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61. 发明授权

US4814231A Thermoplastic resin-silicone composite shaped article 失效
标题翻译：热塑性树脂 - 硅胶复合成型制品
公开(公告)号：US4814231A
公开(公告)日：1989-03-21
申请号：US917194
申请日：1986-10-09
申请人： Masayuki Onohara , Kenji Kawai , Masaru Shibata , Akira Igarashi , Nobuhisa Kawaguchi
发明人： Masayuki Onohara , Kenji Kawai , Masaru Shibata , Akira Igarashi , Nobuhisa Kawaguchi
IPC分类号： A61L33/06 , B32B27/08 , B32B27/32 , C08J7/04 , B32B15/08 , B32B17/10 , B32B18/00
CPC分类号： C08J7/047 , A61L33/068 , B32B27/08 , B32B27/322 , C08J2483/00 , Y10T428/1334 , Y10T428/1341 , Y10T428/31598 , Y10T428/31663 , Y10T428/31667
摘要： A thermoplastic resin-silicone composite shaped article comprising (a) a shaped article of a thermoplastic resin selected from the group consisting of olefin resins, urethane resins and styrene resins and (b) a cured layer of an addition polymerization type silicone composition adhering to the one or both surfaces of the shaped article of a thermoplastic resin. To the surface of the above shaped article of a thermoplastic resin to which the above cured layer of an addition polymerization type silicone composition does not adhere, there may adhere another cured layer of the above addition polymerization type silicone composition. To either or both of these cured layers, there may further adhere a layer of the above thermoplastic resin, other thermoplastic resin, a silicone rubber, a silicone resin, glass, ceramics or a metal.
摘要翻译：一种热塑性树脂硅酮复合成形制品，其包括（a）选自烯烃树脂，聚氨酯树脂和苯乙烯树脂的热塑性树脂的成型制品和（b）粘附到所述热塑性树脂 - 硅氧烷复合成型制品的加成聚合型硅氧烷组合物的固化层热塑性树脂成形制品的一个或两个表面。在加成聚合型有机硅组合物的上述固化层不附着的热塑性树脂的上述成形体的表面上，可以附着上述加成聚合型有机硅组合物的另一固化层。对于这些固化层中的任一种或两者，还可以粘附上述热塑性树脂，其它热塑性树脂，硅橡胶，硅树脂，玻璃，陶瓷或金属的层。

62. 发明授权

US4778461A Heart valve prosthesis and process for its production 失效
标题翻译：心脏瓣膜假体及其生产过程
公开(公告)号：US4778461A
公开(公告)日：1988-10-18
申请号：US931755
申请日：1986-11-17
申请人： Hanns Pietsch , Holger Kartheus , Hans-Joachim Holtzmann , Gunther Sachau , Helmut Reul
发明人： Hanns Pietsch , Holger Kartheus , Hans-Joachim Holtzmann , Gunther Sachau , Helmut Reul
IPC分类号： A61L26/00 , A61F2/24 , A61L27/02 , A61L27/18 , A61L33/00 , A61L33/06 , B29C41/14 , B29C41/20 , B29C67/24 , B29C70/68
CPC分类号： A61L27/507 , A61F2/2412 , A61L27/02 , A61L27/18 , A61L33/0005 , A61L33/068 , B29C41/14 , B29C41/20 , B29C67/246 , B29C70/68 , B29K2083/005 , Y10S623/90
摘要： A heart valve prosthesis for replacing the aortic valve or the pulmonary valve, consisting of a support ring with at least two commissure supports in each case and flexible cusps, is characterized in that the height of the support ring including the commissure supports is less than the total height of the heart valve prosthesis.
摘要翻译：用于更换主动脉瓣或肺动脉瓣的心脏瓣膜假体，其由在每种情况下具有至少两个连合支撑件的支撑环和柔性尖端组成，其特征在于，包括连合支撑件的支撑环的高度小于心脏瓣膜假体的总高度。

63. 发明授权

US4657542A Medical instrument used for storage of blood 失效
标题翻译：医用仪器用于储存血液
公开(公告)号：US4657542A
公开(公告)日：1987-04-14
申请号：US695052
申请日：1985-01-25
申请人： Yoshinori Ohachi
发明人： Yoshinori Ohachi
IPC分类号： A61L29/00 , A61L33/00 , A61L33/06 , C08K5/12 , A61B19/00
CPC分类号： A61L33/064 , A61L33/0052 , A61L33/0058 , C08K5/12
摘要： A medical instrument is disclosed which is a shaped article of a resin composition comprising 100 parts by weight of a vinyl chloride type resin, 10 to 80 parts by weight of a di-n-alkyl ester of phthalic acid whose alkyl groups each possess 8 to 14 carbon atoms and whose numbers of carbon atoms in said alkyl groups average 9 to 14, and 1 to 18 parts by weight of a stabilizer. The medical instrument exudes only an extremely small amount of plasticizer and excels in permeability to gas.
摘要翻译：公开了一种医疗仪器，其是树脂组合物的成型制品，其包含100重量份的氯乙烯类树脂，10至80重量份的邻苯二甲酸的二正烷基酯，其烷基各自具有8至 14个碳原子，其烷基中的碳原子数平均为9〜14，和1〜18重量份的稳定剂。医疗器械只散发极少量的增塑剂，而且对气体的渗透性优异。

64. 发明授权

US4582762A Soft vinyl chloride resin-silicone composite shaped article 失效
标题翻译：软氯乙烯树脂硅胶复合成型制品
公开(公告)号：US4582762A
公开(公告)日：1986-04-15
申请号：US665978
申请日：1984-10-29
申请人： Masayuki Onohara , Masaru Shibata , Akira Igarashi , Nobuhisa Kawaguchi
发明人： Masayuki Onohara , Masaru Shibata , Akira Igarashi , Nobuhisa Kawaguchi
IPC分类号： B32B27/00 , A61L33/06 , B32B27/08 , B32B27/30 , B32B27/32 , B32B37/00 , C08J7/04 , B32B9/04
CPC分类号： A61L33/068 , B32B27/08 , B32B27/322 , C08J7/047 , C08J2327/06 , C08J2483/04 , Y10S128/21 , Y10S138/07 , Y10T428/1341 , Y10T428/1379 , Y10T428/31511 , Y10T428/3158 , Y10T428/31663 , Y10T428/31667 , Y10T428/3192 , Y10T428/31935
摘要： A soft vinyl chloride resin-silicone composite shaped article consisting of a soft vinyl chloride resin shaped article and a cured layer of an addition polymerization type silicone composition adhered to the surface of the vinyl chloride resin shaped article, wherein said addition polymerization type silicone composition contains an organohydrogenpolysiloxane having at least two hydrogen atoms directly bonding with silicon atoms in each molecule, in an amount enough to provide one to six such hydrogen atoms per one vinyl group of the silicone composition. The above composite shaped article has a very high bonding strength between the vinyl chloride resin shaped article and the cured layer of an addition polymerization type silicone composition.
摘要翻译：一种软氯乙烯树脂硅酮复合成型制品，其由软氯乙烯树脂成型制品和粘附在氯乙烯树脂成形制品表面上的加成聚合型有机硅组合物的固化层组成，其中所述加成聚合型有机硅组合物含具有至少两个氢原子的有机氢聚硅氧烷，其直径与每个分子中的硅原子键合，其量足以为硅氧烷组合物的每个乙烯基提供1至6个这样的氢原子。上述复合成型制品在氯乙烯树脂成形制品和加成聚合型有机硅组合物的固化层之间具有非常高的粘结强度。

65. 发明授权

US4530964A Pharmaceutically active copolymers, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：药物活性共聚物，其制备方法和含有它们的药物组合物
公开(公告)号：US4530964A
公开(公告)日：1985-07-23
申请号：US478468
申请日：1983-03-24
申请人： Raymund Machovich , Miklos Nagy , Judit Gyorgyi nee Edelenyi , Istvan Horvath , Miklos Low , Katalin Csomor , Egon Karpati , Laszlo Szporny , Lajos Kisfaludy
发明人： Raymund Machovich , Miklos Nagy , Judit Gyorgyi nee Edelenyi , Istvan Horvath , Miklos Low , Katalin Csomor , Egon Karpati , Laszlo Szporny , Lajos Kisfaludy
IPC分类号： C08F16/00 , A61K31/78 , A61K31/795 , A61L33/06 , A61P7/02 , C08F8/44 , C08F16/02 , C08F20/00 , C08F216/00 , C08F216/06 , C08F220/00 , C08F220/04 , C08F228/00 , C08F228/02
CPC分类号： C08F228/00 , A61K31/78 , A61K31/795 , A61L33/064 , C08F220/04
摘要： The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation. The new copolymers comprise the units of the formula I ##STR1## wherein X stands for hydrogen or methyl and Y is hydrogen, units of the formula III ##STR2## optionally units of the formula II ##STR3## wherein Z' is hydrogen, and chain terminating units, formed from the units of the formulae I, III and optionally II under the conditions of copolymerization, in a statistical arrangement, and the pharmaceutically acceptable salts thereof, which contain, in addition to the above chain-members, units of the formulae IV and/or V ##STR4## wherein A is a cation/ satisfactorily replace the organogenic heparin, or give a synergistic combination with that,
摘要翻译：本发明涉及具有肝素样活性的新的药物活性共聚物及其药学上可接受的盐及其制备方法。新的共聚物包含式I的单元/ I /其中X代表氢或甲基，Y是氢，式III的单元/ III /任选的式II单元/ IMAGE /其中Z'为氢，以及由式I，III和任选II的单元在统计学排列的共聚条件下形成的链终止单元及其药学上可接受的盐，除了上述链成员，式IV和/或V的单元/ IV / / V /其中A

66. 发明授权

US4464337A Dialysis processing of preserved living cells and cell components 失效
标题翻译：保存活细胞和细胞成分的透析处理
公开(公告)号：US4464337A
公开(公告)日：1984-08-07
申请号：US508017
申请日：1983-06-27
申请人： Allen Zelman
发明人： Allen Zelman
IPC分类号： A01N1/02 , A61J1/00 , A61J1/20 , A61L33/06 , B01J19/00 , A01N1/00 , B01D13/00
CPC分类号： A61J1/20 , A01N1/02 , A01N1/0221 , A61L33/06
摘要： A method and apparatus of processing biological fluids by adding or removing preservatives or simply removing water comprises providing a bag of semi-permeable membrane which contains the biological fluid and bathing the bag with dialysate having controlled osmolality. The preservative or water can thus be removed or added to the bag directly through the semi-permeable membrane by controlling the osmolality of the dialysate without exposing the biological fluid to contaminants. In the case of whole or components of blood, the blood or blood components can be collected in the bag, processed for preservation, and prepared for use then administered, all in the same bag.
摘要翻译：通过添加或除去防腐剂或简单地除去水来处理生物流体的方法和装置包括提供包含生物流体的半透膜袋，并用具有受控重量摩尔渗透压浓度的透析液洗涤该袋。因此可以通过控制透析液的渗透压而不将生物液体暴露于污染物，从而通过半渗透膜将防腐剂或水直接除去或添加到袋中。在血液的全部或成分的情况下，可以将血液或血液成分收集在袋中，加工保存，并准备使用，然后全部在同一袋中。

67. 发明授权

US4394462A Mixtures of polymers for medical use 失效
标题翻译：用于医疗用途的聚合物的混合物
公开(公告)号：US4394462A
公开(公告)日：1983-07-19
申请号：US417323
申请日：1982-09-13
申请人： Christian Pusineri , Jean Goletto
发明人： Christian Pusineri , Jean Goletto
IPC分类号： A61L29/04 , A61L33/00 , A61L33/06 , C08G18/08 , C08L27/06 , C08L75/08 , C08L75/12 , C08J9/14
CPC分类号： C08L27/06 , A61L29/049 , A61L33/0023 , A61L33/062 , C08G18/0814 , C08L75/12 , C08L75/08
摘要： A process for preparing polymers compositions of a mixture of vinyl chloride polymer and polyurethane with tertiary amine and/or ammonium groups.
摘要翻译：一种制备氯乙烯聚合物和聚氨酯与叔胺和/或铵基团的混合物的聚合物组合物的方法。

68. 发明授权

US4379864A Polymeric compositions and hydrogels formed therefrom 失效
公开(公告)号：US4379864A
公开(公告)日：1983-04-12
申请号：US240739
申请日：1981-03-05
申请人： Paul M. Gallop , Donald R. Korb
发明人： Paul M. Gallop , Donald R. Korb
IPC分类号： A01N25/10 , A61K6/083 , A61K9/20 , A61L27/16 , A61L27/52 , A61L33/00 , A61L33/06 , B01D71/40 , B29D11/02 , C08F220/28 , G02B1/04 , C08F220/20
CPC分类号： C08F220/28 , A01N25/10 , A61K6/083 , A61K9/2027 , A61L27/16 , A61L27/52 , A61L33/0064 , A61L33/064 , B01D71/40 , B29D11/02 , G02B1/043
摘要： The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.

69. 发明授权

US4373009A Method of forming a hydrophilic coating on a substrate 失效
标题翻译：在基材上形成亲水涂层的方法
公开(公告)号：US4373009A
公开(公告)日：1983-02-08
申请号：US264957
申请日：1981-05-18
申请人： R. Alastair Winn
发明人： R. Alastair Winn
IPC分类号： A61L15/16 , A61B17/11 , A61F2/00 , A61L17/00 , A61L27/34 , A61L29/00 , A61L29/08 , A61L31/10 , A61L33/00 , A61L33/06 , A61M23/00 , A61M25/00 , B05D20060101 , B05D1/36 , B05D7/02 , B05D7/26 , B32B27/08 , C08G18/62 , C08J20060101 , C08J5/12 , C08J7/04 , C08J7/12 , C09K3/18 , G01N33/544
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0088 , A61L33/064 , A61L33/066 , B05D7/02 , C08G18/6283 , C08J7/047 , C08J7/12 , C09K3/18 , G01N33/544 , C08J2439/00 , Y10T428/31562 , Y10T428/31573 , Y10T428/31576 , Y10T428/3158
摘要： A method of forming a hydrophlic coating on a substrate comprised of applying a hydrophilic copolymer capable of chemically reacting with a coupling agent which will promote adhesion to the substrate. A polyisocyanate coupling agent is applied to the surface from a solvent solution followed by applying the hydrophilic copolymer from solvent solution. In certain instances, the copolymer and isocyanate can be simultaneously applied from a solvent solution. The resulting hydrophilic coating is thrombo resistant, biocompatable and stable.
摘要翻译：在基材上形成亲水涂层的方法，其包括施加能够与促进与基材粘合的偶联剂化学反应的亲水共聚物。将多异氰酸酯偶联剂从溶剂溶液施加到表面，然后从溶剂溶液中涂布亲水性共聚物。在某些情况下，可以从溶剂溶液中同时使用共聚物和异氰酸酯。所得亲水涂层具有抗血栓，生物相容性和稳定性。

70. 发明授权

US4323486A Albumin-fixed resin, production thereof, and therapeutical use thereof 失效
标题翻译：白蛋白固定树脂，其制备及其治疗用途
公开(公告)号：US4323486A
公开(公告)日：1982-04-06
申请号：US205997
申请日：1980-11-12
申请人： Hideaki Suzuki , Gentaro Yamashita
发明人： Hideaki Suzuki , Gentaro Yamashita
IPC分类号： A61L33/00 , A61L33/06 , A61M1/36 , B01D15/08 , B01J20/32 , C08G18/58 , C08G81/00 , C08H1/00 , C08L63/00 , C07G7/00 , C08L89/00 , C09J3/24
CPC分类号： C08G81/00 , A61L33/068 , A61M1/3687 , B01D15/08 , B01J20/262 , B01J20/267 , B01J20/28019 , B01J20/3092 , B01J20/3212 , B01J20/3221 , B01J20/3274 , C08G18/3228 , C08G18/3246 , C08G18/325 , C08G18/58 , C08G18/584 , C08G18/7671 , C08L63/00 , B01J2220/58
摘要： The present invention provides an albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being ionically bound to the amino groups of the epoxy resin and to the hydroxyl groups by hydrogen bonding, and the amount of said albumin fixed being at least about 25% by weight based on the epoxy resin, and also provides a process for producing the albumin-fixed resin, which comprises(1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule and a polyamine compound containing at least two primary and/or secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said compounds to addition reaction to produce an insufficiently crosslinked pre-polymer, and then reacting the pre-polymer with at least one compound selected from the group consisting of organic polyisocyanates, organic polyisothiocyanates and organic polycarboxylic acid halides to crosslink it fully, and(2) contacting the resulting crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof intimately with an aqueous solution containing albumin optionally after partially neutralizing the amino groups of the epoxy resin.The albumin-fixed resin is useful for removing albumin-binding noxious substances such as bilirubin contained in the blood of a warm-blooded animal.
摘要翻译：本发明提供一种白蛋白固定树脂，其包含交联的水不溶性树脂和化学键合的白蛋白，所述水不溶性树脂是交联的环氧树脂，其含有约1至约30毫当量的氨基和约1至约50毫当量的羟基，其中所述白蛋白通过氢键键合到环氧树脂的氨基和羟基上，并且所述白蛋白的量相对于环氧树脂为至少约25重量％，和还提供了生产白蛋白固定树脂的方法，其包括（1）（a）在分子中使含有至少两个环氧基的多环氧化合物和包含至少两个伯和/或仲氨基的多胺化合物在在惰性介质中进行加成反应以产生完全交联的树脂，或（b）使所述化合物进行加成反应以产生不充分的交联预聚物，然后使预聚物与选自有机多异氰酸酯，有机多异氰酸酯和有机多羧酸卤化物中的至少一种化合物反应以使其完全交联，和（2）使所得到的交联环氧树脂 1至约30毫当量的氨基和约1至约50毫克的羟基/克，与含有白蛋白的水溶液密切相关，任选地在部分中和环氧树脂的氨基之后。白蛋白固定树脂可用于除去白血病结合的有毒物质如温血动物血液中所含的胆红素。

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