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1. 发明授权

US4844086A Cross correlation analysis in brain electrical activity mapping 失效
标题翻译：脑电活动映射中的互相关分析
公开(公告)号：US4844086A
公开(公告)日：1989-07-04
申请号：US37982
申请日：1987-04-13
申请人： Frank H. Duffy
发明人： Frank H. Duffy
IPC分类号： G06F17/00
CPC分类号： A61B5/0484 , A61B5/742 , A61B5/743
摘要： A diagnostic method is disclosed wherein brain evoked potential (EP) data from a plurality of electrode sites on the patient's head is gathered and compared with a comparable EP for normal patients by forming (1) the cross-correlation between the patient's EP and the normal EP, (2) the maximum cross-correlation for any time shift in a selected period or C.sub.max, and (3) the time shift T.sub.max at which the maximum correlation occurs. Selected ones of these values for particular evoked potentials are used to compute diagnostic feature values, and a plurality of diagnostic feature values are used to achieve a diagnosis of brain pathology.
摘要翻译：公开了一种诊断方法，其中收集来自患者头部上的多个电极部位的脑诱发电位（EP）数据，并将其与正常患者的可比EP进行比较，形成（1）患者EP与正常患者之间的互相关 EP，（2）在所选择的周期或Cmax中任何时间移位的最大互相关，以及（3）发生最大相关性的时移Tmax。用于特定诱发电位的这些值中的选定值用于计算诊断特征值，并且使用多个诊断特征值来实现脑病理学的诊断。

2. 发明授权

US4408616A Brain electricaL activity mapping 失效
标题翻译：脑电活动测绘
公开(公告)号：US4408616A
公开(公告)日：1983-10-11
申请号：US264043
申请日：1981-05-15
申请人： Frank H. Duffy , Norman D. Culver
发明人： Frank H. Duffy , Norman D. Culver
IPC分类号： A61B5/0484 , G06F17/00 , A61B5/04
CPC分类号： A61B5/0484 , A61B5/7257 , A61B5/4088 , A61B5/4094 , A61B5/7203
摘要： Topographic displays of brain electrical activity are produced from matrices of data derived from evoked potential (EP) and steady-state responses of skull transducers. In different aspects, EP responses are displayed at a variable frame rate, the rate of data sampling is sufficient to capture rapid transient events, difference matrices are derived as the difference between matrices corresponding to two different brain conditions, the baseline of the EP responses is zeroed based on the average prestimulus response, and the steady-state response is analyzed by Fourier transforms. In other aspects, statistical comparison matrices representing statistical differences between corresponding elements in two matrices are generated, a coefficient-of-variance matrix is generated, additional display matrices are temporally interpolated, response waveforms are previewed and tagged for elimination from further processing, the topographic maps are displayed on a video monitor with appropriate scaling of the data to the tones of the display, and additional display points are interpolated between the measured data points for display.
摘要翻译：脑电活动的地形显示是从诱发电位（EP）和头骨传感器的稳态响应得到的数据矩阵产生的。在不同方面，EP响应以可变帧速率显示，数据采样速率足以捕获快速瞬态事件，差分矩阵被导出为对应于两个不同脑条件的矩阵之间的差异，EP响应的基线为基于平均预激响应归零，并通过傅立叶变换分析稳态响应。在其他方面，生成表示两个矩阵中的相应元素之间的统计差异的统计比较矩阵，生成方差系数矩阵，附加显示矩阵被时间插值，预测和标记响应波形以便进一步处理，地形地图通过适当的数据缩放显示在视频监视器上，并显示在所测量的数据点之间，并在显示的测量数据点之间插入附加的显示点。

3. 再颁专利

USRE34015E Brain electrical activity mapping 失效
公开(公告)号：USRE34015E
公开(公告)日：1992-08-04
申请号：US83848
申请日：1987-08-07
申请人： Frank H. Duffy
发明人： Frank H. Duffy
IPC分类号： G06F17/00
CPC分类号： A61B5/0484
摘要： Apparatus for generating a topographic display of information on brain electrical activity based on responses of electrical-activity transducers placed on the skull. In different aspects, the brain is stimulated at pseudorandom intervals to produce EP responses; matrices corresponding to the electrical responses are processed to generate a statistical comparison matrix and the corresponding display map is grid sector analyzed; a series of tests is administered some of which put the brain in a simple resting state, others putting the brain in nonresting states of varying activity level; statistical comparison matrixes are generated representing the statistical difference between normal and abnormal groups at different skull locations with respect to different brain activities; significance probability maps are generated each representing the statistical difference between a patient and the normal population with respect to different brain activities; and an epileptic spike is caused, a sufficient number of data matrices is generated to capture onset of the spike, and the frame rate of display of the corresponding topographic maps is selectably changed for observing the onset.

4. 发明授权

US4815474A Temporal trajectory analysis in brain electrical activity mapping 失效
标题翻译：脑电活动映射中的时间轨迹分析
公开(公告)号：US4815474A
公开(公告)日：1989-03-28
申请号：US37981
申请日：1987-04-13
申请人： Frank H. Duffy
发明人： Frank H. Duffy
IPC分类号： A61B5/0476 , A61B5/04
CPC分类号： A61B5/0476
摘要： Pathological changes in brain electrical activity over time caused by for example growth of a lesion are detected by producing a brain electrical activity map such as a statistical probability map, and then selecting a template or mask surrounding a suspect area, summating values of the map within the template area to form an aggregate statistical feature, and then plotting the feature over a period of time, e.g. several weeks, to form a trend plot characteristic of brain electrical activity changes.
摘要翻译：通过产生诸如统计概率图之类的脑电活动图，然后选择围绕可疑区域的模板或掩模来检测由例如病变生长导致的脑电活动随时间的病理变化，模板区域以形成一个聚合统计特征，然后在一段时间内绘制特征，例如几周，形成脑电活动变化的趋势图特征。

5. 发明授权

US4841983A Spatial trajectory analysis in brain electrical activity mapping 失效
标题翻译：大脑电活动映射中的空间轨迹分析
公开(公告)号：US4841983A
公开(公告)日：1989-06-27
申请号：US38037
申请日：1987-04-13
申请人： Frank H. Duffy
发明人： Frank H. Duffy
IPC分类号： G06F17/00
CPC分类号： A61B5/0484
摘要： A method is disclosed for utilizing brain evoked potentials for characterizing brain pathology. A brain electrical activity map is prepared from a patient's evoked potential data, and the centers of gravity of peaks of the evoked potential are calculated for a sequence of frames of the map, and plotted in a single frame to provide a spatial trajectory which may then be compared to a patient norm in order to detect and characterize brain pathology.
摘要翻译：公开了一种利用脑诱发电位来表征脑病理学的方法。根据患者的诱发电位数据准备脑电活动图，并且针对图的帧序列计算诱发电位峰值的重心，并绘制在单个帧中以提供空间轨迹，然后可以随后与患者规范进行比较，以检测和表征脑病理学。

6. 发明授权

US4421122A Brain electrical activity mapping 失效
标题翻译：脑电活动测绘
公开(公告)号：US4421122A
公开(公告)日：1983-12-20
申请号：US263939
申请日：1981-05-15
申请人： Frank H. Duffy
发明人： Frank H. Duffy
IPC分类号： A61B5/0484 , G06F17/00 , A61B5/04
CPC分类号： A61B5/0484 , A61B5/4094 , A61B5/7257
摘要： Apparatus for generating a topographic display of information on brain electrical activity based on responses of electrical-activity transducers placed on the skull. In different aspects, the brain is stimulated at pseudorandom intervals to produce EP responses; matrices corresponding to the electrical responses are processed to generate a statistical comparison matrix and the corresponding display map is grid sector analyzed; a series of tests is administered some of which put the brain in a simple resting state, others putting the brain in nonresting states of varying activity level; statistical comparison matrixes are generated representing the statistical difference between normal and abnormal groups at different skull locations with respect to different brain activities; significance probability maps are generated each representing the statistical difference between a patient and the normal population with respect to different brain activities; and an epileptic spike is caused, a sufficient number of data matrices is generated to capture onset of the spike, and the frame rate of display of the corresponding topographic maps is selectably changed for observing the onset.
摘要翻译：用于基于放置在头骨上的电活动换能器的响应产生关于脑电活动的信息的地形显示的装置。在不同方面，以伪随机间隔刺激大脑产生EP反应; 对应于电响应的矩阵被处理以产生统计比较矩阵，并且相应的显示图是网格扇区分析的; 一些测试被管理，其中一些使大脑处于简单的静止状态，其他测试将大脑置于不同活动水平的非活动状态; 生成统计比较矩阵，代表不同头脑位置处的正常组和异常组之间相对于不同脑活动的统计学差异; 生成显着性概率图，每个都代表患者与正常人群相对于不同大脑活动的统计学差异; 并且引起癫痫尖峰，产生足够数量的数据矩阵以捕获尖峰的开始，并且可选择地改变对应的地形图的帧速率以观察发作。

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