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71. 发明授权

US4988624A Lymphotoxin DNA, lymphotoxin expression vector 失效
标题翻译：淋巴毒素DNA，淋巴毒素表达载体
公开(公告)号：US4988624A
公开(公告)日：1991-01-29
申请号：US882109
申请日：1986-07-03
申请人： Tetsu Kakutani , Kenji Yamashita , yasuhiro Ikenaka , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Tetsu Kakutani , Kenji Yamashita , yasuhiro Ikenaka , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07K14/525 , C12N15/19 , C12N15/85
CPC分类号： C07K14/525 , C12N15/85
摘要： A chromosomal DNA sequence which codes for human lymphotoxin, a lymphotoxin expression vector which contains a DNA sequence wherein a chromosomal DNA sequence coding for human lymphotoxin and promoter region which functions in animal cell are linked together, lymphotoxin resistant cell line, transformed animal cell culture which is formed by transforming cultured animal cell with a lymphotoxin expression vector which contains a chromosomal DNA sequence coding for human lymphotoxin and, a process for preparing human lymphotoxin, which comprises transforming cultured animal cell with a lymphotoxin expression vector which contains a chromosomal DNA sequence coding for human lymphotoxin, culturing the transformed cell culture to produce human lymphotoxin, and collecting the human lymphotoxin.According to the present invention, LT which is expected for application as the antitumor agent can be produced effectively in a large amount.
摘要翻译：编码人淋巴毒素的染色体DNA序列，含有DNA序列的淋巴毒素表达载体，其中编码人类淋巴毒素的染色体DNA序列和在动物细胞中起作用的启动子区连接在一起，淋巴毒素抗性细胞系，转化的动物细胞培养物是通过用含有编码人淋巴毒素的染色体DNA序列的淋巴毒素表达载体转化培养的动物细胞，以及制备人淋巴毒素的方法形成的，其包括用含有染色体DNA序列编码的淋巴毒素表达载体转化培养的动物细胞，人淋巴毒素，培养转化的细胞培养物以产生人淋巴毒素，并收集人淋巴毒素。根据本发明，可以有效地大量生产预期用作抗肿瘤剂的LT。

72. 发明授权

US4987562A Semiconductor layer structure having an aluminum-silicon alloy layer 失效
标题翻译：具有铝 - 硅合金层的半导体层结构
公开(公告)号：US4987562A
公开(公告)日：1991-01-22
申请号：US234781
申请日：1988-08-22
申请人： Kiyoshi Watanabe
发明人： Kiyoshi Watanabe
IPC分类号： H01L23/532 , H01L29/47
CPC分类号： H01L29/47 , H01L23/53223 , H01L2924/0002
摘要： A semiconductor layer structure includes an alloy layer of aluminum and silicon formed on a silicon substrate. The concentration of silicon contained in the aluminum-silicon alloy layer is within a range of 10 to 75 weight percent. A barrier layer is formed on top of the aluminum-silicon alloy layer, and a metallic layer is formed on top of the barrier layer.

73. 发明授权

US4965261A Substituted benzoxazinorifamycin derivative and antibacterial agent containing the same 失效
标题翻译：取代的苯并恶嗪利霉素衍生物和含有它们的抗菌剂
公开(公告)号：US4965261A
公开(公告)日：1990-10-23
申请号：US324499
申请日：1989-03-16
申请人： Fumihiko Kanoo , Takehiko Yamane , Hideo Kondo , Takuji Hashizume , Katsuji Yamashita , Kazunori Hosoe , Fumiyuki Kuze , Kiyoshi Watanabe
发明人： Fumihiko Kanoo , Takehiko Yamane , Hideo Kondo , Takuji Hashizume , Katsuji Yamashita , Kazunori Hosoe , Fumiyuki Kuze , Kiyoshi Watanabe
IPC分类号： C07D498/18
CPC分类号： C07D498/18
摘要： A rifamycin derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, R.sup.2 is an alkyl group having 1 to 4 carbon atoms, and A is a group having the formula: ##STR2## in which n is an integer of 3 to 5, or group having the formula: ##STR3## in which R.sup.3 is a alkyl group having 1 to 5 carbon atoms; or a salt thereof. The rifamycin derivative (I) exhibits a strong antibacterial activity against Gram-positive bacteria and acid-fast bacteria, and also exhibits a strong antibacterial activity against tubercle bacilli.

74. 发明授权

US4909960A Semiconductor resin composition 失效
标题翻译：半导体树脂组成
公开(公告)号：US4909960A
公开(公告)日：1990-03-20
申请号：US249532
申请日：1988-09-27
申请人： Kiyoshi Watanabe , Toshio Shiina , Yukio Shimazaki , Hideki Yagyu , Katsutoshi Hanawa , Moritada Marumo
发明人： Kiyoshi Watanabe , Toshio Shiina , Yukio Shimazaki , Hideki Yagyu , Katsutoshi Hanawa , Moritada Marumo
IPC分类号： C08L23/04 , C08K3/04 , C08L23/06 , C08L23/08 , C08L23/16 , H01B1/24
CPC分类号： H01B1/24 , C08K3/04 , C08L23/0853 , C08L23/0869 , C08L2203/202 , C08L2205/03 , C08L23/06 , C08L23/16
摘要： A semiconductive resin composition comprising 100 parts by weight of a polymer component comprising an ethylene-based copolymer, an ethylene-propylene rubber, and a low molecular weight polyethylene having an average molecular weight of 1,000 to 4,000 and 40 parts by weight or more of electroconductive carbon black.

75. 发明授权

US4906593A Method of producing a contact plug 失效
标题翻译：接触插头的制造方法
公开(公告)号：US4906593A
公开(公告)日：1990-03-06
申请号：US166832
申请日：1988-03-04
申请人： Yoshimi Shioya , Yuji Furumura , Yasushi Ohyama , Shin-ichi Inoue , Tsutomu Ogawa , Kiyoshi Watanabe , Hiroshi Goto
发明人： Yoshimi Shioya , Yuji Furumura , Yasushi Ohyama , Shin-ichi Inoue , Tsutomu Ogawa , Kiyoshi Watanabe , Hiroshi Goto
IPC分类号： H01L21/28 , H01L21/3205 , H01L21/768 , H01L29/45
CPC分类号： H01L21/76886 , H01L21/76877 , H01L21/76879 , H01L29/456 , H01L2924/0002 , Y10S148/02 , Y10S148/026
摘要： A method of producing a semiconductor device comprising the steps of: forming a window or contact hole in an insulating layer to expose a portion of a semiconductor substrate or a lower conductor line; forming semiconductor material (silicon) in the window; substituting the material with a metal (tungsten) by reaction of the semiconductor material with a metal compound (WF.sub.6 gas); and forming a conductor line over the metal within the window.
摘要翻译：一种制造半导体器件的方法，包括以下步骤：在绝缘层中形成窗口或接触孔以暴露半导体衬底或下导体线的一部分; 在窗户中形成半导体材料（硅）; 通过半导体材料与金属化合物（WF 6气体）的反应用金属（钨）代替材料; 并在窗内的金属上形成导线。

76. 发明授权

US4863859A Process for preparing optically active glycerol derivatives 失效
标题翻译：光学活性甘油衍生物的制备方法
公开(公告)号：US4863859A
公开(公告)日：1989-09-05
申请号：US822494
申请日：1986-01-27
申请人： Shigeki Hamaguchi , Takehisa Ohashi , Kiyoshi Watanabe
发明人： Shigeki Hamaguchi , Takehisa Ohashi , Kiyoshi Watanabe
IPC分类号： C12P11/00 , C12P41/00
CPC分类号： C12P41/004 , C12P11/00
摘要： A process for preparing optically active glycerol derivatives by a biochemical resolution which comprises (i) subjecting an ester having the general formula [(R,S)-I]: ##STR1## wherein X is a halogen atom, R is an aliphatic hydrocarbon group of C.sub.1 to C.sub.8 and R' is an aromatic hydrocarbon group or an aliphatic hydrocarbon group of C.sub.1 to C.sub.2, to the action of enzymes derived from either microorganisms or animal organs, wherein said enzymes have a stereo selective esterase activity to asymmetrically hydrolyze the ester having the general formula [(R,S)-I] to give a mixture of an optically active alcohol having the general formula (II)*: ##STR2## wherein X and R' are as above and an optically active ester having the general formula (I)*: ##STR3## wherein X, R and R' are as above, and (ii) obtaining the optically active alcohol having the general formula (II)* and the optically active ester having the general formula (I)* by separating operations.In accordance with the present invention, there can be provided a process for preparing optically active glycerol derivatives, wherein the optically active ester having the general formula (I)* and the optically active alcohol having the general formula (II)* can be easily obtained.
摘要翻译：一种通过生化分解制备光学活性甘油衍生物的方法，其包括（i）使具有通式[（R，S）-I]的酯：其中X为卤素原子，R是C1至C8的脂族烃基，R'是C1至C2的芳族烃基或脂族烃基，来自微生物或动物器官的酶的作用，其中所述酶具有立体声选择性酯酶活性以不对称地水解具有通式[（R，S）-I]的酯，得到具有通式（II）的光学活性醇的混合物：其中X和R （I）*：其中X，R和R'如上所述，和（ii）获得具有通式（I）的光学活性酯，其具有通式（I） II）*和具有通式（I）*的光学活性酯通过分离操作。根据本发明，可以提供一种制备光学活性甘油衍生物的方法，其中可以容易地获得具有通式（I）*的光学活性酯和具有通式（II）*的光学活性醇。

77. 发明授权

US4786723A 7-hydroxyguanine compounds, process for preparing said compounds, and anti-tumor agent containing the same 失效
标题翻译： 7-羟基鸟嘌呤化合物，所述化合物的制备方法和含有该化合物的抗肿瘤剂
公开(公告)号：US4786723A
公开(公告)日：1988-11-22
申请号：US844687
申请日：1986-03-27
申请人： Mikio Kitahara , Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Mikio Kitahara , Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P35/00 , C07H19/16 , C07H19/167 , C07H19/173 , C12P19/40 , C12R1/01 , C12R1/025 , C12R1/07 , C12R1/13 , C12R1/18 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/38 , C07H17/00 , C07H15/12 , C07H19/06
CPC分类号： C07H19/16
摘要： Novel 7-hydroxyguanine compounds of the formula: ##STR1## wherein R is hydrogen atom or hydroxy, and a salt thereof, which have excellent anti-tumor activity, process for preparing the compounds, and anti-tumor agent containing said compound as an active ingredient.
摘要翻译：具有下式的新型7-羟基鸟嘌呤化合物：其中R是氢原子或羟基，其盐具有优异的抗肿瘤活性，制备该化合物的方法和含有所述化合物的抗肿瘤剂作为活性成分。

78. 发明授权

US4690919A Benzoxazinorifamycin derivative, process for preparing the same and antibacterial agent containing the same 失效
标题翻译：苯并恶嗪利霉素衍生物，其制备方法和含有它们的抗菌剂
公开(公告)号：US4690919A
公开(公告)日：1987-09-01
申请号：US826398
申请日：1986-02-05
申请人： Takehiko Yamane , Takuji Hashizume , Katsuji Yamashita , Kiyoshi Watanabe
发明人： Takehiko Yamane , Takuji Hashizume , Katsuji Yamashita , Kiyoshi Watanabe
IPC分类号： C07D498/18 , C07D519/00 , A61K31/535
CPC分类号： C07D498/18 , C07D519/00
摘要： A novel rifamycin derivative having the general formula (I): ##STR1## or salts thereof, a process for preparing the same and antibacterial agents containing the same as an effective component.The rifamycin derivative of the present invention having the general formula (I) shows a strong antibacterial activity against the Gram-positive bacteria and the acid-fast bacteria.
摘要翻译：具有通式（I）的新型利福霉素衍生物或其盐，其制备方法和含有该有效成分的抗菌剂。具有通式（I）的本发明的利福霉素衍生物显示出对革兰氏阳性菌和耐酸细菌的强抗菌活性。

79. 发明授权

US4540665A Process for producing D-.beta.-hydroxyalkanoic acid 失效
标题翻译：生产D-β-羟基链烷酸的方法
公开(公告)号：US4540665A
公开(公告)日：1985-09-10
申请号：US475603
申请日：1983-03-15
申请人： Junzo Hasegawa , Masahiro Ogura , Hiroshi Kanema , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Junzo Hasegawa , Masahiro Ogura , Hiroshi Kanema , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P7/42 , C12N1/14 , C12N1/16 , C12N1/32 , C12N15/00 , C12P1/02 , C12R1/72
CPC分类号： C12P7/42 , Y10S435/921
摘要： A process for producing D-.beta.-hydroxyalkanoic acids by utilizing microorganisms having an ability of stereospecifically converting alkanoic acids, 2-alkenoic acids or alcohols into D-.beta.-hydroxyalkanoic acids.
摘要翻译：通过利用具有立体选择性将链烷酸，2-链烯酸或醇转化为D-β-羟基链烷酸的能力的微生物来生产D-β-羟基链烷酸的方法。

80. 发明授权

US4431656A 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient 失效
标题翻译： 3,5-二叔丁基苯乙烯衍生物，其盐和含有该活性成分的药物组合物
公开(公告)号：US4431656A
公开(公告)日：1984-02-14
申请号：US337168
申请日：1982-01-05
申请人： Ikuo Katsumi , Hideo Kondo , Katsuji Yamashita , Takayoshi Hidaka , Kazunori Hosoe , Yutaka Ariki , Toshiaki Yamashita , Kiyoshi Watanabe
发明人： Ikuo Katsumi , Hideo Kondo , Katsuji Yamashita , Takayoshi Hidaka , Kazunori Hosoe , Yutaka Ariki , Toshiaki Yamashita , Kiyoshi Watanabe
IPC分类号： C07C49/248 , C07C49/747 , C07C49/753 , C07C49/835 , C07C59/52 , C07C59/90 , C07D233/96 , C07D307/58 , A61K31/415 , C07D307/26
CPC分类号： C07C255/00 , C07C49/248 , C07C49/747 , C07C49/753 , C07C49/835 , C07C59/52 , C07C59/90 , C07D233/96 , C07D307/58 , Y10S514/825 , Y10S514/916
摘要： Novel compounds, 3,5-di-tert-butylstyrene derivatives and their salts, are disclosed, which derivatives are represented by the general formula: ##STR1## wherein R.sup.1 stands for an acyloxy group represented by R.sup.3 COO (R.sup.3 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.6), an alkoxyl group of R.sub.4 O (R.sup.4 is an alkyl group with C.sub.1 -C.sub.4), a hydroxyl group, or a hydrogen atom; R.sup.2 stands for ##STR2## (R.sup.5 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.3 and X.sup.1 is CH.sub.2 or an oxygen atom), ##STR3## (R.sup.5 and X.sup.1 are each the same as defined above), or ##STR4## (X.sup.2 is an oxygen or sulfur atom). There are also disclosed an anti-inflammatory, analgesic, and antipyretic pharmaceutical composition and an anti-platelet aggregation pharmaceutical composition, both pharmaceutical compositions comprising the foregoing 3,5-di-tert-butylstyrene derivative or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients.
摘要翻译：公开了新的化合物，3,5-二叔丁基苯乙烯衍生物及其盐，该衍生物由以下通式表示：其中R1代表由R3COO表示的酰氧基（R3是氢原子或具有C1-C6的烷基），R4O的烷氧基（R4是具有C1-C4的烷基），羟基或氢原子; R2代表（R5是氢原子或具有C1-C3和X1是CH2的烷基或氧原子），＆lt; IMAGE＆gt;（R5和X1各自与上述相同）或（X2是氧或硫原子）。还公开了抗炎，镇痛和解热药物组合物和抗血小板聚集药物组合物，两种药物组合物包含前述3,5-二叔丁基苯乙烯衍生物或其药学上可接受的盐作为活性成分与药物赋形剂的关联。

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