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1. 发明申请

US20140141515A1 DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS 审中-公开
标题翻译： DNA复制系统，用于高产快速生产疫苗和单克隆抗体在植物中的治疗
公开(公告)号：US20140141515A1
公开(公告)日：2014-05-22
申请号：US13944589
申请日：2013-07-17
申请人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
发明人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
IPC分类号： C12N15/82
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8258
摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
摘要翻译：植物病毒载体在快速生产蛋白质方面具有巨大的潜力，但不是简单的。这里描述了用于高产率和快速生产低聚蛋白复合物（包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb））的基于双恶病毒的系统。特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

2. 发明授权

US06194560B1 Oral immunization with transgenic plants 有权
标题翻译：用转基因植物进行口服免疫
公开(公告)号：US06194560B1
公开(公告)日：2001-02-27
申请号：US09191852
申请日：1998-11-12
申请人： Charles J. Arntzen , Hugh S. Mason , Tariq A. Haq
发明人： Charles J. Arntzen , Hugh S. Mason , Tariq A. Haq
IPC分类号： A61K39108
CPC分类号： C07K14/005 , A61K39/00 , C07K14/245 , C12N15/8258 , C12N2770/16022 , Y02A50/472
摘要： The oral vaccines and oral vaccine adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogens and adjuvants when the transgenic plant material expressing the antigens is fed to animals.
摘要翻译：本发明的口服疫苗和口服疫苗佐剂在转基因植物中生产，然后通过消耗转基因植物来施用。构建天然和合成编码免疫原性试剂表达的DNA序列，其在饲喂可食用植物，植物组织或衍生植物材料时能够在动物中引起免疫应答，植物转化以在植物细胞中稳定或短暂表达。本发明提供了用于通过转基因植物免疫动物的第一已知功能方法，其中当将表达抗原的转基因植物材料供给动物时，植物表达作为免疫原和佐剂的细菌抗原。

3. 发明授权

US07879338B2 Vectors and methods for immunization against norovirus using transgenic plants 有权
标题翻译：使用转基因植物免疫诺如病毒的载体和方法
公开(公告)号：US07879338B2
公开(公告)日：2011-02-01
申请号：US10895791
申请日：2004-07-21
申请人： William D.O. Hamilton , Koen Hellendoorn , Timothy D. Jones , Dwayne D. Kirk , Hugh S. Mason , Xiuren Zhang , Charles J. Arntzen
发明人： William D.O. Hamilton , Koen Hellendoorn , Timothy D. Jones , Dwayne D. Kirk , Hugh S. Mason , Xiuren Zhang , Charles J. Arntzen
IPC分类号： C12N15/40 , C12N5/04 , C12N1/21 , A61K39/125 , A01H5/00 , A01H5/08 , A01H5/10
CPC分类号： C12N15/8258 , A61K2039/5258 , A61K2039/542 , C07K14/005 , C12N2770/16022
摘要： The present invention relates to a synthetic plant-optimized nucleic acid molecule having a Norwalk virus capsid protein coding nucleotide sequence, and nucleic acid constructs, host cells, expression systems, and plants having the plant-optimized Norwalk virus nucleic acid molecule. The present invention also relates to a method of producing Norwalk virus capsid protein virus-like particles in a transgenic plant or transgenic plant seed transformed with a plant-optimized nucleic acid molecule encoding Norwalk virus capsid protein. The plant or a component thereof can be administered to a subject under conditions effective to immunize the subject against disease resulting from infection by a Norovirus, including Norwalk virus. An oral vaccine for immunization of a subject against Norwalk virus infection is also disclosed.
摘要翻译：本发明涉及具有Norwalk病毒衣壳蛋白编码核苷酸序列的合成植物优化核酸分子，以及具有植物优化诺瓦克病毒核酸分子的核酸构建体，宿主细胞，表达系统和植物。本发明还涉及在用植物优化的编码诺瓦克病毒衣壳蛋白的核酸分子转化的转基因植物或转基因植物种子中产生诺瓦克病毒衣壳蛋白病毒样颗粒的方法。植物或其组分可以在有效免疫受试者的病症下施用于受诺如病毒（包括诺瓦克病毒）感染引起的疾病的病症。还公开了用于免疫Norwalk病毒感染的受试者的口服疫苗。

4. 发明授权

US07527810B1 Oral immunology using plant product containing hepatitis surface antigen 有权
标题翻译：口服免疫学使用含有肝炎表面抗原的植物产品
公开(公告)号：US07527810B1
公开(公告)日：2009-05-05
申请号：US09420695
申请日：1999-10-19
申请人： Yasmin Thanavala , Charles Joel Arntzen , Hugh S. Mason
发明人： Yasmin Thanavala , Charles Joel Arntzen , Hugh S. Mason
IPC分类号： A01N65/00 , A01N63/02 , A61K45/00 , A61K39/00 , A61K39/29
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/292 , A61K2039/5156 , A61K2039/542 , A61K2039/55544 , C12N15/8258 , C12N2730/10122 , C12N2730/10134 , Y02A50/386 , Y02A50/388 , Y02A50/40 , Y02A50/403 , Y02A50/407 , Y02A50/472 , Y10S514/894
摘要： A method for obtaining an immune response to hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the HBsAg. It has now been discovered that the animal may be made immunoreceptive to HBsAg either by administering the plant material containing HBsAg in conjunction with a suitable adjuvant or by prior primary immunization. When the animal is made immunoreceptive by a prior, e.g. primary, immunization, an immune response to HBsAg may be boosted in the animal by feeding the animal the plant material containing the HBsAg. For example, an animal, e.g. a human, that previously had a positive response to primary immunization against hepatitis B, can have a booster response to HBsAg by feeding the animal the antigen in a plant material. The plant material is a substance comprising a physiologically acceptable plant material, especially potatoes, containing hepatitis B surface antigen (HBsAg). The HBsAg in the plant results from expression by the plant of HBsAg due to genetic alteration.
摘要翻译：通过将植物材料中的抗原供给到对HBsAg免疫接受的动物来获得对乙型肝炎表面抗原（HBsAg）的免疫应答的方法。现在已经发现，通过将含有HBsAg的植物材料与合适的佐剂联合或通过先前的初次免疫，可以使动物对HBsAg免疫接种。当动物由先前的，例如，初级免疫，对HBsAg的免疫应答可以通过向动物喂养含有HBsAg的植物材料来增强动物的免疫应答。例如，动物，例如，以前对乙型肝炎初次免疫有正面反应的人可以通过将动物的抗原喂养在植物材料中而对HBsAg具有加强反应。植物材料是包含生理上可接受的植物材料，特别是含有乙型肝炎表面抗原（HBsAg）的马铃薯的物质。植物中的HBsAg由于遗传改变而由HBsAg植物表达。

5. 发明授权

US06770799B2 Expression of recombinant human acetylcholinesterase in transgenic plants 有权
公开(公告)号：US06770799B2
公开(公告)日：2004-08-03
申请号：US09810861
申请日：2001-03-16
申请人： Tsafrir S. Mor , Hermona Soreq , Charles J. Arntzen , Hugh S. Mason
发明人： Tsafrir S. Mor , Hermona Soreq , Charles J. Arntzen , Hugh S. Mason
IPC分类号： A01H100
CPC分类号： C12N15/8242 , C12N9/18 , C12N15/8257
摘要： Briefly stated, the invention includes a method of making a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, and regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant. Another embodiment of the invention includes a method of making a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant, and isolating or purifying from the transgenic plant or a part thereof a physiologically active human acetylcholinesterase.

6. 发明授权

US06395964B1 Oral immunization with transgenic plants 失效
标题翻译：用转基因植物进行口服免疫
公开(公告)号：US06395964B1
公开(公告)日：2002-05-28
申请号：US08817906
申请日：1997-08-04
申请人： Charles J. Arntzen , Hugh S. Mason , Haq A. Tariq , John D. Clements
发明人： Charles J. Arntzen , Hugh S. Mason , Haq A. Tariq , John D. Clements
IPC分类号： C12N504
CPC分类号： C07K14/28 , A61K39/04 , A61K39/08 , A61K39/39 , A61K2039/53 , A61K2039/542 , A61K2039/55544 , C07K14/245 , C12N15/8258
摘要： The oral antigens and adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed, and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogen and adjuvants when the transgenic plant material expressing the antigens is fed to animals.
摘要翻译：本发明的口服抗原和佐剂在转基因植物中产生，然后通过消耗转基因植物施用。构建天然和合成编码免疫原性表达的DNA序列，其在饲喂可食用植物，植物组织或衍生植物材料时能够在动物中引起免疫应答，植物转化用于在植物细胞中稳定或瞬时表达。本发明提供了用于通过转基因植物免疫动物的第一已知功能方法，其中当将表达抗原的转基因植物材料供给动物时，植物表达作为免疫原和佐剂的细菌抗原。

7. 发明授权

US10080799B2 Methods and compositions related to glycoprotein-immunoglobulin fusions 有权
公开(公告)号：US10080799B2
公开(公告)日：2018-09-25
申请号：US13578575
申请日：2011-02-11
申请人： Hugh S. Mason , Seong Hee Bhoo , Sun Hee Rosenthal , Charles J. Arntzen
发明人： Hugh S. Mason , Seong Hee Bhoo , Sun Hee Rosenthal , Charles J. Arntzen
IPC分类号： A61K39/29 , C07K19/00 , C07K16/10 , A61K39/12 , A61K38/00 , A61K39/00
CPC分类号： A61K39/29 , A61K38/00 , A61K39/12 , A61K2039/55566 , C07K16/10 , C07K19/00 , C07K2317/13 , C07K2317/24 , C07K2319/30 , C12N2760/14134 , C12N2770/24234 , Y02A50/397
摘要： Disclosed herein are compositions and methods for eliciting immune responses against HCV antigens. In particular embodiments, the compounds and methods elicit immune responses against all or a segment of HCV glycoprotein E1 and/or HCV glycoprotein E2.

8. 发明授权

US08513397B2 DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants 有权
标题翻译：用于在植物中高水平快速生产疫苗和单克隆抗体治疗剂的DNA复制子系统
公开(公告)号：US08513397B2
公开(公告)日：2013-08-20
申请号：US13060414
申请日：2009-08-27
申请人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
发明人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
IPC分类号： C12N15/34 , C12N15/117 , C12N15/13 , C12N15/36 , C12N15/82 , C12N5/10
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8258
摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
摘要翻译：植物病毒载体在快速生产蛋白质方面具有很大的潜力，但并不简单。这里描述了用于高产率和快速生产低聚蛋白复合物的双基因病毒的系统，包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb）。特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

9. 发明申请

US20110262966A1 DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS 有权
标题翻译： DNA复制系统，用于高产快速生产疫苗和单克隆抗体在植物中的治疗
公开(公告)号：US20110262966A1
公开(公告)日：2011-10-27
申请号：US13060414
申请日：2009-08-27
申请人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
发明人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
IPC分类号： C12P1/00 , C12P21/00 , C12P19/34 , C12N15/63
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8258
摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
摘要翻译：植物病毒载体在快速生产蛋白质方面具有很大的潜力，但并不简单。这里描述了用于高产率和快速生产低聚蛋白复合物的双基因病毒的系统，包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb）。特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

10. 发明授权

US07572466B1 Oral immunology using plant product containing a non-enteric pathogen antigen 有权
标题翻译：口服免疫学使用含有非肠道病原体抗原的植物产品
公开(公告)号：US07572466B1
公开(公告)日：2009-08-11
申请号：US09464416
申请日：1999-12-16
申请人： Yasmin Thanavala , Charles Joel Arntzen , Hugh S. Mason
发明人： Yasmin Thanavala , Charles Joel Arntzen , Hugh S. Mason
IPC分类号： A01N65/00 , A01N63/02 , A61K45/00 , A61K39/00 , A61K39/29
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/292 , A61K2039/5156 , A61K2039/542 , A61K2039/545 , A61K2039/555 , A61K2039/55505 , A61K2039/55544 , A61K2039/57 , C12N15/8258 , C12N2730/10122 , C12N2730/10134 , Y02A50/386 , Y02A50/388 , Y02A50/40 , Y02A50/403 , Y02A50/407 , Y02A50/472
摘要： A method for obtaining an immune response to a non-enteric pathogen antigen (NEPA) such as hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the NEPA. It has now been discovered that the animal may be made immunoreceptive to the NEPA such as HBsAg by administering the plant material containing the NEPA in conjunction with a suitable adjuvant. The plant material is a substance comprising a physiologically acceptable plant material, especially potatoes, containing the NEPA, e.g. hepatitis B surface antigen (HBsAg). The NEPA, e.g. HBsAg in the plant results from expression by the plant of the NEPA due to genetic alteration.
摘要翻译：通过将植物材料中的抗原喂养到对NEPA免疫接受的动物，获得对非肠道病原体抗原（NEPA）如乙型肝炎表面抗原（HBsAg）的免疫应答的方法。现在已经发现，通过将含有NEPA的植物材料与合适的佐剂联合，可以使动物对NEPA例如HBsAg免疫接种。植物材料是包含生理上可接受的植物材料，特别是包含NEPA的土豆的物质，例如，乙型肝炎表面抗原（HBsAg）。 NEPA，例如植物中的HBsAg由于遗传改变而由NEPA植物的表达产生。

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