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71. 发明授权

US07704276B2 Endoprostheses and methods of manufacture 失效
标题翻译：内假体和制造方法
公开(公告)号：US07704276B2
公开(公告)日：2010-04-27
申请号：US11541196
申请日：2006-09-30
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/90
CPC分类号： A61F2/90 , A61F2/848 , A61F2002/825 , A61F2210/0004 , A61F2250/0014 , A61F2250/0036 , A61F2250/0039 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： A woven tubular endoprosthesis comprising means for locking the endoprosthesis in a deployed configuration is disclosed. The means for locking the endoprosthesis may comprise locking protrusions, notches, a chemical bond, a curable bond, or other mechanism. The woven fibers comprising the endoprosthesis may be hollow and comprise circumferentially oriented polymeric chains, and may be filled with a curable material. A method of treatment using an endoprosthesis according to the invention is also disclosed.
摘要翻译：公开了一种编织管状内假体，其包括用于将内置假体锁定在展开构造中的装置。用于锁定内假体的装置可以包括锁定突起，凹口，化学键，可固化键或其它机构。包含内用假体的编织纤维可以是中空的并且包括周向取向的聚合物链，并且可以用可固化材料填充。还公开了使用根据本发明的内置假体的治疗方法。

72. 发明授权

US07641828B2 Methods of making orthodontic appliances 有权
标题翻译：制造矫正器具的方法
公开(公告)号：US07641828B2
公开(公告)日：2010-01-05
申请号：US10963252
申请日：2004-10-12
申请人： Joseph M. DeSimone , Robert E. Tricca
发明人： Joseph M. DeSimone , Robert E. Tricca
IPC分类号： B29C59/00
CPC分类号： A61C7/08 , C08F2/46
摘要： Methods of making a removable dental positioning appliance include forming a sheet of transparent crystalline polymeric material into a shell having cavities shaped to receive and reposition teeth from a first orientation to a successive orientation. The polymeric material may then be annealed at a temperature above its glass transition temperature or cured if a curable material to enhance characteristics of the polymeric material. The polymeric material may be coated with a second transparent material.
摘要翻译：制造可移除牙齿定位装置的方法包括将透明结晶聚合物材料片形成为具有成形为容纳和重新定位牙齿从第一取向到连续取向的空腔的外壳。然后可以在高于其玻璃化转变温度的温度下对聚合物材料进行退火，或者如果是可固化的材料固化以增强聚合物材料的特性，则可以进行退火。聚合物材料可以用第二透明材料涂覆。

73. 发明申请

US20090281250A1 METHODS AND MATERIALS FOR FABRICATING MICROFLUIDIC DEVICES 有权
标题翻译：制备微流体装置的方法和材料
公开(公告)号：US20090281250A1
公开(公告)日：2009-11-12
申请号：US12063284
申请日：2006-08-09
申请人： Joseph M. DeSimone , Jason P. Rolland , Ginger M. Dennison Rothrock , Paul Resnick
发明人： Joseph M. DeSimone , Jason P. Rolland , Ginger M. Dennison Rothrock , Paul Resnick
IPC分类号： C08L67/00 , C08G18/71 , B05D3/00 , C08F2/48 , B44C1/22 , B29C33/40 , G03F7/00 , F15C3/00 , F15C5/00 , G05D7/00
CPC分类号： B29C59/005 , B01L3/502707 , B01L2300/0887 , B01L2300/12 , B29C33/3878 , B29C33/405 , B29C65/48 , B29C65/4835 , B29C65/4845 , B29C65/485 , B29C65/521 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/723 , B29C66/727 , B29C66/91431 , B29C66/919 , B29C66/949 , B29C66/9534 , B29K2883/00 , B29L2031/756 , B81B2201/051 , B81C99/0085 , C08G18/10 , C08G18/5015 , C08G18/8175 , C08G59/30 , C08G65/007 , C08L71/02 , C08L75/16 , Y10T137/0318 , Y10T137/2224 , C08G18/50 , B29C65/00 , B29K2027/18 , B29K2027/12
摘要： Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.
摘要翻译：提供材料和方法用于制造微流体装置。这些材料包括具有多个固化官能团的低表面能含氟聚合物组合物。这些材料可以包括多个可光固化和/或热固化的官能团，使得可以制造层压装置。所述材料在烃溶剂存在下也基本上不溶胀。

74. 发明申请

US20090220789A1 TAGGANTS AND METHODS AND SYSTEMS FOR FABRICATING SAME 审中-公开
标题翻译：标签及其制作方法及系统
公开(公告)号：US20090220789A1
公开(公告)日：2009-09-03
申请号：US12162264
申请日：2007-01-29
申请人： Joseph M. DeSimone , Ginger Denison Rothrock , Benjamin W. Maynor
发明人： Joseph M. DeSimone , Ginger Denison Rothrock , Benjamin W. Maynor
IPC分类号： B32B1/00 , C08L27/00
CPC分类号： G09F3/00 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10T428/2982
摘要： A micro or nanoparticle (206) can include or can be a taggant. The particle (206) has a shape corresponding to a mold and includes unique characteristics. The unique characteristics can be the shape of the particle, molecular content of the particle, or physical characteristics incorporated into or onto the particle. In use, the taggant can be incorporated into an article of manufacture and includes characteristics configured to identify the origin, authenticity, expiration, owner or the like of the article.
摘要翻译：微型或纳米颗粒（206）可以包括或可以是标记物。颗粒（206）具有与模具相对应的形状，并且包括独特的特性。独特的特征可以是颗粒的形状，颗粒的分子含量或结合到颗粒中或颗粒上的物理特性。在使用中，标签牌可以并入制造品，并且包括被配置为识别物品的原产地，真实性，期满，所有者等的特征。

75. 发明申请

US20090061152A1 Methods for fabricating isolated micro- and nano- structures using soft or imprint lithography 有权
标题翻译：使用软或压印光刻制造隔离微结构和纳米结构的方法
公开(公告)号：US20090061152A1
公开(公告)日：2009-03-05
申请号：US11825469
申请日：2007-07-06
申请人： Joseph M. DeSimone , Jason P. Rolland , Benjamin W. Maynor , Larken E. Euliss , Ginger Denison Rothrock , Ansleye Dennis , Edward T. Samulski , R. Jude Samulski
发明人： Joseph M. DeSimone , Jason P. Rolland , Benjamin W. Maynor , Larken E. Euliss , Ginger Denison Rothrock , Ansleye Dennis , Edward T. Samulski , R. Jude Samulski
IPC分类号： B32B3/12 , B29C35/04 , B32B27/00 , C12N5/06 , C12N15/87 , C08G73/24
CPC分类号： A61K9/14 , A61K9/0097 , A61K9/5138 , A61K9/5153 , A61K9/5192 , A61K47/34 , B81C99/0085 , B82Y10/00 , B82Y40/00 , G03F7/0002 , H01L51/0004 , H01L51/0021 , Y10T428/24273 , Y10T428/24479 , Y10T428/3154
摘要： The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.
摘要翻译：目前公开的主题描述了基于氟化弹性体的材料，特别是基于全氟聚醚（PFPE）的材料在高分辨率软或压印光刻应用中的应用，例如微米和纳米级复制成型，以及第一纳米接触使用弹性体模具成型有机材料以产生高保真特征。因此，目前公开的主题描述了使用软或压印光刻技术生产任何形状的独立的，分离的纳米结构的方法。

76. 发明授权

US07285287B2 Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses 有权
标题翻译：提供生物相容性管腔内假体的二氧化碳辅助方法
公开(公告)号：US07285287B2
公开(公告)日：2007-10-23
申请号：US10662621
申请日：2003-09-15
申请人： Michael S. Williams , Joseph M. DeSimone
发明人： Michael S. Williams , Joseph M. DeSimone
IPC分类号： A61L29/00
CPC分类号： A61L31/14 , A61L27/34 , A61L27/50 , A61L31/10
摘要： Methods of producing biocompatible intraluminal prostheses are provided and include immersing polymeric material of an intraluminal prosthesis in a densified carbon dioxide composition under controlled conditions such that toxic materials are absorbed by the densified carbon dioxide composition.
摘要翻译：提供了生产生物相容性管腔内假体的方法，包括将腔内假体的聚合材料浸入致密化二氧化碳组合物的受控条件下，使有毒物质被致密二氧化碳组合物吸收。

77. 发明授权

US06929904B2 Positive tone lithography with carbon dioxide development systems 失效
标题翻译：正音光刻与二氧化碳开发系统
公开(公告)号：US06929904B2
公开(公告)日：2005-08-16
申请号：US10294223
申请日：2002-11-14
申请人： Joseph M. DeSimone
发明人： Joseph M. DeSimone
IPC分类号： G03F7/004 , G03F7/039 , G03F7/32 , G03F7/30
CPC分类号： G03F7/0392 , G03F7/0046 , G03F7/32
摘要： A process of forming a resist image in a microelectronic substrate, the process comprises the steps of: (a) providing a substrate having a polymer coating thereon, wherein the polymer is insoluble in water having a pH less than or equal to a specified pH (e.g., 7.0, 6, 5, or 4); then (b) imagewise exposing the coating to radiation such that exposed and unexposed coating portions are formed, with said exposed coating portions being soluble in water having a pH less than or equal to said specified pH7.0; and then (c) contacting said coating to a developing composition comprising carbon dioxide and water, said water having a specified pH less than or equal to 7.0 (and preferably a pH of about 2 or 3 to 4, 5 or 6; i.e. a specified pH less than or equal to 6, 5, or 4), so that said exposed coating portions are preferentially removed from the substrate as compared to said unexposed coating portions to form an image thereon.
摘要翻译：一种在微电子衬底中形成抗蚀剂图像的方法，该方法包括以下步骤：（a）提供其上具有聚合物涂层的基底，其中聚合物不溶于pH小于或等于特定pH的水中例如，7.0,6,5或4）; 然后（b）将涂层成像曝光到辐射，使得形成暴露和未曝光的涂布部分，所述暴露的涂布部分可溶于pH小于或等于所述指定pH7.0的水中; 然后（c）使所述涂层与包含二氧化碳和水的显影组合物接触，所述水的特定pH小于或等于7.0（优选pH为约2或3至4，5或6;即指定的 pH小于或等于6,5或4），使得与所述未曝光的涂布部分相比，所述暴露的涂布部分优先从基底去除以在其上形成图像。

78. 发明授权

US06887266B2 Endoprostheses and methods of manufacture 失效
标题翻译：内假体和制造方法
公开(公告)号：US06887266B2
公开(公告)日：2005-05-03
申请号：US10342622
申请日：2003-01-15
申请人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
发明人： Michael S. Williams , Richard A. Glenn , Jeffrey A. Smith , Kevin D. Holbrook , Joseph M. DeSimone
IPC分类号： A61F2/00 , A61F2/82 , A61F2/90 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61F2/90 , A61F2/848 , A61F2002/825 , A61F2220/005 , A61F2220/0058 , A61F2250/0014 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： Improved endoprostheses comprising a delivery configuration and a deployed configuration and methods of manufacture are disclosed. Some embodiments according to the invention comprise woven tubular structures and means for maintaining said structures in their expanded configurations. In one embodiment of the invention, locking elements disposed on one or more fibers maintain said endoprosthesis in its deployed configuration. In alternative embodiments, one or more axial members may maintain said endoprosthesis in its deployed configuration. In yet additional alternative embodiments, a chemical bond or thermocouple may maintain said endoprosthesis in its deployed configuration. Some embodiments according to the invention may comprise erodible material.
摘要翻译：公开了包括输送配置和部署配置和制造方法的改进的内假体。根据本发明的一些实施例包括织造管状结构和用于将所述结构保持在其扩展构型中的装置。在本发明的一个实施例中，设置在一个或多个纤维上的锁定元件将所述内部假体保持在其展开构型中。在替代实施例中，一个或多个轴向构件可以将所述内假体保持在其展开构造中。在另外的替代实施例中，化学键或热电偶可以将所述内假体保持在其展开的构型中。根据本发明的一些实施例可以包括可侵蚀的材料。

79. 发明授权

US06716945B2 Multimodal fluoropolymers and methods of making the same 失效
标题翻译：多峰含氟聚合物及其制备方法
公开(公告)号：US06716945B2
公开(公告)日：2004-04-06
申请号：US09860413
申请日：2001-05-18
申请人： Joseph M. DeSimone , George W. Roberts , Paul A. Charpentier
发明人： Joseph M. DeSimone , George W. Roberts , Paul A. Charpentier
IPC分类号： C08F21422
CPC分类号： C08F14/18 , C08F14/22 , C08F2/04
摘要： A method for forming a fluoropolymer comprises providing a reaction mixture comprising carbon dioxide, at least one fluoromonomer, and an initiator; and reacting the at least one fluoromonomer in the reaction mixture to form a fluoropolymer. The fluoropolymer has a multimodal molecular weight distribution.
摘要翻译：形成含氟聚合物的方法包括提供包含二氧化碳，至少一种含氟单体和引发剂的反应混合物; 并使反应混合物中的至少一种含氟单体反应形成含氟聚合物。含氟聚合物具有多峰分子量分布。

80. 发明授权

US06517633B1 Apparatus for meniscus coating with liquid carbon dioxide 失效
标题翻译：液体二氧化碳弯液面涂装设备
公开(公告)号：US06517633B1
公开(公告)日：2003-02-11
申请号：US09567646
申请日：2000-05-09
申请人： Ruben G. Carbonell , Joseph M. DeSimone , Brian J. Novick
发明人： Ruben G. Carbonell , Joseph M. DeSimone , Brian J. Novick
IPC分类号： B05C302
CPC分类号： D06M23/105 , B05D1/18 , B05D2401/90 , D06B1/08 , D06B3/10 , D06M23/00 , D06M23/10
摘要： A method of coating a substrate comprises immersing a surface portion of a substrate in a liquid or supercritical first phase. The first phase comprises carbon dioxide and a coating component such as a polymer. The substrate is then withdrawn from the first phase into a distinct second phase such as a gas atmosphere so that the coating component is deposited on said surface portion. The withdrawal step is followed by separating the carbon dioxide from the coating component (e.g., by evaporation, venting, heating, etc.) so that the coating component is retained as a coating layer formed on the surface portion. Apparatus for carrying out the method by free meniscus coating, or employing a metering element such as a knife, blade, or roll, are also disclosed.
摘要翻译：涂覆基材的方法包括将基材的表面部分浸入液体或超临界第一相中。第一相包括二氧化碳和涂料组分如聚合物。然后将衬底从第一相中排出到不同的第二相，例如气体气氛中，使得涂层组分沉积在所述表面部分上。撤回步骤之后是将二氧化碳与涂料组分分离（例如，通过蒸发，排气，加热等），使得涂料组分作为形成在表面部分上的涂层而被保留。还公开了通过自由弯液面涂覆或采用诸如刀，刀片或辊的计量元件来执行该方法的装置。

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