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    • 63. 发明授权
    • Polyhydric alcohol stabilized antiperspirant salt solutions
    • 多元醇稳定止汗剂盐溶液
    • US6010688A
    • 2000-01-04
    • US881237
    • 1997-06-25
    • Yan-Fei Shen
    • Yan-Fei Shen
    • A61K8/26A61K8/28A61K8/34A61K8/44A61Q15/00C01F7/48C01F7/56C01F7/64C01F7/66A61K7/34
    • C01F7/66A61K8/26A61K8/28A61K8/34A61K8/345A61K8/44A61Q15/00C01F7/48C01F7/56
    • The present invention relates to methods of making enhanced efficacy antiperspirant salts and particularly stabilized aqueous polyhydric alcohol solutions of such salts. One such method involves stabilizing an aqueous solution of an enhanced efficacy antiperspirant salt by adding an effective amount of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups. A second disclosed method involves preparing an enhanced efficacy aluminum antiperspirant salt by heating an aqueous solution of an aluminum antiperspirant salt in the presence of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups at a temperature of at least 50.degree. C. for a time sufficient to convert the salt to an enhanced salt. A third disclosed method is an improvement in the method of making an aluminum hydroxy halide or an aluminum hydroxy nitrate by reacting aluminum with an aqueous solution of aluminum halide or aluminum nitrate (or with aqueous hydrogen halide or nitric acid), wherein the improvement comprises including a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups in the reaction mixture. Also disclosed are compositions produced by the foregoing methods.
    • 本发明涉及制备增强功效的止汗剂盐和特别稳定的这类盐的多元醇水溶液的方法。 一种这样的方法包括通过加入有效量的具有3至6个碳原子和3至6个羟基的多元醇来稳定增强的功效止汗剂盐的水溶液。 第二个所公开的方法包括通过在至少50℃的温度下,在具有3至6个碳原子的多元醇和3至6个羟基的存在下加热铝止汗剂盐水溶液来制备增强的功效性的铝止汗剂盐 在足够的时间将盐转化成增强的盐。 第三个公开的方法是通过使铝与卤化铝或硝酸铝(或卤化氢或硝酸水溶液)的水溶液反应制备铝羟基卤化物或羟基硝酸铝的方法的改进,其中改进包括 在反应混合物中具有3至6个碳原子和3至6个羟基的多元醇。 还公开了通过上述方法制备的组合物。
    • 66. 发明授权
    • Methods for preparing basic aluminum compounds with ultrasound
    • 用超声波制备碱性铝化合物的方法
    • US5254230A
    • 1993-10-19
    • US916299
    • 1992-07-17
    • Vijay K. JoshiJawahar C. Parekh
    • Vijay K. JoshiJawahar C. Parekh
    • C01F7/00C01F7/48C01F7/56C01F7/66C01F7/68C01F11/36C01F11/46C01F11/48C01B7/00
    • C01F7/56C01F7/48C01F7/66C01F7/68
    • Processes are provided for preparing basic aluminum compounds of Formula I:Al.sub.2 (OH).sub.6-a X.sub.a (I)wherein X is Cl.sup.-, Br.sup.-, F.sup.-, I.sup.-, SO.sub.4.sup.= or NO.sub.3.sup.- and a is about 0.9 to 4, the compound being characterized by size exclusion chromatography as having a Band I percent aluminum value of about 5% or less and a Band II percent aluminum value of about 50% to 90%, which comprise (a) suspending an aluminum metal in an aqueous medium to form a slurry, (b) applying ultrasonic energy to the slurry, (c) reacting the sonicated slurry with an aluminum compound of Formula IIAl.sub.n X.sub.m (II)or an acid of Formula III:H.sub.n X (III)wherein X is Cl.sup.-, Br.sup.-, F.sup.-, I.sup.-, SO.sub.4.sup.= or NO.sub.3.sup.-, n is 1 or 2 and m is 3, at a temperature of about 45.degree. C. to 100.degree. C. to form a reaction product.
    • 提供制备式I的碱性铝化合物的方法:其中X是Cl - ,Br-,F-,I-,SO 4 =或NO 3 - 的Al 2(OH)6-a X a(I),a是约0.9-4, 该化合物的特征在于尺寸排阻色谱法,其具有约5%或更低的I级铝值,并且具有约50%至90%的Band II%铝值,其包含(a)将铝金属悬浮在水性介质 (b)向浆料中施加超声能量,(c)将超声处理的浆料与式IIAlnXm(II)的铝化合物或式III的酸:其中X是Cl-的HnX(III)反应, Br-,F-,I-,SO4 =或NO3-,n为1或2,m为3,在约45℃至100℃的温度下反应形成反应产物。