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1. 发明授权

US08513397B2 DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants 有权
标题翻译：用于在植物中高水平快速生产疫苗和单克隆抗体治疗剂的DNA复制子系统
公开(公告)号：US08513397B2
公开(公告)日：2013-08-20
申请号：US13060414
申请日：2009-08-27
申请人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
发明人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
IPC分类号： C12N15/34 , C12N15/117 , C12N15/13 , C12N15/36 , C12N15/82 , C12N5/10
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8258
摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
摘要翻译：植物病毒载体在快速生产蛋白质方面具有很大的潜力，但并不简单。这里描述了用于高产率和快速生产低聚蛋白复合物的双基因病毒的系统，包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb）。特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

2. 发明申请

US20110262966A1 DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS 有权
标题翻译： DNA复制系统，用于高产快速生产疫苗和单克隆抗体在植物中的治疗
公开(公告)号：US20110262966A1
公开(公告)日：2011-10-27
申请号：US13060414
申请日：2009-08-27
申请人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
发明人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
IPC分类号： C12P1/00 , C12P21/00 , C12P19/34 , C12N15/63
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8258
摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
摘要翻译：植物病毒载体在快速生产蛋白质方面具有很大的潜力，但并不简单。这里描述了用于高产率和快速生产低聚蛋白复合物的双基因病毒的系统，包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb）。特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

3. 发明申请

US20140141515A1 DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS 审中-公开
标题翻译： DNA复制系统，用于高产快速生产疫苗和单克隆抗体在植物中的治疗
公开(公告)号：US20140141515A1
公开(公告)日：2014-05-22
申请号：US13944589
申请日：2013-07-17
申请人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
发明人： Hugh S. Mason , Zhong Huang , Qiang Chen , Charles J. Arntzen , Shuo Yuan , Brooke Hjelm
IPC分类号： C12N15/82
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8258
摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.
摘要翻译：植物病毒载体在快速生产蛋白质方面具有巨大的潜力，但不是简单的。这里描述了用于高产率和快速生产低聚蛋白复合物（包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb））的基于双恶病毒的系统。特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

4. 发明授权

US09337371B2 Cam turntable, sun-tracking device equipped with same and control method for the device 有权
标题翻译：凸轮转盘，太阳跟踪装置配备相同的控制方法
公开(公告)号：US09337371B2
公开(公告)日：2016-05-10
申请号：US13582801
申请日：2011-08-16
申请人： Zhong Huang
发明人： Zhong Huang
IPC分类号： H01L31/042 , H02N6/00 , H01L31/052 , F24J2/54 , F16H1/16
CPC分类号： H01L31/052 , F16H1/16 , F24S30/452 , F24S2030/11 , F24S2030/13 , H02S20/00 , H02S20/32 , Y02E10/47 , Y02E10/50
摘要： Provided are a cam turntable (2), a sun-tracking device equipped with the cam turntable (2) and a control method for the device. The sun-tracking device comprises a support mechanism for mounting a photovoltaic assembly (1), and an azimuth driving device, which is a cam turntable (2), fixed on the support mechanism for adjusting the azimuth thereof. The sun-tracking device adjusts the azimuth of the support mechanism for mounting the photovoltaic assembly (1) by utilizing the cam turntable (2) as the azimuth driving device, so that harmful incoming impact loads on the sun-tracking device as a whole are transferred into friction forces which are then transferred and alleviated, therefore it is advantageous in avoiding damages to subsequent driving devices due to the excessively large impact loads, especially in protecting the precision of a control worm gear (2-12) from being affected, which in turn extends the service life of the sun-tracking device as a whole. The device has high safety, large load capacity, and the function of automatic gap adjustment.
摘要翻译：提供一种凸轮转盘（2），配备有凸轮转台（2）的太阳跟踪装置和该装置的控制方法。太阳追踪装置包括用于安装光伏组件（1）的支撑机构和作为凸轮转台（2）的方位驱动装置，其固定在支撑机构上用于调节其方位角。太阳跟踪装置通过利用作为方位驱动装置的凸轮转台（2）来调节用于安装光伏组件（1）的支撑机构的方位角，使得整个太阳跟踪装置上的有害的进入冲击载荷为转移到摩擦力中，然后被转移和减轻，因此有利的是避免由于过大的冲击载荷而对随后的驱动装置造成的损害，特别是在保护控制蜗轮（2-12）不受影响的精度方面，从而延长了整个太阳跟踪装置的使用寿命。该装置具有安全性高，承载能力大，自动间隙调整功能。

5. 发明授权

US5869837A Radiation imaging panel 失效
标题翻译：辐射成像面板
公开(公告)号：US5869837A
公开(公告)日：1999-02-09
申请号：US776140
申请日：1997-03-31
申请人： Zhong Huang
发明人： Zhong Huang
IPC分类号： G01T1/00 , A61B6/00 , G01T1/24 , H01L27/14 , H01L27/146 , H04N5/33
CPC分类号： H01L27/14609 , H01L27/14643 , H01L27/14658 , H01L27/14676
摘要： A radiation imaging system comprising a capacitive coupling radiation detector for directly converting incidence radiation to electrical charges, a storage capacitor for storing the generated charges, a read-out switch for periodically outputting the charges stored on the storage capacitor, and a reset switch for periodically re-setting the radiation detector.
摘要翻译： PCT No.PCT / CA94 / 00407 Sec。 371日期1997年3月31日 102（e）1997年3月31日PCT PCT 1994年7月27日PCT公布。公开号WO96 / 03773 日期：1996年2月8日一种辐射成像系统，包括用于将入射辐射直接转换为电荷的电容耦合辐射检测器，用于存储产生的电荷的存储电容器，用于周期性地输出存储在存储电容器上的电荷的读出开关，以及用于周期性地重新设置辐射检测器的复位开关。

6. 发明申请

US20100151573A1 Compositions and methods for delivery of molecules to selectin-ligand-expressing and selectin-expressing cells 审中-公开
标题翻译：将分子递送到选择蛋白 - 配体表达和选择蛋白表达细胞的组合物和方法
公开(公告)号：US20100151573A1
公开(公告)日：2010-06-17
申请号：US12590965
申请日：2009-11-17
申请人： Michael R. King , Zhong Huang
发明人： Michael R. King , Zhong Huang
IPC分类号： C12N5/00 , C12M1/00
CPC分类号： A61K47/6913 , A61K9/1271
摘要： The present invention is directed to methods for delivery of payload molecules to selected cells. The method comprises payload carrying delivery vehicles tagged with selectin or selectin-ligands. The payload carrying delivery vehicles are immobilized on flow surfaces and payload is delivered to targeted cells during rolling. The invention is also directed to compositions and devices for carrying out the method.
摘要翻译：本发明涉及将有效载荷分子递送到所选择的细胞的方法。该方法包括用选择素或选择素 - 配体标记的载体载体递送载体。承载运载载体的载荷被固定在流动表面上，有效载荷在滚动过程中被传送到目标细胞。本发明还涉及用于实施该方法的组合物和装置。

7. 发明申请

US20050272240A1 Method and process intermediate for electrostatic discharge protection in flat panel imaging detectors 有权
标题翻译：平板成像探测器中静电放电保护的方法和过程中间体
公开(公告)号：US20050272240A1
公开(公告)日：2005-12-08
申请号：US10859678
申请日：2004-06-02
申请人： Zhong Huang
发明人： Zhong Huang
IPC分类号： H01L21/84 , H01L27/02 , H01L27/12 , H01L27/146 , H01L29/04
CPC分类号： H01L27/14643 , H01L21/84 , H01L27/0248 , H01L27/12 , H01L27/14692
摘要： Shorting bars are provided for electrostatic discharge protection as a portion of trace deposition in a photodiode array. During normal processing for etching of the metal layers, the shorting bars are removed without additional processing requirements. Additional shorting elements are provided by employing FET silicon layers having traces in contact with the array traces to provide extended ESD protection until removal of those shorting elements during normal processing for opening vias for photodiode bottom contact.
摘要翻译：短路棒用作静电放电保护，作为光电二极管阵列中的痕量沉积的一部分。在金属层的蚀刻的正常处理期间，除去短路棒而不需要额外的加工要求。通过采用具有与阵列迹线接触的迹线的FET硅层来提供额外的短路元件，以提供延长的ESD保护，直到在正常处理期间去除这些短路元件以打开用于光电二极管底部接触的通孔。

8. 发明授权

US09279914B2 Condensing lens, compound-eye lens condenser, and compound-eye concentrating solar cell assembly 有权
标题翻译：冷凝透镜，复眼透镜冷凝器和复眼集中太阳能电池组件
公开(公告)号：US09279914B2
公开(公告)日：2016-03-08
申请号：US13582829
申请日：2011-08-15
申请人： Zhong Huang , Han Liu , Shaochun Li
发明人： Zhong Huang , Han Liu , Shaochun Li
IPC分类号： G02B27/14 , G02B13/18 , G02B3/02 , G02B3/00 , G02B3/06 , G02B19/00 , H01L31/054
CPC分类号： G02B3/0037 , F24S23/30 , G02B3/00 , G02B3/0056 , G02B3/06 , G02B19/0014 , G02B19/0042 , G02B19/0076 , G02B27/0961 , H01L31/0543 , Y02E10/40 , Y02E10/52
摘要： A condensing lens, compound-eye lens condenser, and compound-eye concentrating-type solar cell assembly. The condensing lens is a convex lens that can reflect mutually parallel incident lights (3) onto a receiving surface (4) on the outer side of the lens and thus form spots. If the vertical distance from the contact point of any incident lights (3) contacting the lens to a light axis (103) of the lens is x, the vertical distance between a projection point formed from the incident light (3) reflecting onto the receiving surface (4) and the center of the spot is m, the radius of the lens is a, and the radius of the spot is b, then the lens meets the following condition: x/m=a/b. The condensing lens has a high transmission rate, and the energy distribution of the spots is more even after condensing, the transmission rate is 90% to 93%, and the energy distribution curve of the spots transmitted through the condensing lens is similar to saddle-shaped.
摘要翻译：聚光透镜，复眼透镜冷凝器，复眼集中式太阳能电池组件。聚光透镜是可以将相互平行的入射光（3）反射到透镜外侧的接收表面（4）上并因此形成光斑的凸透镜。如果与透镜接触到透镜的光轴（103）的任何入射光（3）的接触点的垂直距离为x，则从入射光（3）形成的投影点反射到接收体上的垂直距离表面（4），点的中心为m，透镜的半径为a，光点的半径为b，则透镜满足以下条件：x / m = a / b。聚光透镜具有较高的透光率，聚光后的斑点能量分布更均匀，透射率为90％〜93％，透过聚光透镜的光斑的能量分布曲线与鞍形相似，成形。

9. 发明申请

US20130139867A1 CONDENSING LENS, COMPOUND-EYE LENS CONDENSER, AND COMPOUND-EYE CONCENTRATING SOLAR CELL ASSEMBLY 有权
标题翻译：冷凝透镜，化合物镜片冷凝器和化合物浓缩太阳能电池组件
公开(公告)号：US20130139867A1
公开(公告)日：2013-06-06
申请号：US13582829
申请日：2011-08-15
申请人： Zhong Huang
发明人： Zhong Huang
IPC分类号： G02B3/00 , H01L31/052 , G02B3/06
CPC分类号： G02B3/0037 , F24S23/30 , G02B3/00 , G02B3/0056 , G02B3/06 , G02B19/0014 , G02B19/0042 , G02B19/0076 , G02B27/0961 , H01L31/0543 , Y02E10/40 , Y02E10/52
摘要： A condensing lens, compound-eye lens condenser, and compound-eye concentrating-type solar cell assembly. The condensing lens is a convex lens that can reflect mutually parallel incident lights (3) onto a receiving surface (4) on the outer side of the lens and thus form spots. If the vertical distance from the contact point of any incident lights (3) contacting the lens to a light axis (103) of the lens is x, the vertical distance between a projection point formed from the incident light (3) reflecting onto the receiving surface (4) and the center of the spot is m, the radius of the lens is a, and the radius of the spot is b, then the lens meets the following condition: x/m=a/b. The condensing lens has a high transmission rate, and the energy distribution of the spots is more even after condensing, the transmission rate is 90% to 93%, and the energy distribution curve of the spots transmitted through the condensing lens is similar to saddle-shaped.
摘要翻译：聚光透镜，复眼透镜冷凝器，复眼集中式太阳能电池组件。聚光透镜是可以将相互平行的入射光（3）反射到透镜外侧的接收表面（4）上并因此形成光斑的凸透镜。如果与透镜接触到透镜的光轴（103）的任何入射光（3）的接触点的垂直距离为x，则从入射光（3）形成的投影点反射到接收体上的垂直距离表面（4），点的中心为m，透镜的半径为a，光点的半径为b，则透镜满足以下条件：x / m = a / b。聚光透镜具有较高的透光率，聚光后的斑点能量分布更均匀，透射率为90％〜93％，透过聚光透镜的光斑的能量分布曲线与鞍形相似，成形。

10. 发明申请

US20130133719A1 CAM TURNTABLE, SUN-TRACKING DEVICE EQUIPPED WITH SAME AND CONTROL METHOD FOR THE DEVICE 有权
标题翻译： CAM可伸缩的，具有相同装置的太阳跟踪装置和装置的控制方法
公开(公告)号：US20130133719A1
公开(公告)日：2013-05-30
申请号：US13582801
申请日：2011-08-16
申请人： Zhong Huang
发明人： Zhong Huang
IPC分类号： H01L31/052
CPC分类号： H01L31/052 , F16H1/16 , F24S30/452 , F24S2030/11 , F24S2030/13 , H02S20/00 , H02S20/32 , Y02E10/47 , Y02E10/50
摘要： Provided are a cam turntable (2), a sun-tracking device equipped with the cam turntable (2) and a control method for the device. The sun-tracking device comprises a support mechanism for mounting a photovoltaic assembly (1), and an azimuth driving device, which is a cam turntable (2), fixed on the support mechanism for adjusting the azimuth thereof. The sun-tracking device adjusts the azimuth of the support mechanism for mounting the photovoltaic assembly (1) by utilizing the cam turntable (2) as the azimuth driving device, so that harmful incoming impact loads on the sun-tracking device as a whole are transferred into friction forces which are then transferred and alleviated, therefore it is advantageous in avoiding damages to subsequent driving devices due to the excessively large impact loads, especially in protecting the precision of a control worm gear (2-12) from being affected, which in turn extends the service life of the sun-tracking device as a whole. The device has high safety, large load capacity, and the function of automatic gap adjustment.
摘要翻译：提供一种凸轮转盘（2），配备有凸轮转台（2）的太阳跟踪装置和该装置的控制方法。太阳追踪装置包括用于安装光伏组件（1）的支撑机构和作为凸轮转台（2）的方位驱动装置，其固定在支撑机构上用于调节其方位角。太阳跟踪装置通过利用作为方位驱动装置的凸轮转台（2）来调节用于安装光伏组件（1）的支撑机构的方位角，使得整个太阳跟踪装置上的有害的进入冲击载荷为转移到摩擦力中，然后被转移和减轻，因此有利的是避免由于过大的冲击载荷而对随后的驱动装置造成的损害，特别是在保护控制蜗轮（2-12）不受影响的精度方面，从而延长了整个太阳跟踪装置的使用寿命。该装置具有安全性高，承载能力大，自动间隙调整功能。

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