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1. 发明授权

US4393058A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4393058A
公开(公告)日：1983-07-12
申请号：US188417
申请日：1980-09-18
申请人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Yoshiyuki Koyama , Takashi Yoshida
发明人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Yoshiyuki Koyama , Takashi Yoshida
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C45/71 , C07D213/80 , C07D213/82 , C07D213/85 , C07D501/36
CPC分类号： C07D213/80 , C07C45/71 , C07D213/82 , C07D213/85
摘要： Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R.sub.3 represents hydrogen or a lower alkyl group; R.sub.4 represents hydrogen or a hydroxyl group; and R.sub.5 represents ##STR2## wherein R.sub.6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a --(CH.sub.2).sub.n --SO.sub.3 Na group, or a --(CH.sub.2).sub.n --COR.sub.9 group [wherein R.sub.9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an ##STR3## group, (wherein R.sub.10 and R.sub.11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R.sub.7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R.sub.8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.
摘要翻译：描述头孢菌素化合物，其中间体化合物及其制备方法; 化合物具有式（I）其中R 1和R 2各自表示氢，羟基，低级烷氧基或取代或未取代的苯基烷氧基; R3表示氢或低级烷基; R4代表氢或羟基; 其中R6为氢，低级烷基，氨基烷基，氨基烷基， - （CH2）n-SO3Na基或 - （CH2）n-COR9基[ 其中R 9为羟基，OM基（其中M为碱金属），烷氧基或基团（其中R10和R11可以相同或不同，表示氢或烷基组），n为0或1〜4的整数]。 R7是氢，低级烷基，氨基或取代或未取代的芳基; R8代表氢或低级烷基; 或其药学上可接受的盐。

2. 发明授权

US4331597A Penicillin compounds 失效
标题翻译：青霉素化合物
公开(公告)号：US4331597A
公开(公告)日：1982-05-25
申请号：US193317
申请日：1980-10-02
申请人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Takashi Yoshida , Shunzo Fukatsu
发明人： Osamu Makabe , Yasushi Murai , Tuneo Okonogi , Masahiro Onodera , Takashi Yoshida , Shunzo Fukatsu
IPC分类号： A61K31/43 , A61P31/04 , C07D499/00 , C07D499/64 , C07D499/68 , C07D499/70
CPC分类号： C07D499/00
摘要： Penicillin compounds and methods for the production thereof are described, said penicillin compounds being represented by the formula (I) ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents hydrogen, a lower alkyl group, a halogen atom, a lower alkoxy group, a hydroxyl group, or a substituted or unsubstituted phenylalkoxy group except that R.sub.1, R.sub.2, and R.sub.3 cannot all represent hydrogen simultaneously; R.sub.4 represents hydrogen or a lower alkyl group; and R.sub.5 represents hydrogen or a hydroxyl group.
摘要翻译：描述了青霉素化合物及其制备方法，所述青霉素化合物由式（I）表示：其中R 1，R 2和R 3各自表示氢，低级烷基，卤原子，低级烷氧基，羟基或取代或未取代的苯基烷氧基，除了R1，R2和R3不能全部同时代表氢; R4代表氢或低级烷基; R5表示氢或羟基。

3. 发明授权

US5334723A 2-piperidinecarboxylic acid derivative, oncogene suppressor and agent for obtaining revertants 失效
标题翻译： 2-哌啶羧酸衍生物，癌基因抑制剂和获得回复体的试剂
公开(公告)号：US5334723A
公开(公告)日：1994-08-02
申请号：US937112
申请日：1992-08-31
申请人： Tsuneo Okonogi , Osamu Makabe , Yuichi Yamamoto , Osamu Itoh , Tsutomu Tsuruoka , Takayuki Usui , Seiji Shibahara , Kozo Nagaoka , Shigeharu Inouye , Nobuko Okada , Susumu Nishimura
发明人： Tsuneo Okonogi , Osamu Makabe , Yuichi Yamamoto , Osamu Itoh , Tsutomu Tsuruoka , Takayuki Usui , Seiji Shibahara , Kozo Nagaoka , Shigeharu Inouye , Nobuko Okada , Susumu Nishimura
IPC分类号： C07D211/90 , C07D211/76 , C07D211/86 , C07D211/88
CPC分类号： C07D211/90
摘要： A novel 2-piperidinecarboxylic acid derivative represented by the formula: ##STR1## wherein X represents an oxygen atom, a sulfur atom or a nitrogen atom to which a hydrogen atom is bound; and * represents that the configuration of the carbon atom binding to the carboxyl group is (S), (R) or a mixture of (S) and (R); and a pharmaceutically acceptable salt thereof which exerts an antitumor effect over a wide range of tumor cells.
摘要翻译：由下式表示的新颖的2-哌啶羧酸衍生物：其中X表示与氢原子结合的氧原子，硫原子或氮原子; 和*表示与羧基结合的碳原子的构型是（S），（R）或（S）和（R）的混合物。和其药学上可接受的盐在广泛的肿瘤细胞上发挥抗肿瘤作用。

4. 发明授权

US5258324A Megakaryocyte colony stimulating factor and process for its preparation 失效
标题翻译：巨核细胞集落刺激因子及其制备方法
公开(公告)号：US5258324A
公开(公告)日：1993-11-02
申请号：US668493
申请日：1991-03-20
申请人： Keita Matsunaga , Shinichiro Kuriya , Kiyoyuki Ogata , Hiroyuki Hamaguchi , Chuhei Nojiri , Osamu Makabe , Takeo Nomura , Kozo Nagaoka
发明人： Keita Matsunaga , Shinichiro Kuriya , Kiyoyuki Ogata , Hiroyuki Hamaguchi , Chuhei Nojiri , Osamu Makabe , Takeo Nomura , Kozo Nagaoka
IPC分类号： A61K38/00 , C07K14/53 , C12N5/08 , C12P21/02 , A01N37/18 , A61K37/00 , C07K3/00
CPC分类号： C07K14/53 , A61K38/00
摘要： A novel megakaryocyte colony stimulating factor has been isolated from the supernatant of the culture obtained by cultivating a cell strain of a human large cell lung cancer. When the factor is applied to human or murine bone-marrow cells in vitro, it forms a megakaryocyte colony. Also, the factor increases the number of platelets in peripheral blood in vivo.
摘要翻译： PCT No.PCT / JP89 / 00960 Sec。 371日期1991年3月20日 102（e）1991年3月20日PCT PCT 1989年9月21日PCT公布。第WO90 / 03397号公报 1990年04月5日。从通过培养人大细胞肺癌的细胞株获得的培养物的上清液中分离出新的巨核细胞集落刺激因子。当该因子在体外应用于人或鼠骨髓细胞时，其形成巨核细胞集落。此外，该因子增加了体外外周血中的血小板数量。

5. 发明授权

US4258184A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US4258184A
公开(公告)日：1981-03-24
申请号：US020224
申请日：1979-03-13
申请人： Fumio Kai , Takashi Tsuruoka , Osamu Makabe , Shigeharu Inouye , Hitoshi Ikeda , Yuzo Kazuno , Shokichi Nakajima , Shigeo Seki , Taro Niida
发明人： Fumio Kai , Takashi Tsuruoka , Osamu Makabe , Shigeharu Inouye , Hitoshi Ikeda , Yuzo Kazuno , Shokichi Nakajima , Shigeo Seki , Taro Niida
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/36 , C07D501/56
CPC分类号： C07D501/36 , A61K31/545
摘要： Novel cephalosporin derivatives having formulae (V) and (III): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8 and A are defined as in the specification.
摘要翻译：具有式（V）和（III）的新型头孢菌素衍生物：其中R 1，R 2，R 3，R 4，R 8和A如说明书中所定义。

6. 发明授权

US4783415A Gene coding for signal peptides and utilization thereof 失效
标题翻译：信号肽的基因编码及其利用
公开(公告)号：US4783415A
公开(公告)日：1988-11-08
申请号：US716495
申请日：1985-03-27
申请人： Shigeru Hoshiko , Osamu Makabe , Shunzo Fukatsu , Kozo Nagaoka
发明人： Shigeru Hoshiko , Osamu Makabe , Shunzo Fukatsu , Kozo Nagaoka
IPC分类号： C12N9/28 , C12N15/76 , C12N15/00 , C07H21/04 , C12N1/20 , C12P19/34 , C12P21/00 , C12P21/02 , C12P21/04
CPC分类号： C12N9/2417 , C12N15/76 , C07K2319/00 , C07K2319/02 , Y10S930/30
摘要： A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1.A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment.The present invention may be applied to the production of a desired protein which will be secreted outside the host microorganism. .
摘要翻译：公开了编码信号肽的基因的DNA片段，该片段将用于通过掺入载体DNA中而使用属于链霉菌属（Streptomyces）属的细菌作为宿主的宿主 - 载体系统。该片段包含具有编码在附图中具有X至Y的氨基酸序列的肽的碱基序列的DNA。还公开了用于转化属于链霉菌属的细菌的载体质粒。质粒包含编码来自吸水链霉菌SF-1084株的细胞外α-淀粉酶的碱基序列的DNA片段或其突变体，并入载体质粒中的DNA片段将用于使用属于链霉菌属的细菌作为宿主，并且还具有表达DNA片段的基因信息所需的DNA片段。本发明可以用于生产将被分泌到宿主微生物外部的所需蛋白质。。

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