专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5141946A Azole derivatives and anti-ulcerative composition containing same 失效
标题翻译：唑衍生物和含有其的抗溃疡组合物
公开(公告)号：US5141946A
公开(公告)日：1992-08-25
申请号：US716622
申请日：1991-06-14
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
IPC分类号： C07D487/04 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61P1/04 , C07D471/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D513/04
摘要： Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in whichA, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represnts a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-memebered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integrer from 0 to 2.The compounds are useful in treating ulcers.
摘要翻译：通式（I）的化合物：其中A，B，C和D各自表示-CH =或-N =，条件是其中至少一个为 -N =; X表示-NH-，-O-或-S-; Y表示 - （CH 2）p - ，其中p是0至4的整数，-C（CH 3）2 - ， - CH 2 CH = CH - ， - CH 2 CO - ， - CF 2 - 或-CH 2 COCH 2 - R1表示氢原子，C1-4烷基，卤素原子或C1-4烷氧基; R2表示氢原子，羟基，饱和或不饱和的C1-6烷基，C1-6烷氧基，羧基，可以任意取代的饱和或不饱和的C 1-12烷氧基羰基，环烷氧基羰基，含有至少一个氮原子的饱和或不饱和五元或六元杂环基团，任选具有一个或多个氮原子和/或氧原子，其可以任选地被缩合和/或取代，-CONR 3 R 4，-NR 3 R 4，-OCOR 3或 - NHCONHR 3其中R3和R4可以相同或不同，表示可以任选被取代的C 1-6烷基或环烷基，m和n各自表示0至2的整数。该化合物可用于处理溃疡

2. 发明授权

US5200407A Azole derivatives and anti-ulcerative composition containing same 失效
标题翻译：唑衍生物和含有其的抗溃疡组合物
公开(公告)号：US5200407A
公开(公告)日：1993-04-06
申请号：US716621
申请日：1991-06-14
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Naoki Yamazaki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
IPC分类号： C07D471/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D513/04
摘要： Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integer from 0 to 2.
摘要翻译：通式（I）的化合物：其中A，B，C和D各自表示-CH =或-N =，条件是其中至少一个为 -N =; X表示-NH-，-O-或-S-; Y表示 - （CH 2）p - ，其中p是0至4的整数，-C（CH 3）2 - ， - CH 2 CH = CH - ， - CH 2 CO - ， - CF 2 - 或-CH 2 COCH 2 - R1表示氢原子，C1-4烷基，卤素原子或C1-4烷氧基; R2表示氢原子，羟基，饱和或不饱和的C1-6烷基，C1-6烷氧基，羧基，可以任意取代的饱和或不饱和的C 1-12烷氧基羰基，环烷氧基羰基，含有至少一个氮原子的饱和或不饱和五元或六元杂环基，任选具有一个或多个氮和/或氧原子，其可以任选地被缩合和/或取代，-CONR 3 R 4，-NR 3 R 4，-OCOR 3或 - NHCONHR 3其中R3和R4可以相同或不同，表示可以被任意取代的C 1-6烷基或环烷基，m和n各自表示0〜2的整数。

3. 发明授权

US5079255A Thiazolo [4,5-6] pyridine derivatives and anti-ulcerative composition containing same 失效
标题翻译：噻唑（4,5-6）吡啶衍生物和含有其的抗 - 组合物
公开(公告)号：US5079255A
公开(公告)日：1992-01-07
申请号：US544671
申请日：1990-06-27
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Yamazaki Naoki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Yamazaki Naoki , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Motohiro Nishio , Tomoya Machinami , Seiji Shibahara , Takashi Tsuruoka , Shigeharu Inouye
IPC分类号： C07D487/04 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61P1/04 , C07D471/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D513/04
摘要： Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integer from 0 to 2.

4. 发明授权

US5185347A Piperidine compounds and antiulcer composition containing the same 失效
标题翻译：哌啶化合物和含有它们的抗微生物组合物
公开(公告)号：US5185347A
公开(公告)日：1993-02-09
申请号：US700985
申请日：1991-05-16
申请人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka , Shigeharu Inoye
发明人： Kiyoaki Katano , Tamako Tomomoto , Hiroko Ogino , Fumiya Hirano , Yasukatsu Yuda , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka , Shigeharu Inoye
IPC分类号： C07D401/12 , A61K31/4427 , A61K31/445 , A61P1/04 , C07D235/28 , C07D401/14
CPC分类号： C07D235/28
摘要： A piperidine compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a hydroxymethyl group, --CO.sub.2 R.sup.3, or ##STR2## wherein R.sup.3 represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms; R.sup.4 represents a hydroxyl group, a lower alkoxy group having from 1 to 4 carbon atoms or --NR.sup.6 R.sup.7 (wherein R.sup.6 and R.sup.7, which may be the same or different, each represent a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms); and R.sup.5 represents a hydrogen atom, a lower alkanoyl group having from 1 to 4 carbon atoms, or a chlorobenzoyl group; R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a substituted or unsubstituted benzyl group, or a (2,2,6,6-tetramethylpiperidin-1-yl)ethyl group; and n represents 0 or an integer of 1 or 2,and an antiulcer composition containing said piperidine compound.

5. 发明授权

US5294629A Benzothiazole and benzimidazole derivatives and antiulcer agent containing the same 失效
标题翻译：苯并噻唑和苯并咪唑衍生物和含有它们的抗溃疡剂
公开(公告)号：US5294629A
公开(公告)日：1994-03-15
申请号：US037671
申请日：1993-03-25
申请人： Tomoya Machinami , Kazue Yasufuku , Seiji Shibahara , Fumiya Hirano , Yasukatsu Yuda , Motohiro Nishio , Yuji Matsuhashi , Takashi Tsuruoka , Kiyoaki Katano , Shigeharu Inoye
发明人： Tomoya Machinami , Kazue Yasufuku , Seiji Shibahara , Fumiya Hirano , Yasukatsu Yuda , Motohiro Nishio , Yuji Matsuhashi , Takashi Tsuruoka , Kiyoaki Katano , Shigeharu Inoye
IPC分类号： C07D235/28 , C07D277/74 , A61K31/415 , A61K31/425 , C07D277/76
CPC分类号： C07D235/28 , C07D277/74
摘要： A novel benzothiazole or benzimidazole derivative represented by formula (I) ##STR1## wherein X represents a sulfur atom or a NH group; R.sup.1 represents a hydrogen atom, a lower alkoxy group, a chlorine atom, a bromine atom or an iodine atom; R.sup.2 represents a hydrogen atom a substituted or unsubstituted lower alkyl group, a vinyl group, an aryl group or an acyl group; m is an integer of 1, 2 or 3; and n is an integer of 0, 1 or 2, which shows an excellent acid secretion suppressing effect and gastric mucosa protecting effect, and an antiulcer agent containing the same as an active ingredient.
摘要翻译：由式（I）表示的新型苯并噻唑或苯并咪唑衍生物其中X表示硫原子或NH基团; R1表示氢原子，低级烷氧基，氯原子，溴原子或碘原子; R2代表氢原子取代或未取代的低级烷基，乙烯基，芳基或酰基; m为1,2或3的整数; n为0或1或2的整数，表现出优异的酸分泌抑制效果和胃粘膜保护作用，以及含有作为活性成分的抗溃疡剂。

6. 发明授权

US5399566A Pyridine derivatives having angiotensin II antagonism 失效
标题翻译：具有血管紧张素II拮抗作用的吡啶衍生物
公开(公告)号：US5399566A
公开(公告)日：1995-03-21
申请号：US752557
申请日：1991-09-10
申请人： Kiyoaki Katano , Hiroko Ogino , Eiki Shitara , Hiromi Watanabe , Jun Nagura , Naomi Osada , Yasuyuki Ichimaru , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka
发明人： Kiyoaki Katano , Hiroko Ogino , Eiki Shitara , Hiromi Watanabe , Jun Nagura , Naomi Osada , Yasuyuki Ichimaru , Fukio Konno , Tomoya Machinami , Takashi Tsuruoka
IPC分类号： C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/80 , C07D221/04 , C07D401/10 , C07D401/12 , A61K31/44
CPC分类号： C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/80 , C07D221/04 , C07D401/10 , C07D401/12
摘要： The invention provides compounds represented by the following formula (I) ##STR1## or a pharmaceutically acceptable salts thereof wherein A represents ##STR2## B represents a carboxy or tetrazolyl group; and X represents --O--, --NH-- or --S(O).sub.t --.The compounds possess angiotensin II antagonism, and may be used as an antihypertensive agent, a therapeutic agent to congestive heart failure, an antianxiety agent and a cognitive enhancing agent.
摘要翻译： PCT No.PCT / JP91 / 00822 Sec。 371日期1991年9月10日 102（e）1991年9月10日PCT PCT 1991年6月19日PCT公布。 No.W091 / 19697 PCT出版物 1991年12月26日，本发明提供由下式（I）表示的化合物或其药学上可接受的盐，其中A表示羧基或四唑基; X表示-O - ， - NH-或-S（O）t - 。该化合物具有血管紧张素II拮抗作用，可用作抗高血压药，充血性心力衰竭的治疗剂，抗焦虑剂和认知增强剂。

7. 发明授权

US4785090A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US4785090A
公开(公告)日：1988-11-15
申请号：US704077
申请日：1985-02-21
申请人： Takashi Tsuruoka , Seiji Shibahara , Katsuyoshi Iwamatsu , Tsuneo Okonogi , Satoru Nakabayashi , Yasushi Murai , Hiroko Ogino , Kiyoaki Katano , Takashi Yoshida , Shigeharu Inoue , Shunzo Fukatsu , Shinichi Kondo
发明人： Takashi Tsuruoka , Seiji Shibahara , Katsuyoshi Iwamatsu , Tsuneo Okonogi , Satoru Nakabayashi , Yasushi Murai , Hiroko Ogino , Kiyoaki Katano , Takashi Yoshida , Shigeharu Inoue , Shunzo Fukatsu , Shinichi Kondo
IPC分类号： C07D213/64 , C07D213/68 , C07D221/04 , C07D501/36 , C07D501/38 , A61K31/545
CPC分类号： C07D221/04 , C07D213/64 , C07D213/68
摘要： This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.p B wherein p is 0 or an integer of 1-3 and B is amino, alkyl-substituted amino, hydroxy, carboxy, carbamoyl, trifluoromethyl, sulfonic acid, sulfonic acid amide, alkylthio or cyano or, when m is 0, is alkyl of 1-5 carbon atoms, which may optionally be substituted by halogen, alkenyl, a group ##STR6## wherein R.sup.8 is hydrogen, alkyl of 1-4 carbon atoms or phenyl, or cyclopropyl, and a salt thereof.
摘要翻译：这是一类具有下式的抗菌化合物：其中Y是直链或支链烷基或烯基链，3-6个碳原子的环烷基甲基，每个基团任选被卤素取代，或基团< 其中n为0或1-3的整数，A为基团-COR 3，其中R 3为羟基，其中R 4和R 5可以相同或不同，为氢或1-5碳的烷基原子，基团或含有氮和/或硫的5-或6-元杂环基，R 1和R 2可以相同或不同，为氢，1-5个碳原子的烷基或R1 并且R 2可以组合在一起形成3-5个碳原子的亚烷基，Z是下式的基团：其中m是0或3-5的整数，R6是氢或1-3个碳的烷基原子和R 7，当m是3-5的整数时，是1-5个碳原子的烷基，烯基，环丙基，基团 - （CH 2）pB，其中p是0或1-3的整数，B是氨基，烷基取代的氨基羟基，羧基，氨基甲酰基，三氟甲基，磺酸，磺酸酰胺，烷硫基或氰基，或当m为0时，其为1-5个碳原子的烷基，其可任选被卤素，链烯基，基团其中R8是氢，1-4个碳原子的烷基或苯基，或环丙基及其盐。

8. 发明授权

US5028601A Cephalosporin compounds and antibacterial agents 失效
标题翻译：头孢菌素化合物和抗菌剂
公开(公告)号：US5028601A
公开(公告)日：1991-07-02
申请号：US184323
申请日：1988-04-21
申请人： Shinichi Kondo , Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Satoru Nakabayashi , Hiroko Ogino , Takashi Yoshida , Masaji Sezaki
发明人： Shinichi Kondo , Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Satoru Nakabayashi , Hiroko Ogino , Takashi Yoshida , Masaji Sezaki
IPC分类号： C07D501/00 , C07D501/20
CPC分类号： C07D501/00
摘要： Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

9. 发明授权

US4758557A Cephalosporin derivatives and bactericides containing the same 失效
标题翻译：头孢菌素衍生物和含有相同的杀菌剂
公开(公告)号：US4758557A
公开(公告)日：1988-07-19
申请号：US872316
申请日：1986-06-09
申请人： Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Hiroko Ogino , Ryoichi Okamoto , Takashi Yoshida , Masaji Sezaki , Fumio Kai , Shigeharu Inoue , Shinichi Kondo
发明人： Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Hiroko Ogino , Ryoichi Okamoto , Takashi Yoshida , Masaji Sezaki , Fumio Kai , Shigeharu Inoue , Shinichi Kondo
IPC分类号： A61K31/545 , C07D501/24 , C07D501/36 , C07D501/46
CPC分类号： C07D501/24
摘要： Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: ##STR1## wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); ##STR2## or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): ##STR3## or an unsubstituted or substituted pyridinium group of a formula (I-3); ##STR4## or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):--S--Het (I-4).
摘要翻译：由下式（I）表示的头孢菌素化合物及其药学上可接受的盐对各种致病细菌（包括铜绿假单胞菌）具有广泛的杀菌谱，并且可用作人和动物的致病性疾病的杀菌剂：其中A代表式（I-1）的未取代或取代的吡啶硫基; （I-1）或式（I-2）的未取代或取代的吡啶硫基：式（I-2）或未取代或取代的式（I-3）吡啶鎓基; （I-3）或式（I-4）的5-或6-元杂环硫或二环杂环硫基：-S-Het（I-4）。

10. 发明授权

US06583144B2 Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same 失效
标题翻译：含氮杂环化合物和包含其的高脂血症治疗剂
公开(公告)号：US06583144B2
公开(公告)日：2003-06-24
申请号：US10127491
申请日：2002-04-23
申请人： Naoto Ohkura , Takashi Tsuruoka , Takayuki Usui , Yukiko Hiraiwa , Tetsuya Matsushima , Masaharu Shiotani , Tetsutaro Niizato , Yuuko Nakatani , Shigeki Suzuki , Chidsuko Kuroda , Kiyoaki Katano
发明人： Naoto Ohkura , Takashi Tsuruoka , Takayuki Usui , Yukiko Hiraiwa , Tetsuya Matsushima , Masaharu Shiotani , Tetsutaro Niizato , Yuuko Nakatani , Shigeki Suzuki , Chidsuko Kuroda , Kiyoaki Katano
IPC分类号： A61K31495
CPC分类号： C07D409/12 , C07D209/46 , C07D217/24 , C07D265/22 , C07D279/08 , G03F7/2049 , Y10S977/915
摘要： Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein B from the liver. Therefore, they are useful for the prevention or treatment of hyperlipidemia (particularly hyper-very-low-density-lipoproteinemia) and arteriosclerotic diseases, such as cardiac infarction, or pancreatitis induced by hyperlipidemia. wherein A represents group —CR1R2—(CH2)i— where R1 and R2 each represent a hydrogen atom or alkyl, —CH═CH—, —O—CH2—, or —S(O)j—CH2—; B represents a hydrogen or halogen atom; X represents —CR3R4R5, —NR6R7, —(CH2—CH═C(CH3)—CH2)p—CH2CH═C(CH3)2, alkyl, cycloalkyl, phenyl, cinnamyl, or heteroaromatic ring; Y represents —(CH2)q—, —CH═CH—, —NR8—, an oxygen atom, or a bond; Z represents carbonyl or a bond; K represents alkylene or a bond; L represents —CH═CH— or a bond; and M represents a hydrogen atom, alkyl, cycloalkyl, phenyl, heterocyclic ring, biphenyl, or diphenylmethyl.
摘要翻译：公开了由式（I）表示的化合物及其药学上可接受的盐和溶剂化物。该化合物可以抑制肝脏中甘油三酯的生物合成，并可以抑制含有载脂蛋白B的脂蛋白从肝脏的分泌。因此，它们可用于预防或治疗由高脂血症引起的高脂血症（特别是超低密度脂蛋白血症）和动脉硬化疾病如心肌梗死或胰腺炎。其中A代表基团-CR1R2-（CH2）i - 其中R1和R2各自表示氢原子或烷基，-CH = CH-，-O-CH2-或-S（O）j-CH2-; B表示氢或卤素原子; X代表-CR3R4R5，-NR6R7， - （CH2-CH = C（CH3）-CH2）p-CH2CH = C（CH3）2，烷基，环烷基，苯基，肉桂基或杂芳族环; Y表示 - （CH 2）q - ， - CH = CH - ， - NR 8 - ，氧原子或键; Z表示羰基或键; K表示亚烷基或键; L表示-CH = CH-或键; M代表氢原子，烷基，环烷基，苯基，杂环，联苯基或二苯基甲基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式