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1. 发明申请

US20090098615A1 GENETICALLY MODIFIED CELLS AND METHODS FOR CONVERTING (R)-METHYLMALONYL COA TO (S)-METHYLMALONYL COA 审中-公开
标题翻译：遗传修饰的细胞和将（R） - 甲基丙二醇转化为（S） - 甲基丙二醇的方法
公开(公告)号：US20090098615A1
公开(公告)日：2009-04-16
申请号：US11935351
申请日：2007-11-05
申请人： Daniel SANTI , Larry Peck , Linda Dayem , James Kealey
发明人： Daniel SANTI , Larry Peck , Linda Dayem , James Kealey
IPC分类号： C12P19/32
CPC分类号： C12N9/90 , C12P11/00 , C12P19/62
摘要： Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-type E. coli host cells.
摘要翻译：包含重组DNA表达载体的重组大肠杆菌宿主细胞可以产生S-甲基丙二酰辅酶A，这是通过大多数模块化聚酮化合物合成产生聚酮化合物所需的底物，所述重组DNA表达载体驱动丙酸杆菌或肉桂链霉菌分解酶丙酸杆菌歧化酶的甲基丙二酰CoA变位酶的表达不存在于野生型大肠杆菌宿主细胞中。

2. 发明申请

US20070092954A1 Production of polyketides 有权
标题翻译：聚酮化合物的生产
公开(公告)号：US20070092954A1
公开(公告)日：2007-04-26
申请号：US11200525
申请日：2005-08-08
申请人： Robert Arslanian , Gary Ashley , Scott Frykman , Bryan Julien , Leonard Katz , Chaitan Khosla , Janice Lau , Peter Licari , Rika Regentin , Daniel Santi , Li Tang
发明人： Robert Arslanian , Gary Ashley , Scott Frykman , Bryan Julien , Leonard Katz , Chaitan Khosla , Janice Lau , Peter Licari , Rika Regentin , Daniel Santi , Li Tang
IPC分类号： C12P17/00 , C07D417/02
CPC分类号： C07D405/06 , C07D313/00 , C07D413/06 , C07D417/06 , C07D491/04 , C12N1/20 , C12N9/00 , C12N15/52 , C12N15/74 , C12P17/00 , C12P17/16 , C12P17/167 , C12P17/181 , C12R1/01
摘要： Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
摘要翻译：重组粘球菌宿主细胞可用于产生聚酮化合物，包括可从发酵液中纯化并结晶的埃坡霉素和埃坡霉素类似物。

3. 发明申请

US20060106094A1 Synthetic discodermolide analogs 有权
标题翻译：合成discodermolide类似物
公开(公告)号：US20060106094A1
公开(公告)日：2006-05-18
申请号：US11261686
申请日：2005-10-28
申请人： Kurt Sundermann , Simon Shaw , Daniel Santi
发明人： Kurt Sundermann , Simon Shaw , Daniel Santi
IPC分类号： C07D309/30 , A61K31/366
CPC分类号： C07D309/30 , C07D307/33
摘要： Synthetic discodermolide analogs having utility as antiproliferative agents, having a structure represented by formula A where RA through RE and XA are as defined herein.
摘要翻译：具有用作抗增殖剂的合成的discodermolide类似物，其具有由式A表示的结构，其中R A至R E和X A A的定义如本文所定义。

4. 发明申请

US20050287645A1 Overproduction hosts for biosynthesis of polyketides 审中-公开
标题翻译：用于生物合成聚酮化合物的过量生产宿主
公开(公告)号：US20050287645A1
公开(公告)日：2005-12-29
申请号：US11019909
申请日：2004-12-21
申请人： Daniel Santi , Robert McDaniel , Li Tang , Chaitan Khosla
发明人： Daniel Santi , Robert McDaniel , Li Tang , Chaitan Khosla
IPC分类号： C12N15/09 , C12N1/21 , C12N15/52 , C12P19/62 , C12R1/01 , C12N15/74
CPC分类号： C12N15/52 , C12P19/62
摘要： Generic overproduction host cells can be used to produce any polyketide and obviate the need for performing conventional strain improvement.
摘要翻译：通常的过量产生宿主细胞可用于产生任何聚酮化合物，并且消除了进行常规应变改进的需要。

5. 发明授权

US06750205B2 Motilide compounds 有权
标题翻译：化合物
公开(公告)号：US06750205B2
公开(公告)日：2004-06-15
申请号：US10409429
申请日：2003-04-07
申请人： Gary Ashley , Mark Burlingame , Christopher Carreras , Daniel Santi
发明人： Gary Ashley , Mark Burlingame , Christopher Carreras , Daniel Santi
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR9, where R9 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R10 and R11 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl alkynylaryl or R2 and R3 together form a cycloalkyl or a cycloaryl moiety; R4 is hydrogen or methyl; R5 is hydrogen, hydroxyl, oxo, or together with R6 and the carbons to which they are attached form a cyclic carbonate; R6 is hydrogen, hydroxyl, OR12 where R12 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate; R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; R8 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, x is a single or a double bond.
摘要翻译：本发明提供下式的新型大环内酯化合物，其中R是羟基或甲氧基; R 1选自氢，羟基，卤素，NH 2，OR 9，其中R 9是C 1 -C 10 烷基，C 2 -C 10烯基，C 2 -C 10炔基，芳基或杂芳基，R 10和R 11各自独立地为氢，C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基或芳基; R 2和R 3各自独立地选自氢，C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，芳基，烷基芳基，烯基芳基炔基芳基或R 2和R 3一起形成环烷基或环芳基部分; R 4是氢或甲基; R 5是氢，羟基，氧代或与R 6一起，并且它们连接的碳形成环状碳酸酯; 其中R 12是C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，或与R 5一起形成的碳原子和它们所连接的碳原子形成环状碳酸酯; R 7是甲基，C 3 -C 10烷基，C 2 -C 10烯基，C 2 -C 10 炔基，烷基芳基，烯基芳基，炔基芳基，酰氨基烷基芳基，酰氨基烯基芳基或酰胺基炔基芳基; R 8是C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，烷基芳基，链烯基芳基，炔基芳基，酰氨基烷基芳基，酰胺基烯基芳基或酰胺基炔基芳基; x是单键或双键。

6. 发明授权

US06503737B1 Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster 有权
标题翻译：与FK-520聚酮化合物基因簇内的fkbA基因相关的分离的核酸
公开(公告)号：US06503737B1
公开(公告)日：2003-01-07
申请号：US09410551
申请日：1999-10-01
申请人： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
发明人： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC分类号： C12P1962
CPC分类号： C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
摘要： Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
摘要翻译：包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。

7. 发明申请

US20090186378A1 Polynucleotides encoding the fkbB gene of the FK-520 polyketide synthase gene cluster 有权
标题翻译：编码FK-520聚酮化合物基因簇的fkbB基因的多核苷酸
公开(公告)号：US20090186378A1
公开(公告)日：2009-07-23
申请号：US10885305
申请日：2004-07-06
申请人： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
发明人： Christopher Reeves , Daniel Chu , Chaitan Khosla , Daniel Santi , Kai Wu
IPC分类号： C12P21/04 , C12N15/11 , C12P17/16 , C12N1/21 , C12N15/00
CPC分类号： C07D498/18 , C07K2319/00 , C12N9/1029 , C12N9/1205 , C12N15/52 , C12P17/188 , C12P19/32
摘要： Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
摘要翻译：包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。

8. 发明申请

US20090111869A1 BENZOQUINONE ANSAMYCINS 审中-公开
标题翻译：苯并喹酮安慰剂
公开(公告)号：US20090111869A1
公开(公告)日：2009-04-30
申请号：US12141732
申请日：2008-06-18
申请人： Daniel SANTI , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
发明人： Daniel SANTI , David C. Myles , Zong-Qiang Tian , C. Richard Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
IPC分类号： A61K31/395 , A61P35/00 , A61K31/337 , A61K31/366
CPC分类号： C07D491/08 , C07D225/06
摘要： The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
摘要翻译：本发明涉及可用于治疗癌症和其它特征在于不期望的细胞增殖或过度增殖的其它疾病或病症的苯醌安莎霉素类似物。涉及施用这样的苯醌安莎霉素类似物（任选地与HSP90客户蛋白质的抑制剂组合）的治疗可用于治疗癌症和非癌性疾病状况。

9. 发明申请

US20070270396A1 Geldanamycin compounds and method of use 有权
公开(公告)号：US20070270396A1
公开(公告)日：2007-11-22
申请号：US11825501
申请日：2007-07-06
申请人： Daniel Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
发明人： Daniel Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
IPC分类号： A61K31/395 , C07D225/06
CPC分类号： A61K31/33 , A61K31/675 , A61K31/7052 , C07D225/00
摘要： Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.

10. 发明授权

US07011959B1 Heterologous production of polyketides 有权
标题翻译：聚酮化合物的异源生产
公开(公告)号：US07011959B1
公开(公告)日：2006-03-14
申请号：US09699136
申请日：2000-10-27
申请人： Daniel Santi , Larry Peck , Linda Dayem , James Kealey
发明人： Daniel Santi , Larry Peck , Linda Dayem , James Kealey
IPC分类号： C12P19/62
CPC分类号： C12N9/90 , C12P11/00 , C12P19/62
摘要： Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases and is not present in wild-type E. coli host cells.
摘要翻译：包含重组DNA表达载体的重组大肠杆菌宿主细胞可以产生S-甲基丙二酰辅酶A，其是通过大多数模块化聚酮化合物生产聚酮化合物所需的底物，该重组DNA表达载体驱动来自丙酸杆菌或肉桂链霉菌分解酶的丙糖酰基辅酶A变位酶的表达合成酶并且不存在于野生型大肠杆菌宿主细胞中。

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