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81. 发明授权

US07416558B2 Drug-eluting stent cover and method of use 有权
标题翻译：药物洗脱支架盖及使用方法
公开(公告)号：US07416558B2
公开(公告)日：2008-08-26
申请号：US11497706
申请日：2006-08-01
申请人： Philip S. Yip , James Jacobs , Syed Hossainy , Jon Becker , Timothy A. Limon
发明人： Philip S. Yip , James Jacobs , Syed Hossainy , Jon Becker , Timothy A. Limon
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/90 , A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/005 , A61F2250/0036 , A61F2250/0067 , A61F2250/0071 , Y10S623/903
摘要： An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.
摘要翻译：血管内支架包括由用于控制释放治疗药物的网格和用于在血管中局部药物治疗中递送治疗药物的筛网制成的洗脱鞘。洗脱鞘附着到支架结构的外表面区域的至少一部分上，并且由设计成颈部向下的网眼制成，以适应径向向外的力，导致支架的均匀膨胀。洗脱鞘可以装载至少一种用于在治疗部位释放的治疗药物，以便于修复受损血管。支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。

82. 发明申请

US20080113081A1 Methods for Modifying Balloon of a Catheter Assembly 审中-公开
标题翻译：改造导管组装气球的方法
公开(公告)号：US20080113081A1
公开(公告)日：2008-05-15
申请号：US12018122
申请日：2008-01-22
申请人： Syed Hossainy , Srinivasan Sridharan
发明人： Syed Hossainy , Srinivasan Sridharan
IPC分类号： B05D5/00
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/105
摘要： Methods for modifying a balloon of a catheter assembly are disclosed.
摘要翻译：公开了用于修改导管组件的球囊的方法。

83. 发明申请

US20070191937A1 Remote activation of an implantable device 审中-公开
公开(公告)号：US20070191937A1
公开(公告)日：2007-08-16
申请号：US11784882
申请日：2007-04-09
申请人： Syed Hossainy
发明人： Syed Hossainy
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/91575 , A61F2250/0001 , A61F2250/0068
摘要： The invention is directed to an implantable device, such as a stent, for delivering a therapeutic substance. The device includes a reservoir containing a therapeutic substance and an energy converter to cause the release of the substance.

84. 发明申请

US20070116856A1 Composite stent with regioselective material 有权
公开(公告)号：US20070116856A1
公开(公告)日：2007-05-24
申请号：US11641236
申请日：2006-12-18
申请人： Syed Hossainy , Orlando Padilla , Daryush Mirzaee
发明人： Syed Hossainy , Orlando Padilla , Daryush Mirzaee
IPC分类号： A61L33/00
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/075 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2230/0076 , A61F2250/0018 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10S623/916
摘要： A composite stent and a method for making the same are provided.

85. 发明申请

US20070055364A1 Controlled disintegrating implantable medical devices 有权
标题翻译：受控分解的可植入医疗器械
公开(公告)号：US20070055364A1
公开(公告)日：2007-03-08
申请号：US11210344
申请日：2005-08-23
申请人： Syed Hossainy , David Gale , Florian Ludwig
发明人： Syed Hossainy , David Gale , Florian Ludwig
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/622
摘要： Implantable medical devices for treating bodily disorders local and distally to a region of implantation are disclosed.
摘要翻译：公开了用于治疗局部和远端到植入区域的身体障碍的可植入医疗装置。

86. 发明申请

US20070032634A1 Method for extending shelf-life of constructs of semi-crystallizable polymers 有权
公开(公告)号：US20070032634A1
公开(公告)日：2007-02-08
申请号：US11195974
申请日：2005-08-02
申请人： David Gale , Syed Hossainy , Bin Huang , Klaus Kleine
发明人： David Gale , Syed Hossainy , Bin Huang , Klaus Kleine
IPC分类号： C08F6/00
CPC分类号： C08J3/005 , A61L31/06 , A61L31/148 , C08J2367/04 , C08L67/04 , C08L2666/02
摘要： This invention relates to a method of extending the shelf-life of constructs, in particular bioabsorbable stents, comprising semi-crystalline polymers by increasing the crystallinity of the polymers.

87. 发明申请

US20060265043A1 Method and apparatus for treating vulnerable plaque 审中-公开
标题翻译：治疗易损斑块的方法和装置
公开(公告)号：US20060265043A1
公开(公告)日：2006-11-23
申请号：US11388355
申请日：2006-03-24
申请人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
发明人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy , Jessica Chiu , Mina Chow , Eugene Michal , Charles Claude , William Webler
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B5/02007 , A61B2017/22077 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/077 , A61F2220/0058 , A61F2250/0067 , A61M1/3613 , A61M25/104 , A61M2025/105 , A61M2025/1056 , A61M2025/107 , A61M2025/1086 , A61M2025/1095
摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.
摘要翻译：描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

88. 发明申请

US20060142541A1 Poly(ester amide) block copolymers 有权
标题翻译：聚（酯酰胺）嵌段共聚物
公开(公告)号：US20060142541A1
公开(公告)日：2006-06-29
申请号：US11023837
申请日：2004-12-27
申请人： Syed Hossainy
发明人： Syed Hossainy
IPC分类号： C08G63/08
CPC分类号： C08G69/44 , A61K47/593 , A61K47/595 , A61K47/64 , A61L27/34 , A61L31/10 , C08L77/12
摘要： Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can obtain a copolymer with a Tg for mechanical integrity in drug-delivery stent applications. The copolymer can be used alone or optionally in combination with a biobeneficial material and/or a biocompatible polymer to form an implantable device or a coating on an implantable device. When the copolymer is used in combination with a biobeneficial material, the copolymer and the biobeneficial material can be co-deposited or applied in sequence during the coating process. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.
摘要翻译：本文提供了包含含有聚（酯酰胺）（PEA）和硬嵌段（B）的软嵌段（A）的共聚物。共聚物可以是AB，ABA或BAB型嵌段共聚物中的任一种。通过改变PEA嵌段和硬嵌段的相对量，可以获得在药物递送支架应用中机械完整性的具有Tα的共聚物。共聚物可以单独使用或任选地与生物有益材料和/或生物相容性聚合物组合使用以在可植入装置上形成可植入装置或涂层。当共聚物与生物有益材料组合使用时，共聚物和生物有益材料可以在涂覆过程中按顺序共沉积或应用。由共聚物形成的涂层也可以包括生物活性剂。可植入装置可以植入患者体内以治疗，预防或改善诸如动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉吻合增殖等障碍人工移植物，胆管阻塞，输尿管梗阻和/或肿瘤阻塞。

89. 发明申请

US20060121089A1 Coatings for implantable medical devices 失效
公开(公告)号：US20060121089A1
公开(公告)日：2006-06-08
申请号：US11338058
申请日：2006-01-23
申请人： Eugene Michal , Syed Hossainy , Ashok Shah
发明人： Eugene Michal , Syed Hossainy , Ashok Shah
IPC分类号： A61K31/56 , A61K31/4745 , A61K31/337 , C08F120/02 , C08F120/62 , A61F2/00
CPC分类号： A61L31/10 , A61K31/337 , A61K31/4745 , A61K31/56 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , C08F8/00 , C08F8/30 , C08F8/32 , C08F2800/10 , C08F2810/50 , C08G18/6212 , C08G18/711 , C09D151/003 , C09D151/06 , C09D151/08 , C09D175/04 , C08L2666/02 , C08L2666/04 , C08L2666/14 , C08F216/06 , C08F8/34 , C08F210/02 , C08F8/14
摘要： The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.

90. 发明申请

US20060078588A1 Biocompatible coatings for stents 有权
标题翻译：用于支架的生物相容性涂层
公开(公告)号：US20060078588A1
公开(公告)日：2006-04-13
申请号：US11288754
申请日：2005-11-28
申请人： Syed Hossainy
发明人： Syed Hossainy
IPC分类号： A61F2/00 , B05D3/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/606
摘要： A coating for a medical device, particularly for a stent, is described. The coating comprises a polymer and a biologically responsive compound. The coating can also contain a drug to provide enhanced therapeutic effect.
摘要翻译：描述了用于医疗装置的涂层，特别是用于支架的涂层。涂层包含聚合物和生物响应性化合物。涂层还可以含有药物以提供增强的治疗效果。

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