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1. 发明授权

US4306556A Method and apparatus for storing and preparing cryopreserved blood 失效
标题翻译：储存和制备冷冻保存血液的方法和装置
公开(公告)号：US4306556A
公开(公告)日：1981-12-22
申请号：US119423
申请日：1980-02-07
申请人： Allen Zelman
发明人： Allen Zelman
IPC分类号： A01N1/02 , A61J1/00 , A61J1/20 , A61L33/06
CPC分类号： A61J1/20 , A01N1/02 , A01N1/0263 , A01N1/0268 , A61L33/06
摘要： A bag for containing blood or blood components comprising a closed container made of material which is permeable to a cryoprotective agent, such as glycerol, which may be added to the blood or blood components directly through the permeable walls of the blood bag. The cryoprotective agent protects the blood or blood components when the blood is frozen for storage and the cryoprotective agent can thereafter be removed through the permeable walls of the container without contaminating the blood therein. An apparatus and process is also disclosed for the cryoprotective agent to be added or removed from the blood bag using electric current, hydrostatic pressure, centrifugal force or osmosis.
摘要翻译：一种用于容纳血液或血液成分的袋子，包括由可冷冻保护剂（例如甘油）渗透的材料制成的密封容器，其可以通过血袋的可渗透壁直接加入到血液或血液成分中。当冷冻保存血液时，冷冻保护剂保护血液或血液成分，然后可以通过容器的可渗透壁将冷冻保护剂除去，而不会污染血液。还公开了使用电流，静水压力，离心力或渗透从血袋中加入或除去的冷冻保护剂的装置和方法。

2. 发明授权

US4920105A Membrane pouch 失效
标题翻译：膜袋
公开(公告)号：US4920105A
公开(公告)日：1990-04-24
申请号：US71666
申请日：1987-07-09
申请人： Allen Zelman
发明人： Allen Zelman
IPC分类号： A61J1/00 , A61J1/10 , A61J1/20 , A61J3/00 , A61L2/00 , A61L2/08 , B01D61/00 , C02F1/68
CPC分类号： A61J1/20 , A61J3/00 , A61L2/0035 , A61L2/08 , B01D61/002 , B01D61/005 , C02F1/688 , C02F1/445
摘要： A membrane pouch, for rehydrating sterile intravenous and other solutions for non-sterilized fresh water, has a double bag construction. An inner bag made of semipermeable membrane material holds the sterile solutes to be rehydrated. The membrane material is permeable by water but impermeable to contaminants and a large molecular weight solute contained in the bag. An outer waterproof bag encloses the membrane bag and serves as a container for fresh water. Each bag has a sealable valve for providing access to the interior thereof. A high molecular weight dye located in the outer bag provides a visible indication of the existence of any discontinuity in the membrane bag. A low molecular weight, water soluble, non-toxic substance having a high osmotic pressure can be placed inside the membrane bag to accelerate the osmotic transfer of sterile water from the outer bag into the inner membrane bag.
摘要翻译：用于再次水化无菌静脉内和其他非灭菌淡水溶液的膜袋具有双袋结构。由半透膜制成的内袋保持无菌溶质再水化。膜材料可透过水，但对污染物不透气，袋子中所含的大分子量溶质。外部防水袋围绕膜袋，用作淡水容器。每个袋子都具有可密封的阀门，用于提供对其内部的通路。位于外袋中的高分子量染料提供膜袋中存在任何不连续性的可见指示。具有高渗透压力的低分子量水溶性无毒物质可以放置在膜袋的内部，以加速无菌水从外袋向内膜袋的渗透转移。

3. 发明授权

US4464337A Dialysis processing of preserved living cells and cell components 失效
标题翻译：保存活细胞和细胞成分的透析处理
公开(公告)号：US4464337A
公开(公告)日：1984-08-07
申请号：US508017
申请日：1983-06-27
申请人： Allen Zelman
发明人： Allen Zelman
IPC分类号： A01N1/02 , A61J1/00 , A61J1/20 , A61L33/06 , B01J19/00 , A01N1/00 , B01D13/00
CPC分类号： A61J1/20 , A01N1/02 , A01N1/0221 , A61L33/06
摘要： A method and apparatus of processing biological fluids by adding or removing preservatives or simply removing water comprises providing a bag of semi-permeable membrane which contains the biological fluid and bathing the bag with dialysate having controlled osmolality. The preservative or water can thus be removed or added to the bag directly through the semi-permeable membrane by controlling the osmolality of the dialysate without exposing the biological fluid to contaminants. In the case of whole or components of blood, the blood or blood components can be collected in the bag, processed for preservation, and prepared for use then administered, all in the same bag.
摘要翻译：通过添加或除去防腐剂或简单地除去水来处理生物流体的方法和装置包括提供包含生物流体的半透膜袋，并用具有受控重量摩尔渗透压浓度的透析液洗涤该袋。因此可以通过控制透析液的渗透压而不将生物液体暴露于污染物，从而通过半渗透膜将防腐剂或水直接除去或添加到袋中。在血液的全部或成分的情况下，可以将血液或血液成分收集在袋中，加工保存，并准备使用，然后全部在同一袋中。

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