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1. 发明授权

US5019372A Magnetically modulated polymeric drug release system 失效
标题翻译：磁调制聚合物药物释放系统
公开(公告)号：US5019372A
公开(公告)日：1991-05-28
申请号：US579050
申请日：1990-09-07
申请人： Judah Folkman , Robert S. Langer, Jr. , Dean S. T. Hsieh
发明人： Judah Folkman , Robert S. Langer, Jr. , Dean S. T. Hsieh
IPC分类号： A61K9/00 , A61K9/50
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/5094
摘要： A magnetically responsive composition for the modulated, sustained administration of a biologically active substance, the composition being in the form of a body sized and shaped for placement in the environment of use, the environment including an aqueous fluid, the body comprising, in admixture, a first phase comprising a biocompatible, plastically deformable, polymeric matrix, the polymeric matrix being insoluble in the environment of use, a second phase having a biologically active substance distributed throughout the matrix to be released to the aqueous fluid outside the matrix, and a third phase comprising a magnetically responsive substance encapsulated within the matrix so that, upon exposure of the body to an oscillating magnetic field, the rate of release of the biologically active substance to the aqueous fluid is increased.
摘要翻译：一种用于调节，持续施用生物活性物质的磁响应组合物，所述组合物为身体形式，其尺寸和形状用于放置在使用环境中，所述环境包括水性流体，所述身体包含混合物，第一阶段，其包含生物相容性，可塑性变形的聚合物基质，所述聚合物基质不溶于使用环境，第二相具有分布在整个基质中的生物活性物质以释放到基质外部的水性流体，其包括包封在基质内的磁响应物质，使得当身体暴露于振荡磁场时，生物活性物质释放到水性流体的速率增加。

2. 发明授权

US4357312A Method of making prolonged release body 失效
标题翻译：延长释放体的方法
公开(公告)号：US4357312A
公开(公告)日：1982-11-02
申请号：US283826
申请日：1981-07-16
申请人： Dean S. T. Hsieh , Robert S. Langer, Jr.
发明人： Dean S. T. Hsieh , Robert S. Langer, Jr.
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K31/74 , A61K31/78
CPC分类号： A61K9/2027
摘要： In a method of making a biologically compatible, water-insoluble polymeric body for the controlled, prolonged release of a biologically active substance to a surrounding aqueous environment, the method including forming a liquid mixture containing the polymer, the active substance, and an organic solvent capable of dissolving the polymer, and solidifying the liquid mixture to form the polymeric body, the improvement wherein the liquid mixture further comprises water, the solidification is carried out by cooling the liquid mixture to a temperature sufficiently low to cause the water in the mixture to freeze, thereby creating channels in the body for the release of the active substance therefrom, and removing the organic solvent and the water from the body.
摘要翻译：在制备生物相容的水不溶性聚合物体的方法中，用于将生物活性物质受控地延长释放到周围的水性环境中，所述方法包括形成含有聚合物，活性物质和有机溶剂的液体混合物能够溶解聚合物，并固化液体混合物以形成聚合体，改进之处在于，液体混合物还包含水，凝固通过将液体混合物冷却到足够低的温度以使混合物中的水从而在体内形成用于释放活性物质的通道，并从体内除去有机溶剂和水。

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