system can reconstruct a detailed model of a patient's torso surface. The body-surface mapping system may also use a catheter in addition to the body surface electrodes to compute both endocardial and epicardial voltage distributions.
摘要翻译：公开了体表映射系统，其使用多个电极来映射人体躯干的至少一部分，而不必调整电极的位置。体表映射系统激励电极的分组或区域，然后比较和调整通过电极的每个分组或区域驱动的电流以产生近均匀的场。身体表面映射系统的电极可以通过能够感测电极间距离的导线相互连接，使得系统可以重建患者躯干表面的详细模型。除了身体表面电极之外，体表映射系统还可以使用导管来计算心内膜和心外膜电压分布。

10. 发明申请

US20100168735A1 SYSTEM AND METHOD FOR ASSESSING COUPLING BETWEEN AN ELECTRODE AND TISSUE 有权
标题翻译：用于评估电极和组织之间的耦合的系统和方法
公开(公告)号：US20100168735A1
公开(公告)日：2010-07-01
申请号：US12650060
申请日：2009-12-30
申请人： Don Curtis Deno , Stephan P. Miller , Lewis C. Hill , Yuriy Malinin , Haris Sih
发明人： Don Curtis Deno , Stephan P. Miller , Lewis C. Hill , Yuriy Malinin , Haris Sih
IPC分类号： A61B18/12
CPC分类号： A61B18/00 , A61B5/053 , A61B5/6885 , A61B5/6886 , A61B18/1233 , A61B18/14 , A61B18/1492 , A61B2018/00178 , A61B2018/00642 , A61B2018/00773 , A61B2018/00875 , A61B2090/065
摘要： A system and method for assessing a degree of coupling between an electrode and tissue in a body is provided. Values for first and second components of a complex impedance (e.g., resistance and reactance or impedance magnitude and phase angle) between the electrode and the tissue are obtained. These values are used together with a standardization value indicative of a deviation from a reference standard by a parameter associated with at least one of the body, the electrode and another component of the system to calculate a coupling index that is indicative of a degree of coupling between the electrode and the tissue. The coupling index may be displayed to a clinician in a variety of ways to indicate the degree of coupling to the clinician. The system and method find particular application in ablation of tissue by permitting a clinician to create lesions in the tissue more effectively and safely.
摘要翻译：提供了一种用于评估身体中电极和组织之间的耦合程度的系统和方法。获得电极和组织之间的复阻抗的第一和第二分量的值（例如，电阻和电抗或阻抗幅度和相位角）。这些值与表示与参考标准的偏差的标准化值一起使用与系统的主体，电极和另一部件中的至少一个相关联的参数来计算表示耦合度的耦合指数在电极和组织之间。耦合指数可以以各种方式显示给临床医生以指示与临床医生的耦合程度。该系统和方法通过允许临床医生更有效和安全地在组织中产生损伤来发现组织消融中的特定应用。

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