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71. 发明授权

US5294705A Process for the preparation of a 3-substituted thio-3-cephem compound 失效
标题翻译： 3-取代的硫代-3-头孢烯化合物的制备方法
公开(公告)号：US5294705A
公开(公告)日：1994-03-15
申请号：US853730
申请日：1992-06-03
申请人： Yuichi Yamamoto , Tsuneo Okonogi , Seiji Shibahara , Shigeharu Inoue
发明人： Yuichi Yamamoto , Tsuneo Okonogi , Seiji Shibahara , Shigeharu Inoue
IPC分类号： C07D501/00 , C07D501/04 , C07D501/59
CPC分类号： C07D501/00 , Y02P20/55
摘要： An ester of 7-acylamido-3-acylthio-3- or -2-cephem-4-carboxylic acid represented by general formula (1) ##STR1## wherein R.sup.1 is an acyl group, R.sup.2 is a carboxyl-protecting group, R.sup.3 is a lower alkyl group, an aryl group or a substituted aryl group, or a mixture of two or more of said ester is used as the starting compound and is reacted wit a tertiary amine and also a secondary amine. Then the tertiary amine salt compound as formed as the reaction product is reacted with a compound of formula (4)R.sup.4 --X (4)wherein R.sup.4 is a lower alkyl group, a cycloalkyl group or a heterocyclic group or a heterocyclic group-substituted methyl group and X is a leaving group, whereby the desired ester of 7-acylamido-3-substituted thio-3-cephem-4-carboxylic acid of formula (5) ##STR2## can be produced preferentially, conveniently and efficiently.
摘要翻译： PCT No.PCT / JP90 / 01599 Sec。 371日期：1992年6月3日 102（e）日期1992年6月3日PCT 1990年12月7日PCT PCT。公开号WO91 / 09037 1991年6月27日，由通式（1）表示的7-酰基氨基-3-酰硫基-3-或2-头孢烯-4-羧酸酯（*化学结构*）（1）其中R1为酰基，R2为羧基保护基，R3为低级烷基，芳基或取代芳基，或两种或多种所述酯的混合物用作起始化合物，并与叔胺以及仲胺。然后将作为反应产物形成的叔胺盐化合物与式（4）R4-X（4）的化合物反应，其中R4是低级烷基，环烷基或杂环基或杂环基取代的甲基并且X是离去基团，由此可以优选地，方便地制备所需的式（5）的7-酰基酰胺基-3-取代的硫代-3-头孢烯-4-羧酸的酯（*化学结构*）（5）并有效地。

72. 发明授权

US5294629A Benzothiazole and benzimidazole derivatives and antiulcer agent containing the same 失效
标题翻译：苯并噻唑和苯并咪唑衍生物和含有它们的抗溃疡剂
公开(公告)号：US5294629A
公开(公告)日：1994-03-15
申请号：US037671
申请日：1993-03-25
申请人： Tomoya Machinami , Kazue Yasufuku , Seiji Shibahara , Fumiya Hirano , Yasukatsu Yuda , Motohiro Nishio , Yuji Matsuhashi , Takashi Tsuruoka , Kiyoaki Katano , Shigeharu Inoye
发明人： Tomoya Machinami , Kazue Yasufuku , Seiji Shibahara , Fumiya Hirano , Yasukatsu Yuda , Motohiro Nishio , Yuji Matsuhashi , Takashi Tsuruoka , Kiyoaki Katano , Shigeharu Inoye
IPC分类号： C07D235/28 , C07D277/74 , A61K31/415 , A61K31/425 , C07D277/76
CPC分类号： C07D235/28 , C07D277/74
摘要： A novel benzothiazole or benzimidazole derivative represented by formula (I) ##STR1## wherein X represents a sulfur atom or a NH group; R.sup.1 represents a hydrogen atom, a lower alkoxy group, a chlorine atom, a bromine atom or an iodine atom; R.sup.2 represents a hydrogen atom a substituted or unsubstituted lower alkyl group, a vinyl group, an aryl group or an acyl group; m is an integer of 1, 2 or 3; and n is an integer of 0, 1 or 2, which shows an excellent acid secretion suppressing effect and gastric mucosa protecting effect, and an antiulcer agent containing the same as an active ingredient.
摘要翻译：由式（I）表示的新型苯并噻唑或苯并咪唑衍生物其中X表示硫原子或NH基团; R1表示氢原子，低级烷氧基，氯原子，溴原子或碘原子; R2代表氢原子取代或未取代的低级烷基，乙烯基，芳基或酰基; m为1,2或3的整数; n为0或1或2的整数，表现出优异的酸分泌抑制效果和胃粘膜保护作用，以及含有作为活性成分的抗溃疡剂。

73. 发明授权

US5200407A Azole derivatives and anti-ulcerative composition containing same 失效
标题翻译：唑衍生物和含有其的抗溃疡组合物
公开(公告)号：US5200407A
公开(公告)日：1993-04-06
申请号：US716621
申请日：1991-06-14
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
IPC分类号： C07D471/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D513/04
摘要： Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integer from 0 to 2.
摘要翻译：通式（I）的化合物：其中A，B，C和D各自表示-CH =或-N =，条件是其中至少一个为 -N =; X表示-NH-，-O-或-S-; Y表示 - （CH 2）p - ，其中p是0至4的整数，-C（CH 3）2 - ， - CH 2 CH = CH - ， - CH 2 CO - ， - CF 2 - 或-CH 2 COCH 2 - R1表示氢原子，C1-4烷基，卤素原子或C1-4烷氧基; R2表示氢原子，羟基，饱和或不饱和的C1-6烷基，C1-6烷氧基，羧基，可以任意取代的饱和或不饱和的C 1-12烷氧基羰基，环烷氧基羰基，含有至少一个氮原子的饱和或不饱和五元或六元杂环基，任选具有一个或多个氮和/或氧原子，其可以任选地被缩合和/或取代，-CONR 3 R 4，-NR 3 R 4，-OCOR 3或 - NHCONHR 3其中R3和R4可以相同或不同，表示可以被任意取代的C 1-6烷基或环烷基，m和n各自表示0〜2的整数。

74. 发明授权

US4971961A Cephalosporin compounds and antibacterial agents 失效
标题翻译：头孢菌素化合物和抗菌剂
公开(公告)号：US4971961A
公开(公告)日：1990-11-20
申请号：US266050
申请日：1988-11-02
申请人： Kaysuyoshi Iwamatsu , Kenji Sakagami , Kunio Atsumi , Takashi Yoshida , Seiji Shibahara , Takashi Tsuruoka , Shinichi Kondo
发明人： Kaysuyoshi Iwamatsu , Kenji Sakagami , Kunio Atsumi , Takashi Yoshida , Seiji Shibahara , Takashi Tsuruoka , Shinichi Kondo
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36
CPC分类号： C07D501/00 , Y02P20/55
摘要： This invention provides cephalosporin compounds represented by the following general formula: ##STR1## wherein R.sup.1 and R.sup.2 are same or different hydrogen atom or a lower alkyl group of 1 to 5 carbon atoms; R.sup.3 is a lower alkyl group which may optionally be substituted with a halogen atome (or atoms), an alkenyl group, or a cycloalkylmethyl group of 3 to 6 carbon atoms; and A is hydrogen atom or residue of a nucleophilic compound and pharmacologically acceptable salts thereof. These compounds have broad-spectrum antibacterial activity against Gram-positive and -negative bacteria including Pseudomonas aeruginosa, as well as against a great variety of .beta.-lactamase-producing strains.

75. 发明授权

US4929633A Actinonin derivatives having physiological activities 失效
标题翻译：猕猴桃衍生物具有生理活性
公开(公告)号：US4929633A
公开(公告)日：1990-05-29
申请号：US203888
申请日：1988-06-08
申请人： Seiji Shibahara , Yukiko Takahashi , Yuji Matsuhashi , Mitsugu Hachisu , Shinichi Kondo , Tomio Takeuchi , Takaaki Aoyagi
发明人： Seiji Shibahara , Yukiko Takahashi , Yuji Matsuhashi , Mitsugu Hachisu , Shinichi Kondo , Tomio Takeuchi , Takaaki Aoyagi
IPC分类号： A61K31/40 , A61P25/28 , C07D207/08
CPC分类号： C07D207/08
摘要： As new compounds are provided a class of derivatives of actinonin represented by the general formula ##STR1## where R is a hydrogen or a lower alkyl group, which can exhibit the enzyme-inhibitory activities to a limited range of peptidases and show a remarkable enzyme-specificity, and which are effective to treat a cycloheximide-induced experimental amnesia in mice and are expectable to be useful to treat an amnesia in a mammalian animal, including human.

76. 发明授权

US09146425B2 Liquid crystal display and method of manufacturing the same 有权
标题翻译：液晶显示器及其制造方法
公开(公告)号：US09146425B2
公开(公告)日：2015-09-29
申请号：US13527738
申请日：2012-06-20
申请人： Shunichi Suwa , Seiji Shibahara , Masashi Miyakawa , Masahiko Nakamura , Tadaaki Isozaki
发明人： Shunichi Suwa , Seiji Shibahara , Masashi Miyakawa , Masahiko Nakamura , Tadaaki Isozaki
IPC分类号： C09K19/00 , G02F1/1337 , C09K19/56 , C09K19/10 , C09K19/30 , G02F1/137
CPC分类号： G02F1/133711 , C09K19/10 , C09K19/3001 , C09K19/56 , G02F1/133703 , G02F1/133707 , G02F1/133723 , G02F1/133753 , G02F1/133788 , G02F2001/133726 , G02F2001/133742 , G02F2001/133757 , G02F2001/13712 , Y10T428/10 , Y10T428/1005
摘要： Disclosed herein is a liquid crystal display having a liquid crystal display element, the liquid crystal display element including: a pair of alignment films provided on mutually facing sides of a pair of substrates; and a liquid crystal layer which is provided between the pair of alignment films and contains a liquid crystal molecule having a negative dielectric anisotropy, wherein at least one of the pair of alignment films contains a cross-linked compound obtained by cross-linking a polymer compound having a cross-linkable functional group as a side chain, the liquid crystal layer further contains a molecule which has a ring structure and a spacer linking the ring structure, and the liquid crystal molecule is given a pre-tilt by the cross-linked compound.
摘要翻译：本发明是一种具有液晶显示元件的液晶显示器，该液晶显示元件包括：设置在一对基板的相对面侧的一对取向膜; 以及液晶层，其设置在所述一对取向膜之间并且包含具有负介电各向异性的液晶分子，其中所述一对取向膜中的至少一个包含通过交联高分子化合物获得的交联化合物具有可交联官能团作为侧链的情况下，液晶层还含有具有环结构的分子和连接环结构的间隔基，并且通过交联化合物给予液晶分子的预倾斜。

77. 发明申请

US20090168009A1 LIQUID CRYSTAL MATERIAL, LIQUID CRYSTAL DISPLAY DEVICE AND LIQUID CRYSTAL DISPLAY 有权
标题翻译：液晶材料，液晶显示装置和液晶显示
公开(公告)号：US20090168009A1
公开(公告)日：2009-07-02
申请号：US12336014
申请日：2008-12-16
申请人： Seiji Shibahara
发明人： Seiji Shibahara
IPC分类号： G02F1/13 , C09K19/00
CPC分类号： C09K19/3444 , C09K19/12 , C09K19/14 , C09K19/16 , C09K19/2007 , C09K19/22 , C09K19/3003 , C09K19/3028 , C09K19/3098 , C09K19/32 , C09K19/322 , C09K19/3402 , C09K19/3491 , C09K2019/0481 , C09K2019/3027 , C09K2019/3422 , G02F1/0081 , G02F1/13725 , G02F2001/133742 , G02F2001/13712 , Y10T428/10
摘要： A liquid crystal display device capable of obtaining good display characteristics and good response characteristics is provided. A liquid crystal material being a paraelectric material, the liquid crystal material includes: a liquid crystal molecule exhibiting a nematic liquid crystal phase at room temperature and including one or more cyclic structures; and a bent-shaped molecule including cyclic structures which are large in number compared to the cyclic structures included in the liquid crystal molecule.
摘要翻译：提供能够获得良好的显示特性和良好的响应特性的液晶显示装置。作为顺电材料的液晶材料，所述液晶材料包括：在室温下显示向列型液晶相并且包含一个或多个环状结构的液晶分子; 以及包含与包含在液晶分子中的环状结构相比数量多的循环结构的弯曲形分子。

78. 发明授权

US5488038A Dibekacin derivatives and arbekacin derivatives active against resistant bacteria 失效
标题翻译：敌百虫素衍生物和对抗性细菌有活性的阿贝卡星衍生物
公开(公告)号：US5488038A
公开(公告)日：1996-01-30
申请号：US154002
申请日：1993-11-18
申请人： Shinichi Kondo , Seiji Shibahara , Takayuki Usui , Toshiaki Kudo , Shuichi Gomi , Atsushi Tamura , Yoko Ikeda , Daishiro Ikeda , Tomio Takeuchi
发明人： Shinichi Kondo , Seiji Shibahara , Takayuki Usui , Toshiaki Kudo , Shuichi Gomi , Atsushi Tamura , Yoko Ikeda , Daishiro Ikeda , Tomio Takeuchi
IPC分类号： C07H15/236 , A61K31/70 , C07H15/22
CPC分类号： C07H15/234
摘要： As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.
摘要翻译：现在提供新的二卡辛衍生物和新的阿贝卡星衍生物2' - 氨基-2' - 脱氧胆碱，2“ - 氨基-5,2” - 脱氧胆酸，2“ - 氨基-2'-脱氧阿糖胞苷，2 “ - 氨基-5,2” - 双脱氧肉豆蔻素，2“ - 氨基-5,2” - 双脱氧-5-表 - 氟代贝卡星和2“ - 氨基-5,2” - 双脱氧-5-表所有这些都表现出对各种革兰氏阳性和革兰氏阴性细菌的高抗菌活性，包括耐甲氧西林金黄色葡萄球菌等抗性细菌，对哺乳动物毒性低，可用作细菌治疗的抗菌剂感染。

79. 发明授权

US5407918A 16-membered macrolide derivatives and process for producing the same 失效
标题翻译： 16元大环内酯衍生物及其制备方法
公开(公告)号：US5407918A
公开(公告)日：1995-04-18
申请号：US143125
申请日：1993-10-29
申请人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
发明人： Keiichi Ajito , Ken-ichi Kurihara , Akira Shimizu , Shuichi Gomi , Nobue Kikuchi , Minako Araake , Tsuneo Ishizuka , Aiko Miyata , Osamu Hara , Seiji Shibahara
IPC分类号： C07H17/08 , C12P19/62 , A61K31/70 , C12P19/60
CPC分类号： C07H17/08
摘要： 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 represents a straight-chain alkyl group having 1 to 3 carbon atoms; R.sup.2 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.3 represents a hydrogen atom or a COR.sup.6 group, wherein R.sup.6 is as defined above; R.sup.4 represents a straight-chain alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted allyl group; and R.sup.5 represents a substituted or unsubstituted, straight-chain or branched alkyl, alkenyl or aralkyl group having 1 to 10 carbon atoms; and pharmaceutically acceptable salts thereof are disclosed. These compounds show excellent and long-acting antimicrobial activities. A novel process for producing these 16-membered macrolide derivatives is further disclosed.
摘要翻译：由式（I）表示的16元大环内酯衍生物：其中R 1表示氢原子或COR 6基团，其中R 6表示具有1至3个碳原子的直链烷基; R2表示氢原子或COR6基团，其中R6如上所定义; R3表示氢原子或COR6基团，其中R6如上所定义; R4表示碳原子数1〜4的直链烷基或取代或未取代的烯丙基; R 5表示具有1〜10个碳原子的取代或未取代的直链或支链烷基，烯基或芳烷基; 及其药学上可接受的盐。这些化合物显示出优异的长效抗菌活性。进一步公开了一种制备这些16元大环内酯衍生物的新方法。

80. 发明授权

US5334723A 2-piperidinecarboxylic acid derivative, oncogene suppressor and agent for obtaining revertants 失效
标题翻译： 2-哌啶羧酸衍生物，癌基因抑制剂和获得回复体的试剂
公开(公告)号：US5334723A
公开(公告)日：1994-08-02
申请号：US937112
申请日：1992-08-31
申请人： Tsuneo Okonogi , Osamu Makabe , Yuichi Yamamoto , Osamu Itoh , Tsutomu Tsuruoka , Takayuki Usui , Seiji Shibahara , Kozo Nagaoka , Shigeharu Inouye , Nobuko Okada , Susumu Nishimura
发明人： Tsuneo Okonogi , Osamu Makabe , Yuichi Yamamoto , Osamu Itoh , Tsutomu Tsuruoka , Takayuki Usui , Seiji Shibahara , Kozo Nagaoka , Shigeharu Inouye , Nobuko Okada , Susumu Nishimura
IPC分类号： C07D211/90 , C07D211/76 , C07D211/86 , C07D211/88
CPC分类号： C07D211/90
摘要： A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.
摘要翻译：由下式表示的新颖的2-哌啶羧酸衍生物：其中X表示与氢原子结合的氧原子，硫原子或氮原子; 和*表示与羧基结合的碳原子的构型是（S），（R）或（S）和（R）的混合物。和其药学上可接受的盐在广泛的肿瘤细胞上发挥抗肿瘤作用。

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