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    • 74. 发明授权
    • Benzopyrans
    • 苯并吡喃
    • US4841078A
    • 1989-06-20
    • US639038
    • 1984-08-09
    • James F. EgglerMichael R. JohnsonLawrence Sherman
    • James F. EgglerMichael R. JohnsonLawrence Sherman
    • C07C37/055C07C39/08C07C43/23C07C61/39C07D311/22C07D311/58C07D405/12C07D407/12C07D417/12C07D491/10C07D493/06C07D493/10
    • C07D405/12C07C255/00C07C37/055C07C41/30C07C61/39C07D311/22C07D311/58C07D407/12C07D417/12C07D491/10C07D493/06C07D493/10
    • Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH.sub.2 or NR.sub.6 ; R.sub.6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups;A' is:(1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 1 or 2; when B is hydrogen, A is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 0 or 1, when taken together A and OR.sub.1 form a lactone or certain derivatives thereof;(2) A' is ##STR2## (3) A' is Q.sub.3 ; Q is CO.sub.2 R.sub.7, COR.sub.8, C(OH)R.sub.8 R.sub.9, CN, CONR.sub.12 R.sub.13, CH.sub.2 NR.sub.12 R.sub.13, CH.sub.2 NHCOR.sub.14, CH.sub.2 NHSO.sub.2 R.sub.17 or 5-tetrazoyl;Q.sub.3 is ##STR3## 5-tetrazolyl, CH.sub.2 CONHCOR.sub.7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH.sub.2, or COCH.sub.2 Q.sub.4 where Q.sub.4 is CN or COOH or certain esters thereof;R.sub.1 is hydrogen, benzyl or certain acyl groups; R.sub.4 is hydrogen, certain alkyl or certain aralkyl groups; R.sub.5 is hydrogen or certain alkyl groups; Z is (C.sub.1 -C.sub.9)alkylene, optionally interrupted by O, S, SO or SO.sub.2 ; and W is hydrogen, methyl, certain aryl or cycloalkyl groups; useful in mammals as analgesics, tranquilizers, anteimetic agents, diuretics, anticonvulsants, antidiarrheals, antitussives, in treatment of glaucoma, and intermediates therefore.
    • 式(I')的双环稠合苯并噻唑类化合物及其药学上可接受的阳离子和酸加成盐,其中M为O,CH 2或NR 6; R6是氢,甲酰基,苄氧羰基或某些烷氧基烷基,烷酰基,烷基,芳烷基或芳烷基羰基; A'为:(1)其中A和B之一为氢,使得当A为氢时,B为C(R2R3)(CH2)fQ且f为1或2; 当B为氢时,A为C(R2R3)(CH2)fQ,f为0或1,当A和OR1一起形成内酯或其某些衍生物时; (2)A'是(3)A'是Q3; Q是CO 2 R 7,COR 8,C(OH)R 8 R 9,CN,CONR 12 R 13,CH 2 NR 12 R 13,CH 2 NHCOR 14,CH 2 NHSO 2 R 17或5-四唑基; Q 4是CN或COOH或其某些酯; Q 3是CN,COOH或其某些酯;其中Q 4是CN或COOH或其某些酯; R1是氢,苄基或某些酰基; R4是氢,某些烷基或某些芳烷基; R5是氢或某些烷基; Z是(C1-C9)亚烷基,任选地被O,S,SO或SO 2中断; W是氢,甲基,某些芳基或环烷基; 因此在哺乳动物中作为止痛剂,止痛剂,促炎剂,利尿剂,抗惊厥药,止泻药,镇咳药,治疗青光眼有用。
    • 77. 发明授权
    • Liquid crystalline esters and mixtures
    • 液晶酯和混合物
    • US4550981A
    • 1985-11-05
    • US530830
    • 1983-09-09
    • Martin PetrzilkaMartin SchadtAlois Villiger
    • Martin PetrzilkaMartin SchadtAlois Villiger
    • C07C29/147C07C31/135C07C61/12C07C61/39C07C63/49C07C63/72C07C69/773C07C69/90C07C205/39C07C205/43C07C255/34C07C255/50C07C255/51C09K19/00C09K19/20C09K19/30G02F1/13C07C79/26C07C121/52
    • C07C255/00C07C205/43C07C29/147C07C309/00C07C31/1355C07C61/12C07C61/39C07C63/49C07C63/72C09K19/2007C09K19/3068C07B2200/09C07C2101/14
    • Compounds of the formula ##STR1## wherein X.sup.2 is a single covalent bond or --COO--; X.sup.1 is a single covalent bond, --COO--, --CH.sub.2 CH.sub.2 -- or when X.sup.2 is --COO--, X.sup.1 also can be p--C.sub.6 H.sub.4 --, p--C.sub.6 H.sub.4 --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 --p--C.sub.6 H.sub.4, p--C.sub.6 H.sub.4 --COO-- or --COO--p--C.sub.6 H.sub.4 ; ring A is a benzene ring or trans-1,4-cyclohexylene; ring B is a benzene ring or when X.sup.2 is --COO-- and X.sup.1 is a single covalent bond, --COO-- or --CH.sub.2 CH.sub.2 --, ring B also can be trans-1,4-cyclohexylene; Z.sup.1, Z.sup.2 and Z.sup.3 individually are hydrogen or when positioned on a benzene ring which is not linked directly with a further ring via a single covalent bond, Z.sup.1, Z.sup.2 and Z.sup.3 also can be halogen, cyano or methyl; Y.sup.2 is cyano, nitro, 2,2-dicyanovinyl or when Y.sup.1 is hydrogen Y.sup.2 also can be 2,2-dicyano-1-methylvinyl; Y.sup.1 is halogen, cyano, C.sub.1 -C.sub.3 -alkyl or, when X.sup.1 includes a benzene ring or --COO-- or Y.sup.2 is nitro or at least one of Z.sup.1 and Z.sup.2 is other than hydrogen, Y.sup.1 also can be hydrogen; and R.sup.1 is C.sub.1 -C.sub.12 -alkyl or when positioned on a benzene ring R.sup.1 also can be C.sub.1 -C.sub.12 -alkoxy, their manufacture and use in liquid crystalline mixtures are described.
    • 其中X 2是单个共价键或-COO-; X 1是单个共价键,-COO - , - CH 2 CH 2 - 或当X 2是-COO-时,X 1也可以是对-C 6 H 4 - ,p-C 6 H 4 -CH 2 CH 2 - , - CH 2 CH 2-p-C 6 H 4,p-C 6 H 4 -CO 2 - 或-COO-p-C6H4; 环A是苯环或反式-1,4-亚环己基; 环B为苯环,或者当X2为-COO-且X1为单一共价键时,可以为-COO-或-CH2CH2-,环B也可为反式-1,4-亚环己基; Z1,Z2和Z3分别为氢或当位于不与另一个环通过单个共价键直接连接的苯环上时,Z 1,Z 2和Z 3也可以是卤素,氰基或甲基; Y2是氰基,硝基,2,2-二氰基乙烯基或当Y1是氢时,Y2也可以是2,2-二氰基-1-甲基乙烯基; Y1是卤素,氰基,C1-C3-烷基,或当X1包括苯环或-COO-或Y2是硝基或Z1和Z2中的至少一个不是氢时,Y1也可以是氢; R1为C1-C12烷基,或者当位于苯环R1上时,也可以是C1-C12-烷氧基,它们在液晶混合物中的制备和应用被描述。