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81. 发明授权

US5854221A Endothelial cell proliferation inhibitor and method of use 失效
标题翻译：内皮细胞增殖抑制剂及其使用方法
公开(公告)号：US5854221A
公开(公告)日：1998-12-29
申请号：US763528
申请日：1996-12-12
申请人： Yihai Cao , M. Judah Folkman , Michael S. O'Reilly
发明人： Yihai Cao , M. Judah Folkman , Michael S. O'Reilly
IPC分类号： A61K38/00 , C12N9/68 , C07K14/00
CPC分类号： C12N9/6435 , C12Y304/21007 , A61K38/00
摘要： The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial cell proliferation inhibitor is a protein having a molecular weight of approximately 14 kD and having an amino acid sequence substantially similar to Kringle 5 of a plasminogen molecule, that has the ability to inhibit endothelial cell proliferation in in vitro assays.
摘要翻译：本发明包括内皮抑制剂及其使用方法。内皮细胞增殖抑制剂是具有约14kD分子量的蛋白质，其具有基本上类似于纤溶酶原分子的Kringle 5的氨基酸序列，其在体外测定中具有抑制内皮细胞增殖的能力。

82. 发明授权

US5789182A System for assaying binding to a heparin-binding growth factor receptor 失效
标题翻译：用于测定与肝素结合生长因子受体结合的系统
公开(公告)号：US5789182A
公开(公告)日：1998-08-04
申请号：US166717
申请日：1993-12-14
申请人： Avner Yayon , David M. Ornitz , Michael Klagsbrun , Philip Leder , John G. Flanagan
发明人： Avner Yayon , David M. Ornitz , Michael Klagsbrun , Philip Leder , John G. Flanagan
IPC分类号： C07K14/50 , C07K14/71 , C12N9/16 , G01N33/50 , G01N33/74 , C12Q1/00 , C12N15/09
CPC分类号： G01N33/5008 , C07K14/503 , C07K14/71 , C12N9/16 , G01N33/74 , C07K2319/034 , C07K2319/32 , C07K2319/61 , G01N2500/00
摘要： A homogeneous population of cells having on average (1) a number of cell surface low-affinity heparin-binding growth factor (HBGF) sites per cell less than 20% of the number of such binding sites found on wild-type CHO-K1 cells (ATCC Accession No. CCL61), and at least three times the number of cell surface high-affinity HBGF receptors per cell found on such CHO-K1 cells; and an assay system utilizing such cells.
摘要翻译：平均每个细胞的细胞表面平均少量细胞表面低亲和力肝素结合生长因子（HBGF）位点的均匀群体少于在野生型CHO-K1细胞上发现的这种结合位点数目的20％（ATCC登录号CCL61），并且在这种CHO-K1细胞上发现的每个细胞的细胞表面高亲和力HBGF受体的数目的至少三倍; 以及利用这种细胞的测定系统。

83. 发明授权

US5234956A Method of preventing NMDA receptor complex-mediated neuronal damage 失效
标题翻译：预防NMDA受体复合物介导的神经元损伤的方法
公开(公告)号：US5234956A
公开(公告)日：1993-08-10
申请号：US949342
申请日：1992-09-22
申请人： Stuart A. Lipton
发明人： Stuart A. Lipton
IPC分类号： A61K9/70 , A61K31/195 , A61K31/21 , A61K31/215 , A61K31/295 , A61K38/44 , A61P3/08 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/28 , A61P31/12 , A61P37/04
CPC分类号： A61K9/7023 , A61K31/195 , A61K31/21 , A61K31/295
摘要： Disclosed is a method for reducing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitric-oxide generating compound, or a physiologically acceptable salt thereof, in a concentration effective to cause such reduction. Also disclosed is a method for reducing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal nitroprusside, nitroglycerin, or a derivative of one of those compounds, in a concentration effective to cause such reduction.
摘要翻译：公开了通过向哺乳动物施用有效引起这种还原的浓度的一氧化氮产生化合物或其生理上可接受的盐来降低哺乳动物中NMDA受体介导的神经元损伤的方法。还公开了通过以有效引起这种还原的浓度向哺乳动物硝普钠，硝酸甘油或其中一种化合物的衍生物施用来减少哺乳动物中NMDA受体介导的神经元损伤的方法。

84. 发明授权

US5200177A Treatment of atopic disorders with gamma-interferon 失效
标题翻译：用γ-干扰素治疗特应性疾病
公开(公告)号：US5200177A
公开(公告)日：1993-04-06
申请号：US912564
申请日：1992-07-13
申请人： Donald Y. M. Leung , Raif S. Geha
发明人： Donald Y. M. Leung , Raif S. Geha
IPC分类号： A61K38/21
CPC分类号： A61K38/217 , Y10S514/826 , Y10S514/861
摘要： A method of treating patients having chronic, severe allergic disorders, such as atopic dermatitis or steroid-dependent asthma, with gamma interferon is disclosed. The method involves treating patients afflicated with atopic dermatitis or steroid-dependent asthma with effective dosages of gamma interferon, which reduces the clinical severity of their disease.
摘要翻译：公开了用γ-干扰素治疗患有慢性，严重过敏性疾病如特应性皮炎或类固醇依赖性哮喘的患者的方法。该方法涉及用有效剂量的γ干扰素治疗患有特应性皮炎或类固醇依赖性哮喘的患者，其降低其疾病的临床严重性。

85. 发明授权

US5019372A Magnetically modulated polymeric drug release system 失效
标题翻译：磁调制聚合物药物释放系统
公开(公告)号：US5019372A
公开(公告)日：1991-05-28
申请号：US579050
申请日：1990-09-07
申请人： Judah Folkman , Robert S. Langer, Jr. , Dean S. T. Hsieh
发明人： Judah Folkman , Robert S. Langer, Jr. , Dean S. T. Hsieh
IPC分类号： A61K9/00 , A61K9/50
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/5094
摘要： A magnetically responsive composition for the modulated, sustained administration of a biologically active substance, the composition being in the form of a body sized and shaped for placement in the environment of use, the environment including an aqueous fluid, the body comprising, in admixture, a first phase comprising a biocompatible, plastically deformable, polymeric matrix, the polymeric matrix being insoluble in the environment of use, a second phase having a biologically active substance distributed throughout the matrix to be released to the aqueous fluid outside the matrix, and a third phase comprising a magnetically responsive substance encapsulated within the matrix so that, upon exposure of the body to an oscillating magnetic field, the rate of release of the biologically active substance to the aqueous fluid is increased.
摘要翻译：一种用于调节，持续施用生物活性物质的磁响应组合物，所述组合物为身体形式，其尺寸和形状用于放置在使用环境中，所述环境包括水性流体，所述身体包含混合物，第一阶段，其包含生物相容性，可塑性变形的聚合物基质，所述聚合物基质不溶于使用环境，第二相具有分布在整个基质中的生物活性物质以释放到基质外部的水性流体，其包括包封在基质内的磁响应物质，使得当身体暴露于振荡磁场时，生物活性物质释放到水性流体的速率增加。

86. 发明授权

US4882275A Method of purifying endothelial cell growth factors using immobilized heparin 失效
标题翻译：使用固定化肝素纯化内皮细胞生长因子的方法
公开(公告)号：US4882275A
公开(公告)日：1989-11-21
申请号：US849045
申请日：1986-04-07
申请人： Michael Klagsbrun
发明人： Michael Klagsbrun
IPC分类号： A61K38/00 , C07K14/50 , C07K16/22
CPC分类号： C07K16/22 , C07K14/501 , A61K38/00
摘要： Endothelial cell growth factor (ECG) from various sources possesses a strong and specific affinity for heparin. This strong affinity of ECG for heaprin enables removal of undesired impurities from a mixture comprising ECG by: (a) contacting immobilized heparin with the mixture to form a heparin-ECG complex; (b) separating uncomplexed mixture from the complex; and (c) contacting the complex with a salt solution of a salt concentration and pH effective to separate the ECG from the heparin. The resulting purified ECG (or fragment thereof) is useful in therapeutics and as an additive for cell culturing. The purified ECG is also useful to raise antibodies that are used in therapeutics and in ECG immunoassays.
摘要翻译：来自各种来源的内皮细胞生长因子（ECG）对肝素具有强烈和特异性的亲和力。 ECG对于堆积蛋白的这种强亲合力使得能够通过以下方式从含有ECG的混合物中除去不期望的杂质：（a）使固定化的肝素与混合物接触以形成肝素-ECc复合体; （b）将未络合的混合物与络合物分离; 和（c）使该配合物与盐浓度和pH有效的盐溶液接触以将ECG与肝素分离。所得纯化的ECG（或其片段）可用于治疗学和作为细胞培养的添加剂。纯化的ECG也可用于产生用于治疗和ECG免疫测定中的抗体。

87. 发明授权

US4877778A Method of enhancing lipophile transport using cyclodextrin derivatives 失效
标题翻译：使用环糊精衍生物增强亲油运输的方法
公开(公告)号：US4877778A
公开(公告)日：1989-10-31
申请号：US68921
申请日：1987-07-01
申请人： Thomas O. Carpenter , Josef Pitha
发明人： Thomas O. Carpenter , Josef Pitha
IPC分类号： C08B37/16
CPC分类号： C08B37/0012 , Y10S514/824
摘要： Levels of cholesterol, vitamin A, triglycerides, and other lipophiles in the human circulation can be manipulated by intravenous infusion of cyclodextrin-type compounds. The cyclodextrin-type compound should be highly soluble in water, amorphous and of only moderate molecular weight in order to be easily excreted; one preferred cyclodextrin, 2-hydroxypropyl-.beta.-cyclodextrin with an average molecular weight of 1460, is administered at doses of 0.5 g/kg x day. The serum levels of the lipophiles indicate that the infusion may serve to mobilize the lipophile from tissues, induce its excretion, and furthermore affect its homeostasis.
摘要翻译：人体循环中胆固醇，维生素A，甘油三酯和其他亲脂物的含量可通过静脉输注环糊精型化合物进行操作。环糊精型化合物应高度溶于水，无定形且仅适度分子量，易于排泄; 一种优选的环糊精，平均分子量为1460的2-羟丙基-β-环糊精以0.5g / kg×d的剂量施用。亲脂体的血清水平表明输注可用于从组织中调动亲脂体，诱导其排泄，并进一步影响其体内平衡。

88. 发明授权

US4729380A Iridium 191-M generator 失效
标题翻译：铱191-M发电机
公开(公告)号：US4729380A
公开(公告)日：1988-03-08
申请号：US492336
申请日：1983-05-06
申请人： Salvador Treves , Chris C. Cheng
发明人： Salvador Treves , Chris C. Cheng
IPC分类号： G21G4/08 , A61B5/05
CPC分类号： G21G4/08
摘要： Potassium osmate, of the formula K.sub.2 Os O.sub.2 (OH).sub.4), used to make a column for the generation of Ir-191 m, which is used in first pass angiography to detect cardiac defects in patients.
摘要翻译：用于制备用于产生Ir-191m的柱的通式为K 2 Os O 2（OH）4的锇酸钾），其用于首次血管造影以检测患者的心脏缺陷。

89. 发明授权

US4611353A Infant's garment 失效
标题翻译：婴儿服装
公开(公告)号：US4611353A
公开(公告)日：1986-09-16
申请号：US626685
申请日：1984-07-02
申请人： Heidelise Als , Annie Zeybekoglu
发明人： Heidelise Als , Annie Zeybekoglu
IPC分类号： A41B13/06 , A41B1/12
CPC分类号： A41B13/06
摘要： An infant's garment having a sack portion adapted to receive the legs of an infant, and two flaps attached to the sack adapted to wrap around the infant's arms and overlap behind the body.
摘要翻译：具有适于接收婴儿腿部的袋部分的婴儿衣服，以及适于围绕婴儿的手臂包裹并重叠在身体后面的袋的两个襟翼。

90. 发明授权

US4421122A Brain electrical activity mapping 失效
标题翻译：脑电活动测绘
公开(公告)号：US4421122A
公开(公告)日：1983-12-20
申请号：US263939
申请日：1981-05-15
申请人： Frank H. Duffy
发明人： Frank H. Duffy
IPC分类号： A61B5/0484 , G06F17/00 , A61B5/04
CPC分类号： A61B5/0484 , A61B5/4094 , A61B5/7257
摘要： Apparatus for generating a topographic display of information on brain electrical activity based on responses of electrical-activity transducers placed on the skull. In different aspects, the brain is stimulated at pseudorandom intervals to produce EP responses; matrices corresponding to the electrical responses are processed to generate a statistical comparison matrix and the corresponding display map is grid sector analyzed; a series of tests is administered some of which put the brain in a simple resting state, others putting the brain in nonresting states of varying activity level; statistical comparison matrixes are generated representing the statistical difference between normal and abnormal groups at different skull locations with respect to different brain activities; significance probability maps are generated each representing the statistical difference between a patient and the normal population with respect to different brain activities; and an epileptic spike is caused, a sufficient number of data matrices is generated to capture onset of the spike, and the frame rate of display of the corresponding topographic maps is selectably changed for observing the onset.
摘要翻译：用于基于放置在头骨上的电活动换能器的响应产生关于脑电活动的信息的地形显示的装置。在不同方面，以伪随机间隔刺激大脑产生EP反应; 对应于电响应的矩阵被处理以产生统计比较矩阵，并且相应的显示图是网格扇区分析的; 一些测试被管理，其中一些使大脑处于简单的静止状态，其他测试将大脑置于不同活动水平的非活动状态; 生成统计比较矩阵，代表不同头脑位置处的正常组和异常组之间相对于不同脑活动的统计学差异; 生成显着性概率图，每个都代表患者与正常人群相对于不同大脑活动的统计学差异; 并且引起癫痫尖峰，产生足够数量的数据矩阵以捕获尖峰的开始，并且可选择地改变对应的地形图的帧速率以观察发作。

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