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1. 发明申请

US20100233677A1 FULL GENOME SEQUENCES OF HUMAN RHINOVIRUS STRAINS 审中-公开
标题翻译：人类蛇毒病毒的全基因序列
公开(公告)号：US20100233677A1
公开(公告)日：2010-09-16
申请号：US12703147
申请日：2010-02-09
申请人： Stephen B. Liggett , Claire M. Fraser-Liggett , Ann C. Palmenberg
发明人： Stephen B. Liggett , Claire M. Fraser-Liggett , Ann C. Palmenberg
IPC分类号： C12Q1/70
CPC分类号： C12Q1/70
摘要： Infection by human rhinovirus (HRV) causes upper and lower respiratory tract disease with varying degrees of virulence. The molecular basis of diversity was examined by completing the genome sequences for all known serotypes (n=99) as well as novel field samples. Superimposition of capsid crystal structure and optimal-energy RNA configurations established the alignments. The phylogeny revealed conserved motifs, Glade-specific diversity including a potential new species (clade-D), pan-genome mutations in field isolates, and unexpected recombination that contributes to heterogeneity. A spacer tract near a 5′-UTR cloverleaf was hypervariable, and in analogy with poliovirus, may be associated with virulence. A previously unidentified configuration consistent with non-scanning internal ribosome entry may account for rapid protein translation. The data density from complete sequences of the HRV reference serotypes provided high resolution for this degree of modeling, and serves as a platform for full genome-based epidemiologic studies, for viral diagnostics and prognostics, and for antiviral compounds and vaccines.
摘要翻译：人类鼻病毒（HRV）的感染导致上呼吸道和下呼吸道疾病具有不同程度的毒力。通过完成所有已知血清型（n = 99）的基因组序列以及新的野外样本来检查多样性的分子基础。衣壳晶体结构和最佳能量RNA配置的叠加建立了比对。系统发育显示保守的基序，Glade特异性多样性，包括潜在的新物种（进化枝D），野外分离物中的泛基因组突变以及有助于异质性的意外重组。 5'-UTR三叶草附近的间隔区是高变的，类似于脊髓灰质炎病毒可能与毒力相关。与非扫描内部核糖体进入一致的先前未鉴定的构型可以解释快速的蛋白质翻译。来自HRV参考血清型的完整序列的数据密度为该程度的建模提供了高分辨率，并且作为用于病毒诊断和预后以及用于抗病毒化合物和疫苗的全基因组流行病学研究的平台。

2. 发明授权

US5912167A Autocatalytic cleavage site and use thereof in a protein expression vector 失效
标题翻译：自动催化裂解位点及其在蛋白质表达载体中的应用
公开(公告)号：US5912167A
公开(公告)日：1999-06-15
申请号：US468790
申请日：1995-06-06
申请人： Ann C. Palmenberg , Michael A. Hoffman , Harry Hahn , Lee R. Martin
发明人： Ann C. Palmenberg , Michael A. Hoffman , Harry Hahn , Lee R. Martin
IPC分类号： C07K14/085 , C12N9/50 , C12N15/09 , C12N7/00 , C12N15/00
CPC分类号： C07K14/005 , C12N9/50 , C12N2770/32322
摘要： A nucleic acid construct comprising at least two copies of a nucleic acid sequence encoding an autocatalytic peptide cleavage site is disclosed. This site preferably comprises the amino acid sequence DX(D,E)XNPGP. A method of exposing an animal to an antigenic amino acid sequence is also disclosed.
摘要翻译：公开了包含编码自身催化肽切割位点的核酸序列的至少两个拷贝的核酸构建体。该位点优选包含氨基酸序列DX（D，E）XNPGP。还公开了将动物暴露于抗原性氨基酸序列的方法。

3. 发明授权

US5229111A Method of inhibiting picornavirus disease 失效
标题翻译：抑制微小RNA病毒病的方法
公开(公告)号：US5229111A
公开(公告)日：1993-07-20
申请号：US648098
申请日：1991-01-31
申请人： Ann C. Palmenberg , Gregory M. Duke , Jorge E. Osorio
发明人： Ann C. Palmenberg , Gregory M. Duke , Jorge E. Osorio
IPC分类号： A61K39/125 , C12N7/00 , C12N7/04
CPC分类号： C12N7/00 , A61K39/12 , A61K39/125 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , C12N2770/32234 , C12N2770/32261
摘要： A method for inhibiting picornavirus disease in non-murine mammals is disclosed. A vaccine containing a live, recombinant, attenuated picornavirus with a shortened poly(C) tract is administered to the mammal. Preferably, the picornavirus in the vaccine is of the same genus as the disease-causing picornavirus and has a shortened poly(C) tract. The administration of the vaccine causes antibodies effective against the disease-causing picornavirus to be formed in vivo. In one embodiment of the invention, a vaccine containing Mengovirus with a shortened poly(C) tract can be used as a vaccine for both pigs and monkeys.
摘要翻译：公开了一种用于在非鼠哺乳动物中抑制小RNA病毒病的方法。向哺乳动物施用含有具有缩短的聚（C）道的活的，重组的，减毒的小核糖核酸病毒的疫苗。优选地，疫苗中的小核糖核酸病毒与致病微小RNA病毒具有相同的属性，并且具有缩短的聚（C）道。疫苗的施用导致在体内形成对于致病微小RNA病毒有效的抗体。在本发明的一个实施方案中，含有缩短的聚（C）链的孟诺病毒的疫苗可用作猪和猴两者的疫苗。

4. 发明授权

US4937190A Translation enhancer 失效
标题翻译：翻译增强剂
公开(公告)号：US4937190A
公开(公告)日：1990-06-26
申请号：US109132
申请日：1987-10-15
申请人： Ann C. Palmenberg , Gregory M. Duke , Parks, Griffith D.
发明人： Ann C. Palmenberg , Gregory M. Duke , Parks, Griffith D.
IPC分类号： C12N15/00 , C12N15/67 , C12P21/02
CPC分类号： C12P21/02 , C12N15/00 , C12N15/67
摘要： Disclosed in this patent are DNA sequences, RNA sequences, vectors, and hosts that incorporate a translation enhancer region derived from the 5' non-coding region of a cardiovirus. The enhancer acts at the RNA level (as opposed to the DNA level) to enhance production of proteins in cell free media. Proteinaceous material which is produced will not have attached to it any undesired material from the enhancer sequence. The invention is especially useful to enable efficient production of selected viral proteins of picornoviruses.
摘要翻译：在该专利中公开的是包含衍生自心脏病毒的5'非编码区的翻译增强子区的DNA序列，RNA序列，载体和宿主。增强子作用于RNA水平（与DNA水平相反）以增强无细胞培养基中蛋白质的产生。产生的蛋白质材料将不会与增强子序列中的任何不需要的物质连接。本发明特别有助于有效地生产选择性的细小病毒病毒蛋白质。

5. 发明授权

US07947493B2 Compositions and methods for regulating mRNA transcription and translation 有权
标题翻译：调节mRNA转录和翻译的组成和方法
公开(公告)号：US07947493B2
公开(公告)日：2011-05-24
申请号：US10888143
申请日：2004-07-09
申请人： Ann C. Palmenberg , Aleksey G. Aminev , Rachel P. Groppo
发明人： Ann C. Palmenberg , Aleksey G. Aminev , Rachel P. Groppo
IPC分类号： C12N15/00 , C12N15/10 , C12N15/11 , C12N15/34
CPC分类号： C07K14/005 , A61K2039/5256 , C12N15/67 , C12N2770/32222 , C12N2770/32243
摘要： The invention relates to compositions, specifically novel nucleic acid constructs encoding a cardiovirus 2A polypeptide operably linked to suitable promoters. Also, disclosed are methods whereby the nucleic acid constructs are introduced into cells or cell free systems to regulate cellular mRNA transcription and cap-dependent or internal ribosomal entry site (IRES)-dependent mRNA translation.
摘要翻译：本发明涉及组合物，特别是编码与合适的启动子可操作地连接的心脏病毒2A多肽的新型核酸构建体。还公开了将核酸构建体引入细胞或无细胞系统以调节细胞mRNA转录和帽依赖性或内部核糖体进入位点（IRES） - 依赖性mRNA翻译的方法。

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