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81. 发明授权

US3940382A 1,2'-Di-N-substituted kanamycin B compounds 失效
标题翻译： 1,2 {40-N-取代卡那霉素B化合物
公开(公告)号：US3940382A
公开(公告)日：1976-02-24
申请号：US499601
申请日：1974-08-22
申请人： Hamao Umezawa , Kenji Maeda , Shinichi Kondo , Sumio Umezawa
发明人： Hamao Umezawa , Kenji Maeda , Shinichi Kondo , Sumio Umezawa
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , B01J23/00 , C07B61/00 , C07H15/236 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： New antibacterial agents, 1,2'-di-N-(.alpha.-hydroxyaminoacyl)-kanamycin B and 1,2'-di-N-(.alpha.-hydroxyaminoacyl)-3',4'-dideoxy kanamycin B are described together with methods for their preparation and use.
摘要翻译：新的抗菌剂，1,2'-二-N-（α-羟基氨基酰基） - 卡那霉素B和1,2'-二-N-（α-羟基氨基酰基）-3'，4'-双脱氧卡那霉素B与其准备和使用方法。

82. 发明授权

US08871980B2 Process for producing hydrogen or heavy hydrogens, and hydrogenation (protiation, deuteration or tritiation) of organic compounds using same 有权
标题翻译：生产氢或重氢的方法，以及使用它们的有机化合物的氢化（促进，氘化或氚化）
公开(公告)号：US08871980B2
公开(公告)日：2014-10-28
申请号：US13817637
申请日：2011-08-16
申请人： Hironao Sajiki , Yasunari Monguchi , Yoshinari Sawama , Shinichi Kondo
发明人： Hironao Sajiki , Yasunari Monguchi , Yoshinari Sawama , Shinichi Kondo
IPC分类号： B01J31/00 , B01J37/00 , C08F4/02 , C08F4/60 , C07C209/00 , C07C45/61 , C07C41/24 , C07C41/26 , C01B3/08 , C07B35/02 , C01B4/00 , C07C29/17 , C07B35/06 , C07C5/10 , C07C221/00 , C07C29/143 , C07C213/02 , C07B59/00 , C07C209/36 , C07C1/26 , C07C5/09 , C07B31/00 , C07C41/20
CPC分类号： C01B3/10 , C01B3/08 , C01B4/00 , C01B2203/0277 , C01B2203/1047 , C01B2203/1064 , C07B31/00 , C07B35/02 , C07B35/06 , C07B59/00 , C07B2200/05 , C07C1/26 , C07C5/09 , C07C5/10 , C07C29/143 , C07C29/17 , C07C41/20 , C07C41/24 , C07C41/26 , C07C45/61 , C07C209/36 , C07C213/02 , C07C221/00 , C07C2523/745 , C07C2601/14 , Y02E60/364 , C07C215/68 , C07C211/58 , C07C217/84 , C07C225/22 , C07C33/20 , C07C43/2055 , C07C33/22 , C07C43/205 , C07C43/23 , C07C49/807 , C07C15/18 , C07C13/28 , C07C15/24 , C07C15/52 , C07C9/15
摘要： An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.
摘要翻译：本发明的目的是提供一种方便地提供氢或重氢的方法，而不需要大规模设备和能够方便地进行氢化（促进，氘化或氚化）反应的方法，而不需要使用昂贵的试剂和特殊的催化剂。生产方法包括生产氢或重氢的方法，包括在催化剂金属存在下使水或重水进行机械化学反应，以及生产氢化（肟化或氘代或氚化）有机化合物的方法，有机化合物和水或重水在催化剂金属存在下进行机械化学反应。

83. 发明授权

US08202613B2 Multilayer pellet and method for producing the same 有权
标题翻译：多层颗粒及其制造方法
公开(公告)号：US08202613B2
公开(公告)日：2012-06-19
申请号：US11434204
申请日：2006-05-16
申请人： Shinichi Kondo , Takashi Sanada
发明人： Shinichi Kondo , Takashi Sanada
IPC分类号： B32B5/66
CPC分类号： C08F255/00 , B29B9/12 , B29C47/0011 , B29C47/06 , B29C2793/009 , B29K2025/00 , B29K2055/02 , B29K2059/00 , B29K2067/00 , B29K2067/006 , B29K2069/00 , B29K2075/00 , B29K2077/00 , B29K2079/08 , B29K2105/0008 , B29K2105/0026 , B29K2105/0032 , B29K2105/0044 , B29K2105/005 , B29K2105/16 , C08F255/02 , C08F285/00 , C08J3/12 , C08L51/006 , C08L51/06 , C08L53/00 , C08L55/02 , Y10T428/2991 , Y10T428/2998 , C08L2666/02
摘要： Disclosed are multilayer pellets comprising a core of a first material comprising a first thermoplastic resin and a sheath layer of a second material comprising a second thermoplastic resin, the sheath layer surrounding the core, wherein (i) the first thermoplastic resin has a melt index, measured at a temperature of 230° C. and a load of 21.2 N, of 200 g/10 min or more, provided that the melt index of the second thermoplastic resin measured at a temperature of 230° C. and a load of 21.2 N is different from that of the first thermoplastic resin or (ii) the first thermoplastic resin is a modified thermoplastic resin having a structure originating in a compound having an unsaturated group.
摘要翻译：公开了包括第一材料的芯的多层颗粒，其包含第一热塑性树脂和包含第二热塑性树脂的第二材料的皮层，所述第一热塑性树脂的芯层包围芯，其中（i）第一热塑性树脂具有熔融指数，在230℃的温度和21.2N的负荷下测定为200g / 10分钟以上，条件是在230℃的温度和21.2N的负荷下测定的第二热塑性树脂的熔体指数与第一热塑性树脂不同，或（ii）第一热塑性树脂是具有起源于具有不饱和基团的化合物的结构的改性热塑性树脂。

84. 发明申请

US20110300068A1 AGENT FOR PROPHYLAXIS OR TREATMENT OF CANCER 审中-公开
标题翻译：癌症预防或治疗药物
公开(公告)号：US20110300068A1
公开(公告)日：2011-12-08
申请号：US13138146
申请日：2010-01-12
申请人： Tatsuya Watanabe , Shinichi Kondo , Ryosuke Katsuyama
发明人： Tatsuya Watanabe , Shinichi Kondo , Ryosuke Katsuyama
IPC分类号： A61K51/10 , A61P35/00 , G01N33/574 , A61K49/00 , C07K16/22 , A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention provides an agent for the prophylaxis or treatment of kidney cancer or urinary bladder cancer, and a diagnostic reagent for these cancers which comprise an antibody against nerve growth factor 2/neurotrophin-3 or a partial peptide thereof or a salt thereof, which antibody neutralizes nerve growth factor 2/neurotrophin-3 and does not cross-react with the Nerve Growth Factor.
摘要翻译：本发明提供了预防或治疗肾癌或膀胱癌的药剂，以及这些癌症的诊断试剂，其包含抗神经生长因子2 /神经营养因子-3或其部分肽或其盐的抗体，其中抗体中和神经生长因子2 /神经营养因子-3，并且不与神经生长因子交叉反应。

85. 发明申请

US20100144658A1 NOVEL ANTIBIOTICS, BISPOLIDES A1, A2, AND A3 AS WELL AS BISPOLIDES B1, B2A, B2B AND B3 AND PROCESSES FOR PRODUCING SAID ANTIBIOTICS 有权
标题翻译：新型抗生素，BISPOLIDES A1，A2和A3作为双酚A B1，B2A，B2B和B3以及生产抗生素的方法
公开(公告)号：US20100144658A1
公开(公告)日：2010-06-10
申请号：US12300468
申请日：2007-05-15
申请人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
发明人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
IPC分类号： A61K31/7048 , A61P31/04 , C07H17/08 , C12P19/60 , C12N1/20
CPC分类号： C07H17/04 , A61K31/04 , A61K31/7048 , C12P17/08 , A61K2300/00
摘要： Seven novel antibiotic substances could be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below. These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in human and animals.The general formula (III):
摘要翻译：可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株产生七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。这些双吡啶衍生物是具有如以下通式（III）统称的化学结构的新化合物。这些双糖苷酸各自对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高的抗菌活性，因此这些双吡啶苷各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。通式（III）：

86. 发明申请

US20100086911A1 PREVENTIVE/THERAPEUTIC AGENT FOR CANCER 审中-公开
标题翻译：癌症预防/治疗药物
公开(公告)号：US20100086911A1
公开(公告)日：2010-04-08
申请号：US11885447
申请日：2006-03-02
申请人： Ryosuke Katsuyama , Shinichi Kondo
发明人： Ryosuke Katsuyama , Shinichi Kondo
IPC分类号： C12Q1/68 , C07K16/00 , C07H21/00 , C12N5/00 , C12Q1/02 , G01N33/53 , C07K14/00
CPC分类号： G01N33/57407 , G01N33/5011 , G01N33/57415 , G01N2510/00
摘要： Identification of a novel target molecule for preventing/treating cancer and a preventive/remedy agent for cancer which targets the molecule, specifically, an agent for promoting the apoptosis in cancer cells and/or inhibiting the growth of cancer cells and a preventive/remedy agent for cancer, which comprise an antibody against a protein including the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or SEQ ID NO: 10; an antisense polynucleotide of the protein (preferably, siRNA against mRNA of the protein); and a substance controlling the expression and/or activity of the protein, are provided by the present invention. A method of screening for a substance that promotes apoptosis in cancer cells and/or inhibits the growth of cancer cells and a preventive/remedy substance for cancer, in which the method comprises using a protein (preferably a cell producing the protein), an antibody against the protein, or a polynucleotide encoding the protein, is also provided by the present invention.
摘要翻译：用于预防/治疗癌症的新型靶分子的鉴定和靶向分子的癌症的预防/补救剂，特别是用于促进癌细胞凋亡和/或抑制癌细胞生长的药剂和预防/补救剂包括与包含与SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8所示的氨基酸序列相同或基本上相同的氨基酸序列的蛋白质的抗体，或SEQ ID NO：10; 蛋白质的反义多核苷酸（优选地，针对蛋白质的mRNA的siRNA）; 和控制蛋白质的表达和/或活性的物质由本发明提供。一种筛选促进癌细胞凋亡和/或抑制癌细胞生长的物质和癌症预防/治疗物质的方法，其中该方法包括使用蛋白质（优选产生该蛋白质的细胞），抗体本发明还提供了针对蛋白质或编码该蛋白质的多核苷酸。

87. 发明授权

US07300982B2 Process for producing modified polyethylene resin 失效
标题翻译：生产改性聚乙烯树脂的方法
公开(公告)号：US07300982B2
公开(公告)日：2007-11-27
申请号：US10800672
申请日：2004-03-16
申请人： Shinichi Kondo , Takashi Sanada
发明人： Shinichi Kondo , Takashi Sanada
IPC分类号： C08F267/04 , C08F255/02
CPC分类号： C08F255/00 , C08F255/02
摘要： A process for producing a modified polyethylene resin, which comprises the step of melt kneading at least: (A) 100 parts by weight of a polyethylene resin, (B) from 0.1 to 20 parts by weight of at least one compound selected from the group consisting of: (B1) a compound having in its molecule (i) at least one carbon-carbon double or triple bond and (ii) at least one polar group, and (B2) a compound having in its molecule (iii) an OR group and (iv) at least two specific functional groups, and (C) from 0.01 to 20 parts by weight of an organic peroxide having a decomposition temperature of from 50 to 115° C., at which temperature a half-life thereof is 1 minute.
摘要翻译：一种改性聚乙烯树脂的制造方法，其特征在于，至少将（A）100重量份的聚乙烯树脂，（B），0.1〜20重量份的至少一种选自包括：（B1）在其分子中具有（i）至少一个碳 - 碳双键或三键的化合物和（ii）至少一个极性基团，和（B2）在其分子中具有（OR）OR 基团和（iv）至少两个特定官能团，和（C）0.01至20重量份的分解温度为50-115℃的有机过氧化物，其中半衰期为1 分钟。

88. 发明授权

US06913105B2 Shock-absorbing mechanism for power-transmission device 有权
标题翻译：动力传动装置的减震机构
公开(公告)号：US06913105B2
公开(公告)日：2005-07-05
申请号：US10403010
申请日：2003-04-01
申请人： Toshiyuki Masuda , Masao Sakamoto , Shinichi Kondo , Masao Kishi
发明人： Toshiyuki Masuda , Masao Sakamoto , Shinichi Kondo , Masao Kishi
IPC分类号： B60K17/22 , B60K17/24 , F16D3/84 , F16F7/12 , B60K17/02 , B60K17/26
CPC分类号： B60K17/24 , F16F7/12
摘要： A shock-absorbing mechanism for a power-transmission device includes a cylindrical driven-side shaft coupled to the driving-side shaft through a constant-velocity joint to be axially relatively slidable with respect to the driving-side shaft, a center bearing for rotatably supporting the driving-side shaft to the vehicle body, and a labyrinth mechanism for sealing the inside of the center bearing. An end of the driven-side shaft on the side of the driving-side shaft is disposed axially opposite to the labyrinth mechanism. When the two shafts are slid in the direction to approach each other by an axial load input thereto, the end of the driven-side shaft collides axially with the labyrinth mechanism.
摘要翻译：用于动力传递装置的减震机构包括：圆柱形从动侧轴，其通过等速度接头联接到驱动侧轴线，以相对于驱动侧轴轴向相对滑动;中心轴承，用于可旋转将驱动侧轴支撑到车身，以及用于密封中心轴承内部的迷宫机构。驱动侧轴侧的从动侧轴的端部与迷宫机构轴向地相对配置。当两轴通过输入轴向载荷彼此接近的方向滑动时，从动侧轴的端部与迷宫机构轴向碰撞。

89. 发明申请

US20050080198A1 Process for producing modified polyolefin resin 失效
标题翻译：改性聚烯烃树脂的制造方法
公开(公告)号：US20050080198A1
公开(公告)日：2005-04-14
申请号：US10865897
申请日：2004-06-14
申请人： Shinichi Kondo , Takashi Sanada
发明人： Shinichi Kondo , Takashi Sanada
IPC分类号： C08F255/00 , C08F255/02 , C08F287/00 , C08F16/00
CPC分类号： C08F287/00 , C08F255/00 , C08F255/02 , C08F220/34
摘要： There is provided a process for producing a modified polyolefin resin, which comprises the step of melt kneading at least the following components (A), (B) and (C): (A) 100 parts by weight of a polyolefin resin, (B) from 0.1 to 20 parts by weight of a compound containing an amino group and an unsaturated bond, and (C) from 0.01 to 20 parts by weight of an organic peroxide.
摘要翻译：提供一种改性聚烯烃树脂的制造方法，其特征在于，至少将以下成分（A），（B）和（C）熔融混炼的步骤：（A）将100重量份聚烯烃树脂（B ）0.1〜20重量份含有氨基和不饱和键的化合物，（C）0.01〜20重量份的有机过氧化物。

90. 发明授权

US5849797A D-.beta.-lysylmethanediamine derivatives and preparation thereof 失效
标题翻译： D-β-赖氨酰基甲二胺衍生物及其制备
公开(公告)号：US5849797A
公开(公告)日：1998-12-15
申请号：US793912
申请日：1997-02-24
申请人： Shinichi Kondo , Yoko Ikeda , Tomio Takeuchi , Rie Shinei , Shuichi Gomi , Seiji Shibahara , Hiroo Hoshino
发明人： Shinichi Kondo , Yoko Ikeda , Tomio Takeuchi , Rie Shinei , Shuichi Gomi , Seiji Shibahara , Hiroo Hoshino
IPC分类号： A61K31/16 , A61P31/12 , A61P31/18 , A61P37/04 , C07C231/02 , C07C231/12 , C07C237/10 , C07C233/05
CPC分类号： C07C237/10
摘要： Now are provided (R)-3,6-diamino-N-(.omega.-aminoalkyl)-hexanamides which are novel compounds having the general formula (I): ##STR1## wherein n stands for 2-5, and which may be for example, (R)-3,6-diamino-N-(2-aminoethyl)hexanamide (n=2) and (R)-3,6-diamino-N-(3-aminopropyl)hexanamide (n=3). Their preparation process is also provided. These novel compounds and acid addition salts thereof have activities inhibitory against Gram-positive bacteria, Gram-negative bacteria and AIDS virus, as well as tumor cells and are chemically stable. These novel compounds and their salts are useful as chemotherapeutic agents for diseases caused by these bacteria or virus and also as antitumor agent.
摘要翻译： PCT No.PCT / JP95 / 01680 Sec。 371日期1997年2月24日 102（e）1997年2月24日PCT PCT 1995年8月24日PCT公布。公开号WO96 / 06069 日期：1996年2月29日提供（R）-3,6-二氨基-N-（ω-氨基烷基） - 己酰胺，它们是具有通式（I）的新化合物：其中n代表2 -5，其可以是例如（R）-3,6-二氨基-N-（2-氨基乙基）己酰胺（n = 2）和（R）-3,6-二氨基-N-（3-氨基丙基）己酰胺（n = 3）。还提供了他们的准备过程。这些新化合物及其酸加成盐具有抑制革兰氏阳性菌，革兰氏阴性菌和艾滋病病毒以及肿瘤细胞的活性，并具有化学稳定性。这些新化合物及其盐可用作由这些细菌或病毒引起的疾病的化学治疗剂，也可用作抗肿瘤剂。

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