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1. 发明申请

US20050009070A1 Localized temperature control for spatial arrays of reaction media 有权
标题翻译：反应介质空间阵列的局部温度控制
公开(公告)号：US20050009070A1
公开(公告)日：2005-01-13
申请号：US10851682
申请日：2004-05-21
申请人： German Arciniegas , Jeff Ceremony , Daniel Chu , Charles Ragsdale
发明人： German Arciniegas , Jeff Ceremony , Daniel Chu , Charles Ragsdale
IPC分类号： B01L3/00 , B01L7/00 , B01L9/06 , C12M1/34 , C12P19/34 , C12Q1/68
CPC分类号： B01L7/54 , B01L3/50851 , B01L7/52 , B01L9/06 , B01L2300/044 , B01L2300/0829 , B01L2300/12 , B01L2300/1805 , B01L2300/1822 , B01L2300/1838 , B01L2300/1883 , B01L2400/0475 , B01L2400/0487 , B01L2400/049
摘要： Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within the array, the region containing either a single reaction vessel or a group of reaction vessels.
摘要翻译：在诸如多孔板的空间阵列中同时进行的多个反应中的单独温度控制通过具有单独控制的热电模块实现，每个模块从阵列内的单个区域提供热量或从其中提取热量，该区域包含单反应容器或一组反应容器。

2. 发明申请

US20060246572A1 AUTOMATIC ELECTROPORATION OPTIMIZATION SYSTEM 审中-公开
标题翻译：自动电机优化系统
公开(公告)号：US20060246572A1
公开(公告)日：2006-11-02
申请号：US11458039
申请日：2006-07-17
申请人： Charles Ragsdale , Julie Moore , William Heiser , Tony Chiu , Keith Kaste
发明人： Charles Ragsdale , Julie Moore , William Heiser , Tony Chiu , Keith Kaste
IPC分类号： C12M1/42
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/0476 , A61N1/30
摘要： Systems, methods and algorithms for automatically performing optimization of an electroporation system. A system according to the present invention typically includes a cuvette holding assembly configured to hold a plurality of electroporation cuvettes, wherein each cuvette includes a first and second electrode, and a shocking chamber configured to hold the cuvette holding assembly, the chamber having a commutator assembly configured to provide an electrical contact to the first electrode of each of the plurality of cuvettes in turn. The system also typically includes a control system communicably coupled to the shocking chamber, wherein the control system controls the commutator to automatically contact the first electrode of each cuvette in an order and to provide a potential across the cuvette electrodes when contact is made.
摘要翻译：用于自动执行电穿孔系统优化的系统，方法和算法。根据本发明的系统通常包括配置成容纳多个电穿孔比色皿的比色皿保持组件，其中每个比色皿包括第一和第二电极，以及构造成保持反应杯保持组件的震动室，所述室具有换向器组件被配置为依次向所述多个比色皿中的每一个的第一电极提供电接触。该系统还通常包括可通信地耦合到震动室的控制系统，其中控制系统控制换向器以按顺序自动接触每个反应杯的第一电极，并且当接触时提供穿过反应杯电极的电位。

3. 发明申请

US20070112260A1 Manual and automatic probe calibration 失效
标题翻译：手动和自动探头校准
公开(公告)号：US20070112260A1
公开(公告)日：2007-05-17
申请号：US11640077
申请日：2006-12-15
申请人： Mohamed Diab , Massi Kiani , Charles Ragsdale , James Lepper
发明人： Mohamed Diab , Massi Kiani , Charles Ragsdale , James Lepper
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/0205 , A61B5/02427 , A61B5/14552 , A61B5/6826 , A61B5/6838 , A61B2562/08 , G01J3/02 , G01J3/0254 , G01J3/027 , G01J3/0275 , G01J3/0291 , G01J3/10 , G01J2003/2866 , G01N21/255 , G01N21/274 , G01N21/31 , G01N21/3151 , G01N21/39 , G01N2021/3144 , G01N2201/0627
摘要： Embodiments of the present disclosure include an optical probe capable of communicating identification information to a patient monitor in addition to signals indicative of intensities of light after attenuation by body tissue. The identification information may indicate operating wavelengths of light sources, indicate a type of probe, such as, for example, that the probe is an adult probe, a pediatric probe, a neonatal probe, a disposable probe, a reusable probe, or the like. The information could also be utilized for security purposes, such as, for example, to ensure that the probe is configured properly for the oximeter, to indicate that the probe is from an authorized supplier, or the like. In one preferred embodiment, coding resistors could be provided across the light sources to allow additional information about the probe to be coded without added leads. However, any device could be used without it being used in parallel.
摘要翻译：本公开的实施例还包括能够向身体组织衰减之后除了表示光强度的信号之外，向患者监视器传送识别信息的光学探针。识别信息可以指示光源的操作波长，指示探针的类型，例如探针是成人探针，儿科探针，新生儿探针，一次性探针，可重复使用的探针等。该信息也可以用于安全目的，例如，以确保探针被适当地配置用于血氧计，以指示探针来自授权供应商等。在一个优选实施例中，编码电阻器可以跨越光源提供，以允许关于探针的附加信息被编码而没有添加引线。但是，任何设备都可以在没有并行使用的情况下使用。

4. 发明申请

US20060274922A1 Imaging method and apparatus 有权
标题翻译：成像方法和装置
公开(公告)号：US20060274922A1
公开(公告)日：2006-12-07
申请号：US10829407
申请日：2004-04-20
申请人： Charles Ragsdale
发明人： Charles Ragsdale
IPC分类号： G06K9/00
CPC分类号： G01N21/6452 , G01N2021/4709 , G01N2021/6419 , G01N2021/6471 , G01N2201/067 , G01N2201/0691
摘要： A method is provided for measuring a response to a stimulus of a plurality of samples spots of a sample using a measuring system having a measurement range to generate an image of the sample in digital space. The method includes, for each sample, while measuring the response, varying the stimulus to include at least one stimulus value where the measured response corresponds to a value in an intermediate portion of the measuring range, and storing a value of the measured response that corresponds to a value in the intermediate portion of the measurement range, and the stimulus value that produced that value of the measured response.
摘要翻译：提供一种用于使用具有测量范围的测量系统来测量对样本的多个采样点的刺激的响应的方法，以在数字空间中生成样本的图像。该方法包括对于每个样本，在测量响应的同时，改变刺激以包括至少一个刺激值，其中测量的响应对应于测量范围的中间部分中的值，并且存储对应于测量范围的测量响应的值到测量范围的中间部分中的值，以及产生测量响应值的刺激值。

5. 发明授权

US08222909B2 Electroporation system with dial-in time constant 有权
标题翻译：电穿孔系统具有拨入时间常数
公开(公告)号：US08222909B2
公开(公告)日：2012-07-17
申请号：US12535289
申请日：2009-08-04
申请人： Charles Ragsdale
发明人： Charles Ragsdale
IPC分类号： G01R27/08 , G01R25/00 , C12N13/00
CPC分类号： C12N13/00 , C12M35/02
摘要： Methods, systems, and apparatus provide an accurate time constant for electroporation. A model voltage function is created (analog, digital, or combination) to provide a model voltage having the desired time constant. A voltage is applied to the sample. A comparing circuit compares the output voltage, which may be attenuated, to the model voltage and provides an output control signal. This output signal is used to modify a resistance in parallel with the sample, thereby altering the output voltage to approximate the model voltage, which has the desired time constant. In one aspect, the control signal may be used to turn on and off a transistor that is in series with a resistor in order to modify the parallel resistance.
摘要翻译：方法，系统和装置为电穿孔提供准确的时间常数。产生模型电压功能（模拟，数字或组合）以提供具有所需时间常数的模型电压。对样品施加电压。比较电路将可能衰减的输出电压与模型电压进行比较，并提供输出控制信号。该输出信号用于与样本并行地修改电阻，从而改变输出电压以接近具有期望时间常数的模型电压。在一个方面，控制信号可以用于接通和关断与电阻器串联的晶体管，以便改变并联电阻。

6. 发明申请

US20080106238A1 Resistor pulse modulation 有权
标题翻译：电阻脉冲调制
公开(公告)号：US20080106238A1
公开(公告)日：2008-05-08
申请号：US11857679
申请日：2007-09-19
申请人： Charles Ragsdale
发明人： Charles Ragsdale
IPC分类号： H02J7/00
CPC分类号： C12N13/00 , A61N1/327 , C12M35/02 , H03K3/53
摘要： Systems, methods, apparatus, and circuits for controlling an electrical signal transmitted to a sample load are provided. The electrical signal produced by a capacitor is controlled via a control signal sent to a variable resistance device that is connected in parallel with the sample load. The variable resistance device includes a resistance and a switch in series. The control signal opens and closes the switch, thus providing a variable resistance based on the amount of time the switch is closed.
摘要翻译：提供了用于控制传输到样本负载的电信号的系统，方法，装置和电路。由电容器产生的电信号通过发送到与样本负载并联连接的可变电阻器件的控制信号进行控制。可变电阻装置包括电阻和串联的开关。控制信号打开和关闭开关，从而根据开关关闭的时间量提供可变电阻。

7. 发明申请

US20100049372A1 ELECTROPORATION SYSTEM WITH DIAL-IN TIME CONSTANT 有权
标题翻译：具有DIAL-IN时间的电气系统
公开(公告)号：US20100049372A1
公开(公告)日：2010-02-25
申请号：US12535289
申请日：2009-08-04
申请人： Charles Ragsdale
发明人： Charles Ragsdale
IPC分类号： G06F1/26 , C12N13/00 , C12M1/42
CPC分类号： C12N13/00 , C12M35/02
摘要： Methods, systems, and apparatus provide an accurate time constant for electroporation. A model voltage function is created (analog, digital, or combination) to provide a model voltage having the desired time constant. A voltage is applied to the sample. A comparing circuit compares the output voltage, which may be attenuated, to the model voltage and provides an output control signal. This output signal is used to modify a resistance in parallel with the sample, thereby altering the output voltage to approximate the model voltage, which has the desired time constant. In one aspect, the control signal may be used to turn on and off a transistor that is in series with a resistor in order to modify the parallel resistance.
摘要翻译：方法，系统和装置为电穿孔提供准确的时间常数。产生模型电压功能（模拟，数字或组合）以提供具有所需时间常数的模型电压。对样品施加电压。比较电路将可能衰减的输出电压与模型电压进行比较，并提供输出控制信号。该输出信号用于与样本并行地修改电阻，从而改变输出电压以接近具有期望时间常数的模型电压。在一个方面，控制信号可以用于接通和关断与电阻器串联的晶体管，以便改变并联电阻。

8. 发明申请

US20070249036A1 Apparatus for High-Throughput Electroporation 有权
标题翻译：高通量电穿孔仪
公开(公告)号：US20070249036A1
公开(公告)日：2007-10-25
申请号：US11627235
申请日：2007-01-25
申请人： Charles Ragsdale , John Fuller , Nicholas Stephens
发明人： Charles Ragsdale , John Fuller , Nicholas Stephens
IPC分类号： C12M1/42
CPC分类号： C12M35/02 , C12M23/12
摘要： An electroporator for high-throughput electroporation is constructed with a well plate in which each well has internal electrodes that extend beyond the opening of the well to form contact areas, either as horizontal platforms extending laterally from the well rims or as extended heights of thin electrode plates. The electroporator also includes a lid that contains circuitry and electrical contacts that mate with the exposed contact areas in the well plate. The interchangeability of lids allows the wells to be shocked according to different protocols.
摘要翻译：用于高通量电穿孔的电穿孔机构造有井板，其中每个井具有延伸超过井的开口的内部电极以形成接触区域，或者作为从井壁横向延伸的水平平台或者作为薄电极的扩展高度盘子电动机还包括盖子，其包含与孔板中暴露的接触区域相配合的电路和电触点。盖子的互换性允许孔根据不同的方案而受到冲击。

9. 发明申请

US20070231873A1 MULTI-CHANNEL ELECTROPORATION SYSTEM 失效
标题翻译：多通道电气系统
公开(公告)号：US20070231873A1
公开(公告)日：2007-10-04
申请号：US11567373
申请日：2006-12-06
申请人： Charles Ragsdale
发明人： Charles Ragsdale
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12N13/00 , C12M35/02
摘要： Systems, methods and apparatus provide flexible and efficient high throughput electroporation systems. An electrical pulse may be transmitted to any number of channels of a multi-channel sample plate. Drivers can provide the selection of which channels to transmit the electrical pulse. To provide efficient transitions between electrical pulses, discharge circuits provide efficient means achieve a desired voltage.
摘要翻译：系统，方法和设备提供灵活高效的高通量电穿孔系统。电脉冲可以传输到多通道样品板的任何数量的通道。驱动器可以选择哪些通道来传输电脉冲。为了在电脉冲之间提供有效的转换，放电电路提供实现所需电压的有效装置。

10. 发明申请

US20070092125A1 Imaging method and apparatus 有权
标题翻译：成像方法和装置
公开(公告)号：US20070092125A1
公开(公告)日：2007-04-26
申请号：US11638602
申请日：2006-12-12
申请人： Charles Ragsdale
发明人： Charles Ragsdale
IPC分类号： G06K9/00
CPC分类号： G01N21/6452 , G01N2021/4709 , G01N2021/6419 , G01N2021/6471 , G01N2201/067 , G01N2201/0691
摘要： A method is provided for measuring a response to a stimulus of a plurality of samples spots of a sample using a measuring system having a measurement range to generate an image of the sample in digital space. The method includes, for each sample, while measuring the response, varying the stimulus to include at least one stimulus value where the measured response corresponds to a value in an intermediate portion of the measuring range, and storing a value of the measured response that corresponds to a value in the intermediate portion of the measurement range, and the stimulus value that produced that value of the measured response.
摘要翻译：提供一种用于使用具有测量范围的测量系统来测量对样本的多个采样点的刺激的响应的方法，以在数字空间中生成样本的图像。该方法包括对于每个样本，在测量响应的同时，改变刺激以包括至少一个刺激值，其中测量的响应对应于测量范围的中间部分中的值，并且存储对应于测量范围的测量响应的值到测量范围的中间部分中的值，以及产生测量响应值的刺激值。

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