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81. 发明申请

US20060276623A1 Semi-synthetic glycopeptides with antibiotic activity 失效
公开(公告)号：US20060276623A1
公开(公告)日：2006-12-07
申请号：US11361852
申请日：2006-02-24
申请人： Daniel Chu , Maria Preobrazhenskaya , Svetlana Printsevskaya , Eugenia Olsufyeva
发明人： Daniel Chu , Maria Preobrazhenskaya , Svetlana Printsevskaya , Eugenia Olsufyeva
IPC分类号： C07K9/00 , A61K38/14
CPC分类号： A61K38/14 , C07K9/008
摘要： Semi-synthetic glycopeptides having antibacterial activity are based on modifications of the eremomycin, A82846B, vancomycin, teicoplanin, and A-40,926 scaffolds, in particular, acylation of the sugar moieties on these scaffolds with certain acyl groups; and/or conversion of an acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides; or having a combination of an alkylation modification of the amino substituent on the amino-substituted sugar moiety on these scaffolds with certain alkyl groups or acylation modification of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain alkyl groups, and conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

82. 发明申请

US20050141893A1 Power polarization beam combiner and its applications in fiber communication 失效
标题翻译：功率偏振光束组合器及其在光纤通信中的应用
公开(公告)号：US20050141893A1
公开(公告)日：2005-06-30
申请号：US10845093
申请日：2004-05-14
申请人： Chih-Tsung Shih , Chen-Bin Huang , Daniel Chu , Yu-Chen Yu
发明人： Chih-Tsung Shih , Chen-Bin Huang , Daniel Chu , Yu-Chen Yu
IPC分类号： G02B6/122 , G02B6/34 , G02B6/42 , H04J14/02
CPC分类号： G02B6/2726 , B82Y20/00 , G02B6/1225 , G02B6/2773
摘要： This specification discloses a power polarization beam combiner and its applications in fiber communications. The power polarization beam combiner uses the photonic band gap formed in a photonic crystal to produce a left-hand material with a negative refractive index and high dispersion rate. Using such properties of the photonic crystal, several beams with different wavelengths and polarizations are combined and output to a common port.
摘要翻译：本说明书公开了一种功率偏振光束组合器及其在光纤通信中的应用。功率偏振光束组合器使用形成在光子晶体中的光子带隙产生具有负折射率和高色散速率的左手材料。使用光子晶体的这种性质，将具有不同波长和偏振度的多个光束组合并输出到公共端口。

83. 发明申请

US20050124597A1 Novel guanidinyl derivatives 审中-公开
标题翻译：新型胍基衍生物
公开(公告)号：US20050124597A1
公开(公告)日：2005-06-09
申请号：US10503401
申请日：2003-02-03
申请人： Rustum Boyce , Daniel Chu , David P. Lentini
发明人： Rustum Boyce , Daniel Chu , David P. Lentini
IPC分类号： A61K31/33 , A61K38/00 , A61P3/10 , C07K5/078
CPC分类号： C07K5/06165 , A61K38/00 , C07K5/06139
摘要： A variety of small, guanidino group-containing molecules capable of acting as MC4-R agonists are provided. The compounds have various structures provided herein. The compounds are useful in treating MC4-R mediated diseases and may be formulated into pharmaceutical formulations and compositions.
摘要翻译：提供了能够作为MC4-R激动剂的各种含有胍基的小分子。化合物具有本文提供的各种结构。该化合物可用于治疗MC4-R介导的疾病，并且可以配制成药物制剂和组合物。

84. 发明申请

US20050009070A1 Localized temperature control for spatial arrays of reaction media 有权
标题翻译：反应介质空间阵列的局部温度控制
公开(公告)号：US20050009070A1
公开(公告)日：2005-01-13
申请号：US10851682
申请日：2004-05-21
申请人： German Arciniegas , Jeff Ceremony , Daniel Chu , Charles Ragsdale
发明人： German Arciniegas , Jeff Ceremony , Daniel Chu , Charles Ragsdale
IPC分类号： B01L3/00 , B01L7/00 , B01L9/06 , C12M1/34 , C12P19/34 , C12Q1/68
CPC分类号： B01L7/54 , B01L3/50851 , B01L7/52 , B01L9/06 , B01L2300/044 , B01L2300/0829 , B01L2300/12 , B01L2300/1805 , B01L2300/1822 , B01L2300/1838 , B01L2300/1883 , B01L2400/0475 , B01L2400/0487 , B01L2400/049
摘要： Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.
摘要翻译：在诸如多孔板的空间阵列中同时进行的多个反应中的单独温度控制通过具有单独控制的热电模块实现，每个模块从阵列内的单个区域提供热量或从其中提取热量，该区域包含单反应容器或一组反应容器。

85. 发明授权

US06759536B2 Polynucleotides encoding the fkbA gene of the FK-520 polyketide synthase gene cluster 有权
标题翻译：编码FK-520聚酮化合物基因簇的fkbA基因的多核苷酸
公开(公告)号：US06759536B2
公开(公告)日：2004-07-06
申请号：US09940316
申请日：2001-08-27
申请人： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
发明人： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC分类号： C07D22118
CPC分类号： C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
摘要： Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
摘要翻译：包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。

86. 发明授权

US06593302B2 Macrolide antiinfective agents 有权
标题翻译：大环内酯类抗感染药
公开(公告)号：US06593302B2
公开(公告)日：2003-07-15
申请号：US10075466
申请日：2002-02-13
申请人： Daniel Chu , Gary Ashley
发明人： Daniel Chu , Gary Ashley
IPC分类号： A61K3170
CPC分类号： C07H17/08 , Y02P20/55
摘要： Compounds of the formula wherein Ra is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); or ORa is replaced by H; Rb is H or halogen; Rc is H or a protecting group; Rd is methyl, unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); Re is H or a protecting group; L is methylene or carbonyl; T is —O—, —N(R)—, —N(OR)—, —N(NHCOR)—, —N(N═CHR)—, or —N(NHR)— wherein R is H or Ra as defined above, with the proviso that when L is methylene, T is —O—; one of Z and Y is H and the other is OH, protected OH, or amino, mono- or dialkylamino, protected amino, or an amino heterocycle or Z and Y together are ═O, ═NOH or a derivatized oxime; including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof, are antimicrobial agents.
摘要翻译：化学式R a的化合物是H; 取代或未取代的烷基（1-10C）; 取代或未取代的烯基（2-10C）; 取代或未取代的炔基（2-10C）; 取代或未取代的芳基（4-14C）; 取代或未取代的芳基烷基（5-20℃）; 或ORa被H代替; Rb是H或卤素; Rc是H或保护基; Rd是甲基，未取代的烷基（3-10C）; 取代的烷基（1-10C）; 取代或未取代的炔基（2-10C）; 取代或未取代的芳基（4-14C）; 取代或未取代的芳基烷基（5-20℃）; 取代或未取代的芳基烯基（5-20℃）; 取代或未取代的芳基炔基（5-20℃）; 取代或未取代的酰氨基芳基烷基（5-20℃）; 取代或未取代的酰氨基芳基烯基（5-20℃）; 或取代或未取代的酰氨基芳基炔基（5-20℃）; Re是H或保护基; L是亚甲基或羰基; T是-O-，-N（R） - ， - N（OR） - ， - N（NHCOR） - ，-N（N = CHR） - 或-N（NHR） - ，其中R是如上定义的H或Ra，条件是当L是亚甲基时，T是-O-; Z和Y之一是H 另一个是OH，保护的OH或氨基，单或二烷基氨基，保护的氨基或氨基杂环，或Z和Y一起为= O，= NOH或衍生的肟;包括其任何药学上可接受的盐和任何立体异构形式，其立体异构形式的混合物是抗微生物剂。

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