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1. 发明授权

US09975841B2 Large molecule and polymer flame retardants 有权
公开(公告)号：US09975841B2
公开(公告)日：2018-05-22
申请号：US14716545
申请日：2015-05-19
申请人： MegaMatter Inc.
发明人： Roopak Mitra , Haydn Mitchell , Harrison Ewan , Arlin Krigel , Philip Costanzo
IPC分类号： C08F34/02 , C08G63/02 , C07H23/00 , C07D307/60 , C07D307/77 , C07C63/00 , C07C61/39 , C07D307/00 , C07D307/93 , C08G63/00 , C08L5/00 , C08L93/04 , C08L99/00 , C07D307/83 , C08G63/06
CPC分类号： C07C61/39 , C07D307/00 , C07D307/60 , C07D307/77 , C07D307/83 , C07D307/93 , C08G63/00 , C08G63/06 , C08L5/00 , C08L93/04 , C08L99/00
摘要： Disclosed herein are flame retardant compounds and polymer compositions containing these flame retardant compounds. The flame retardant compounds can be derived from biological sources and can include coordinated metal ions.

2. 发明授权

US09938221B2 Substituted aromatic compounds and pharmaceutical uses thereof 有权
公开(公告)号：US09938221B2
公开(公告)日：2018-04-10
申请号：US14563523
申请日：2014-12-08
申请人： PROMETIC BIOSCIENCES INC.
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-Francois Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04 , C07C57/42
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.

3. 发明授权

US09500949B2 Chemically-amplified positive resist composition and resist patterning process using the same 有权
标题翻译：化学扩增的正性抗蚀剂组合物和使用其的抗蚀剂图案化工艺
公开(公告)号：US09500949B2
公开(公告)日：2016-11-22
申请号：US14625892
申请日：2015-02-19
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Daisuke Domon , Keiichi Masunaga , Satoshi Watanabe , Masaki Ohashi , Masahiro Fukushima
IPC分类号： G03F7/004 , C07C61/135 , C07C61/15 , C07C61/26 , C07C61/28 , C07C61/39 , C07C61/40 , C07C63/08 , C07C63/68 , C07C69/76 , G03F7/039 , G03F7/20
CPC分类号： G03F7/0045 , C07C61/135 , C07C61/15 , C07C61/26 , C07C61/28 , C07C61/39 , C07C61/40 , C07C63/08 , C07C63/68 , C07C69/76 , G03F7/0046 , G03F7/0392 , G03F7/0395 , G03F7/0397 , G03F7/2041
摘要： The present invention provides a chemically-amplified positive resist composition including a sulfonium salt capable of providing a pattern having an extremely high resolution with low line edge roughness, and also provides a resist patterning process using the same.The present invention was accomplished by a chemically-amplified positive resist composition including: (A) a salt represented by the following general formula (1); and (B) a resin containing a repeating unit represented by the following general formula (U-1) that dissolves by acid action and increases solubility in an alkaline developer, and a resist patterning process using the same.

4. 发明申请

US20070106087A1 Therapeutic Malonic Acid/Acetic Acid C60 Tri-Adducts of Buckminsterfullerene and Methods Related Thereto 有权
标题翻译：治疗性丙烯酸/乙酸C60三聚体富马酸的三加合物及其相关方法
公开(公告)号：US20070106087A1
公开(公告)日：2007-05-10
申请号：US11424175
申请日：2006-06-14
申请人： Laura Dugan , Eva Lovett , Joshua Hardt , Kevin Quick
发明人： Laura Dugan , Eva Lovett , Joshua Hardt , Kevin Quick
IPC分类号： C07C69/74 , C07C63/00 , A61K31/19
CPC分类号： C07C61/39 , A61K31/19 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B32/152 , C07C69/753 , C07C2604/00
摘要： Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adducts of buckminsterfullerene of the general formula C60R3, wherein each R is independently selected from groups of the formula ═CR1R2 wherein each R1 and R2 is independently selected from the group consisting of —H and —COOH, provided, however, that at least one of the R1's and R2's is a hydrogen. Processes for preparing and uses of the same for treating neuronal injury and for life-extension are also disclosed and claimed herein.
摘要翻译：本文公开和要求保护的是e，e，通式C 60 R 3 N 3的buckminsterfullerene的丙二酸/乙酸三加合物，其中每个R独立地选自其中每个R 1和R 2各自独立地选自以下基团：其中R 1，R 2，由-H和-COOH组成，但是，R 1和R 2中的至少一个是氢。本文还公开并要求保护其用于治疗神经元损伤和终身延伸的制备和用途的方法。

5. 发明申请

US20060287317A1 SPHINGOSINE KINASE INHIBITORS 有权
标题翻译：丝氨酸激酶抑制剂
公开(公告)号：US20060287317A1
公开(公告)日：2006-12-21
申请号：US11424423
申请日：2006-06-15
申请人： Charles Smith , Kevin French , Yan Zhuang
发明人： Charles Smith , Kevin French , Yan Zhuang
IPC分类号： A61K31/535 , A61K31/5375 , A61K31/495 , A61K31/44 , A61K31/40
CPC分类号： C07C61/39 , C07C49/323 , C07C49/563 , C07C49/567 , C07C49/573 , C07C61/40 , C07C69/738 , C07C211/27 , C07C211/29 , C07C211/48 , C07C211/52 , C07C215/76 , C07C217/58 , C07C217/60 , C07C233/49 , C07C233/59 , C07C233/60 , C07C233/62 , C07C255/44 , C07C255/56 , C07C275/30 , C07C317/32 , C07C323/40 , C07C2601/02 , C07C2603/74 , C07D207/09 , C07D207/27 , C07D209/08 , C07D209/86 , C07D209/88 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/89 , C07D233/24 , C07D233/64 , C07D257/04 , C07D263/58 , C07D277/42 , C07D277/46 , C07D277/82 , C07D295/027 , C07D295/13 , C07D295/30 , C07D317/58 , C07D333/20 , C07D333/22 , C07D333/28 , C07D487/04
摘要： The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.
摘要翻译：本发明涉及取代的金刚烷化合物，其药物组合物，其制备方法和抑制鞘氨醇激酶以及治疗或预防过度增殖性疾病，炎性疾病或血管生成疾病的方法。

6. 发明申请

US20050240057A1 Method for preparing indan-1,3-dicarboxylic acid 失效
标题翻译：茚满-1,3-二羧酸的制备方法
公开(公告)号：US20050240057A1
公开(公告)日：2005-10-27
申请号：US10706694
申请日：2003-11-12
申请人： Timothy Watson , Mark Guzman , Patrice Arpin
发明人： Timothy Watson , Mark Guzman , Patrice Arpin
IPC分类号： C07C51/08
CPC分类号： C07C253/30 , C07C51/08 , C07C2602/08 , C07C61/39 , C07C255/47 , C07C61/29
摘要： A method for preparing indan-1,3-dicarboxylic acid compounds which are useful intermediates in the syntheses of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.
摘要翻译：在芳基稠合的氮杂多环化合物的合成中作为治疗神经和心理障碍的药物的制备茚满-1,3-二羧酸化合物的方法。

7. 发明授权

US6156924A Anti-viral compounds 失效
标题翻译：抗病毒化合物
公开(公告)号：US6156924A
公开(公告)日：2000-12-05
申请号：US214530
申请日：1999-01-06
申请人： William J. Hornback , Scott C. Mauldin , John E. Munroe
发明人： William J. Hornback , Scott C. Mauldin , John E. Munroe
IPC分类号： C07C61/39 , C07C69/00 , C07C229/08 , C07C237/12 , C07C251/44 , C07C271/22 , C07C249/02 , C07C249/04
CPC分类号： C07C69/00 , C07C229/08 , C07C237/12 , C07C251/44 , C07C271/22 , C07C61/39 , C07C2103/00 , C07C2103/26
摘要： The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
摘要翻译： PCT No.PCT / US97 / 07438 Sec。 371日期1999年1月6日 102（e）1999年1月6日PCT PCT 1997年5月2日PCT公布。公开号WO97 / 42156 PCT 日期1997年11月13日本发明通过抑制病毒与宿主细胞的融合来提供抑制包膜病毒的化合物。感染的细胞，易感染的细胞或有需要的哺乳动物可能会抑制病毒。

8. 发明授权

US5508299A Imidazolyl-substituted cyclohexane derivatives 失效
标题翻译：咪唑基取代的环己烷衍生物
公开(公告)号：US5508299A
公开(公告)日：1996-04-16
申请号：US80853
申请日：1993-06-21
申请人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
发明人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
IPC分类号： A61K31/415 , A61K31/41 , A61K31/4164 , A61P9/10 , A61P9/12 , A61P13/12 , A61P43/00 , C07C61/39 , C07C69/75 , C07D233/68 , C07D233/70 , C07D233/92 , C07D317/12 , C07D317/20 , C07D317/30 , C07D317/44 , C07D403/10
CPC分类号： C07D403/10 , C07C61/39 , C07C69/75 , C07D233/68
摘要： Imidazolyl-substituted cyclohexane derivatives are prepared by reacting appropriate cyclohexane derivatives with substituted imidazoles and subsequent variation of the substituents.The imidazolyl-substituted cyclohexane derivatives can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译：咪唑基取代的环己烷衍生物通过使适当的环己烷衍生物与取代的咪唑反应并随后取代基的变化来制备。咪唑基取代的环己烷衍生物可用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。

9. 发明授权

US5276053A Polycyclic amines useful as cerebrovascular agents 失效
标题翻译：用作脑血管药物的多环胺
公开(公告)号：US5276053A
公开(公告)日：1994-01-04
申请号：US957323
申请日：1992-10-06
申请人： Graham Johnson
发明人： Graham Johnson
IPC分类号： C07C45/51 , C07C45/56 , C07C45/59 , C07C45/68 , C07C49/67 , C07C49/697 , C07C49/753 , C07C61/39 , C07C62/34 , C07C69/00 , C07C211/42 , C07C215/44 , C07C217/52 , C07C225/20 , C07C233/06 , C07C235/40 , C07C243/36 , C07C247/10 , C07C271/24 , C07C271/36 , C07C395/00 , C07D209/48 , C07D211/74 , C07D221/16 , C07D265/34 , C07D307/00 , C07D311/58 , C07D311/80 , C07D315/00 , C07D317/72 , C07D333/54 , C07D333/74 , C07D335/02 , C07D335/04 , C07D335/06 , C07D335/10 , C07F7/08 , C07D495/00 , A61K31/35 , A61K31/38
CPC分类号： C07D209/48 , C07C211/42 , C07C215/44 , C07C217/52 , C07C225/20 , C07C233/06 , C07C235/40 , C07C243/36 , C07C247/10 , C07C271/24 , C07C271/36 , C07C395/00 , C07C45/511 , C07C45/562 , C07C45/59 , C07C45/68 , C07C49/67 , C07C49/697 , C07C49/753 , C07C61/39 , C07C62/34 , C07C69/753 , C07D211/74 , C07D221/16 , C07D265/34 , C07D307/00 , C07D311/58 , C07D311/80 , C07D315/00 , C07D317/72 , C07D333/54 , C07D333/74 , C07D335/02 , C07D335/04 , C07D335/06 , C07D335/10 , C07F7/0812 , C07F7/0818 , C07C2101/18 , C07C2103/10 , C07C2103/18 , C07C2103/26 , C07C2103/30
摘要： A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.
摘要翻译：公开了一系列多环胺，衍生物，制备化合物的方法，新型中间体，含有它们的组合物，以及用于治疗和预防脑血管障碍的方法。

10. 发明授权

US4870084A Bicyclic benzo fused pyran compounds used for nausea treatment and prevention 失效
标题翻译：用于恶心治疗和预防的双环苯并稠合吡喃化合物
公开(公告)号：US4870084A
公开(公告)日：1989-09-26
申请号：US278635
申请日：1988-12-01
申请人： James F. Eggler , Michael R. Johnson , Lawrence S. Melvin, Jr.
发明人： James F. Eggler , Michael R. Johnson , Lawrence S. Melvin, Jr.
IPC分类号： C07C37/055 , C07C39/08 , C07C43/23 , C07C61/39 , C07D311/22 , C07D311/58 , C07D405/12 , C07D407/12 , C07D417/12 , C07D491/10 , C07D493/06 , C07D493/10
CPC分类号： C07D405/12 , C07C255/00 , C07C37/055 , C07C41/30 , C07C61/39 , C07D311/22 , C07D311/58 , C07D407/12 , C07D417/12 , C07D491/10 , C07D493/06 , C07D493/10
摘要： Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH.sub.2 or NR.sub.6 ; R.sub.6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups;A' is:(1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 1 or 2; when B is hydrogen, A is C(R.sub.2 R.sub.3)(CH.sub.2).sub.f Q and f is 0 or 1, when taken together A and OR.sub.1 form a lactone or certain derivatives thereof;(2) A' is ##STR2## (3) A' is Q.sub.3 ; Q is CO.sub.2 R.sub.7, COR.sub.8, C(OH)R.sub.8 R.sub.9, CN, CONR.sub.12 R.sub.13, CH.sub.2 NR.sub.12 R.sub.13, CH.sub.2 NHCOR.sub.14, CH.sub.2 NHSO.sub.2 R.sub.17 or 5-tetrazoyl;Q.sub.3 is ##STR3## 5-tetrazolyl, CH.sub.2 CONHCOR.sub.7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH.sub.2, or COCH.sub.2 Q.sub.4 where Q.sub.4 is CN or COOH or certain esters thereof;R.sub.1 is hydrogen, benzyl or certain acyl groups; R.sub.4 is hydrogen, certain alkyl or certain aralkyl groups; R.sub.5 is hydrogen or certain alkyl groups; Z is (C.sub.1 -C.sub.9) alkylene, optionally interrupted by O, S, SO or SO.sub.2 ; and W is hydrogen, methyl, certain aryl or cycloalkyl groups; useful in mammals as analgesics, tranquilizers, antiemetic agents, diuretics, anticonvulsants, antidiarrheals, antitussives, in treatment of glaucoma, and intermediates therefore.
摘要翻译：式（I'）的双环稠合苯并噻唑类化合物及其药学上可接受的阳离子和酸加成盐，其中M为O，CH 2或NR 6; R6是氢，甲酰基，苄氧羰基或某些烷氧基烷基，烷酰基，烷基，芳烷基或芳烷基羰基; A'为：（1）其中A和B之一为氢，使得当A为氢时，B为C（R2R3）（CH2）fQ且f为1或2; 当B为氢时，A为C（R2R3）（CH2）fQ，f为0或1，当A和OR1一起形成内酯或其某些衍生物时; （2）A'是（3）A'是Q3; Q是CO 2 R 7，COR 8，C（OH）R 8 R 9，CN，CONR 12 R 13，CH 2 NR 12 R 13，CH 2 NHCOR 14，CH 2 NHSO 2 R 17或5-四唑基; Q 4是CN或COOH或其某些酯; Q 3是CN，COOH或其某些酯;其中Q 4是CN或COOH或其某些酯; R1是氢，苄基或某些酰基; R4是氢，某些烷基或某些芳烷基; R5是氢或某些烷基; Z是（C1-C9）亚烷基，任选地被O，S，SO或SO 2中断; W是氢，甲基，某些芳基或环烷基; 因此在哺乳动物中作为止痛剂，镇定剂，止吐剂，利尿剂，抗惊厥药，止泻药，镇咳药，在治疗青光眼中有用。

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