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81. 发明授权

US07004175B2 System and method for percutaneous coronary artery bypass 失效
公开(公告)号：US07004175B2
公开(公告)日：2006-02-28
申请号：US10436863
申请日：2003-05-13
申请人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
发明人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
IPC分类号： A61B19/00
CPC分类号： A61F2/82 , A61B17/32053 , A61B2017/00243 , A61B2017/00252 , A61B2017/1135 , A61B2017/306 , A61B2090/3929 , A61B2090/3945 , A61B2090/3958 , A61F2/06 , A61F2/064 , A61F2/90 , A61F2/958 , A61F2250/0098 , Y10S623/902
摘要： A percutaneous system for bypassing a restriction in a native vessel of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. An aperture is formed in the aorta. The graft is inserted into the aorta and the first end of the graft is connected to the aorta about the aperture in the aorta. An aperture is then formed in the native vessel distal of the restriction. The second end of the graft is connected to the native vessel about the aperture therein such that the lumen in the graft communicates with the aorta and the native vessel.

82. 发明授权

US06953466B2 Methods for delivering a therapeutic implant to tissue 失效
标题翻译：将治疗性植入物递送至组织的方法
公开(公告)号：US06953466B2
公开(公告)日：2005-10-11
申请号：US10837612
申请日：2004-05-04
申请人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
发明人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
IPC分类号： A61B17/00 , A61B17/32 , A61B17/34 , A61B19/00 , A61F2/02 , A61L29/16 , A61M25/00 , A61M31/00 , A61M37/00
CPC分类号： A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/320084 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0004 , A61M2025/0089
摘要： A method for delivering a therapeutic implant to a tissue is provided. This method includes providing an elongate catheter having a distal end including a lumen, providing a carrier including a therapeutic agent, placing the carrier including the therapeutic agent into the lumen, advancing the distal end of the catheter to the tissue, and depositing the carrier including the therapeutic agent into the tissue.
摘要翻译：提供了将治疗性植入物递送到组织的方法。该方法包括提供细长的导管，其具有包括内腔的远端，提供包括治疗剂的载体，将包括治疗剂的载体放置在内腔中，将导管的远端推进到组织，以及沉积载体，包括治疗剂进入组织。

83. 发明授权

US06923787B2 Catheter having an improved balloon-to-catheter bond 有权
标题翻译：导管具有改善的气球与导管接合
公开(公告)号：US06923787B2
公开(公告)日：2005-08-02
申请号：US10027417
申请日：2001-12-20
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61L29/00 , A61F2/958 , A61M25/00 , A61M29/00 , A61B1/267 , A61B6/00 , A61M31/00
CPC分类号： A61M25/0014
摘要： A tie layer insert is disclosed to aid in bond formation between an expandable balloon and a distal portion of a catheter shaft. The tie layer insert can be a single layer applied directly to the structural surfaces, or alternatively, the tie layer may be incorporated into a preformed polymeric insert. In the latter embodiment, the polymeric insert may include several layers of polymeric material. During the manufacturing process, the preformed polymeric insert is positioned between the distal portion of the expandable balloon and the catheter shaft. The entire distal region is then processed to form a sealably bonded expandable balloon to the distal end of the catheter shaft.
摘要翻译：公开了一种连接层插入件，以帮助可扩张气囊和导管轴的远端部分之间的结合。连接层插入件可以是直接施加到结构表面的单层，或者可以将粘结层结合到预成型的聚合物插入物中。在后一实施例中，聚合物插入物可以包括几层聚合材料。在制造过程中，预成型的聚合物插入件位于可膨胀气囊的远端部分和导管轴之间。然后整个远端区域被处理以形成可密封地结合的可扩张气囊到导管轴的远端。

84. 发明申请

US20050143550A1 Solid state polymerized medical devices 审中-公开
标题翻译：固态聚合医疗器械
公开(公告)号：US20050143550A1
公开(公告)日：2005-06-30
申请号：US11062657
申请日：2005-02-22
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61L29/00 , A61L31/00 , B29C71/02 , C08J7/00 , C08G18/00 , C08G63/02
CPC分类号： C08J7/00 , Y10T428/1307 , Y10T428/1352
摘要： Device articles such as medical devices and parts thereof are thermoformed of a thermoplastic condensable polymer composition. After thermoforming the article is subjected to a solid state polymerization step.
摘要翻译：诸如医疗装置及其部件的装置制品由热塑性可冷凝聚合物组合物热成型。热成型后，制品经受固态聚合步骤。

85. 发明授权

US06881372B2 Solid state polymerized medical services 有权
标题翻译：固态聚合医疗服务
公开(公告)号：US06881372B2
公开(公告)日：2005-04-19
申请号：US10224764
申请日：2002-08-20
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61L29/00 , A61L31/00 , B29C71/02 , C08J7/00 , B29C45/00
CPC分类号： C08J7/00 , Y10T428/1307 , Y10T428/1352
摘要： Device articles such as medical devices and parts thereof are thermoformed of a thermoplastic condensable polymer composition. After thermoforming the article is subjected to a solid state polymerization step.
摘要翻译：诸如医疗装置及其部件的装置制品由热塑性可冷凝聚合物组合物热成型。热成型后，制品经受固态聚合步骤。

86. 发明申请

US20050043459A1 Composition and process for manufacturing PBT catheter balloons 审中-公开
标题翻译：制造PBT导管气球的组成和工艺
公开(公告)号：US20050043459A1
公开(公告)日：2005-02-24
申请号：US10935294
申请日：2004-09-07
申请人： Lixiao Wang , Jianhua Chen
发明人： Lixiao Wang , Jianhua Chen
IPC分类号： A61L29/06 , A61M25/00 , A61M25/16 , C08K3/38 , C08L67/02
CPC分类号： A61M25/1029 , A61L29/06 , A61M2025/1031 , C08K3/38 , C08L67/02 , Y10T428/1352 , Y10T428/139 , C08L2666/02
摘要： A processing technique and a composition which allow compositions of PBT polymers or copolymers to be formed into blow molded articles, especially medical balloons such as dilatation or stent placement balloons, from extruded tubular parisons. The process includes a longitudinal stretch step run at a temperature below the Tg of the polymeric material and a radial expansion step run at a temperature above the Tg of the polymeric material. During the longitudinal stretch step, the tubing is subjected to high internal pressure. In the composition a small amount of boric acid is added to the polybutylene terephthalate in a melt blend to give a formulation which has reduced crystallinity after extrusion and which can more readily fashioned into high strength blow molded articles than PBT by itself. Articles, which may be formed using the invention include medical device balloon articles in which the polymer consists essentially of PBT optionally blended with boric acid.
摘要翻译：一种加工技术和组合物，其允许PBT聚合物或共聚物的组合物从挤出的管状型坯形成吹塑制品，特别是医疗气囊如膨胀或支架放置气球。该方法包括在低于聚合物材料的Tg的温度下运行的纵向拉伸步骤和在高于聚合物材料的Tg的温度下运行的径向膨胀步骤。在纵向拉伸步骤期间，管道受到高的内部压力。在组合物中，在熔融共混物中将少量硼酸加入到聚对苯二甲酸丁二醇酯中，得到挤出后结晶度降低且比PBT本身更容易形成高强度吹塑制品的制剂。可以使用本发明形成的制品包括其中聚合物基本上由PBT任选与硼酸共混的医疗装置球囊制品。

87. 发明授权

US06756094B1 Balloon structure with PTFE component 有权
标题翻译：气球结构采用PTFE组分
公开(公告)号：US06756094B1
公开(公告)日：2004-06-29
申请号：US09514929
申请日：2000-02-28
申请人： Lixiao Wang , John Jianhua Chen
发明人： Lixiao Wang , John Jianhua Chen
IPC分类号： A61M2510
CPC分类号： A61M25/1029 , A61L29/041 , A61L29/12 , A61M25/10 , A61M2025/1075 , Y10T428/1334 , Y10T428/139 , Y10T428/1393 , C08L27/18
摘要： A medical balloon having a high burst strength and the ability to return to its preinflation diameter following repeated inflation may be prepared from a first inner layer of material, a second intermediate layer of expanded PTFE and a third outer layer of material.
摘要翻译：可以从第一内层材料，膨胀PTFE的第二中间层和第三外层材料制备具有高破裂强度和在反复充气之后恢复到其预充气直径的能力的医用气囊。

88. 发明授权

US06730377B2 Balloons made from liquid crystal polymer blends 有权
标题翻译：由液晶聚合物混合物制成的气球
公开(公告)号：US06730377B2
公开(公告)日：2004-05-04
申请号：US10055585
申请日：2002-01-23
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： B32B108
CPC分类号： A61L29/04 , Y10T428/1352 , Y10T428/139 , Y10T428/1393
摘要： A portion of a medical device formed from a melt blend of a polyesterimide anhydride liquid crystal polymer and at least one other polymer.
摘要翻译：医疗器械的一部分由聚酯酰亚胺酐液晶聚合物和至少一种其它聚合物的熔融共混物形成。

89. 发明授权

US06585719B2 Low profile metal/polymer tubes 失效
标题翻译：薄型金属/聚合物管
公开(公告)号：US06585719B2
公开(公告)日：2003-07-01
申请号：US09754668
申请日：2001-01-04
申请人： Lixiao Wang
发明人： Lixiao Wang
IPC分类号： A61M2500
CPC分类号： A61M25/0009 , A61M25/0043 , A61M25/0662 , A61M25/104 , A61M2025/0063 , A61M2025/0183
摘要： The present invention relates generally to elongate support members, preferably for use with a catheter for performing medical procedures including percutaneous transluminal coronary angioplasty. An elongate support member comprising a proximal end and a distal end is disclosed. The proximal end of the elongate support member is formed to define a plurality of flanges. A linkage connects the flanges, and a lumen within the shaft is defined by connecting the flanges. The elongate support member comprises an improved catheter shaft design that maintains pushability, flexibility, and torquability while limiting kinking.
摘要翻译：本发明一般涉及细长的支撑构件，优选用于与用于执行包括经皮腔内冠状动脉血管成形术在内的医疗程序的导管一起使用。公开了一种包括近端和远端的细长支撑构件。细长支撑构件的近端形成为限定多个凸缘。连接件连接法兰，并通过连接法兰来限定轴内的内腔。细长的支撑构件包括改进的导管轴设计，其在保持扭转能力的同时保持推力，柔性和扭矩。

90. 发明授权

US06475184B1 Catheter shaft 失效
标题翻译：导管轴
公开(公告)号：US06475184B1
公开(公告)日：2002-11-05
申请号：US09593193
申请日：2000-06-14
申请人： Yiqun Bruce Wang , Lixiao Wang , Daniel J. Horn
发明人： Yiqun Bruce Wang , Lixiao Wang , Daniel J. Horn
IPC分类号： A61M1100
CPC分类号： A61M25/0043 , A61M25/0021 , A61M25/0032 , A61M25/0662 , A61M2025/0034 , A61M2025/0063
摘要： A catheter shaft in accordance with one embodiment of the present invention comprises a support member including a distal end, a proximal end, and a plurality of elongate flanges extending therebetween. Each elongate flange has a fixed end and a free end. The fixed end of each flange being fixed to a central portion of the elongate support member. In a preferred embodiment, a sheath is disposed about the support member of the catheter shaft.
摘要翻译：根据本发明的一个实施例的导管轴包括支撑构件，该支撑构件包括在其间延伸的远端，近端和多个细长凸缘。每个细长法兰具有固定端和自由端。每个凸缘的固定端固定到细长支撑构件的中心部分。在优选实施例中，护套围绕导管轴的支撑构件设置。

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