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71. 发明授权

US07678334B2 Sample processing devices 有权
公开(公告)号：US07678334B2
公开(公告)日：2010-03-16
申请号：US11399244
申请日：2006-04-06
申请人： William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood
发明人： William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood
IPC分类号： G01N1/00 , G01N21/00 , G01N15/06 , G01N1/10 , B01L3/00
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/50255 , B01L3/502707 , B01L3/502738 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F27B9/16 , F27D5/00 , Y10T436/25 , Y10T436/2575
摘要： Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group of process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

72. 发明申请

US20080314895A1 ENHANCED SAMPLE PROCESSING DEVICES, SYSTEMS AND METHODS 有权
公开(公告)号：US20080314895A1
公开(公告)日：2008-12-25
申请号：US12205170
申请日：2008-09-05
申请人： William Bedingham , Raj Rajagopal , Barry W. Robole
发明人： William Bedingham , Raj Rajagopal , Barry W. Robole
IPC分类号： H05B6/78
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/027 , B01L2300/0681 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1861 , B01L2400/0409 , B01L2400/0661 , B01L2400/0677 , B03C1/30 , F27B9/16 , F27D5/00 , G01N35/0098 , H05B6/80 , Y10T436/2575
摘要： Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.

73. 发明授权

US07347976B2 Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix 失效
标题翻译：在疏水基质中使用亲水性固体载体从生物混合物中除去有机分子的方法和装置
公开(公告)号：US07347976B2
公开(公告)日：2008-03-25
申请号：US10027226
申请日：2001-12-20
申请人： Ranjani V. Parthasarathy , Raj Rajagopal , Vicky L. Morris , William Bedingham , Barry W. Robole
发明人： Ranjani V. Parthasarathy , Raj Rajagopal , Vicky L. Morris , William Bedingham , Barry W. Robole
IPC分类号： B01L11/00
CPC分类号： C12N15/1006 , Y10T428/25 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Methods and devices for removing small negatively charged molecules from a biological sample mixture that uses a solid-phase extraction material that includes a hydrophilic solid support at least partially embedded within a hydrophobic matrix.
摘要翻译：用于从使用固相萃取材料的生物样品混合物中去除小负电荷分子的方法和装置，所述固相萃取材料包括至少部分嵌入疏水基质内的亲水性固体支持物。

74. 发明申请

US20080050276A1 MODULAR SAMPLE PROCESSING APPARATUS KITS AND MODULES 有权
标题翻译：模块化样品加工装置和模块
公开(公告)号：US20080050276A1
公开(公告)日：2008-02-28
申请号：US11930628
申请日：2007-10-31
申请人： William Bedingham , Barry Robole
发明人： William Bedingham , Barry Robole
IPC分类号： G01N37/00
CPC分类号： G01N35/025
摘要： Modular sample processing apparatus kits that can provide a user with the flexibility to customize a disk-based assay in view of a variety of factors are disclosed. The sample processing apparatus kits of the present invention include one or more process modules that can be retained within openings in a frame. The frame and process modules of the sample processing apparatus kits are preferably adapted for use in sample processing systems that compress the apparatus. The process modules may contain different reagents to perform different tests on the same sample materials or a variety of sample materials. As a result, a single sample processing apparatus can be used to perform a variety of different tests and may include a quality control module capable of providing feedback to the user as to the accuracy of the processes run using the sample processing apparatus. Methods of using the sample processing apparatus that include deforming the process modules and frame are also disclosed.
摘要翻译：公开了可以根据各种因素为用户提供定制基于磁盘的测定的灵活性的模块化样品处理装置套件。本发明的样品处理装置试剂盒包括可以保持在框架中的开口内的一个或多个处理模块。样品处理装置套件的框架和处理模块优选地适用于压缩装置的样品处理系统。过程模块可以包含不同的试剂以对相同的样品材料或各种样品材料进行不同的测试。结果，可以使用单个样本处理装置来执行各种不同的测试，并且可以包括质量控制模块，其能够向用户提供关于使用样本处理装置运行的处理的准确性的反馈。还公开了使用包括使处理模块和框架变形的样品处理装置的方法。

75. 发明授权

US07323660B2 Modular sample processing apparatus kits and modules 有权
标题翻译：模块化样品处理设备套件和模块
公开(公告)号：US07323660B2
公开(公告)日：2008-01-29
申请号：US11174756
申请日：2005-07-05
申请人： William Bedingham , Barry W. Robole
发明人： William Bedingham , Barry W. Robole
IPC分类号： F27B9/16 , F27B9/36 , G01N35/04 , C12Q1/34
CPC分类号： G01N35/025
摘要： Modular sample processing apparatus kits that can provide a user with the flexibility to customize a disk-based assay in view of a variety of factors are disclosed. The sample processing apparatus kits of the present invention include one or more process modules that can be retained within openings in a frame. The frame and process modules of the sample processing apparatus kits are preferably adapted for use in sample processing systems that compress the apparatus. The process modules may contain different reagents to perform different tests on the same sample materials or a variety of sample materials. As a result, a single sample processing apparatus can be used to perform a variety of different tests and may include a quality control module capable of providing feedback to the user as to the accuracy of the processes run using the sample processing apparatus. Methods of using the sample processing apparatus that include deforming the process modules and frame are also disclosed.
摘要翻译：公开了可以根据各种因素为用户提供定制基于磁盘的测定的灵活性的模块化样品处理装置套件。本发明的样品处理装置试剂盒包括可以保持在框架中的开口内的一个或多个处理模块。样品处理装置套件的框架和处理模块优选地适用于压缩装置的样品处理系统。过程模块可以包含不同的试剂以对相同的样品材料或各种样品材料进行不同的测试。结果，可以使用单个样本处理装置来执行各种不同的测试，并且可以包括质量控制模块，其能够向用户提供关于使用样本处理装置运行的处理的准确性的反馈。还公开了使用包括使处理模块和框架变形的样品处理装置的方法。

76. 发明申请

US20060228811A1 Sample processing devices 失效
公开(公告)号：US20060228811A1
公开(公告)日：2006-10-12
申请号：US11323700
申请日：2005-12-30
申请人： William Bedingham , Chad Carter , Robert Harkins , Michael Harms , Christopher Kokaisel , Diane North , Kenneth Wood
发明人： William Bedingham , Chad Carter , Robert Harkins , Michael Harms , Christopher Kokaisel , Diane North , Kenneth Wood
IPC分类号： G01N1/00
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/50255 , B01L3/502707 , B01L3/502738 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F27B9/16 , F27D5/00 , Y10T436/25 , Y10T436/2575
摘要： Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

77. 发明授权

US07026168B2 Sample processing devices 失效
公开(公告)号：US07026168B2
公开(公告)日：2006-04-11
申请号：US09895010
申请日：2001-06-28
申请人： William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood
发明人： William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood
IPC分类号： G01N1/00 , G01N21/00 , G01N15/06 , G01N1/10 , B01L3/00
CPC分类号： G01N35/00069 , B01L3/5025 , B01L3/50255 , B01L3/502707 , B01L3/502738 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2200/142 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F27B9/16 , F27D5/00 , Y10T436/25 , Y10T436/2575
摘要： Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

78. 发明申请

US20050199500A1 Sample processing device with unvented channel 有权
标题翻译：采样处理设备，带有通道
公开(公告)号：US20050199500A1
公开(公告)日：2005-09-15
申请号：US10610949
申请日：2003-07-01
申请人： Samuel Gason , William Bedingham , Bathsheba Chong Conklin , Patrick Coleman , Peter Ludowise , Isidro Zarraga
发明人： Samuel Gason , William Bedingham , Bathsheba Chong Conklin , Patrick Coleman , Peter Ludowise , Isidro Zarraga
IPC分类号： B01L3/00 , G01N27/26 , G01N27/27 , G01N27/403 , G01N27/453
CPC分类号： B01L3/502753 , B01L3/502707 , B01L3/502738 , B01L3/502746 , B01L2200/0642 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0409 , B01L2400/0415 , B01L2400/0677 , B01L2400/0683 , Y10T436/113332
摘要： A device includes a substrate having first and second major surfaces and a hub that defines an axis of rotation for the substrate, and an unvented channel having a plurality of connected compartments. Methods for using devices of the invention are also disclosed.
摘要翻译：一种装置包括具有第一和第二主表面的基板和限定用于基板的旋转轴线的毂，以及具有多个连接隔室的未通气通道。还公开了使用本发明装置的方法。

79. 发明申请

US20050180890A1 Systems for using sample processing devices 有权
标题翻译：使用样品处理设备的系统
公开(公告)号：US20050180890A1
公开(公告)日：2005-08-18
申请号：US11082374
申请日：2005-03-16
申请人： William Bedingham , James Aysta , Barry Robole
发明人： William Bedingham , James Aysta , Barry Robole
IPC分类号： C12N15/09 , B01L3/00 , B01L7/00 , B01L9/00 , C12M1/00 , G01N35/00 , G01N35/02
CPC分类号： B01L3/50851 , B01L7/52 , B01L7/54 , B01L9/523 , B01L2300/0803 , B01L2300/1861 , G01N35/025 , G01N2035/00326 , Y10T436/111666
摘要： Sample processing systems for processing sample materials located in sample processing devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate with raised and/or non-planar thermal structures on which the sample processing devices are located during operation of the systems. The systems may also include structure to urge the sample processing devices against the base plate and thermal structures.
摘要翻译：公开了用于处理位于与系统分开的样品处理装置中的样品的样品处理系统。样品处理系统包括具有凸起和/或非平面热结构的旋转底板，其中样品处理装置在系统的操作期间位于其上。该系统还可以包括将样品处理装置推靠在基板和热结构上的结构。

80. 发明授权

US06889468B2 Modular systems and methods for using sample processing devices 有权
标题翻译：使用样品处理设备的模块化系统和方法
公开(公告)号：US06889468B2
公开(公告)日：2005-05-10
申请号：US10034993
申请日：2001-12-28
申请人： William Bedingham , James E. Aysta , Barry W. Robole
发明人： William Bedingham , James E. Aysta , Barry W. Robole
IPC分类号： C12N15/09 , B01L3/00 , B01L7/00 , B01L9/00 , C12M1/00 , G01N35/00 , G01N35/02 , F27D11/00
CPC分类号： B01L3/50851 , B01L7/52 , B01L7/54 , B01L9/523 , B01L2300/0803 , B01L2300/1861 , G01N35/025 , G01N2035/00326 , Y10T436/111666
摘要： Sample processing systems and methods of using those systems for processing sample materials located in devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include connection apparatus that allow for rapid and easy removal and/or replacement of base plates.
摘要翻译：公开了使用这些系统来处理位于与系统分离的设备中的样品材料的样品处理系统和方法。样品处理系统包括在系统操作期间样品处理装置位于其上的旋转底板。这些系统还包括允许快速且容易地移除和/或更换底板的连接装置。

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