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1. 发明授权

US5334723A 2-piperidinecarboxylic acid derivative, oncogene suppressor and agent for obtaining revertants 失效
标题翻译： 2-哌啶羧酸衍生物，癌基因抑制剂和获得回复体的试剂
公开(公告)号：US5334723A
公开(公告)日：1994-08-02
申请号：US937112
申请日：1992-08-31
申请人： Tsuneo Okonogi , Osamu Makabe , Yuichi Yamamoto , Osamu Itoh , Tsutomu Tsuruoka , Takayuki Usui , Seiji Shibahara , Kozo Nagaoka , Shigeharu Inouye , Nobuko Okada , Susumu Nishimura
发明人： Tsuneo Okonogi , Osamu Makabe , Yuichi Yamamoto , Osamu Itoh , Tsutomu Tsuruoka , Takayuki Usui , Seiji Shibahara , Kozo Nagaoka , Shigeharu Inouye , Nobuko Okada , Susumu Nishimura
IPC分类号： C07D211/90 , C07D211/76 , C07D211/86 , C07D211/88
CPC分类号： C07D211/90
摘要： A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.
摘要翻译：由下式表示的新颖的2-哌啶羧酸衍生物：其中X表示与氢原子结合的氧原子，硫原子或氮原子; 和*表示与羧基结合的碳原子的构型是（S），（R）或（S）和（R）的混合物。和其药学上可接受的盐在广泛的肿瘤细胞上发挥抗肿瘤作用。

2. 发明授权

US4985445A Cancer cell metastasis inhibitors and novel compounds 失效
标题翻译：癌细胞转移抑制剂和新化合物
公开(公告)号：US4985445A
公开(公告)日：1991-01-15
申请号：US307387
申请日：1989-02-06
申请人： Tsutomu Tsuruoka , Satoru Nakabayashi , Harumi Fukuyasu , Yuuko Ishii , Takashi Tsuruoka , Haruo Yamamoto , Shigeharu Inouye , Shinichi Kondo
发明人： Tsutomu Tsuruoka , Satoru Nakabayashi , Harumi Fukuyasu , Yuuko Ishii , Takashi Tsuruoka , Haruo Yamamoto , Shigeharu Inouye , Shinichi Kondo
IPC分类号： A61K31/445 , C07D211/76
CPC分类号： A61K31/445 , C07D211/76
摘要： Sugar lactams such as N-(3-phenylpropyl)-1-deoxynojirimycin, 1-deoxynojirimycin, D-glucaro-.delta.-lactam, 6-O-triphenylmethyl-D-gluco-.delta.-lactam, etc. and new derivatives thereof which markedly inhibit metastasis of cancer cells.

3. 发明授权

US4563472A Iodoallyl and iodopropargyl substituted tetrazoles and anti-microbial compositions thereof 失效
标题翻译：碘代烯丙基和碘炔丙基取代的四唑及其抗微生物组合物
公开(公告)号：US4563472A
公开(公告)日：1986-01-07
申请号：US433011
申请日：1982-10-06
申请人： Shigeharu Inouye , Taro Niida , Keinosuke Miyauchi , Kuniomi Matsumoto , Eiichi Akita , Masao Koyama , Fumio Kai , Takashi Tsuruoka
发明人： Shigeharu Inouye , Taro Niida , Keinosuke Miyauchi , Kuniomi Matsumoto , Eiichi Akita , Masao Koyama , Fumio Kai , Takashi Tsuruoka
IPC分类号： A01N43/36 , A01N43/50 , A01N43/56 , A01N43/653 , A01N43/713 , C07D207/34 , C07D207/42 , C07D233/91 , C07D257/04 , C07D257/06 , C07D521/00 , A61K31/41
CPC分类号： C07D257/04 , A01N43/36 , A01N43/50 , A01N43/56 , A01N43/653 , A01N43/713 , C07D207/34 , C07D207/42 , C07D231/12 , C07D233/56 , C07D233/91 , C07D249/08 , C07D257/06
摘要： Triiodoallyl- or iodopropargyl-substituted heterocyclic aromatic compounds which can be prepared by reacting unsubstituted- or substituted nitrogen-containing heterocyclic compounds with corresponding iodine containing alcohol reactive derivatives in the presence of a base in an inert organic solvent. These new heterocyclic aromatic compounds have remarkable antibacterial and antifungal activities and are useful as antibacterial and antifungal agents in medicinal, agricultural and industrial fields.
摘要翻译：三碘代烯丙基或碘炔丙基取代的杂环芳族化合物，其可以通过在碱存在下在惰性有机溶剂中使未取代或取代的含氮杂环化合物与相应的含碘醇反应性衍生物反应来制备。这些新的杂环芳族化合物具有显着的抗菌和抗真菌活性，可用作药用，农业和工业领域的抗菌和抗真菌剂。

4. 发明授权

US4552584A Herbicidal composition and herbicidal processes 失效
标题翻译：除草成分和除草过程
公开(公告)号：US4552584A
公开(公告)日：1985-11-12
申请号：US495819
申请日：1983-05-18
申请人： Tetsuo Takematsu , Makoto Konnai , Kunitaka Tachibana , Takashi Tsuruoka , Shigeharu Inouye , Tetsuro Watanabe
发明人： Tetsuo Takematsu , Makoto Konnai , Kunitaka Tachibana , Takashi Tsuruoka , Shigeharu Inouye , Tetsuro Watanabe
IPC分类号： A01N33/26 , A01N37/32 , A01N39/04 , A01N57/20 , A01P13/00 , C07F9/32 , A01N43/58
CPC分类号： A01N57/20
摘要： A known antibiotic, SF-1293 substance and salts thereof have now been found to exhibit high herbicidal effects against a wide variety of herbaceous and woody plants, but they are non-phytotoxic particularly to a useful woody plant, Chamaecyparis obtusa. The herbicidal effects of these SF-1293 substances can be noticeably enhanced by applying in combination with certain known herbicides or compounds having biological activities.
摘要翻译：现已发现已知的抗生素SF-1293物质及其盐对各种草本植物和木本植物表现出高除草效果，但特别是对有用的木本植物Chamaecyparis obtusa而言是非植物毒性。通过与某些已知的具有生物活性的除草剂或化合物组合使用，可以显着提高这些SF-1293物质的除草效果。

5. 发明授权

US4448601A Herbicidal compositions and herbicidal processes 失效
标题翻译：除草组合物和除草过程
公开(公告)号：US4448601A
公开(公告)日：1984-05-15
申请号：US334042
申请日：1981-12-23
申请人： Tetsuo Takematsu , Makoto Konnai , Kunitaka Tachibana , Takashi Tsuruoka , Shigeharu Inouye , Tetsuro Watanabe
发明人： Tetsuo Takematsu , Makoto Konnai , Kunitaka Tachibana , Takashi Tsuruoka , Shigeharu Inouye , Tetsuro Watanabe
IPC分类号： A01N33/26 , A01N37/32 , A01N39/04 , A01N57/20 , A01P13/00 , C07F9/32 , A01N57/00
CPC分类号： A01N57/20
摘要： A known antibiotic, SF-1293 substance and salts thereof have now been found to exhibit high herbicidal effects against a wide variety of herbaceous and woody plants, but they are non-phytotoxic particularly to a useful woody plant, Chamaecyparis obtusa. The herbicidal effects of these SF-1293 substances can be noticeably enhanced by applying in combination with certain known herbicides or compounds having biological activities.
摘要翻译：现已发现已知的抗生素SF-1293物质及其盐对各种草本植物和木本植物表现出高除草效果，但特别是对有用的木本植物Chamaecyparis obtusa而言是非植物毒性。通过与某些已知的具有生物活性的除草剂或化合物组合使用，可以显着提高这些SF-1293物质的除草效果。

6. 发明授权

US4226610A Herbicidal compounds, preparation thereof and herbicides containing the same 失效
标题翻译：除草化合物，其制备方法和含有它们的除草剂
公开(公告)号：US4226610A
公开(公告)日：1980-10-07
申请号：US27900
申请日：1979-04-06
申请人： Tetsuo Takematsu , Makoto Konnai , Akira Suzuki , Kunitaka Tachibana , Takashi Tsuruoka , Shigeharu Inouye , Tetsuro Watanabe
发明人： Tetsuo Takematsu , Makoto Konnai , Akira Suzuki , Kunitaka Tachibana , Takashi Tsuruoka , Shigeharu Inouye , Tetsuro Watanabe
IPC分类号： A01N33/08 , A01N57/20 , A01P13/00 , C07F9/30 , C07K5/08 , A01N57/00 , C07C103/52 , C07F9/02
CPC分类号： A01N57/20 , C07F9/301 , C07K5/0827
摘要： Novel compounds represented by formula (I) or (II) are provided: ##STR1## They can control annual and perennial weeds, shrubs and aquatic plants more effectively than their mother compounds, or (2-amino-4-methylphosphinobutyryl)alanylalanine and 2-amino-4-methylphosphinobutanoic acid, respectively.
摘要翻译：提供了由式（I）或（II）表示的新型化合物：其中，（I）（II）。它们可以分别比其母体化合物，（2-氨基-4-甲基膦酰基丁酰基）丙氨酸和2-氨基-4-甲基膦酸丁酯更有效地控制一年生和多年生杂草，灌木和水生植物。

7. 发明授权

US4216226A Antiviral agent and treatment of viral infections 失效
标题翻译：抗病毒药物和病毒感染的治疗
公开(公告)号：US4216226A
公开(公告)日：1980-08-05
申请号：US910627
申请日：1978-05-30
申请人： Harumi Fukuyasu , Zenichiro Ohya , Katsuo Kawakami , Takahiko Kikuchi , Takashi Shomura , Takashi Tsuruoka , Tetsuro Watanabe , Yuzo Kazuno , Shigeharu Inouye , Yasuharu Sekizawa
发明人： Harumi Fukuyasu , Zenichiro Ohya , Katsuo Kawakami , Takahiko Kikuchi , Takashi Shomura , Takashi Tsuruoka , Tetsuro Watanabe , Yuzo Kazuno , Shigeharu Inouye , Yasuharu Sekizawa
IPC分类号： A61K31/195 , A61K31/22 , A61K31/395 , A61K31/44 , A61K31/66 , A61P31/12 , A61P31/16 , A61P31/22 , C07D213/65 , C07F9/38
CPC分类号： C07F9/3808 , A61K31/195 , A61K31/22 , A61K31/44 , A61K31/66
摘要： A new antiviral agent is now provided, which contains as the active ingredient at least one known glycine derivative of the formula: ##STR1## wherein R is a hydrogen atom, R' is a group --CH.sub.2 NH.sub.2, --CH.sub.2 NHCONH.sub.2, --CH.sub.2 NHCONHOH, --CH.sub.2 CH.sub.2 PO(OH).sub.2, ##STR2## or R and R' taken together form a group ##STR3## and R" is a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt of said glycine derivative. This antiviral agent is useful for therapeutic prevention and treatment of diseases caused by various kinds of viruses.
摘要翻译：现在提供一种新的抗病毒剂，其包含作为活性成分的至少一种下列通式的甘氨酸衍生物：其中R是氢原子，R'是基团-CH2NH2，-CH2NHCONH2，-CH2NHCONHOH，-CH2CH2PO （OH）2，或R和R'一起形成基团，R“是氢原子或低级烷基，或所述甘氨酸衍生物的药学上可接受的盐。该抗病毒剂可用于各种病毒引起的疾病的治疗性预防和治疗。

8. 发明授权

US4198416A 5-Alkoxy-picolinic esters and anti-hypertensive composition containing 5-alkoxy-picolinic esters 失效
标题翻译： 5-烷氧基 - 吡啶甲酸酯和含有5-烷氧基 - 吡啶甲酸酯的抗高血压组合物
公开(公告)号：US4198416A
公开(公告)日：1980-04-15
申请号：US944683
申请日：1978-09-22
申请人： Takemi Koeda , Takashi Tsuruoka , Uichi Shibata , Hiroyasu Asaoka , Mitsugu Hachisu , Osamu Itoh , Yasuharu Sekizawa , Shigeharu Inouye , Taro Niida
发明人： Takemi Koeda , Takashi Tsuruoka , Uichi Shibata , Hiroyasu Asaoka , Mitsugu Hachisu , Osamu Itoh , Yasuharu Sekizawa , Shigeharu Inouye , Taro Niida
IPC分类号： C07D213/65 , C07D213/79 , A61K31/44
CPC分类号： C07D213/79 , C07D213/65
摘要： 5-Alkoxy-picolinic esters represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and R.sub.1 represents an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms or an acetyl group; a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an alkoxyalkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an indanyl group; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic esters, and anti-hypertensive compositions containing the 5-alkoxy-picolinic esters.
摘要翻译：由式（I）表示的5-烷氧基 - 吡啶甲酸酯：其中R表示具有1至6个碳原子的烷基，R 1表示未取代的苯基; 被一个或多个具有1至4个碳原子的烷基或乙酰基取代的苯基; 苯酞基; 其中烷基部分和烷氧基部分各自具有1至4个碳原子的烷氧基烷基; 其中烷基部分和烷氧基部分各自具有1至4个碳原子的烷氧基烷氧基烷基; 茚满基; 或具有式“IMAGE”的酰氧基烷基，其中R 2表示氢原子或甲基，R 3表示具有1至5个碳原子的烷基（例如甲基，正丙基，异丁基，叔丁基等），基团），具有1至4个碳原子的烷氧基，苯基，被一个或多个具有1至4个碳原子的烷基取代的苯基，具有1至4个碳原子的烷氧基或卤素原子（例如氯，溴，碘等原子）或其中烷基部分具有1〜3个碳原子的芳烷基，其可用作抗高血压剂，制备5-烷氧基 - 吡啶甲酸酯的方法和含有5-烷氧基 - 吡啶甲酸酯的抗高血压组合物。

9. 发明授权

US4181715A Novel antibiotic substance SF-1540 and its derivative, and process for the production thereof 失效
标题翻译：新型抗生素SF-1540及其衍生物及其制备方法
公开(公告)号：US4181715A
公开(公告)日：1980-01-01
申请号：US908983
申请日：1978-05-24
申请人： Yasumitsu Kondo , Takashi Shomura , Hiroshi Watanabe , Tetsuro Watanabe , Shigeharu Inouye , Taro Niida
发明人： Yasumitsu Kondo , Takashi Shomura , Hiroshi Watanabe , Tetsuro Watanabe , Shigeharu Inouye , Taro Niida
IPC分类号： A61K35/00 , A61K35/74 , A61K35/742
CPC分类号： A61K35/742 , Y10S435/898
摘要： A novel antibiotic substance SF-1540 and a process for preparing the same which comprises culturing a substance SF-1540-producing microorganism belonging to the genus Streptomyces in a medium and isolating and recovering the substance SF-1540 from a cultured broth; a novel derivative of the substance SF-1540 and a process for preparing the same which comprises treating said antibiotic substance SF-1540 with methanol to form the corresponding antibiotic substance SF-1540 derivative.
摘要翻译：一种新型抗生素物质SF-1540及其制备方法，其包括在培养基中培养属于链霉菌属的SF-1540生物微生物，并从培养液中分离回收物质SF-1540; 物质SF-1540的新衍生物及其制备方法，其包括用甲醇处理所述抗生素物质SF-1540以形成相应的抗生素物质SF-1540衍生物。

10. 发明授权

US4122171A Agent for protecting against renal failure 失效
标题翻译：防止肾衰竭的药剂
公开(公告)号：US4122171A
公开(公告)日：1978-10-24
申请号：US786468
申请日：1977-04-11
申请人： Tetsutaro Niizato , Takashi Tsuruoka , Shigeharu Inouye , Takemi Koeda , Taro Niida
发明人： Tetsutaro Niizato , Takashi Tsuruoka , Shigeharu Inouye , Takemi Koeda , Taro Niida
IPC分类号： C07D211/78 , A61K31/445 , A61K31/455 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P13/02 , A61P15/00 , A61P31/04 , C07H15/22 , A61K31/71
CPC分类号： A61K31/70 , A61K31/445
摘要： D-glucaro-1,5-lactam and its pharmaceutically acceptable salts are useful as an agent of protecting against renal failure or damage induced by administration of aminoglycosidic antibiotics.
摘要翻译： D-葡聚糖-1,5-内酰胺及其药学上可接受的盐可用作防止肾衰竭或通过施用氨基糖苷类抗生素诱导的损伤的药剂。

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