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61. 发明授权

US08685387B2 Simian E adenoviruses SAdV-39, -25.2, -26, -30, -37, and -38 有权
标题翻译：猿猴E腺病毒SAdV-39，-25.2，-26，-30，-37和-38
公开(公告)号：US08685387B2
公开(公告)日：2014-04-01
申请号：US12744441
申请日：2008-11-24
申请人： Soumitra Roy , James M Wilson , Luc H Vandenberghe
发明人： Soumitra Roy , James M Wilson , Luc H Vandenberghe
IPC分类号： A61K35/76 , C12N7/01 , C12N15/00 , C12N15/34 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10361 , C12N2760/16122
摘要： A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒SAdV-39，-25.2，-26，-30，-37和-38序列，以及在调控序列控制下的异源基因。还公开了表达猿猴腺病毒SAdV-39，-25.2，-26，-30，-37和-383基因的细胞系。提供了使用载体和细胞系的方法。

62. 发明授权

US08513397B2 DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants 有权
标题翻译：用于在植物中高水平快速生产疫苗和单克隆抗体治疗剂的DNA复制子系统
公开(公告)号：US08513397B2
公开(公告)日：2013-08-20
申请号：US13060414
申请日：2009-08-27
申请人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
发明人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
IPC分类号： C12N15/34 , C12N15/117 , C12N15/13 , C12N15/36 , C12N15/82 , C12N5/10
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8258
摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
摘要翻译：植物病毒载体在快速生产蛋白质方面具有很大的潜力，但并不简单。这里描述了用于高产率和快速生产低聚蛋白复合物的双基因病毒的系统，包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb）。特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

63. 发明授权

US08344208B2 Highly efficient suppressor-dependent protein expression in plants with a viral vector 有权
标题翻译：具有病毒载体的植物中高效抑制因子依赖性蛋白质表达
公开(公告)号：US08344208B2
公开(公告)日：2013-01-01
申请号：US12714057
申请日：2010-02-26
申请人： Christopher M. Kearney , Zun Liu
发明人： Christopher M. Kearney , Zun Liu
IPC分类号： C12N15/34 , C12N15/83 , C12N5/10
CPC分类号： C12N15/8203 , C12N15/8205 , C12N15/8216 , C12N15/8218 , C12N15/8257 , C12N15/8258
摘要： A series of viral vectors derived from foxtail mosaic virus, sunn hemp mosaic virus and white clover mosaic virus sequences, and which are capable of expressing heterologous proteins in plants, including the tobacco, Nicotiana benthamiana, and cowpea, bean, and other legumes with the properties of unusually limited expression in the absence of gene silencing suppressors and high level expression in their presence. In a preferred embodiment, these viral vectors may be introduced via agroinoculation, and expression of the heterologous gene may be inducible with little or no leakiness in the absence of induction.
摘要翻译：一系列病毒载体衍生自狐尾花叶病毒，日光麻花叶病毒和白三叶草花叶病毒序列，并且能够在植物中表达异源蛋白质，包括烟草，烟草，烟草，芸豆，豆和其他豆类，在不存在基因沉默抑制基因的情况下表达异常受限的特性及其存在的高水平表达。在优选的实施方案中，这些病毒载体可以通过农杆菌引入，并且异源基因的表达可以在不存在诱导的情况下很少或没有渗漏性诱导。

64. 发明申请

US20120164106A1 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF 有权
标题翻译：具有不同CAPSID的ADENO相关病毒血症及其使用方法
公开(公告)号：US20120164106A1
公开(公告)日：2012-06-28
申请号：US13253760
申请日：2011-10-05
申请人： David V. Schaffer , Ryan R. Klimczak , James T. Koerber , John G. Flannery
发明人： David V. Schaffer , Ryan R. Klimczak , James T. Koerber , John G. Flannery
IPC分类号： A61K35/76 , A61P27/02 , C12N5/10 , C12N15/34 , C07K14/075 , C12N1/19 , C12N7/01 , A61P27/06
CPC分类号： C12N7/00 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0356 , A61K9/0048 , A61K35/76 , A61K38/00 , A61K38/179 , A61K38/1808 , A61K38/1825 , A61K38/185 , A61K48/0008 , A61K48/0075 , C07K14/005 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14145 , C12N2810/855
摘要： The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
摘要翻译：本公开提供具有改变的衣壳蛋白的腺相关病毒（AAV）病毒颗粒，其中与野生型AAV相比，AAV病毒体显示更大的视网膜细胞感染性。本公开进一步提供将基因产物递送至个体中的视网膜细胞的方法以及治疗眼部疾病的方法。

65. 发明申请

US20110305725A1 METHODS AND COMPOSITIONS FOR IMMUNIZING PIGS AGAINST PORCINE CIRCOVIRUS 审中-公开
标题翻译：用于免疫PORCINE CIRCOVIRUS的PIGS的方法和组合物
公开(公告)号：US20110305725A1
公开(公告)日：2011-12-15
申请号：US13043853
申请日：2011-03-09
申请人： STEPHEN QITU WU
发明人： STEPHEN QITU WU
IPC分类号： A61K39/12 , C12N15/34 , A61P31/20 , C12N15/63 , C12Q1/70 , A61P37/04 , C12N7/00 , A61K39/295
CPC分类号： C12N7/00 , C12N2750/10021 , C12N2750/10034
摘要： The present invention relates to the isolation and identification of two new strains of type 2B porcine circovirus. These two new strains of porcine circovirus may be used for the preparation of vaccine or immunogenic compositions for immunizing pigs against postweaning multisystemic wasting syndrome (PMWS). Accordingly, the invention provides methods for eliciting a protective immune response against a pathogenic porcine circovirus by administering to a pig an immunogenically effective amount of a type 2B porcine circovirus vaccine or immunogenic composition comprising at least one of the porcine circoviruses having a nucleic acid sequence as set forth in SEQ ID NOs: 1 or 2, or at least one protein from at least one of the two new type 2B strains of porcine circovirus as described herein. The invention further relates to protection of a pig from any one or more of the symptoms or sequelae associated with PMWS.
摘要翻译：本发明涉及分离和鉴定2B型猪圆环病毒的两种新菌株。这两种新的猪圆环病毒菌株可用于制备用于免疫猪的断奶多系统消耗综合征（PMWS）的疫苗或免疫原性组合物。因此，本发明提供了通过向猪施用免疫有效量的2B型猪圆环病毒疫苗或免疫原性组合物来引发针对病原性猪圆环病毒的保护性免疫应答的方法，所述免疫原性组合物包含至少一种具有核酸序列的猪圆环病毒如SEQ ID NO：1或2所示，或至少一种来自本文所述的两种新型2B型猪圆环病毒株的蛋白质。本发明还涉及猪与PMWS相关的任何一种或多种症状或后遗症的保护。

66. 发明授权

US07947493B2 Compositions and methods for regulating mRNA transcription and translation 有权
标题翻译：调节mRNA转录和翻译的组成和方法
公开(公告)号：US07947493B2
公开(公告)日：2011-05-24
申请号：US10888143
申请日：2004-07-09
申请人： Ann C. Palmenberg , Aleksey G. Aminev , Rachel P. Groppo
发明人： Ann C. Palmenberg , Aleksey G. Aminev , Rachel P. Groppo
IPC分类号： C12N15/00 , C12N15/10 , C12N15/11 , C12N15/34
CPC分类号： C07K14/005 , A61K2039/5256 , C12N15/67 , C12N2770/32222 , C12N2770/32243
摘要： The invention relates to compositions, specifically novel nucleic acid constructs encoding a cardiovirus 2A polypeptide operably linked to suitable promoters. Also, disclosed are methods whereby the nucleic acid constructs are introduced into cells or cell free systems to regulate cellular mRNA transcription and cap-dependent or internal ribosomal entry site (IRES)-dependent mRNA translation.
摘要翻译：本发明涉及组合物，特别是编码与合适的启动子可操作地连接的心脏病毒2A多肽的新型核酸构建体。还公开了将核酸构建体引入细胞或无细胞系统以调节细胞mRNA转录和帽依赖性或内部核糖体进入位点（IRES） - 依赖性mRNA翻译的方法。

67. 发明授权

US07820440B2 Means and methods for producing adenovirus vectors 有权
标题翻译：用于产生腺病毒载体的方法和方法
公开(公告)号：US07820440B2
公开(公告)日：2010-10-26
申请号：US11800871
申请日：2007-05-07
申请人： Ronald Vogels , Abraham Bout
发明人： Ronald Vogels , Abraham Bout
IPC分类号： C12N15/861 , C12N15/63 , C12N15/11 , C12N15/00 , C12N15/34 , C12N5/00
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , A61K2039/5256 , C12N2710/10343 , C12N2810/6018 , C12N2830/002
摘要： The invention relates to methods and means for producing adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenoviral vector and wherein the E4-orf6 gene product is compatible with one or more products of the E1 gene products provided by the complementing cell, such that the adenoviral vector can be efficiently produced by the complementing cell.
摘要翻译：本发明涉及在补体细胞系上产生腺病毒载体的方法和方法，其中编码核酸的早期区域4开放阅读框6（E4-orf6）存在于腺病毒载体中，其中E4-orf6基因产物与由补体细胞提供的E1基因产物的一种或多种产物，使得腺病毒载体可以通过补体细胞有效产生。

68. 发明授权

US07498306B2 Peptides binding to the phosphatase 2A protein 失效
标题翻译：肽结合磷酸酶2A蛋白
公开(公告)号：US07498306B2
公开(公告)日：2009-03-03
申请号：US11107814
申请日：2005-04-18
申请人： Alphonse Garcia , Frederic Dessauge , Xavier Cayla , Angelita Rebollo
发明人： Alphonse Garcia , Frederic Dessauge , Xavier Cayla , Angelita Rebollo
IPC分类号： A61K38/00 , A61K48/00 , C07K1/00 , C07K14/00 , C07K14/01 , C07K14/075 , C07K16/18 , C07K17/00 , C12N5/06 , C12N5/16 , C12N15/34 , C12N15/86 , G01N33/68
CPC分类号： C07K14/4747
摘要： The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids long and binding in vitro to a phosphatase 2A protein holoenzyme or one of its subunits. The invention also relates to polynucleotides encoding the novel peptides, vectors expressing same, as well as antibodies identifying same and probes identifying transcripts thereof.
摘要翻译：本发明涉及特别可用于抗肿瘤，抗病毒和抗寄生虫治疗的新型合成或天然E4orf4或Bcl-2肽，所述肽小于30个氨基酸长，并且在体外与磷酸酶2A蛋白全酶或其亚基之一结合。本发明还涉及编码新肽的多核苷酸，表达相同的载体，以及鉴定其的抗体和鉴定其转录本的探针。

69. 发明授权

US07189561B2 Production of adenovirus vectors with reduced levels of replication competent adenovirus contamination 失效
标题翻译：生产具有降低复制水平的腺病毒载体的腺病毒载体
公开(公告)号：US07189561B2
公开(公告)日：2007-03-13
申请号：US10946484
申请日：2004-09-21
申请人： Frank L. Graham
发明人： Frank L. Graham
IPC分类号： C12N15/34 , C12N15/64 , C12N15/63 , C12N5/10 , C12N15/861 , C07H21/04
CPC分类号： C12N15/86 , C12N2710/10343 , C12N2800/30 , C12N2830/42 , C12N2840/20
摘要： Methods, cells and recombinant adenoviral vectors are disclosed that permit the production of recombinant adenoviral vector stocks with reduced levels of contamination by replication competent adenoviruses (RCA). In certain embodiments are disclosed early region 1 (E1) deficient recombinant adenoviral vectors and complementing E1 positive host cells whose sequences are designed to avoid formation of RCA by homologous recombination between sequences in the vector and E1 sequences in the cells. One aspect of the invention involves the inversion of the packaging signal in a recombinant adenoviral vector relative to an adjacent or nearby inverted terminal repeat (ITR). Methods include use of site-specific intregrase family recombinases such as Cre or FLP and recombinase recognition sites such as lox sites or frt sites.
摘要翻译：公开了方法，细胞和重组腺病毒载体，其允许通过复制性腺病毒（RCA）产生具有降低的污染水平的重组腺病毒载体原种。在某些实施方案中公开了早期区域1（E1）缺陷型重组腺病毒载体和补体E1阳性宿主细胞，其序列被设计为避免通过载体中的序列和细胞中的E1序列之间的同源重组而形成RCA。本发明的一个方面涉及重组腺病毒载体中相对于邻近或邻近倒置末端重复（ITR）的包装信号的反转。方法包括使用位点特异性整合酶家族重组酶，如Cre或FLP以及重组酶识别位点，如lox位点或frt位点。

70. 发明授权

US06855317B2 Immunological herpes simplex virus antigens and methods for use thereof 失效
标题翻译：免疫性单纯疱疹病毒抗原及其使用方法
公开(公告)号：US06855317B2
公开(公告)日：2005-02-15
申请号：US10073834
申请日：2002-02-11
申请人： David M. Koelle , Lawrence Corey
发明人： David M. Koelle , Lawrence Corey
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K38/00 , A61K39/00 , A61P31/22 , C07K14/035 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/34 , C12N15/38 , C12P21/02 , C12R1/91 , C12R1/93 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/55572 , A61K2039/57 , C07K2319/00 , C12N2710/16622 , C12N2710/16634
摘要： The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by T-cells derived from herpetic lesions or from uterine cervix. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
摘要翻译：本发明提供可用于预防和治疗HSV感染的HSV抗原。本文公开了抗原和/或其组成表位，其被证实被来自疱疹病变或子宫颈的T细胞识别。对本发明的抗原具有特异性的T细胞已经证明了对负载有病毒编码的肽表位的细胞的细胞毒性活性，并且在许多情况下，针对感染HSV的细胞。鉴定负责T细胞特异性的免疫原性抗原提供了改进的抗病毒治疗和预防策略。含有编码本发明抗原的抗原或多核苷酸的组合物提供有效靶向的疫苗，用于预防和治疗HSV感染。

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